MX2022002418A - Composiciones y metodos de tratamiento de enfermedades vasculares. - Google Patents
Composiciones y metodos de tratamiento de enfermedades vasculares.Info
- Publication number
- MX2022002418A MX2022002418A MX2022002418A MX2022002418A MX2022002418A MX 2022002418 A MX2022002418 A MX 2022002418A MX 2022002418 A MX2022002418 A MX 2022002418A MX 2022002418 A MX2022002418 A MX 2022002418A MX 2022002418 A MX2022002418 A MX 2022002418A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- compositions
- vascular diseases
- treating vascular
- vpcs
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/069—Vascular Endothelial cells
- C12N5/0692—Stem cells; Progenitor cells; Precursor cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/165—Vascular endothelial growth factor [VEGF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2513/00—3D culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/54—Collagen; Gelatin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
Abstract
La presente invención se refiere en general a nuevas células progenitoras vasculares derivadas de mesodermo (meso-VPC) y métodos para producir meso-VPC. La presente invención también se refiere a métodos para tratar una enfermedad vascular, tal como la isquemia crítica de las extremidades, mediante la administración de las meso-VPC a un sujeto.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962892724P | 2019-08-28 | 2019-08-28 | |
PCT/US2020/048076 WO2021041591A1 (en) | 2019-08-28 | 2020-08-27 | Compositions and methods of treating vascular diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022002418A true MX2022002418A (es) | 2022-03-22 |
Family
ID=72428364
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022002418A MX2022002418A (es) | 2019-08-28 | 2020-08-27 | Composiciones y metodos de tratamiento de enfermedades vasculares. |
Country Status (12)
Country | Link |
---|---|
US (1) | US20220288131A1 (es) |
EP (1) | EP4022038A1 (es) |
JP (1) | JP2022545737A (es) |
KR (1) | KR20220049618A (es) |
CN (1) | CN115003794A (es) |
AU (1) | AU2020337444A1 (es) |
BR (1) | BR112022003659A2 (es) |
CA (1) | CA3151636A1 (es) |
IL (1) | IL290891A (es) |
MX (1) | MX2022002418A (es) |
TW (1) | TW202122573A (es) |
WO (1) | WO2021041591A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102411018B1 (ko) | 2015-08-18 | 2022-06-20 | 아스텔라스 인스티튜트 포 리제너러티브 메디슨 | 임상 제제 |
CN114231481B (zh) * | 2021-12-21 | 2023-07-18 | 中国人民解放军总医院 | 一种重编程真皮成纤维细胞为内皮祖细胞的化学诱导方法 |
WO2024020399A1 (en) * | 2022-07-19 | 2024-01-25 | Lung Biotechnology Pbc | Methods for differentiating endothelial cells |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2426197A1 (en) | 2006-04-14 | 2012-03-07 | Advanced Cell Technology, Inc. | Hemangio-colony forming cells |
KR20110016913A (ko) | 2008-05-06 | 2011-02-18 | 어드밴스드 셀 테크놀로지, 인코포레이티드 | 혈관 콜로니 형성 세포 및 비-생착성 혈관 세포 |
MX349658B (es) * | 2011-06-09 | 2017-08-08 | Hoffmann La Roche | Metodo para la diferenciacion de las celulas madre pluripotentes en celulas de lecho vascular. |
EP2785359B1 (en) | 2011-11-30 | 2018-08-29 | Astellas Institute for Regenerative Medicine | Mesenchymal stromal cells and uses related thereto |
EP3973967A1 (en) | 2012-12-21 | 2022-03-30 | Astellas Institute for Regenerative Medicine | Methods for production of platelets from pluripotent stem cells and compositions thereof |
KR102411018B1 (ko) | 2015-08-18 | 2022-06-20 | 아스텔라스 인스티튜트 포 리제너러티브 메디슨 | 임상 제제 |
-
2020
- 2020-08-27 CA CA3151636A patent/CA3151636A1/en active Pending
- 2020-08-27 KR KR1020227010049A patent/KR20220049618A/ko unknown
- 2020-08-27 AU AU2020337444A patent/AU2020337444A1/en active Pending
- 2020-08-27 JP JP2022513534A patent/JP2022545737A/ja active Pending
- 2020-08-27 US US17/632,723 patent/US20220288131A1/en active Pending
- 2020-08-27 WO PCT/US2020/048076 patent/WO2021041591A1/en active Application Filing
- 2020-08-27 CN CN202080075551.8A patent/CN115003794A/zh active Pending
- 2020-08-27 BR BR112022003659A patent/BR112022003659A2/pt unknown
- 2020-08-27 TW TW109129322A patent/TW202122573A/zh unknown
- 2020-08-27 EP EP20768457.2A patent/EP4022038A1/en active Pending
- 2020-08-27 MX MX2022002418A patent/MX2022002418A/es unknown
-
2022
- 2022-02-24 IL IL290891A patent/IL290891A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN115003794A (zh) | 2022-09-02 |
WO2021041591A1 (en) | 2021-03-04 |
BR112022003659A2 (pt) | 2022-05-24 |
JP2022545737A (ja) | 2022-10-28 |
EP4022038A1 (en) | 2022-07-06 |
AU2020337444A1 (en) | 2022-03-24 |
US20220288131A1 (en) | 2022-09-15 |
KR20220049618A (ko) | 2022-04-21 |
TW202122573A (zh) | 2021-06-16 |
CA3151636A1 (en) | 2021-03-04 |
IL290891A (en) | 2022-04-01 |
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