CN114869905B

CN114869905B - Whitening scar-removing liquid skin and preparation method and application thereof

Info

Publication number: CN114869905B
Application number: CN202210355985.4A
Authority: CN
Inventors: 卢智慧; 刘琦
Original assignee: Huangpu Institute of Materials
Current assignee: Huangpu Institute of Materials
Priority date: 2022-04-06
Filing date: 2022-04-06
Publication date: 2023-03-24
Anticipated expiration: 2042-04-06
Also published as: CN114869905A

Abstract

The invention relates to a whitening scar-removing liquid skin and a preparation method and application thereof. The whitening scar-removing liquid skin comprises the following components in percentage by mass: 5 to 20 percent of film forming agent, 0.1 to 5 percent of antioxidant, 10 to 50 percent of silicone, 0.1 to 5 percent of penetration enhancer, 2 to 10 percent of exfoliating component, 1 to 10 percent of emulsifier, 0.5 to 5 percent of gel matrix and 10 to 81.3 percent of water; the antioxidant is one or more of sodium erythorbate, ascorbyl palmitate, carotenoid, propyl gallate, butyl hydroxy anisol, grape seed extract, tetrahexyldecyl ascorbate, alpha-tocopherol and alpha-tocopherol acetate; the exfoliating component is one or more of glycolic acid, alpha-hydroxy acid and L-malic acid. The whitening and scar-removing liquid has good skin permeability, strong whitening and moisturizing effects, good scar-removing effect and quick curative effect.

Description

Whitening scar-removing liquid skin and preparation method and application thereof

Technical Field

The invention relates to the technical field of scar removing gel, in particular to whitening scar removing liquid skin and a preparation method and application thereof.

Background

When skin tissues of a human body are seriously injured by burning, scalding, surgical cutting and other physical or biochemical injuries, if the skin tissues cannot be completely and normally repaired by self, the formed wound surface is lack of physiological regulation and control in the healing process, so that fibroblasts excessively grow, collagen in extracellular matrix excessively deposits to form a proliferation scar, and simultaneously, the pigmentation at the scar is caused along with the injury of time and ultraviolet rays, so that the beauty of a patient is influenced, the psychological negative shadow of the patient is seriously caused, and the physiological dysfunction of the skin is seriously caused.

Silicone gel is a globally-used scar treatment product, and the silicone gel is applied to the skin of an affected part and can be quickly dried to form a hydrophobic and breathable film, so that the moisture volatilization of the skin of the affected part is reduced, the hydration of scar tissues is promoted, the collagen hyperplasia is inhibited, and the necrotic cells are assisted to be separated. The existing product components for treating or fading scars on the market have good effect on treating new scars, but have limited curative effect on some old scars and cannot effectively aim at and decompose melanin deposited on the scars of the skin scald. Particularly for some oily skin patients, the cuticle of the skin is thick, and the sebaceous glands have vigorous secretion function and are easy to produce oil, so that the effect of the silicone oil product is not obvious.

At present, a medical silicone gel dressing patch is reported, which consists of unique structural layers and dressing components, the gel consists of high-molecular dimethyl silicone, a medical emulsifier and a hydrogel matrix, and the dressing has single component and relatively common scar removing effect. Or a silicone gel wound dressing, which is mainly composed of high-viscosity silicone oil, volatile silicone oil and fumed silica, has slow scar removing effect, strong greasy feeling after use and is not easy to dry. Or a medical scar repairing silicone gel dressing which consists of polydimethylsiloxane, an emulsifier, a gel matrix, a scar fading factor, a deodorant, a bacteriostatic agent, an antipruritic agent, an anti-contracture medicament, a penetration enhancer, a buffer solution system and purified water, but because of the existence of a skin barrier, the penetration effect of the components such as the scar fading factor, the anti-contracture medicament and the like on the scar skin with longer time is not strong.

Disclosure of Invention

Therefore, the whitening scar-removing liquid skin with good penetration effect, strong whitening and moisturizing effects, good scar-removing effect and quick curative effect is needed to be provided.

The technical scheme is as follows:

the whitening scar-removing liquid skin comprises the following components in percentage by mass:

5 to 20 percent of film forming agent, 0.1 to 5 percent of antioxidant, 10 to 50 percent of silicone, 0.1 to 5 percent of penetration enhancer, 2 to 10 percent of exfoliating component, 1 to 10 percent of emulsifier, 0.5 to 5 percent of gel matrix and 10 to 81.3 percent of water;

the antioxidant is one or more of sodium erythorbate, ascorbyl palmitate, carotenoid, propyl gallate, butyl hydroxy anisole, grape seed extract, tetrahexyldecyl ascorbate, alpha-tocopherol and alpha-tocopherol acetate;

the exfoliating component is one or more of glycolic acid, alpha-hydroxy acid and L-malic acid.

In one embodiment, the whitening and scar-removing liquid skin comprises the following components in percentage by mass:

5 to 15 percent of film forming agent, 0.5 to 4 percent of antioxidant, 10 to 40 percent of silicone, 0.5 to 3 percent of penetration enhancer, 2 to 8 percent of exfoliating component, 1 to 7 percent of emulsifier, 0.5 to 3 percent of gel matrix and 20 to 80.5 percent of water.

5 to 10 percent of film forming agent, 0.5 to 2 percent of antioxidant, 10 to 30 percent of silicone, 0.5 to 1 percent of penetration enhancer, 2 to 6 percent of exfoliating component, 1 to 5 percent of emulsifier, 0.5 to 3 percent of gel matrix and 43 to 80.5 percent of water.

In one embodiment, the silicone is one or more of Q7-9120, dimethicone, dow Corning DC360, and Q7-9180.

In one embodiment, the silicone has a kinematic viscosity of 20cst/25 ℃ to 30000cst/25 ℃.

In one embodiment, the silicone is silicone emulsion droplets with the particle size of 300nm-800nm, and the preparation method of the silicone emulsion droplets comprises the following steps:

the silicone droplets are subjected to an emulsifying dispersion treatment.

In one embodiment, the film forming agent is one or more of polyvinyl alcohol 1788, polyvinyl alcohol 1799, polyvinylpyrrolidone K60, polyvinylpyrrolidone K90, sodium alginate, chitosan, and carboxymethyl cellulose.

In one embodiment, the gel matrix is one or more of carbomer 940, triethanolamine, xanthan gum, sodium polyacrylate, and gelatin.

In one embodiment, the penetration enhancer is one or more of laurocapram, inositol, polyethylene glycol 400 monostearate, isopropyl myristate, N-methylpyrrolidone, and sodium glycocholate.

The emulsifier is one or more of glyceryl stearate, polysorbates, polyoxyethylene lauryl ether, olive oil PEG-7 ester, polyethylene glycol liposome containing at least one phospholipid group, cetyl alcohol and polyethylene glycol 7-hydrogenated castor oil.

In one embodiment, the whitening and scar-removing liquid skin further comprises a preservative, and the preservative is one or more of cason, potassium sorbate, benzoic acid, phenoxyethanol, benzyl alcohol, oxybenzone methyl ester, parabens and polyphenols.

5 to 20 percent of film forming agent, 0.1 to 5 percent of antioxidant, 10 to 50 percent of silicone, 0.1 to 5 percent of penetration enhancer, 2 to 10 percent of exfoliating component, 1 to 10 percent of emulsifier, 0.1 to 5 percent of preservative, 0.5 to 5 percent of gel matrix and 10 to 81.2 percent of water.

The invention also provides a preparation method of the whitening scar-removing liquid skin, which comprises the following steps:

mixing the film forming agent, penetration enhancer and exfoliating agent with part of water to prepare solution A;

mixing the silicone, the emulsifier and the balance of water, and emulsifying to obtain emulsion B;

mixing the gel matrix with the solution A to prepare a gel C;

mixing the emulsion B and an antioxidant with the gel C.

The invention also provides a scar-removing product, which comprises the whitening scar-removing liquid skin.

The invention also provides a whitening and black-removing product which comprises the whitening and scar-removing liquid skin.

The invention has the following beneficial effects:

the invention adopts the specific cutin removing component and the silicone to cooperate, compared with a single silicone product, the invention not only can weaken the skin barrier at the scar, promote the antioxidant component and the silicone to enter scar tissues, more quickly fade melanin and separate necrotic cells, and has better whitening and scar removing effects. Meanwhile, the soft breathable protective film is formed by introducing the solid film forming substance on the affected part in a drying manner, so that the moisture loss can be reduced, the moisturizing effect is achieved, the damage of external ultraviolet rays to the skin can be effectively isolated, the generation of melanin is reduced, and the stratum corneum cells in the step can be taken away when the protective film is removed subsequently, so that the effect of further fading scars is achieved. The penetration enhancer is used in combination to further whiten and remove scar liquid skin and promote active ingredients to enter the skin to play a role. Meanwhile, the emulsifier and the water are used in a matching way, so that the silicone can be emulsified and dispersed into nano-scale silicone emulsion droplet particles, and the silicone emulsion droplet particles can better penetrate through the stratum corneum and enter scar tissues. In addition, because the invention uses water as a dispersion system, compared with pure oily silicone gel, the whitening and scar-removing liquid skin has no greasy and irritating feeling during the use process, no burden on the skin, refreshing and quick drying, no staining on clothes and good sensory evaluation.

Detailed Description

In order that the invention may be more readily understood, reference will now be made to the following more particular description of the invention, examples of which are set forth below. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. These embodiments are provided so that this disclosure will be thorough and complete.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.

The words "preferably," "more preferably," and the like, in the present disclosure mean embodiments of the disclosure that may, in some instances, provide certain benefits. However, other embodiments may be preferred, under the same or other circumstances. Furthermore, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, and is not intended to exclude other embodiments from the scope of the invention.

When a range of values is disclosed herein, the range is considered to be continuous and includes both the minimum and maximum values of the range, as well as each value between such minimum and maximum values. Further, when a range refers to an integer, each integer between the minimum and maximum values of the range is included. Further, when multiple range-describing features or characteristics are provided, the ranges may be combined. In other words, unless otherwise indicated, all ranges disclosed herein are to be understood to encompass any and all subranges subsumed therein.

The whitening scar-removing liquid skin provided by the invention has the advantages of good permeation effect, strong whitening and moisturizing effects, good scar-removing effect and quick curative effect.

The technical scheme is as follows:

the antioxidant is one or more of sodium erythorbate, ascorbyl palmitate, carotenoid, propyl gallate, butyl hydroxy anisole, grape Seed Extract (GSE), tetrahexyldecyl ascorbate, alpha-tocopherol and alpha-tocopherol acetate;

The liquid skin of the invention can soften and remove part of the horny layer, so that the small molecular silicone can conveniently permeate into scar tissues to achieve better treatment effect, and the antioxidant can penetrate through the skin barrier to promote the metabolic decomposition of melanin, and can protect the scar skin by cooperating with the film-forming agent, reduce pigmentation and block ultraviolet injury. The other components are used in a matching way, achieve the effects of whitening and removing scars synergistically.

In the invention, the whitening scar-removing liquid skin contains 5% -20% of film forming agent, and the film forming agent accounts for the mass percent of the whitening scar-removing liquid skin, which can be understood to include but is not limited to: 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19% and 20%. Preferably, the whitening scar-removing liquid skin contains 5% -15% of a film-forming agent. Further preferably, the whitening scar-removing liquid skin contains 5% -10% of film forming agent.

In one embodiment, the film forming agent is one or more of polyvinyl alcohol 1788, polyvinyl alcohol 1799, polyvinylpyrrolidone K60, polyvinylpyrrolidone K90, sodium alginate, chitosan, and carboxymethyl cellulose. Preferably, the film forming agent is one or more of polyvinyl alcohol 1788, polyvinylpyrrolidone K60, sodium alginate, chitosan and carboxymethyl cellulose. Preferably, when the film forming agent is a mixture of two of the above categories, the mixing mass ratio is 1.

In the present invention, the whitening scar-removing liquid skin contains 0.1% -5% of antioxidant, and it is understood that the antioxidant accounts for the mass percentage of the whitening scar-removing liquid skin, including but not limited to: 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.2%, 1.5%, 1.8%, 2%, 2.2%, 2.5%, 2.8%, 3%, 3.2%, 3.5%, 3.8%, 4%, 4.2%, 4.5%, 4.8%, and 5%. Preferably, the whitening scar-removing liquid skin contains 0.5% -4% of antioxidant. Further preferably, the whitening scar-removing liquid skin contains 0.5% -2% of antioxidant.

In the present invention, the antioxidant is one or more of sodium erythorbate, ascorbyl palmitate, carotenoids, propyl gallate, butyl hydroxyanisole, grape seed extract, tetrahexyldecyl ascorbate, alpha-tocopherol and alpha-tocopherol acetate. Preferably, the antioxidant is one or more of Grape Seed Extract (GSE), tetrahexyldecanol ascorbate, alpha-tocopherol, and alpha-tocopherol acetate. Preferably, when the antioxidant is a mixture of two of the above-mentioned kinds, the mixing mass ratio is 1.

In the present invention, the whitening scar-removing liquid skin contains 10% -50% of silicone, and it is understood that the silicone accounts for the mass percentage of the whitening scar-removing liquid skin including but not limited to: 10%, 12%, 15%, 18%, 20%, 22%, 25%, 28%, 30%, 32%, 35%, 38%, 40%, 42%, 45%, 48% and 50%. Preferably, the whitening scar-removing liquid skin contains 10% -40% silicone. Further preferably, the whitening scar-removing liquid skin contains 10% -30% silicone.

In one embodiment, the silicone is one or more of Q7-9120, dimethicone, dow Corning DC360, and Q7-9180. Preferably, the silicone is Q7-9120 and/or dimethicone. Further preferably, the silicone has a kinematic viscosity of 20cst/25 ℃ to 30000cst/25 ℃. Preferably, when the silicone is a mixture of two of the above-mentioned species, the mixing mass ratio is 1.

the silicone droplets are subjected to an emulsifying dispersion treatment. Further, the particle size of the silicone emulsion droplets was changed by changing the stirring rate.

The silicone in the commercial products exists in the form of liquid drops with the particle size of 0.5-10 μm, and the products have poor permeability to scars and unsatisfactory treatment effect due to the physical properties, molecular weight and inherent oil/water partition coefficient of the silicone. The invention creatively emulsifies and disperses the silicone with different viscosities into the emulsion droplet particles with the nanometer scale through the emulsification technology, so that the emulsion droplet particles can better penetrate through the cuticle and enter scar tissues to play a role.

In the present invention, the whitening scar-removing liquid skin contains 0.1% -5% of penetration enhancer, and it is understood that the penetration enhancer accounts for the mass percentage of the whitening scar-removing liquid skin including but not limited to: 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.2%, 1.5%, 1.8%, 2%, 2.2%, 2.5%, 2.8%, 3%, 3.2%, 3.5%, 3.8%, 4%, 4.2%, 4.5%, 4.8%, and 5%. Preferably, the whitening scar-removing liquid skin contains 0.5% -3% of penetration enhancer. Further preferably, the whitening scar-removing liquid skin contains 0.5% -1% of penetration enhancer.

In one embodiment, the penetration enhancer is one or more of laurocapram, inositol, polyethylene glycol 400 monostearate, isopropyl myristate, N-methylpyrrolidone, and sodium glycocholate. Preferably, when the penetration enhancer is formed by mixing two of the above types, the mixing mass ratio is 1.

In the present invention, the whitening scar-removing liquid skin contains 2% -10% of an exfoliating component, and it is understood that the exfoliating component accounts for the mass percentage of the whitening scar-removing liquid skin, including but not limited to: 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 5.5%, 6%, 6.5%, 7%, 7.5%, 8%, 8.5%, 9%, 9.5% and 10%. Preferably, the whitening scar-removing liquid skin contains 2% -8% of an exfoliating component. Further preferably, the whitening scar-removing liquid skin contains 2% -6% of an exfoliating component.

In the present invention, the exfoliating element is one or more of glycolic acid, alpha hydroxy acids and L-malic acid. It will be appreciated that the exfoliating ingredient is glycolic acid, an alpha-hydroxy acid, L-malic acid, a mixture of glycolic acid and an alpha-hydroxy acid, or a mixture of glycolic acid and L-malic acid, or a mixture of an alpha-hydroxy acid and L-malic acid, or a mixture of glycolic acid, an alpha-hydroxy acid and L-malic acid. Further preferably, when the exfoliating agent is a mixture of two of the above-mentioned species, the mixing mass ratio is 1.

In the present invention, the whitening and scar-removing liquid skin contains 1% -10% of emulsifier, and it is understood that the emulsifier accounts for the mass percentage of the whitening and scar-removing liquid skin, including but not limited to: 1%, 1.2%, 1.5%, 1.8%, 2%, 2.2%, 2.5%, 2.8%, 3%, 3.2%, 3.5%, 3.8%, 4%, 4.2%, 4.5%, 4.8%, 5%, 5.5%, 5.8%, 6%, 6.5%, 6.8%, 7%, 7.5%, 7.8%, 8%, 8.5%, 8.8%, 9%, 9.5%, 9.8% and 10%. Preferably, the whitening scar-removing liquid skin contains 1% -7% of an emulsifier. Further preferably, the whitening scar-removing liquid skin contains 1% -5% of an emulsifier.

In one embodiment, the emulsifier is one or more of glyceryl stearate, polysorbates, polyoxyethylene lauryl ether, olive oil PEG-7 esters, polyethylene glycol liposomes containing at least one phospholipid group, cetyl alcohol, and polyethylene glycol 7-hydrogenated castor oil. Preferably, when the emulsifier is a mixture of two of the above categories, the mixing mass ratio is 1.

In one embodiment, the polyethylene glycol liposome comprising at least one phospholipid group is a polyethylene glycol comprising glycerophospholipids.

In the present invention, the whitening and scar-removing liquid skin contains 0.5% -5% of gel matrix, and it is understood that the penetration enhancer accounts for the mass percentage of the whitening and scar-removing liquid skin, including but not limited to: 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.2%, 1.5%, 1.8%, 2%, 2.2%, 2.5%, 2.8%, 3%, 3.2%, 3.5%, 3.8%, 4%, 4.2%, 4.5%, 4.8%, and 5%. Preferably, the whitening scar-removing liquid skin contains 0.5% -3% of a gel matrix.

In one embodiment, the gel matrix is one or more of carbomer 940, triethanolamine, xanthan gum, sodium polyacrylate, and gelatin. In one embodiment, the gel matrix is carbomer 940 and triethanolamine in a mass ratio (0.5-2): 1, and mixing the components.

In the present invention, the whitening and scar-removing liquid skin contains 10% -81.3% of water, and it is understood that the mass percentage of water in the whitening and scar-removing liquid skin includes but is not limited to: 10%, 12%, 15%, 18%, 20%, 22%, 25%, 28%, 30%, 32%, 35%, 38%, 40%, 42%, 45%, 48%, 50%, 52%, 55%, 58%, 60%, 62%, 65%, 68%, 70%, 72%, 75%, 78%, 80%, 80.4%, 80.5%, 81%, 81.1%, 81.2% and 81.3%. Preferably, the whitening scar-removing liquid skin contains 20% -80.5% of water. Further preferably, the whitening scar-removing liquid skin contains 43% -80.5% of water.

In one embodiment, the whitening and scar-removing liquid skin further comprises a preservative selected from one or more of cason, potassium sorbate, benzoic acid, phenoxyethanol, benzyl alcohol, parabens, and polyphenols. Further, the preservative accounts for 0.1% -5% of the skin whitening and scar removing liquid by mass, and it can be understood that the preservative accounts for the skin whitening and scar removing liquid by mass, including but not limited to: 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.2%, 1.5%, 1.8%, 2%, 2.2%, 2.5%, 2.8%, 3%, 3.2%, 3.5%, 3.8%, 4%, 4.2%, 4.5%, 4.8%, and 5%. Preferably, the whitening scar-removing liquid skin contains 0.1% -3% of preservative. Further preferably, the whitening scar-removing liquid skin contains 0.1% -2% of preservative.

5 to 15 percent of film forming agent, 0.5 to 4 percent of antioxidant, 10 to 40 percent of silicone, 0.5 to 3 percent of penetration enhancer, 2 to 8 percent of exfoliating component, 1 to 7 percent of emulsifier, 0.1 to 3 percent of preservative, 0.5 to 3 percent of gel matrix and 20 to 80.4 percent of water.

5 to 10 percent of film forming agent, 0.5 to 2 percent of antioxidant, 10 to 30 percent of silicone, 0.5 to 1 percent of penetration enhancer, 2 to 6 percent of exfoliating component, 1 to 5 percent of emulsifier, 0.1 to 2 percent of preservative, 0.5 to 3 percent of gel matrix and 43 to 80.4 percent of water.

mixing the gel matrix with the solution A to prepare a gel C;

mixing the emulsion B and an antioxidant with the gel C.

Preferably, the preparation method of the whitening and scar-removing liquid skin comprises the following steps:

adding the film forming agent, the penetration enhancer, the preservative and the exfoliating component into purified water with the formula mass of 40-60%, and heating and mixing uniformly at 50-65 ℃ to form a solution A;

mixing the silicone and the emulsifier uniformly, adding the balance of water for emulsification to obtain emulsion B (further, changing the particle size of silicone emulsion droplets by changing the stirring speed and/or changing the amount of silicone, emulsifier and water);

uniformly adding the gel matrix into the solution A, and swelling for 5 hours to prepare a gel C;

and adding the emulsion B and the antioxidant into the gel C, and stirring and mixing uniformly to obtain the whitening scar-removing liquid skin.

The invention also provides a scar-removing product which comprises the whitening scar-removing liquid skin.

Hereinafter, specific examples will be described, and the raw materials used in the examples are all commercially available products unless otherwise specified.

Example 1

The embodiment provides a whitening scar-removing liquid skin and a preparation method thereof.

(1) The whitening and scar-removing liquid skin comprises the following components in percentage by mass:

15% of film forming agent, 5% of antioxidant, 40% of silicone, 4% of penetration enhancer, 10% of exfoliating component, 5% of emulsifier, 1% of preservative, 5% of gel matrix and the balance of purified water;

wherein the film forming agent is polyvinylpyrrolidone K60, the antioxidant is ascorbyl palmitate, the silicone is Q7-9120 at 30000cst/25 ℃, the penetration enhancer is laurocapram, the exfoliating component is L-malic acid, the emulsifier is polyethylene glycol 7-hydrogenated castor oil, the preservative is kasong, and the gel matrix is gelatin.

(2) The preparation method of the whitening scar-removing liquid skin comprises the following steps:

1) Adding the film forming agent, the penetration enhancer, the preservative and the exfoliating component in the formula amount into 50 percent of purified water in the formula amount, and heating and mixing the mixture uniformly at 60 ℃ to form a solution A;

2) Uniformly mixing the silicone and the emulsifier according to the formula amount, and adding the rest water for emulsification to obtain emulsion B, wherein the particle size of silicone emulsion drops is 800nm;

3) Uniformly adding the gel matrix with the formula amount into the solution A, and swelling for 5 hours to prepare gel C;

4) And adding the emulsion B and the antioxidant into the gel C, and stirring and mixing uniformly to obtain the whitening scar-removing liquid skin.

Example 2

5% of film forming agent, 0.5% of antioxidant, 10% of silicone, 0.1% of penetration enhancer, 2% of exfoliating component, 1% of emulsifier, 1% of preservative, 0.5% of gel matrix and the balance of purified water;

the gel comprises a film forming agent, an antioxidant, a penetrating agent, a preservative and a gel matrix, wherein the film forming agent is polyvinylpyrrolidone K60, the antioxidant is ascorbyl palmitate, the silicone is Q7-9120 at 30000cst/25 ℃, the penetrating agent is laurocapram, the exfoliating component is L-malic acid, the emulsifier is polyethylene glycol 7-hydrogenated castor oil, the preservative is kason, and the gel matrix is gelatin.

(2) The preparation method of the whitening and scar-removing liquid skin is the same as that in example 1, wherein the particle size of silicone emulsion drops in the emulsion B is 780nm.

Example 3

15% of film forming agent, 4% of antioxidant, 40% of silicone, 3% of penetration enhancer, 8% of exfoliating component, 7% of emulsifier, 3% of preservative, 3% of gel matrix and the balance of purified water;

the film forming agent is polyvinylpyrrolidone K60, the antioxidant is grape seed extract, the silicone is Q7-9120 with the temperature of 30000cst/25 ℃, the penetration enhancer is laurocapram, the exfoliating component is L-malic acid, the emulsifier is polyethylene glycol 7-hydrogenated castor oil, the preservative is kasong, and the gel matrix is gelatin.

(2) The preparation method of the whitening and scar-removing liquid skin of the embodiment is the same as that of the embodiment 1, wherein the particle size of the silicone emulsion drops in the emulsion B is 750nm.

Example 4

6% of film forming agent, 1% of antioxidant, 20% of silicone, 0.5% of penetration enhancer, 4% of exfoliating component, 2% of emulsifier, 0.5% of preservative, 2% of gel matrix and the balance of purified water;

the film forming agent is chitosan, the antioxidant is butyl hydroxy anisol, the silicone is medical dimeticone with the temperature of 30000cst/25 ℃, the penetration enhancer is inositol, the exfoliating component is glycollic acid, the emulsifier is glyceryl stearate, the preservative is methyl hydroxybenzoate, and the gel matrix is sodium polyacrylate.

(2) The preparation method of the skin whitening and scar removing liquid is the same as that in example 1, wherein the particle size of silicone emulsion drops in the emulsion B is 620nm.

Example 5

the film forming agent is polyvinyl alcohol 1788, the antioxidant is ascorbyl palmitate, the silicone is a mixture of 20cst/25 ℃ medical dimeticone and 30000cst/25 ℃ medical dimeticone according to a mass ratio of 1.

(2) The preparation method of the whitening and scar-removing liquid skin of the embodiment is the same as that of the embodiment 1, wherein the particle size of the silicone emulsion drops in the emulsion B is 300nm.

Example 6

(1) The whitening scar-removing liquid skin comprises the following components in percentage by mass:

8% of film forming agent, 1% of antioxidant, 30% of silicone, 1% of penetration enhancer, 4% of exfoliating component, 2% of emulsifier, 0.5% of preservative, 2% of gel matrix and the balance of purified water.

The film forming agent is polyvinyl alcohol 1788, the antioxidant is tetrahexyldecanol ascorbate and alpha-tocopherol acetate (mass ratio is 1.

(2) The preparation method of the whitening and scar-removing liquid skin is the same as that in example 1, wherein the particle size of silicone emulsion drops in the emulsion B is 480nm.

Example 7

8% of film forming agent, 1% of antioxidant, 30% of silicone, 1% of penetration enhancer, 4% of exfoliating component, 2% of emulsifier, 0.5% of preservative, 2% of gel matrix and the balance of purified water;

the film forming agent is polyvinylpyrrolidone K90, the antioxidant is grape seed extract and tetrahexyldecanol ascorbic acid ester (mass ratio is 1.

Example 8

The film forming agent is polyvinyl alcohol 1788, the antioxidant is carotenoid, the silicone is medical dimeticone with the temperature of 20cst/25 ℃ and medical dimeticone with the temperature of 30000cst/25 ℃ (mass ratio is 1.

Example 9

The film forming agent is polyvinyl alcohol 1788, the antioxidant is alpha-tocopherol, the silicone is 20cst/25 ℃ medical dimethicone and 30000cst/25 ℃ medical dimethicone (mass ratio is 1.

Example 10

The film forming agent is polyvinyl alcohol 1788, the antioxidant is propyl gallate, the silicone is 20cst/25 ℃ medical dimethicone and 30000cst/25 ℃ medical dimethicone (mass ratio is 1.

Example 11

The film forming agent is polyvinyl alcohol 1788, the antioxidant is tetrahexyldecanol ascorbate and alpha-tocopherol acetate (mass ratio of 1.

Example 12

Example 13

Example 14

Example 15

(2) The preparation method of the whitening and scar-removing liquid skin is the same as that in example 1, wherein the particle size of silicone emulsion drops in the emulsion B is 1500nm.

Comparative example 1

The comparative example provides a whitening scar-removing liquid skin and a preparation method thereof. Essentially the same as example 6, except that: no film former was added and the amount of water was increased. The method comprises the following specific steps:

(1) The whitening scar-removing liquid skin of the comparative example comprises the following components in percentage by mass:

1% of antioxidant, 30% of silicone, 1% of penetration enhancer, 4% of exfoliating component, 2% of emulsifier, 0.5% of preservative, 2% of gel matrix and the balance of purified water.

The antioxidant is tetrahexyldecanol ascorbate and alpha-tocopherol acetate (mass ratio is 1.

(2) The preparation method of the skin whitening and scar removing liquid of the comparative example is the same as that of example 1, the addition of the film forming agent is omitted, and in addition, the particle size of silicone emulsion drops in the emulsion B is 480nm.

Comparative example 2

The comparative example provides a whitening scar-removing liquid skin and a preparation method thereof. Essentially the same as example 6, except that: no antioxidant was added and the amount of water was increased. The method comprises the following specific steps:

8% of film forming agent, 30% of silicone, 1% of penetration enhancer, 4% of exfoliating component, 2% of emulsifier, 0.5% of preservative, 2% of gel matrix and the balance of purified water.

The film forming agent is polyvinyl alcohol 1788, the silicone is 20cst/25 ℃ medical dimethicone and 30000cst/25 ℃ medical dimethicone (mass ratio is 1.

(2) The preparation method of the skin whitening and scar removing liquid of the comparative example is the same as that of example 1, the addition of the antioxidant is omitted, and the particle size of silicone emulsion drops in the emulsion B is 480nm.

Comparative example 3

The comparative example provides a whitening scar-removing liquid skin and a preparation method thereof. Essentially the same as example 6, except that: no silicone was added, increasing the amount of water. The method comprises the following specific steps:

8% of film forming agent, 1% of antioxidant, 1% of penetration enhancer, 4% of exfoliating component, 2% of emulsifier, 0.5% of preservative, 2% of gel matrix and the balance of purified water.

(2) The preparation method of the whitening scar-removing liquid skin of the comparative example is the same as that of the example 1, and the addition of silicone is omitted.

Comparative example 4. The following examples of the present invention

The comparative example provides a whitening scar-removing liquid skin and a preparation method thereof. Essentially the same as example 6, except that: no exfoliating agent was added, and the amount of water was increased. The method comprises the following specific steps:

8% of film forming agent, 1% of antioxidant, 30% of silicone, 1% of penetration enhancer, 2% of emulsifier, 0.5% of preservative, 2% of gel matrix and the balance of purified water.

(2) The preparation method of the skin whitening and scar removing liquid of the comparative example is the same as that of example 1, the addition of the exfoliating component is omitted, and the particle size of silicone emulsion drops in the emulsion B is 480nm.

Comparative example 5

Commercially available silicone gels.

Comparative example 6

Centella asiatica ointment is commercially available.

Comparative example 7

The comparative example provides a whitening scar-removing liquid skin and a preparation method thereof. Essentially the same as example 6, except that: green tea extract is used to replace tetrahexyldecanol ascorbate and alpha-tocopherol acetate. The method comprises the following specific steps:

The film forming agent is polyvinyl alcohol 1788, the antioxidant is a green tea extract, the silicone is 20cst/25 ℃ medical dimethicone and 30000cst/25 ℃ medical dimethicone (mass ratio is 1.

(2) The preparation method of the skin whitening and scar removing liquid of the comparative example is the same as that of example 1, wherein the particle size of silicone emulsion drops in the emulsion B is 480nm.

Comparative example 8

The comparative example provides a whitening scar-removing liquid skin and a preparation method thereof. Essentially the same as example 6, except that: azelaic acid was used instead of glycolic acid. The method comprises the following specific steps:

Comparative example 9

The comparative example provides a whitening scar-removing liquid skin and a preparation method thereof. Essentially the same as example 6, except that: the amount of raw materials is changed. The method comprises the following specific steps:

8% of film forming agent, 1% of antioxidant, 30% of silicone, 1% of penetration enhancer, 15% of exfoliating component, 0.1% of emulsifier, 0.5% of preservative, 2% of gel matrix and the balance of purified water.

The film forming agent is polyvinyl alcohol 1788, the antioxidant is tetrahexyldecanol ascorbic acid ester and alpha-tocopherol acetate (1), the silicone is 20cst/25 ℃ medical dimethicone and 30000cst/25 ℃ medical dimethicone (1), the penetration enhancer is laurocapram, the exfoliating component is glycolic acid, the emulsifier is polysorbate 60, the preservative is benzyl alcohol, the gel matrix is carbomer 940 and triethanolamine, and the mass ratio of the two is 1.1.

(2) The preparation method of the skin whitening and scar removing liquid of the comparative example is the same as that of example 1, wherein the particle size of silicone emulsion drops in the emulsion B is 2500nm.

Comparative example 10

The comparative example provides a whitening scar-removing liquid skin and a preparation method thereof. Essentially the same as example 6, except that: astaxanthin is used to replace tetrahexyldecanol ascorbate and alpha-tocopherol acetate. The method comprises the following specific steps:

The film forming agent is polyvinyl alcohol 1788, the antioxidant is astaxanthin, the silicone is 20cst/25 ℃ medical dimethicone and 30000cst/25 ℃ medical dimethicone (mass ratio is 1.

Comparative example 11

The comparative example provides a whitening scar-removing liquid skin and a preparation method thereof. Essentially the same as example 6, except that: ascorbic acid is used to replace tetrahexyldecanol ascorbate and alpha-tocopherol acetate. The method comprises the following specific steps:

The film forming agent is polyvinyl alcohol 1788, the antioxidant is ascorbic acid, the silicone is 20cst/25 ℃ medical dimethicone and 30000cst/25 ℃ medical dimethicone (mass ratio is 1: the penetration enhancer is laurocapram, the exfoliating component is glycolic acid, the emulsifier is polysorbate 60, the preservative is benzyl alcohol, and the gel matrix is carbomer 940 and triethanolamine in a mass ratio of 1.

Comparative example 12

The comparative example provides a whitening scar-removing liquid skin and a preparation method thereof. Essentially the same as example 6, except that: salicylic acid is used instead of glycolic acid. The method comprises the following specific steps:

Comparative example 13

The comparative example provides a whitening scar-removing liquid skin and a preparation method thereof. Essentially the same as example 6, except that: citric acid was used instead of glycolic acid. The method comprises the following specific steps:

The film forming agent is polyvinyl alcohol 1788, the antioxidant is tetrahexyldecanol ascorbic acid ester and alpha-tocopherol acetate (mass ratio is 1.

Comparative example 14

The comparative example provides a whitening scar-removing liquid skin and a preparation method thereof. Essentially the same as example 6, except that: retinol was used instead of glycolic acid. The method comprises the following specific steps:

Comparative example 15

The comparative example provides a whitening scar-removing liquid skin and a preparation method thereof. Essentially the same as example 6, except that: the antioxidant is omitted, and the amount of the exfoliating component is increased. The method comprises the following specific steps:

8% of film forming agent, 30% of silicone, 1% of penetration enhancer, 5% of exfoliating component, 2% of emulsifier, 0.5% of preservative, 2% of gel matrix and the balance of purified water.

Comparative example 16

The comparative example provides a whitening scar-removing liquid skin and a preparation method thereof. Essentially the same as example 6, except that: omitting the addition of exfoliating ingredients and increasing the amount of antioxidants. The method comprises the following specific steps:

8% of film forming agent, 5% of antioxidant, 30% of silicone, 1% of penetration enhancer, 2% of emulsifier, 0.5% of preservative, 2% of gel matrix and the balance of purified water.

Test example 1: liquid skin accelerated aging test

The whitening scar-removing liquid skin prepared by the invention is subjected to accelerated aging test, the silica gel prepared in the embodiment and the comparative example is sealed and then placed in a constant temperature and humidity incubator (temperature: 50 ℃ plus or minus 1 ℃, humidity: 65% + orminus 5%) for 6 months (180 days), then samples are respectively taken for appearance, pH and viscosity test, the microbial limit detection is added in the 6 th month, and the test is compared with the control sample (0 th day):

1. the characteristics are as follows: the test groups are all milky white gel-like, uniform and stable products.

2. pH: a small amount of each sample was taken from the examples, and the pH range was found to fluctuate within 5% by pH measurement.

3. And (3) viscosity testing: the samples of the examples were measured to have a viscosity change of 1% or less by a rotational viscometer.

4. And (3) detecting the microbial limit: after the test group is aged for 6 months, the result still meets the regulation and has no obvious difference with the control group; the results show that the gel temperature: 50 ℃. + -. 1 ℃, humidity: the product is placed for 6 months (180 days) under the condition of 65% +/-5%, all indexes meet the technical requirements of the product, and the product quality is controllable and stable. Substituting the data such as accelerated aging test time, temperature and the like into a calculation formula: TIME _RT ＝TIME _TI ×Q ₁₀ ^(T1-TRT)/10 To obtain: 180 x 2 ^(50-20)/10 Approximately 4 years>24 months, namely the gel of the invention has a useful life of 24 months.

Test example 2: liquid skin sensitization test

The test substance: examples and comparative examples liquid skin prepared

Negative control: blank control

Subject: the total of 100 people, male and female, age 22 to 35 years, average age 28 + -1 years, were eligible for volunteer enrollment, dry skin and oily skin were half each.

The spot pasting test method comprises the following steps: selecting qualified spot test equipment, placing 0.020g-0.025g of a test object in a spot tester by a closed spot test method, externally applying a hypoallergenic adhesive tape to the arm of the test object, removing the test object after 24 hours, observing skin reactions respectively at 0.5 hour, 24 hours and 48 hours after removal, and recording the result according to the skin reaction grading standard in the current effective technical specification.

Spot test standard:

TABLE 1 Patch test Standard

(1) For oily skin, the skin of volunteers in the sample groups of examples and comparative examples has no erythema and edema, the reaction degree is +/-minus or plus, for dry skin, only the skin of examples 1 and 3 and the skin of comparative example 9 has weak erythema, the reaction degree is +/-, and the skin of a blank volunteer has no erythema, so under the experimental condition, for dry skin, the exfoliant component can generate irritation when the concentration is higher, and other samples have no irritation basically.

(2) Trial results and analytical testing

1. Case selection: selecting 620 patients with acne infection, burn, scald, wound or hyperplastic scar formed by wound healing after operation, randomly dividing into 31 groups, wherein each group comprises 20 oily skins, and performing skin treatment by using the examples and the comparative examples;

2. the treatment method comprises the following steps: the liquid skin is coated for 2 to 3 times every day, and the liquid skin is dried to form a film in a quiet period, and the liquid skin is continuously used for 2 months to observe the treatment effect;

3. the therapeutic effect criteria are shown in table 2:

TABLE 2

And adding the scores of the indexes to obtain a total scar severity score, wherein the total scar severity score is mild in a score of 1-5, moderate in a score of 6-10 and severe in a score of 11-15.

Evaluation criteria for effects: efficacy index = (total score before treatment-total score after treatment)/total score before treatment 100%. The evaluation is based on four criteria of basic cure, significant effect, basic effectiveness and ineffectiveness.

Basically curing: the curative effect index is more than or equal to 90 percent; the effect is remarkable: the curative effect index is 70-89%; basically, the method is effective: the curative effect index is 30-69%; and (4) invalidation: the curative effect index is less than 30%. The effective rate is calculated by basic cure, remarkable effect and basic effectiveness, and the treatment results are shown in the following table 3:

TABLE 3

To verify whether the scar silica gel of the present invention achieves the expected effect, 280 patients with pigmentation scars for more than half year due to various causes, around 20 years old were alternatively divided into 14 groups on average, one group using the product of example 2, one group using the product of example 6, one group using the product of example 8, one group using the product of example 12, one group using the product of example 15, one group using the product of comparative example 2, one group using the product of comparative example 4, one group using the product of comparative example 5, one group using the product of comparative example 6, one group using the product of comparative example 7, one group using the product of comparative example 8, one group using the product of comparative example 9, one group using the product of comparative example 15, and one group using the product of comparative example 16.

The using method comprises the following steps: after the skin is cleaned every day, the corresponding scar silica gel sample is smeared on the surface of the scar three times a day, 0.05g of the scar silica gel sample is smeared every square centimeter every time, two months are a treatment course, and the healing effect is observed.

The criteria for efficacy determination are as follows:

the effect is shown: near normal skin color; improvement: scars appear dark brown; slight: scars are purple brown; and (4) invalidation: the scar area is purplish red.

Specific therapeutic effect profiles are shown in table 4 below:

TABLE 4

Item	Show effect	Improvement of life	Light and slight	Invalidation	High efficiency
						Example 2	5	8	5	2	90％
Example 6	15	3	2	0	100％
						Example 8	7	8	5	0	100％
Example 12	12	6	2	0	100％
						Example 15	14	2	4	0	100％
Comparative example 2	0	10	2	8	60％
						Comparative example 4	4	6	3	7	65％
Comparative example 5	3	7	5	5	75％
						Comparative example 6	10	5	3	2	90％
Comparative example 7	4	6	6	4	80％
						Comparative example 8	6	4	6	4	80％
Comparative example 9	2	8	4	6	70％
						Comparative example 15	3	7	4	4	80％
Comparative example 16	4	7	3	4	80％

According to the statistics of results, the effect of using L-malic acid alone as the exfoliating and whitening component in the example 2 on the pigment decomposition is poorer than that of the example 6 using glycolic acid, in addition, the basic cure rate of the scar removing liquid skin of the invention on the hyperplastic scars can reach more than 80%, and the effective rate can reach 100%. The commercially available silicone gel has a good cure rate on hyperplastic scars, but has a general decomposition effect on melanin, asiaticoside has a good treatment effect on pigmentation, the addition of an antioxidant has an obvious effect on melanin lightening, and the effect is further enhanced after the addition of an exfoliating component.

Test example 3: scar uplift index

Scar uplift index (SEI), which is the ratio of the total area of scar tissue to the area of normal tissue beneath the scar, is an accurate and repeatable assessment method for assessing hypertrophic scar formation. Selecting 95 clean-grade New Zealand white rabbits with half male and female parts and 2.5-3kg of body weight, performing intramuscular injection anesthesia by adopting ketamine 0.2ml/kg, sterilizing the ventral skin of the rabbit ears by 75% alcohol, operating under strict aseptic conditions, and cutting off the epidermis, the dermis and the perichondrium by using a skin biopsy device and a surgical knife to keep the cartilage. 6 standard wounds of 5cm diameter were prepared per ear. After the wound surface is exposed after operation and heals by itself, after about 21 days, the rabbit ear hyperplastic scars are formed, 95 white rabbits are randomly divided into 19 groups, and local film coating samples are respectively given to the rabbit ear hyperplastic scars of each group. After the scars are formed, and on the 28 th day and the 56 th day after the samples are coated, the proliferative scars of the rabbit ears of each group are respectively sampled and measured with SEI indexes, the data is the average value of six wound surface measurements, the smaller the index is, the better the performance of inhibiting the proliferation of the scars is, and the specific data are shown in Table 5.

TABLE 5

Item	Day 28	Day 56
			Example 6	1.31±0.15	1.61±0.15
Example 8	1.37±0.26	1.76±0.23
			Example 11	1.40±0.21	1.89±0.28
Example 15	1.43±0.18	1.95±0.19
			Comparative example 2	1.51±0.25	2.88±0.26
Comparative example 3	1.53±0.13	2.44±0.33
			Comparative example 4	1.55±0.33	2.85±0.28
Comparative example 5	1.58±0.27	2.13±0.21
			Comparative example 6	1.55±0.23	3.05±0.29
Comparative example 7	1.47±0.26	2.33±0.35
			Comparative example 8	1.50±0.40	2.56±0.26
Comparative example 9	1.48±0.21	2.61±0.22
			Comparative example 10	1.55±0.28	2.67±0.31
Comparative example 11	1.58±0.20	2.59±0.33
			Comparative example 12	1.48±0.30	2.60±0.18
Comparative example 13	1.57±0.26	2.58±0.28
			Comparative example 14	1.49±0.30	2.48±0.32
Comparative example 15	1.47±0.19	2.78±0.35
			Comparative example 16	1.53±0.29	2.88±0.33
Blank sample	1.67±0.15	3.25±0.22

It can be seen from table 5 that the groups of examples 6, 8, 11 and 15 and the groups of comparative examples 3 and 5 all have the effect of reducing the proliferation thickness of rabbit ears (compared with the blank control), and the groups of examples 6, 8, 11 and 15 have more obvious effect than the group of comparative examples.

The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.

The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims

1. The whitening scar-removing liquid skin is characterized by comprising the following components in percentage by mass:

the exfoliating component is one or more of glycolic acid, alpha-hydroxy acid and L-malic acid;

the silicone is one or more of Q7-9120, medical dimethicone, dow Corning DC360 and Q7-9180;

the kinematic viscosity of the silicone is 20 cst/25-30000 cst/25 ℃;

the film forming agent is one or more of polyvinyl alcohol 1788, polyvinyl alcohol 1799, polyvinylpyrrolidone K60, polyvinylpyrrolidone K90, sodium alginate, chitosan and carboxymethyl cellulose;

the gel matrix is xanthan gum, or one or more of sodium polyacrylate and gelatin, or carbomer 940 and triethanolamine according to a mass ratio (0.5-2): 1 mixing the components;

the penetration enhancer is one or more of laurocapram, inositol, polyethylene glycol 400 monostearate, isopropyl myristate, N-methylpyrrolidone and sodium glycocholate;

2. The whitening and scar-removing liquid skin as claimed in claim 1, is characterized by comprising the following components in percentage by mass:

3. The whitening and scar-removing liquid skin as claimed in claim 2, is characterized by comprising the following components in percentage by mass:

4. The whitening and scar-removing liquid skin as claimed in claim 1, wherein the silicone is silicone emulsion droplets with the particle size of 300nm-800nm, and the preparation method of the silicone emulsion droplets comprises the following steps:

the silicone droplets are subjected to an emulsifying dispersion treatment.

5. The whitening and scar-removing liquid skin as claimed in claim 1, further comprising a preservative, wherein the preservative is one or more of cason, potassium sorbate, benzoic acid, phenoxyethanol, benzyl alcohol, parabens and polyphenols.

6. The whitening and scar-removing liquid skin as claimed in claim 5, is characterized by comprising the following components in percentage by mass:

7. The whitening and scar-removing liquid skin as claimed in claim 1, is characterized by comprising the following components in percentage by mass:

the film forming agent is polyvinyl alcohol 1788, the antioxidant is a mixture of tetrahexyldecanol ascorbate and alpha-tocopherol acetate according to the mass ratio of 1.

8. The whitening and scar-removing liquid skin as claimed in claim 1, is characterized by comprising the following components in percentage by mass:

the film forming agent is polyvinyl alcohol 1788, the antioxidant is carotenoid, the silicone is a mixture of 20cst/25 ℃ medical dimeticone and 30000cst/25 ℃ medical dimeticone according to a mass ratio of 1.

9. The whitening and scar-removing liquid skin as claimed in claim 1, is characterized by comprising the following components in percentage by mass:

the film forming agent is polyvinyl alcohol 1788, the antioxidant is alpha-tocopherol, the silicone is a mixture of 20cst/25 ℃ medical dimethicone and 30000cst/25 ℃ medical dimethicone according to a mass ratio of 1.

10. The method for preparing the whitening and scar-removing liquid skin as claimed in any one of claims 1 to 9, which is characterized by comprising the following steps:

mixing the gel matrix with the solution A to prepare a gel C;

mixing the emulsion B and an antioxidant with the gel C.

11. A scar-removing product comprising the whitening scar-removing liquid skin according to any one of claims 1 to 9.

12. A whitening and black-removing product, which is characterized by comprising the whitening and scar-removing liquid skin as claimed in any one of claims 1 to 9.