CN115137656A - Mild skin-brightening composition and application thereof - Google Patents
Mild skin-brightening composition and application thereof Download PDFInfo
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- CN115137656A CN115137656A CN202211022721.3A CN202211022721A CN115137656A CN 115137656 A CN115137656 A CN 115137656A CN 202211022721 A CN202211022721 A CN 202211022721A CN 115137656 A CN115137656 A CN 115137656A
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
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Abstract
The invention discloses a mild skin brightening composition and application thereof, comprising an acid skin brightening agent and a skin conditioning agent, wherein the content of the acid skin brightening agent is 30-50wt%, and the content of the skin conditioning agent is 0.05-1 wt%. The composition disclosed by the invention can improve the brightness and smoothness of the facial skin, can well reduce the damage of the acid skin brightening agent to the skin barrier, can improve or solve the problems of skin redness and itching caused by the use of the acid skin brightening agent, and has a relatively high practical value.
Description
Technical Field
The invention relates to a skin brightening composition, in particular to a mild skin brightening composition with small skin irritation and an application thereof, and belongs to the technical field of skin care products.
Background
Due to the popularization of scientific knowledge and the improvement of health consciousness, more and more people can help the cuticle which is not timely fallen off in the skin to be stripped through tartaric acid substances, so that the renewal of skin tissues is accelerated, and the skin is enabled to be smooth, bright and fine. However, as this application is becoming more common, the following skin problems, such as the damage of skin barrier function after the peeling of the stratum corneum and even the skin becomes reddish and itchy and sensitive skin is formed, have been revealed, and these adverse problems affect the application of the fruit acid substances in the field of beauty and skin care.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides a mild skin brightening composition, the active ingredients of the composition simultaneously contain an acid skin brightening agent and a specific skin conditioner, and the experiment shows that the adverse effects of the acid skin brightening agent and the specific skin conditioner on the skin are greatly reduced after the acid skin brightening agent and the specific skin conditioner are matched and used, the skin brightening and whitening effects are good, and the good balance between the skin brightening and the adverse stimulation of the skin is realized.
The specific technical scheme of the invention is as follows:
a mild skin lightening composition comprising an acid skin lightening agent in an amount of 30 to 50wt%, e.g. 30wt%, 35wt%, 40wt%, 45wt%, 48wt%, 50wt% and a skin conditioning agent in an amount of 0.05 to 1wt%, e.g. 0.05wt%, 0.08wt%, 0.1wt%, 0.2wt%, 0.3wt%, 0.4wt%, 0.5wt%, 0.6wt%, 0.7wt%, 0.8wt%, 0.9wt%, 1.0wt%.
Furthermore, the acid skin brightening agent is one or more of glycolic acid, lactic acid and salicylic acid, and can be used for metabolizing cells, reducing the coagulation force among epidermal corneocytes, reducing the thickness of stratum corneum and improving the state of rough and dark skin.
Further, the acid skin-lightening agent is preferably a mixture of glycolic acid, lactic acid and salicylic acid. The glycolic acid has small molecular weight and quick penetration, can quickly open skin channels, promote the aged cutin to peel off, and make the skin smooth and fine; the lactic acid has strong hydration, can keep a skin moist environment when the cutin is stripped, and reduces the damage to the skin; the salicylic acid has good antibacterial effect, can balance the secretion of skin oil and reduce the occurrence of comedo and acne. When the glycolic acid and the lactic acid are independently used as the skin brightening agent, the glycolic acid has a good skin brightening effect but can damage the skin to a certain extent, the lactic acid has low irritation to the skin but has a poor skin brightening effect, and the salicylic acid is generally used as an acne removing or oil controlling agent in skin care products. However, in the invention, the three acids can act synergistically under a specific proportion to make the skin bright and smooth, and the skin brightening effect is better than that of the skin brightening effect caused by using one kind of fruit acid alone.
Preferably, the mass ratio of the glycolic acid to the lactic acid to the salicylic acid is 7-10 to 1-3:1, more preferably 8.75:2.25:1. The preferred combination of acid skin lightening agents in combination with skin conditioning agents provides superior results in both skin lightening and skin barrier maintenance.
Furthermore, the skin conditioner is at least one of tremella polysaccharide, sodium hyaluronate cross-linked polymer and rhamnose, can adjust the overall state of the skin, improve the skin resistance and maintain the skin barrier to be undamaged, and is preferably a mixture of the sodium hyaluronate cross-linked polymer and the tremella polysaccharide. In addition, the sodium hyaluronate cross-linked polymer also has the effect of well maintaining the stability of a system, and the composition containing the sodium hyaluronate cross-linked polymer has stronger stability.
Further, the sodium hyaluronate cross-linked polymer used in the present invention has the following requirements: the dynamic viscosity is 70 to 100 mPas.
Further, the mass ratio of the sodium hyaluronate cross-linked polymer to the tremella polysaccharide is 2-5:1.
Further, the content of the acid skin-lightening agent is preferably 35-48wt%, and the content of the skin conditioning agent is preferably 0.1-0.5wt%.
Further, the mild skin lightening compositions of the present invention include, in addition to the acid skin lightening agents and skin conditioning agents described above, a polyol, a thickener, and water. The polyhydric alcohol may be one or more of propylene glycol, glycerol, butylene glycol and sorbitol, and is preferably propylene glycol. The thickener is one or more of xanthan gum, hydroxyethyl cellulose, gum arabic and carboxymethyl cellulose, preferably hydroxyethyl cellulose.
Further, the content of the polyhydric alcohol is 5-15wt%, the content of the thickening agent is 1-3wt%, and the content of the water is complemented to 100wt%.
Further, the invention also provides a preparation method of the mild skin-brightening composition, which comprises the following steps:
(1) Uniformly mixing a thickening agent and polyhydric alcohol to obtain a mixture;
(2) Adding water to the mixture, heating to 40-60 ℃ while stirring, adding a skin conditioner, and stirring at the temperature until a uniform solution is obtained;
(3) Cooling after the solution is completely dissolved, and adding the acid skin brightening agent to obtain the mild skin brightening composition.
Further, in the step (3), the solution is cooled to 25-30 ℃ and then the acid skin brightening agent is added.
Further, the mild skin brightening composition provided by the invention has excellent skin brightening and smoothing effects, and the problems of skin barrier damage, skin redness or itching and other skin sensitivity can be greatly reduced or even avoided when the content of the acid skin brightening agent is less than 50%. Meanwhile, by the synergistic collocation of all the components, the system stability of the composition is higher, and the problems of color change, layering or precipitation and the like can not occur after long-term storage.
The invention has the following beneficial effects:
1. the acid skin brightening agent and the skin conditioner are used in combination, so that the skin brightening agent has the effects of brightening and smoothing the skin, can reduce or avoid the damage to the skin caused by frequent use of the acid skin brightening agent, enhances the barrier function of the skin, and reduces or even avoids the skin sensitivity problems such as reddening or pruritus of the skin.
2. The present invention prefers both acid skin lightening agents and skin conditioning agents, with the preferred acid skin lightening agents and skin conditioning agents achieving an optimal balance between skin lightening and skin damage.
3. The skin conditioner is preferably sodium hyaluronate cross-linked polymer and tremella polysaccharide, and when the skin conditioner is selected from the sodium hyaluronate cross-linked polymer and the tremella polysaccharide, the skin brightening effect is optimal, the adverse effect of the composition on skin is minimal, the composition has good stability, the problems of color change, layering or precipitation and the like can not occur in long-term storage, and the quality guarantee period of the product is prolonged.
4. The composition disclosed by the invention can improve the brightness and smoothness of the facial skin, can avoid the serious damage of the barrier function of the skin, avoids or improves the problems of skin redness and itching caused by frequent use of an acid skin brightening agent, and has a great practical value.
Drawings
FIG. 1 is a graph showing the change in skin roughness before and after the use of the sample of example 1.
Fig. 2 is a graph showing the change in skin whiteness before and after use of the sample of example 1.
Detailed Description
The present application is further described below in conjunction with the following examples, which are included merely to further illustrate and explain the present application and are not intended to limit the present application.
Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although methods and materials similar or equivalent to those described herein can be used in the practice or experimental applications, the materials and methods are described below. In case of conflict, the present specification, including definitions, will control, and the materials, methods, and examples are illustrative only and not intended to be limiting. The present application is further described with reference to the following specific examples, which should not be construed as limiting the scope of the present application.
In the examples described below, the sodium hyaluronate cross-linked polymer used was obtained from Huaxi Biotech Co., ltd and had a dynamic viscosity of 70 to 100 mPas.
Example 1
A composition having the formulation shown in table 1 below, consisting of: 35g of glycolic acid, 9g of lactic acid, 4g of salicylic acid, 0.15g of sodium hyaluronate cross-linked polymer, 0.05g of tremella polysaccharide, 10g of propylene glycol, 1.5g of hydroxyethyl cellulose and the balance of purified water to 100g.
The preparation method comprises the following steps: uniformly mixing a thickening agent (hydroxyethyl cellulose) and polyalcohol (propylene glycol); adding water into the mixture, heating to 40-60 deg.C, adding skin conditioner (sodium hyaluronate cross-linked polymer, tremella polysaccharide), dissolving completely, cooling to 25-30 deg.C, adding acid skin-brightening agent (glycolic acid, lactic acid, salicylic acid), and stirring to dissolve completely to obtain the composition.
Examples and comparative examples
The components and amounts of the thickener, polyol, skin conditioner, acid skin lightening agent in the composition were varied according to the formulation of table 1 below, and then different compositions were prepared according to the method of example 1.
TABLE 1
Verification example 1
1. Skin barrier function test
1.1 volunteer recruitment
Effective volunteers 30.
1.2 volunteer requirements
The skin is healthy when the people are between 25 and 45 years old. The following should be excluded:
a) Those who have undergone cosmetic surgery or other cosmetic modalities that may affect skin test criteria in approximately three months;
b) The tested part is applied with any external medicine within nearly two months;
c) Those who use antihistamines for nearly one week or immunosuppressants for nearly one month;
d) Patients with clinically unhealed inflammatory dermatoses;
e) Insulin-dependent diabetic patients;
f) Patients suffering from asthma or other chronic respiratory diseases undergoing therapy;
g) Those who receive anti-cancer chemotherapy in approximately six months;
h) Patients with immunodeficiency or autoimmune disease;
i) Lactating or pregnant women;
j) Bilateral mastectomy and bilateral underarm lymph node resection;
k) The judgment that the test result is influenced by scars, pigments, atrophy, port wine stains or other flaws in the skin area to be measured;
l) participating in other clinical trial investigators;
m) those with high constitutional sensitivity;
n) non-volunteer participants or those who cannot complete the prescribed content as required by the trial.
1.3 preparation before testing
The subjects before the experiment needed to uniformly clean the forearm flexor test area with facial tissue, sit still in the test environment for 20 minutes, and then mark 3cm x 3cm test areas on the left and right forearm Qu Cefen, each 1cm apart. The initial value of the transdermal water dispersion loss of the test area was measured with a transdermal water dispersion tester TM300 (Courage + Khazaka, germany).
1.4 testing
The test areas were coated with the example and comparative samples in a single pass, each area being coated at 0.5g,2.5 minutes later wiped clean with facial tissue and rinsed clean with warm water, wiped dry and leaving the test site exposed, 2 hours after test use. The test of the same subject must be done by the same instrument and the same tester.
2. Stratum corneum exfoliation test
2.1 volunteer recruitment
The requirements for recruitment of volunteers and preparation prior to testing are given in 1.1,1.2,1.3.
2.2 test methods
Before the experiment, the testee needs to uniformly clean the test areas on the bent sides of the left and right front arms by using facial tissues, sit still in the test environment for 20 minutes after wiping, and then mark test areas of 3cm multiplied by 3cm on the bent sides of the left and right front arms, wherein each test area is separated by 1cm. The examples and comparative samples were then applied in a single pass to the test area, wiped clean after 20 minutes, and dried with a dry tissue after rinsing with warm water. The test area was tested for the percentage of keratinocyte exfoliation 2 hours after drying using a skin microscope PC35 (Courage + Khazaka, germany).
2.3 analysis of results
Keratinocyte exfoliation rate = percentage of area of exfoliated keratinocytes in the selected area.
3. Results of the experiment
3.1 skin Barrier function test results
Transdermal water dispersion loss (TEWL) is an important indicator of skin barrier function, with lower TEWL values indicating better skin barrier function.
TABLE 2 Effect of examples and comparative examples on transdermal moisture loss
| Sample(s) | TEWL(g/cm 2 ·h) |
| Example 1 | 13.46±2 |
| Example 2 | 15.75±3 |
| Example 3 | 15.31±3 |
| Example 4 | 14.22±2 |
| Example 5 | 15.32±3 |
| Example 6 | 14.80±2 |
| Example 7 | 14.40±3 |
| Example 8 | 14.62±3 |
| Example 9 | 15.01±2 |
| Example 10 | 16.51±3 |
| Example 11 | 16.10±3 |
| Example 12 | 15.87±2 |
| Example 13 | 15.01±3 |
| Example 14 | 15.01±3 |
| Example 15 | 13.98±2 |
| Example 16 | 13.70±1 |
| Comparative example 1 | 16.99±3 |
| Comparative example 2 | 16.40±3 |
| Comparative example 3 | 18.91±4 |
| Comparative example 4 | 18.01±3 |
| Comparative example 5 | 17.57±3 |
| Comparative example 6 | 17.64±4 |
| Comparative example 7 | 18.43±3 |
| Comparative example 8 | 12.98±3 |
As can be seen from Table 2, the samples of each example are uniform with a lower amount of transdermal water loss, and the combined use of the acid skin lightening agents of the present invention and the skin conditioning agents has a better skin barrier protecting function as seen from the comparison of example 1 and comparative examples 1-7.
3.2 stratum corneum exfoliation test
The stratum corneum of human skin is exemplified by the forearm, and every square centimeter of epidermis is stripped of 1300 stratum corneum cells per hour, and the outer layer of the stratum corneum that is stripped is also called the parting layer. The stratum corneum is the outermost layer of the epidermis and is composed of dead, anucleated keratinocytes. These anuclear keratinocyte layers contain many melanin granules that are transported by melanocytes. After the samples of examples and comparative examples were used, the dead keratinocytes were exfoliated, and the amount of keratinocytes that could be exfoliated was measured, indicating the degree of exfoliation of the stratum corneum by the samples.
TABLE 3 Effect of examples and comparative examples on exfoliation of stratum corneum
As can be seen from table 3, the samples of examples have significantly better peeling effects on the stratum corneum than the samples of comparative examples (except comparative example 7), with the sample of example 1 having the best peeling effect on the stratum corneum.
Verification example 2 verification of human efficacy
1. Volunteer recruitment
Effective volunteers 30.
2. Requirements of volunteers
The skin is dark when the people are 25-55 years old. The following should be excluded:
a) Those who have undergone cosmetic surgery or other cosmetic modalities that may affect skin test criteria within approximately three months;
b) The tested part is applied with any external medicine within nearly two months;
c) Those who use antihistamines for nearly one week or immunosuppressants for nearly one month;
d) Patients with clinically unhealed inflammatory dermatoses;
e) Insulin dependent diabetes mellitus patients;
f) Patients suffering from asthma or other chronic respiratory diseases undergoing therapy;
g) Those who receive anti-cancer chemotherapy in approximately six months;
h) Patients with immunodeficiency or autoimmune disease;
i) Lactating or pregnant women;
j) Bilateral mastectomy and bilateral underarm lymph node resection;
k) The judger of the test result is influenced by scars, pigments, atrophy, port wine stains or other flaws in the skin area to be measured;
l) participating in other clinical trial investigators;
m) those with high constitutional sensitivity;
n) non-volunteer participants or those who cannot complete the prescribed content as required by the trial.
3. Preparation before testing
Subjects required a uniform cleansing of their faces with the cleanser before the experiment, a 20 minute sitting still in the test environment after drying with a dry facial tissue, and then taking left and right half-face photographs with the VISIA CR facial image analysis system (Canfield, usa).
4. Testing of
The sample of example 1 was applied to the whole face for 2.5 minutes, then wiped dry with a facial tissue and rinsed with warm water to leave the face exposed, and the value 2 hours after use was tested. The test of the same subject must be done by the same tester and the same instrument.
5. Analysis of results
The photos were processed with IPP software.
Percent (%) pore area = average percent pore area
Skin roughness = SD value mean
Skin whiteness ITA = { arc character [ (L x-50)/b x ] } 180/pi, where L values represent luminance coordinates and b values represent chromaticity coordinates.
6. Results of the experiment
6.1 Effect on pores
Table 4 example 1 the sample had a significant reduction in pore area after use compared to before use.
| Sample (I) | Percentage of pore area |
| Before use | 8.92±3 |
| Example 1 after use | 6.43±3* |
6.2 Effect on skin roughness
Table 5 example 1 the samples had significantly reduced skin roughness after use compared to before use.
| Sample(s) | SD value (. Mu.m) |
| Before use | 13.43±4 |
| Example 1 after use | 10.46±3* |
6.3 Effect on skin whiteness
Table 6 example 1 the samples had a significant increase in skin whiteness after use compared to before use.
| Sample (I) | ITA value |
| Before use | 67.79±3 |
| Example 1 after use | 69.86±4* |
Verification example 3 verification of composition stability
Each of the compositions of examples and comparative examples was placed in a 60 ℃ stability test chamber, and the number of days when the appearance of the composition was changed was observed. The appearance change comprises discoloration, delamination or precipitation and the like. The longer the number of days the appearance changed, the better the stability of the composition.
The results of the experiment are shown in table 7 below.
TABLE 7
| Sample (I) | Days at 60 ℃ at which appearance changes |
| Example 1 | 28 days |
| Example 2 | 21 days |
| Example 3 | 27 days |
| Example 4 | 27 days |
| Example 5 | 26 days |
| Example 6 | 28 days |
| Example 7 | 28 days |
| Example 8 | 28 days |
| Example 9 | 27 days |
| Example 10 | 27 days |
| Example 11 | 27 days |
| Example 12 | 24 days |
| Example 13 | 25 days |
| Example 14 | 27 days |
| Example 15 | 27 days |
| Example 16 | 27 days |
| Comparative example 1 | 20 days |
| Comparative example 2 | 20 days |
| Comparative example 3 | 15 days |
| Comparative example 4 | 15 days |
| Comparative example 5 | 15 days |
| Comparative example 6 | 15 days |
| Comparative example 7 | 15 days |
| Comparative example 8 | - -No change during the observation period |
Claims (10)
1. A mild skin lightening composition characterized by: comprises acid skin brightening agent and skin conditioning agent, wherein the content of the acid skin brightening agent is 30-50wt%, and the content of the skin conditioning agent is 0.05-1 wt%.
2. The mild skin lightening composition according to claim 1, wherein: the acid skin-brightening agent is one or more of glycolic acid, lactic acid and salicylic acid.
3. The mild skin lightening composition according to claim 2, characterized in that: the acid skin brightening agent is a mixture of glycolic acid, lactic acid and salicylic acid, the mass ratio of the glycolic acid to the lactic acid to the salicylic acid is 7-10: 2.25:1.
4. The mild skin lightening composition according to claim 1, characterized by: the skin conditioner is at least one of tremella polysaccharide, sodium hyaluronate cross-linked polymer and rhamnose, and is preferably a mixture of the sodium hyaluronate cross-linked polymer and the tremella polysaccharide.
5. The mild skin lightening composition according to claim 1, characterized by: the mass ratio of the sodium hyaluronate cross-linked polymer to the tremella polysaccharide is 2-5:1.
6. The mild skin lightening composition according to claim 1, characterized by: the dynamic viscosity of the sodium hyaluronate cross-linked polymer is 70 to 100mPas.
7. A mild skin lightening composition according to any one of claims 1 to 6, characterized in that: the content of acid skin-brightening agent is 35-48wt%, and the content of skin conditioning agent is 0.1-0.5wt%.
8. A mild skin lightening composition according to any one of claims 1 to 6, characterized in that: also comprises polyol, thickener and water, wherein the content of the polyol is 5-15wt%, the content of the thickener is 1-3wt%, and the content of the water is up to 100wt%.
9. The mild skin lightening composition according to claim 8, wherein: the polyalcohol is one or more of propylene glycol, glycerol, butanediol and sorbitol, and the thickener is one or more of xanthan gum, hydroxyethyl cellulose, acacia gum and carboxymethyl cellulose.
10. Use of the mild skin lightening composition of claim 1 in the preparation of a skin care product.
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Citations (6)
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|---|---|---|---|---|
| JP2005281133A (en) * | 2004-03-26 | 2005-10-13 | Shiseido Co Ltd | Skin care preparation for external use |
| CN110236980A (en) * | 2019-06-27 | 2019-09-17 | 福建师范大学 | A kind of moisturizer and preparation method and application containing tremella polysaccharides |
| CN110693757A (en) * | 2019-11-22 | 2020-01-17 | 广州环亚化妆品科技有限公司 | Hydroxy acid-containing composition, and preparation method and application thereof |
| CN111514073A (en) * | 2020-06-02 | 2020-08-11 | 华熙生物科技股份有限公司 | Composition for repairing skin barrier and improving sun protection index, preparation method and application thereof |
| CN112618400A (en) * | 2021-01-29 | 2021-04-09 | 山东华熙海御生物医药有限公司 | Composition for improving skin color and whitening cosmetic |
| CN113332160A (en) * | 2021-07-22 | 2021-09-03 | 杭州彼心生物科技有限公司 | Cosmetic composition for conditioning peritrichotic skin |
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005281133A (en) * | 2004-03-26 | 2005-10-13 | Shiseido Co Ltd | Skin care preparation for external use |
| CN110236980A (en) * | 2019-06-27 | 2019-09-17 | 福建师范大学 | A kind of moisturizer and preparation method and application containing tremella polysaccharides |
| CN110693757A (en) * | 2019-11-22 | 2020-01-17 | 广州环亚化妆品科技有限公司 | Hydroxy acid-containing composition, and preparation method and application thereof |
| CN111514073A (en) * | 2020-06-02 | 2020-08-11 | 华熙生物科技股份有限公司 | Composition for repairing skin barrier and improving sun protection index, preparation method and application thereof |
| CN112618400A (en) * | 2021-01-29 | 2021-04-09 | 山东华熙海御生物医药有限公司 | Composition for improving skin color and whitening cosmetic |
| CN113332160A (en) * | 2021-07-22 | 2021-09-03 | 杭州彼心生物科技有限公司 | Cosmetic composition for conditioning peritrichotic skin |
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