CN115003335A - 用于施用活性剂的胃驻留系统 - Google Patents

用于施用活性剂的胃驻留系统 Download PDF

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Publication number
CN115003335A
CN115003335A CN202080092586.2A CN202080092586A CN115003335A CN 115003335 A CN115003335 A CN 115003335A CN 202080092586 A CN202080092586 A CN 202080092586A CN 115003335 A CN115003335 A CN 115003335A
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CN
China
Prior art keywords
gastric
arm
polymer
linker
plga
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080092586.2A
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English (en)
Chinese (zh)
Inventor
R·卡纳斯蒂
T·格兰特
D·阿尔特雷特尔
A·韦特
S·穆尔蒂
T·塔伊
J·J·蒙特兹科
M·施瓦兹
J·H·杨
J·德兰
M·段
荆捷
D·C·杜富尔
E·R·W·赖德
N·比海斯
N·德拉托雷
S·霍拉尔
E·贝金
C·西姆赛斯
E·皮克
E·拉伊
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lindera Treatment Co
Original Assignee
Lindera Treatment Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lindera Treatment Co filed Critical Lindera Treatment Co
Publication of CN115003335A publication Critical patent/CN115003335A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202080092586.2A 2019-11-08 2020-11-06 用于施用活性剂的胃驻留系统 Pending CN115003335A (zh)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US201962933313P 2019-11-08 2019-11-08
US201962933211P 2019-11-08 2019-11-08
US201962933210P 2019-11-08 2019-11-08
US201962933226P 2019-11-08 2019-11-08
US201962933348P 2019-11-08 2019-11-08
US62/933,211 2019-11-08
US62/933,226 2019-11-08
US62/933,210 2019-11-08
US62/933,348 2019-11-08
US62/933,313 2019-11-08
US202062992075P 2020-03-19 2020-03-19
US62/992,075 2020-03-19
US202063052905P 2020-07-16 2020-07-16
US63/052,905 2020-07-16
PCT/US2020/059541 WO2021092491A1 (en) 2019-11-08 2020-11-06 Gastric residence systems for administration of active agents

Publications (1)

Publication Number Publication Date
CN115003335A true CN115003335A (zh) 2022-09-02

Family

ID=75849597

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080092586.2A Pending CN115003335A (zh) 2019-11-08 2020-11-06 用于施用活性剂的胃驻留系统

Country Status (10)

Country Link
US (1) US20220387311A1 (https=)
EP (1) EP4054545A4 (https=)
JP (1) JP2022553862A (https=)
CN (1) CN115003335A (https=)
AU (1) AU2020378438A1 (https=)
BR (1) BR112022008908A2 (https=)
CA (1) CA3160665A1 (https=)
IL (1) IL292849A (https=)
MX (1) MX2022005494A (https=)
WO (1) WO2021092491A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025148850A1 (zh) * 2024-01-09 2025-07-17 厦门君德医药科技有限公司 一种胃滞留装置
WO2025153071A1 (en) * 2024-01-18 2025-07-24 Junion Therapeutics (Xiamen) Co., Ltd. Gastric residence article for oral administration
WO2025195482A1 (zh) * 2024-03-22 2025-09-25 厦门君德医药科技有限公司 一种胃滞留装置

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020117855A1 (en) 2018-12-03 2020-06-11 Lyndra, Inc. Stomach simulating device
MX2021011314A (es) 2019-03-20 2021-12-10 Lyndra Therapeutics Inc Capsulas y recubrimientos de capsulas para formas de dosificacion de residencia gastrica.
JP2022525482A (ja) 2019-03-20 2022-05-16 リンドラ セラピューティクス， インコーポレイティド 胃内滞留剤形用のコーティング
CN116234540A (zh) 2020-07-29 2023-06-06 赛康特集团有限责任公司 具有包括交联聚(癸二酸甘油酯)的结构的形状引导控释和滞留
AU2022210426A1 (en) * 2021-01-19 2023-08-24 Nortiva Bio, Inc. Gastric residence systems for administration of risperidone
CA3248763A1 (en) * 2022-01-19 2023-07-27 Nortiva Bio, Inc. Dosage forms for gastric retention
CN115227879B (zh) * 2022-09-15 2023-01-06 北京天星博迈迪医疗器械有限公司 一种用于可降解关节球囊的组合物及其应用、一种可降解关节球囊及其制备方法
WO2024249946A2 (en) * 2023-06-02 2024-12-05 Lyndra Therapeutics, Inc. Manufacturing methods for gastric residence systems
WO2025042350A1 (en) * 2023-08-24 2025-02-27 Junion Therapeutics (Xiamen) Co., Ltd. A gastric residence article for oral administration
WO2025042349A1 (en) * 2023-08-24 2025-02-27 Junion Therapeutics (Xiamen) Co., Ltd. A gastric residence article for oral administration

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101400363A (zh) * 2006-01-18 2009-04-01 Qps有限公司 具有增强的稳定性的药物组合物
US20130225778A1 (en) * 2010-08-06 2013-08-29 Stephen Dean Goodrich Radiopaque shape memory polymers for medical devices
CN108472249A (zh) * 2015-10-23 2018-08-31 林德拉有限公司 用于治疗剂缓释的胃驻留系统及其使用方法
CN108697649A (zh) * 2015-12-08 2018-10-23 林德拉有限公司 用于胃驻留系统的几何构型
TW201902459A (zh) * 2017-06-09 2019-01-16 美商萊恩卓公司 具有釋放速率調節膜之胃的滯留系統
WO2019060458A1 (en) * 2017-09-20 2019-03-28 Lyndra, Inc. ENCAPSULATION OF GASTRIC SYSTEMS
CN110022861A (zh) * 2016-09-30 2019-07-16 林德拉有限公司 用于金刚烷类药物缓释的胃驻留系统

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GB9925962D0 (en) * 1999-11-02 1999-12-29 Novartis Ag Organic compounds
ES2368356T3 (es) * 2007-07-06 2011-11-16 Basf Corporation Composición de retención gástrica basada en un producto de reacción hidrosoluble procedente de un precursor que contiene un grupo vinilo.
JP5905872B2 (ja) * 2010-04-07 2016-04-20 ルピン・リミテッド タペンタドールの制御放出医薬組成物
WO2015191922A1 (en) * 2014-06-11 2015-12-17 Massachusetts Institute Of Technology Enteric elastomers
AU2017268840B2 (en) * 2016-05-27 2022-02-10 Nortiva Bio, Inc. Materials architecture for gastric residence systems
KR20220002905A (ko) * 2019-03-25 2022-01-07 더글라스 파머수티클스 리미티드 서방형 약학 제제

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101400363A (zh) * 2006-01-18 2009-04-01 Qps有限公司 具有增强的稳定性的药物组合物
US20130225778A1 (en) * 2010-08-06 2013-08-29 Stephen Dean Goodrich Radiopaque shape memory polymers for medical devices
CN108472249A (zh) * 2015-10-23 2018-08-31 林德拉有限公司 用于治疗剂缓释的胃驻留系统及其使用方法
CN108697649A (zh) * 2015-12-08 2018-10-23 林德拉有限公司 用于胃驻留系统的几何构型
CN110022861A (zh) * 2016-09-30 2019-07-16 林德拉有限公司 用于金刚烷类药物缓释的胃驻留系统
TW201902459A (zh) * 2017-06-09 2019-01-16 美商萊恩卓公司 具有釋放速率調節膜之胃的滯留系統
WO2019060458A1 (en) * 2017-09-20 2019-03-28 Lyndra, Inc. ENCAPSULATION OF GASTRIC SYSTEMS

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025148850A1 (zh) * 2024-01-09 2025-07-17 厦门君德医药科技有限公司 一种胃滞留装置
WO2025153071A1 (en) * 2024-01-18 2025-07-24 Junion Therapeutics (Xiamen) Co., Ltd. Gastric residence article for oral administration
WO2025195482A1 (zh) * 2024-03-22 2025-09-25 厦门君德医药科技有限公司 一种胃滞留装置

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Publication number Publication date
IL292849A (en) 2022-07-01
US20220387311A1 (en) 2022-12-08
WO2021092491A1 (en) 2021-05-14
MX2022005494A (es) 2022-08-11
CA3160665A1 (en) 2021-05-14
JP2022553862A (ja) 2022-12-26
AU2020378438A1 (en) 2022-06-02
BR112022008908A2 (pt) 2022-10-11
EP4054545A4 (en) 2024-02-14
EP4054545A1 (en) 2022-09-14

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