TW202122573A - 治療血管疾病之組成物及方法 - Google Patents

治療血管疾病之組成物及方法 Download PDF

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TW202122573A
TW202122573A TW109129322A TW109129322A TW202122573A TW 202122573 A TW202122573 A TW 202122573A TW 109129322 A TW109129322 A TW 109129322A TW 109129322 A TW109129322 A TW 109129322A TW 202122573 A TW202122573 A TW 202122573A
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meso
vpc
cells
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hsa
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TW109129322A
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瑪麗亞 米洛祖
奴丹 普拉森
阿姆里塔 辛格
羅伯特 蘭札
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安斯泰來再生醫藥協會
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TW109129322A 2019-08-28 2020-08-27 治療血管疾病之組成物及方法 TW202122573A (zh)

Applications Claiming Priority (2)

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US201962892724P 2019-08-28 2019-08-28
US62/892,724 2019-08-28

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TW202122573A true TW202122573A (zh) 2021-06-16

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US (1) US20220288131A1 (https=)
EP (1) EP4022038A1 (https=)
JP (2) JP2022545737A (https=)
KR (1) KR20220049618A (https=)
CN (1) CN115003794A (https=)
AU (1) AU2020337444A1 (https=)
BR (1) BR112022003659A2 (https=)
CA (1) CA3151636A1 (https=)
IL (1) IL290891A (https=)
MX (1) MX2022002418A (https=)
PH (1) PH12022550392A1 (https=)
TW (1) TW202122573A (https=)
WO (1) WO2021041591A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114231481A (zh) * 2021-12-21 2022-03-25 中国人民解放军总医院 一种重编程真皮成纤维细胞为内皮祖细胞的化学诱导方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108697641A (zh) 2015-08-18 2018-10-23 安斯泰来再生医药协会 临床制剂
EP4372079A4 (en) * 2021-07-15 2025-07-30 Astellas Pharma Inc PERICYTE-LIKE CELLS EXPRESSING VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) AT A HIGH LEVEL
US20240228975A9 (en) * 2022-07-19 2024-07-11 Lung Biotechnology Pbc Methods for Differentiating Endothelial Cells
CN118177150B (zh) * 2024-04-15 2024-12-03 中国医学科学院医学实验动物研究所 遗传多样性高血压小鼠模型的建立与基因转录调控分析

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106434527A (zh) 2006-04-14 2017-02-22 安斯泰来再生医药协会 血管瘤集落形成细胞
CA3186451A1 (en) * 2008-05-06 2009-11-12 Astellas Institute For Regenerative Medicine Hemangio colony forming cells and non-engrafting hemangio cells
WO2010001375A1 (en) * 2008-06-30 2010-01-07 University College Cork, National University Of Ireland, Cork Primitive vascular progenitor cells and uses thereof
US20110305672A1 (en) * 2008-07-25 2011-12-15 University Of Georgia Research Foundation, Inc. COMPOSITIONS FOR MESODERM DERIVED ISL1+ MULTIPOTENT CELLS (IMPs), EPICARDIAL PROGENITOR CELLS (EPCs) AND MULTIPOTENT CD56C CELLS (C56Cs) AND METHODS OF PRODUCING AND USING SAME
US20140045265A1 (en) * 2011-02-16 2014-02-13 Salk Institute For Biological Studies Robust and efficient differentiation of human pluripotent stem cells to multipotent vascular progenitors
RU2618871C2 (ru) * 2011-06-09 2017-05-11 Ф. Хоффманн-Ля Рош Аг Способ дифференциации плюрипотентных стволовых клеток в клетки сосудистого русла
WO2013069661A1 (ja) * 2011-11-08 2013-05-16 国立大学法人名古屋大学 iPS細胞由来血管前駆細胞シート及びその作製方法
SI2785359T1 (sl) 2011-11-30 2018-11-30 Astellas Institute For Regenerative Medicine Mezenhimske stromalne celice in uporabe povezane z njimi
CA2896053A1 (en) 2012-12-21 2014-06-26 Ocata Therapeutics, Inc. Methods for production of platelets from pluripotent stem cells and compositions thereof
WO2015153586A1 (en) * 2014-03-31 2015-10-08 The Johns Hopkins University Pluripotent stem cell therapies for ischemic retinopathies
GB201408712D0 (en) * 2014-05-16 2014-07-02 Univ Leuven Kath Mesodermal progenitor cells
SG11201706706XA (en) * 2015-02-20 2017-09-28 Wisconsin Alumni Res Found Generating arterial endothelial cell populations
WO2016185457A1 (en) * 2015-05-19 2016-11-24 Yeda Research And Development Co. Ltd. Methods of promoting lymphangiogenesis
JP6531335B2 (ja) * 2015-07-17 2019-06-19 国立大学法人京都大学 血管内皮細胞の誘導方法
JP6646311B2 (ja) * 2015-07-17 2020-02-14 国立大学法人京都大学 多能性幹細胞から中胚葉前駆細胞および血液血管前駆細胞への分化誘導法
CN108697641A (zh) 2015-08-18 2018-10-23 安斯泰来再生医药协会 临床制剂
WO2018031404A1 (en) * 2016-08-10 2018-02-15 Indiana University Research And Technology Corporation Method for generating mesoderm and/or endothelial colony forming cell-like cells having in vivo blood vessel forming capacity
WO2019152483A1 (en) * 2018-01-30 2019-08-08 University Of Georgia Research Foundation, Inc. Methods for vascular construction and products therefrom

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114231481A (zh) * 2021-12-21 2022-03-25 中国人民解放军总医院 一种重编程真皮成纤维细胞为内皮祖细胞的化学诱导方法

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JP2022545737A (ja) 2022-10-28
KR20220049618A (ko) 2022-04-21
BR112022003659A2 (pt) 2022-05-24
WO2021041591A1 (en) 2021-03-04
CA3151636A1 (en) 2021-03-04
AU2020337444A1 (en) 2022-03-24
MX2022002418A (es) 2022-03-22
PH12022550392A1 (en) 2022-12-19
CN115003794A (zh) 2022-09-02
IL290891A (en) 2022-04-01
JP2026001090A (ja) 2026-01-06
US20220288131A1 (en) 2022-09-15
EP4022038A1 (en) 2022-07-06

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