CN115003794A - 治疗血管疾病的组合物和方法 - Google Patents
治疗血管疾病的组合物和方法 Download PDFInfo
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- CN115003794A CN115003794A CN202080075551.8A CN202080075551A CN115003794A CN 115003794 A CN115003794 A CN 115003794A CN 202080075551 A CN202080075551 A CN 202080075551A CN 115003794 A CN115003794 A CN 115003794A
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/069—Vascular Endothelial cells
- C12N5/0692—Stem cells; Progenitor cells; Precursor cells
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/165—Vascular endothelial growth factor [VEGF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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- C12N2513/00—3D culture
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/54—Collagen; Gelatin
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Vascular Medicine (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Developmental Biology & Embryology (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962892724P | 2019-08-28 | 2019-08-28 | |
| US62/892,724 | 2019-08-28 | ||
| PCT/US2020/048076 WO2021041591A1 (en) | 2019-08-28 | 2020-08-27 | Compositions and methods of treating vascular diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115003794A true CN115003794A (zh) | 2022-09-02 |
Family
ID=72428364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080075551.8A Pending CN115003794A (zh) | 2019-08-28 | 2020-08-27 | 治疗血管疾病的组合物和方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20220288131A1 (https=) |
| EP (1) | EP4022038A1 (https=) |
| JP (2) | JP2022545737A (https=) |
| KR (1) | KR20220049618A (https=) |
| CN (1) | CN115003794A (https=) |
| AU (1) | AU2020337444A1 (https=) |
| BR (1) | BR112022003659A2 (https=) |
| CA (1) | CA3151636A1 (https=) |
| IL (1) | IL290891A (https=) |
| MX (1) | MX2022002418A (https=) |
| PH (1) | PH12022550392A1 (https=) |
| TW (1) | TW202122573A (https=) |
| WO (1) | WO2021041591A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108697641A (zh) | 2015-08-18 | 2018-10-23 | 安斯泰来再生医药协会 | 临床制剂 |
| EP4372079A4 (en) * | 2021-07-15 | 2025-07-30 | Astellas Pharma Inc | PERICYTE-LIKE CELLS EXPRESSING VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) AT A HIGH LEVEL |
| CN114231481B (zh) * | 2021-12-21 | 2023-07-18 | 中国人民解放军总医院 | 一种重编程真皮成纤维细胞为内皮祖细胞的化学诱导方法 |
| US20240228975A9 (en) * | 2022-07-19 | 2024-07-11 | Lung Biotechnology Pbc | Methods for Differentiating Endothelial Cells |
| CN118177150B (zh) * | 2024-04-15 | 2024-12-03 | 中国医学科学院医学实验动物研究所 | 遗传多样性高血压小鼠模型的建立与基因转录调控分析 |
Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110064705A1 (en) * | 2008-05-06 | 2011-03-17 | Advanced Cell Technology, Inc. | Hemangio colony forming cells and non-engrafting hemangio cells |
| US20110110853A1 (en) * | 2008-06-30 | 2011-05-12 | University College Cork, National University Of Ireland, Cork | Primitive vascular progenitor cells and uses thereof |
| US20110305672A1 (en) * | 2008-07-25 | 2011-12-15 | University Of Georgia Research Foundation, Inc. | COMPOSITIONS FOR MESODERM DERIVED ISL1+ MULTIPOTENT CELLS (IMPs), EPICARDIAL PROGENITOR CELLS (EPCs) AND MULTIPOTENT CD56C CELLS (C56Cs) AND METHODS OF PRODUCING AND USING SAME |
| US20140045265A1 (en) * | 2011-02-16 | 2014-02-13 | Salk Institute For Biological Studies | Robust and efficient differentiation of human pluripotent stem cells to multipotent vascular progenitors |
| EP2718425A1 (en) * | 2011-06-09 | 2014-04-16 | F.Hoffmann-La Roche Ag | Method for differentiation of pluripotent stem cells into vascular bed cells |
| EP2778223A1 (en) * | 2011-11-08 | 2014-09-17 | National University Corporation Nagoya University | Vascular progenitor cell sheet derived from induced pluripotent stem cells, and production method therefor |
| WO2015153586A1 (en) * | 2014-03-31 | 2015-10-08 | The Johns Hopkins University | Pluripotent stem cell therapies for ischemic retinopathies |
| WO2015172207A1 (en) * | 2014-05-16 | 2015-11-19 | Katholieke Universiteit Leuven Ku Leuven Research & Development | Mesodermal progenitor cells |
| WO2016185457A1 (en) * | 2015-05-19 | 2016-11-24 | Yeda Research And Development Co. Ltd. | Methods of promoting lymphangiogenesis |
| JP2017023019A (ja) * | 2015-07-17 | 2017-02-02 | 国立大学法人京都大学 | 多能性幹細胞から中胚葉前駆細胞および血液血管前駆細胞への分化誘導法 |
| CN109689858A (zh) * | 2016-08-10 | 2019-04-26 | 印第安纳大学研究及科技有限公司 | 用于产生具有体内血管形成能力的中胚层和/或内皮集落形成细胞样细胞的方法 |
| WO2019152483A1 (en) * | 2018-01-30 | 2019-08-08 | University Of Georgia Research Foundation, Inc. | Methods for vascular construction and products therefrom |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106434527A (zh) | 2006-04-14 | 2017-02-22 | 安斯泰来再生医药协会 | 血管瘤集落形成细胞 |
| SI2785359T1 (sl) | 2011-11-30 | 2018-11-30 | Astellas Institute For Regenerative Medicine | Mezenhimske stromalne celice in uporabe povezane z njimi |
| CA2896053A1 (en) | 2012-12-21 | 2014-06-26 | Ocata Therapeutics, Inc. | Methods for production of platelets from pluripotent stem cells and compositions thereof |
| SG11201706706XA (en) * | 2015-02-20 | 2017-09-28 | Wisconsin Alumni Res Found | Generating arterial endothelial cell populations |
| JP6531335B2 (ja) * | 2015-07-17 | 2019-06-19 | 国立大学法人京都大学 | 血管内皮細胞の誘導方法 |
| CN108697641A (zh) | 2015-08-18 | 2018-10-23 | 安斯泰来再生医药协会 | 临床制剂 |
-
2020
- 2020-08-27 AU AU2020337444A patent/AU2020337444A1/en active Pending
- 2020-08-27 EP EP20768457.2A patent/EP4022038A1/en active Pending
- 2020-08-27 JP JP2022513534A patent/JP2022545737A/ja active Pending
- 2020-08-27 CA CA3151636A patent/CA3151636A1/en active Pending
- 2020-08-27 BR BR112022003659A patent/BR112022003659A2/pt unknown
- 2020-08-27 CN CN202080075551.8A patent/CN115003794A/zh active Pending
- 2020-08-27 MX MX2022002418A patent/MX2022002418A/es unknown
- 2020-08-27 TW TW109129322A patent/TW202122573A/zh unknown
- 2020-08-27 KR KR1020227010049A patent/KR20220049618A/ko active Pending
- 2020-08-27 PH PH1/2022/550392A patent/PH12022550392A1/en unknown
- 2020-08-27 US US17/632,723 patent/US20220288131A1/en active Pending
- 2020-08-27 WO PCT/US2020/048076 patent/WO2021041591A1/en not_active Ceased
-
2022
- 2022-02-24 IL IL290891A patent/IL290891A/en unknown
-
2025
- 2025-09-25 JP JP2025158999A patent/JP2026001090A/ja active Pending
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110064705A1 (en) * | 2008-05-06 | 2011-03-17 | Advanced Cell Technology, Inc. | Hemangio colony forming cells and non-engrafting hemangio cells |
| US20110110853A1 (en) * | 2008-06-30 | 2011-05-12 | University College Cork, National University Of Ireland, Cork | Primitive vascular progenitor cells and uses thereof |
| US20110305672A1 (en) * | 2008-07-25 | 2011-12-15 | University Of Georgia Research Foundation, Inc. | COMPOSITIONS FOR MESODERM DERIVED ISL1+ MULTIPOTENT CELLS (IMPs), EPICARDIAL PROGENITOR CELLS (EPCs) AND MULTIPOTENT CD56C CELLS (C56Cs) AND METHODS OF PRODUCING AND USING SAME |
| US20140045265A1 (en) * | 2011-02-16 | 2014-02-13 | Salk Institute For Biological Studies | Robust and efficient differentiation of human pluripotent stem cells to multipotent vascular progenitors |
| EP2718425A1 (en) * | 2011-06-09 | 2014-04-16 | F.Hoffmann-La Roche Ag | Method for differentiation of pluripotent stem cells into vascular bed cells |
| EP2778223A1 (en) * | 2011-11-08 | 2014-09-17 | National University Corporation Nagoya University | Vascular progenitor cell sheet derived from induced pluripotent stem cells, and production method therefor |
| WO2015153586A1 (en) * | 2014-03-31 | 2015-10-08 | The Johns Hopkins University | Pluripotent stem cell therapies for ischemic retinopathies |
| WO2015172207A1 (en) * | 2014-05-16 | 2015-11-19 | Katholieke Universiteit Leuven Ku Leuven Research & Development | Mesodermal progenitor cells |
| WO2016185457A1 (en) * | 2015-05-19 | 2016-11-24 | Yeda Research And Development Co. Ltd. | Methods of promoting lymphangiogenesis |
| JP2017023019A (ja) * | 2015-07-17 | 2017-02-02 | 国立大学法人京都大学 | 多能性幹細胞から中胚葉前駆細胞および血液血管前駆細胞への分化誘導法 |
| CN109689858A (zh) * | 2016-08-10 | 2019-04-26 | 印第安纳大学研究及科技有限公司 | 用于产生具有体内血管形成能力的中胚层和/或内皮集落形成细胞样细胞的方法 |
| WO2019152483A1 (en) * | 2018-01-30 | 2019-08-08 | University Of Georgia Research Foundation, Inc. | Methods for vascular construction and products therefrom |
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| HILL K 等: "Human embryonic stem cell-derived vascular progenitor cells capable of endothelial and smooth muscle cell function", 《EXP HEMATOL》, vol. 38, no. 3, 11 January 2010 (2010-01-11), pages 246 - 257 * |
| JAMES D 等: "Expansion and maintenance of human embryonic stem cell-derived endothelial cells by TGFbeta inhibition is Id1 dependent", 《NAT BIOTECHNOL》, vol. 28, no. 2, 17 January 2010 (2010-01-17), pages 161 - 166, XP002682519, DOI: 10.1038/NBT.1605 * |
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2022545737A (ja) | 2022-10-28 |
| KR20220049618A (ko) | 2022-04-21 |
| TW202122573A (zh) | 2021-06-16 |
| BR112022003659A2 (pt) | 2022-05-24 |
| WO2021041591A1 (en) | 2021-03-04 |
| CA3151636A1 (en) | 2021-03-04 |
| AU2020337444A1 (en) | 2022-03-24 |
| MX2022002418A (es) | 2022-03-22 |
| PH12022550392A1 (en) | 2022-12-19 |
| IL290891A (en) | 2022-04-01 |
| JP2026001090A (ja) | 2026-01-06 |
| US20220288131A1 (en) | 2022-09-15 |
| EP4022038A1 (en) | 2022-07-06 |
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