CN1148378C - 15-脱氧精胍林类似物、其制备方法及其治疗应用 - Google Patents

15-脱氧精胍林类似物、其制备方法及其治疗应用 Download PDF

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Publication number
CN1148378C
CN1148378C CNB951021621A CN95102162A CN1148378C CN 1148378 C CN1148378 C CN 1148378C CN B951021621 A CNB951021621 A CN B951021621A CN 95102162 A CN95102162 A CN 95102162A CN 1148378 C CN1148378 C CN 1148378C
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China
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formula
compound
amino
preparation
group
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Expired - Fee Related
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CNB951021621A
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English (en)
Chinese (zh)
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CN1119191A (zh
Inventor
��˹��ŵ��
帕特里斯·雷诺特
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卢克·勒布雷顿
帕特里斯·达塔特里
菲利普·德里帕斯
��������ķ������
索思·萨姆里斯
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Fournier Industrie et Sante SAS
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Fournier Industrie et Sante SAS
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Priority claimed from FR9402125A external-priority patent/FR2716451B1/fr
Application filed by Fournier Industrie et Sante SAS filed Critical Fournier Industrie et Sante SAS
Publication of CN1119191A publication Critical patent/CN1119191A/zh
Application granted granted Critical
Publication of CN1148378C publication Critical patent/CN1148378C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CNB951021621A 1994-02-24 1995-02-22 15-脱氧精胍林类似物、其制备方法及其治疗应用 Expired - Fee Related CN1148378C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR9402125 1994-02-24
FR9402125A FR2716451B1 (fr) 1994-02-24 1994-02-24 Analogues de la 15-déoxyspergualine, leur procédé de préparation et leur utilisation en thérapeutique.
FR9406706 1994-06-01
FR9406706A FR2716452B1 (fr) 1994-02-24 1994-06-01 Analogues de la 15-déoxyspergualine, leur procédé de préparation et leur utilisation en thérapeutique.

Publications (2)

Publication Number Publication Date
CN1119191A CN1119191A (zh) 1996-03-27
CN1148378C true CN1148378C (zh) 2004-05-05

Family

ID=26230971

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB951021621A Expired - Fee Related CN1148378C (zh) 1994-02-24 1995-02-22 15-脱氧精胍林类似物、其制备方法及其治疗应用

Country Status (22)

Country Link
US (1) US5637613A (enExample)
EP (1) EP0669316B1 (enExample)
JP (1) JP2874839B2 (enExample)
KR (1) KR100188991B1 (enExample)
CN (1) CN1148378C (enExample)
AT (1) ATE156117T1 (enExample)
AU (1) AU691847B2 (enExample)
CA (1) CA2143216C (enExample)
CZ (1) CZ287985B6 (enExample)
DE (1) DE69404624T2 (enExample)
DK (1) DK0669316T3 (enExample)
ES (1) ES2106480T3 (enExample)
FI (1) FI950728A7 (enExample)
FR (1) FR2716452B1 (enExample)
GR (1) GR3025164T3 (enExample)
HU (1) HUT70958A (enExample)
NO (1) NO302816B1 (enExample)
NZ (1) NZ270449A (enExample)
RU (1) RU2113431C1 (enExample)
SK (1) SK281058B6 (enExample)
TW (1) TW317562B (enExample)
UA (1) UA37217C2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2734263B1 (fr) * 1995-05-17 1997-06-20 Fournier Ind & Sante Analogues de la 15-deoxyspergualine, leur procede de preparation et leur utilisation en therapeutique
US5985824A (en) * 1997-02-27 1999-11-16 Genzyme Corporation Methods and compositions for treating cystic fibrosis
US5834421A (en) * 1997-02-27 1998-11-10 Genzyme Corporation Methods and compositions for treating cystic fibrosis
US20020142000A1 (en) * 1999-01-15 2002-10-03 Digan Mary Ellen Anti-CD3 immunotoxins and therapeutic uses therefor
DE19923961A1 (de) * 1999-05-25 2000-11-30 Euro Nippon Kayaku Gmbh Verwendung von 15-Deoxyspergualin zur Behandlung von hyperreaktiven entzündlichen Erkrankungen und Autoimmunerkrankungen
JP5878172B2 (ja) * 2010-07-29 2016-03-08 ラボラトワール フルニエ エスアーエス 炎症性眼疾患の治療／予防用化合物
FR2963238B1 (fr) * 2010-07-29 2012-12-28 Fournier Lab Sa Derives de 15-desoxyspergualine pour le traitement et/ou la prevention des maladies inflammatoires oculaires

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5942356A (ja) * 1982-09-02 1984-03-08 Microbial Chem Res Found スパガリン関連化合物およびその製造法
JPS61129119A (ja) * 1984-11-13 1986-06-17 Microbial Chem Res Found 新規免疫抑制剤

Also Published As

Publication number Publication date
KR100188991B1 (ko) 1999-06-01
SK281058B6 (sk) 2000-11-07
AU1028895A (en) 1995-08-31
CZ287985B6 (cs) 2001-03-14
US5637613A (en) 1997-06-10
DE69404624D1 (de) 1997-09-04
JP2874839B2 (ja) 1999-03-24
RU95102479A (ru) 1997-05-10
EP0669316A1 (fr) 1995-08-30
UA37217C2 (uk) 2001-05-15
NO950664D0 (no) 1995-02-22
DE69404624T2 (de) 1998-02-05
ATE156117T1 (de) 1997-08-15
RU2113431C1 (ru) 1998-06-20
TW317562B (enExample) 1997-10-11
NO950664L (no) 1995-08-25
HK1000489A1 (en) 1998-03-27
KR950032097A (ko) 1995-12-20
CA2143216C (en) 1999-04-13
CN1119191A (zh) 1996-03-27
JPH0841007A (ja) 1996-02-13
NO302816B1 (no) 1998-04-27
ES2106480T3 (es) 1997-11-01
HUT70958A (en) 1995-11-28
EP0669316B1 (fr) 1997-07-30
GR3025164T3 (en) 1998-02-27
FI950728L (fi) 1995-08-25
FI950728A7 (fi) 1995-08-25
CA2143216A1 (en) 1995-08-25
FR2716452A1 (fr) 1995-08-25
NZ270449A (en) 1996-08-27
AU691847B2 (en) 1998-05-28
FR2716452B1 (fr) 1996-05-10
FI950728A0 (fi) 1995-02-17
HU9500556D0 (en) 1995-04-28
SK24795A3 (en) 1995-09-13
DK0669316T3 (da) 1998-03-09
CZ50295A3 (en) 1995-10-18

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