KR100188991B1 - 15-데옥시스페르구아린유사체,이들의제조방법및치료학적인용도 - Google Patents

15-데옥시스페르구아린유사체,이들의제조방법및치료학적인용도 Download PDF

Info

Publication number
KR100188991B1
KR100188991B1 KR1019950003654A KR19950003654A KR100188991B1 KR 100188991 B1 KR100188991 B1 KR 100188991B1 KR 1019950003654 A KR1019950003654 A KR 1019950003654A KR 19950003654 A KR19950003654 A KR 19950003654A KR 100188991 B1 KR100188991 B1 KR 100188991B1
Authority
KR
South Korea
Prior art keywords
group
formula
compound
amino
mol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019950003654A
Other languages
English (en)
Korean (ko)
Other versions
KR950032097A (ko
Inventor
르노 빠뜨리쓰
르브르똥 뤽
뒤따르뜨르 페트릭
데르빠스 필립
쌍레뜨 소뜨
Original Assignee
프랑소와 피카르
푸르니에 엥디스트리에 쌍떼
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9402125A external-priority patent/FR2716451B1/fr
Application filed by 프랑소와 피카르, 푸르니에 엥디스트리에 쌍떼 filed Critical 프랑소와 피카르
Publication of KR950032097A publication Critical patent/KR950032097A/ko
Application granted granted Critical
Publication of KR100188991B1 publication Critical patent/KR100188991B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
KR1019950003654A 1994-02-24 1995-02-24 15-데옥시스페르구아린유사체,이들의제조방법및치료학적인용도 Expired - Fee Related KR100188991B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR9402125A FR2716451B1 (fr) 1994-02-24 1994-02-24 Analogues de la 15-déoxyspergualine, leur procédé de préparation et leur utilisation en thérapeutique.
FR9402125 1994-02-24
FR9406706A FR2716452B1 (fr) 1994-02-24 1994-06-01 Analogues de la 15-déoxyspergualine, leur procédé de préparation et leur utilisation en thérapeutique.
FR9406706 1994-06-01

Publications (2)

Publication Number Publication Date
KR950032097A KR950032097A (ko) 1995-12-20
KR100188991B1 true KR100188991B1 (ko) 1999-06-01

Family

ID=26230971

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950003654A Expired - Fee Related KR100188991B1 (ko) 1994-02-24 1995-02-24 15-데옥시스페르구아린유사체,이들의제조방법및치료학적인용도

Country Status (22)

Country Link
US (1) US5637613A (enExample)
EP (1) EP0669316B1 (enExample)
JP (1) JP2874839B2 (enExample)
KR (1) KR100188991B1 (enExample)
CN (1) CN1148378C (enExample)
AT (1) ATE156117T1 (enExample)
AU (1) AU691847B2 (enExample)
CA (1) CA2143216C (enExample)
CZ (1) CZ287985B6 (enExample)
DE (1) DE69404624T2 (enExample)
DK (1) DK0669316T3 (enExample)
ES (1) ES2106480T3 (enExample)
FI (1) FI950728A7 (enExample)
FR (1) FR2716452B1 (enExample)
GR (1) GR3025164T3 (enExample)
HU (1) HUT70958A (enExample)
NO (1) NO302816B1 (enExample)
NZ (1) NZ270449A (enExample)
RU (1) RU2113431C1 (enExample)
SK (1) SK281058B6 (enExample)
TW (1) TW317562B (enExample)
UA (1) UA37217C2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2734263B1 (fr) * 1995-05-17 1997-06-20 Fournier Ind & Sante Analogues de la 15-deoxyspergualine, leur procede de preparation et leur utilisation en therapeutique
US5834421A (en) * 1997-02-27 1998-11-10 Genzyme Corporation Methods and compositions for treating cystic fibrosis
US5985824A (en) * 1997-02-27 1999-11-16 Genzyme Corporation Methods and compositions for treating cystic fibrosis
US20020142000A1 (en) * 1999-01-15 2002-10-03 Digan Mary Ellen Anti-CD3 immunotoxins and therapeutic uses therefor
DE19923961A1 (de) * 1999-05-25 2000-11-30 Euro Nippon Kayaku Gmbh Verwendung von 15-Deoxyspergualin zur Behandlung von hyperreaktiven entzündlichen Erkrankungen und Autoimmunerkrankungen
FR2963238B1 (fr) * 2010-07-29 2012-12-28 Fournier Lab Sa Derives de 15-desoxyspergualine pour le traitement et/ou la prevention des maladies inflammatoires oculaires
WO2012013884A1 (fr) * 2010-07-29 2012-02-02 Laboratoires Fournier Sa Composes pour le traitement/la prevention des maladies inflammatoires oculaires

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5942356A (ja) * 1982-09-02 1984-03-08 Microbial Chem Res Found スパガリン関連化合物およびその製造法
JPS61129119A (ja) * 1984-11-13 1986-06-17 Microbial Chem Res Found 新規免疫抑制剤

Also Published As

Publication number Publication date
FI950728L (fi) 1995-08-25
DE69404624D1 (de) 1997-09-04
HUT70958A (en) 1995-11-28
EP0669316B1 (fr) 1997-07-30
EP0669316A1 (fr) 1995-08-30
HU9500556D0 (en) 1995-04-28
JP2874839B2 (ja) 1999-03-24
RU2113431C1 (ru) 1998-06-20
NZ270449A (en) 1996-08-27
CA2143216C (en) 1999-04-13
TW317562B (enExample) 1997-10-11
SK24795A3 (en) 1995-09-13
CZ287985B6 (cs) 2001-03-14
NO302816B1 (no) 1998-04-27
HK1000489A1 (en) 1998-03-27
JPH0841007A (ja) 1996-02-13
DE69404624T2 (de) 1998-02-05
AU1028895A (en) 1995-08-31
CA2143216A1 (en) 1995-08-25
ATE156117T1 (de) 1997-08-15
RU95102479A (ru) 1997-05-10
CN1119191A (zh) 1996-03-27
FR2716452B1 (fr) 1996-05-10
SK281058B6 (sk) 2000-11-07
GR3025164T3 (en) 1998-02-27
KR950032097A (ko) 1995-12-20
UA37217C2 (uk) 2001-05-15
CZ50295A3 (en) 1995-10-18
DK0669316T3 (da) 1998-03-09
FR2716452A1 (fr) 1995-08-25
FI950728A7 (fi) 1995-08-25
NO950664D0 (no) 1995-02-22
FI950728A0 (fi) 1995-02-17
NO950664L (no) 1995-08-25
US5637613A (en) 1997-06-10
CN1148378C (zh) 2004-05-05
ES2106480T3 (es) 1997-11-01
AU691847B2 (en) 1998-05-28

Similar Documents

Publication Publication Date Title
RU2114823C1 (ru) Аналоги 15-деоксиспергуалина, способ их получения и фармацевтическая композиция на их основе
KR100188991B1 (ko) 15-데옥시스페르구아린유사체,이들의제조방법및치료학적인용도
JPH11503422A (ja) プロテアーゼを阻害するコハク酸誘導体
JPS6323897A (ja) タフトシン類似体、その製法及び医薬組成物
HK1000467B (en) Analogues of the 15-deoxyspergualin, process for their preparation and their use as immunosuppresants
WO1997025982A1 (en) Dicarbonyl-containing compounds
HU206194B (en) Process for producing cyclomethylene-1,2-dicarboxylic acid derivatives and pharmaceutical compositions comprising same
HUT74935A (en) Novel high enantio-selective process for producing pure enantiomeric cyclopentane and cyclopentene-beta-amino acids
US6258976B1 (en) Process for the preparation of polyamines and polyamine derivatives
JP2860778B2 (ja) １５−デオキシスペルグアリン類似体、その製造方法および治療薬
JPH03500880A (ja) レニン阻害剤、その製造方法、その使用のための方法およびそれを含有する組成物
EP0433360A1 (en) IMPROVEMENTS IN OR RELATING TO THE PRODUCTION OF MEDICAMENT PRECURSORS.
WO2000064865A1 (en) Monomers and oligourea peptidomimetics and process for the prepa ration thereof
FR2716451A1 (fr) Analogues de la 15-déoxyspergualine, leur procédé de préparation et leur utilisation en thérapeutique.
HK1000489B (en) Analogs of 15-deoxyspergualine, process for their preparation and their use as immunosuppressive agents

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R13-asn-PN2301

St.27 status event code: A-5-5-R10-R11-asn-PN2301

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

FPAY Annual fee payment

Payment date: 20051219

Year of fee payment: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20070115

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20070115

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R13-asn-PN2301

St.27 status event code: A-5-5-R10-R11-asn-PN2301

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000