CN114796020A - 一种可起泡沫的口腔用组合物 - Google Patents
一种可起泡沫的口腔用组合物 Download PDFInfo
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- CN114796020A CN114796020A CN202210387333.9A CN202210387333A CN114796020A CN 114796020 A CN114796020 A CN 114796020A CN 202210387333 A CN202210387333 A CN 202210387333A CN 114796020 A CN114796020 A CN 114796020A
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- component
- oral composition
- foamable
- sodium
- foamable oral
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Abstract
本发明提供的可起泡沫的口腔用组合物，以质量百分比计，包括以下组分：0.01～1％的组分A，0.01～5％的组分B，0.1～5％的组分C，3～30％的组分D和0.1～10％的表面活性剂；所述组分A包括O‑伞花烃‑5‑醇、尼泊金甲酯、苯氧乙醇、氯己定、西吡氯铵、三氯生、尿囊素、氨甲环酸、丁香酚、百里香酚、叶绿素铜钠盐和冰片中的一种或多种；所述组分B包括聚乙烯吡咯烷酮、月桂酰基肌氨酸钠、烷基糖苷和椰油酰胺丙基甜菜碱中的一种或多种；所述组分C包括纤维素胶、卡拉胶和羟丙基瓜尔胶中的一种或多种；所述组分D包括甘油、山梨醇、聚乙二醇和丙二醇中的一种或多种。本发明提供的可起泡沫的口腔用组合物泡沫持续时间长。
Description
本申请是申请日为2017年10月13日、申请号为201710956784.9、发明名称为《一种可起泡沫的口腔用组合物》的发明专利的分案申请。
技术领域
本发明涉及一种可起泡沫的组合物，其主要用于口腔护理。
背景技术
可起泡的口腔组合物是一种不含摩擦剂的口腔护理产品，一般采用弹簧泵式起泡器，经挤压后形成较丰富的泡沫，可选择性配合指套，硅胶手套或牙刷使用，用于清洁口腔，使用简单、方便。
特别是针对婴幼儿和老年人这样的特殊群体，采用牙刷刷牙的方式很可能为他们脆弱的牙龈带来伤害，而导致他们不喜欢刷牙，采用这种简单的口腔组合物，选择涂抹，能为他们解决刷牙的难题。
并且，有研究者发现将抑菌、防龋等功效成分分别加入在膏体、漱口水和泡沫三种形式的口腔用组合物，配置好相同浓度的溶液后，将羟基磷灰石皮浸泡在这三种溶液中，测定其抑菌、防龋功效成分在羟基磷灰石上的吸附量，发现在泡沫形式的口腔组合物中浸泡的羟基磷灰石片吸附的功效成分浓度明显大于其他两种，这可以说明抑菌、防龋等功效成分物质加入在泡沫形式的口腔组合物中，能较好地吸附在口腔粘膜或牙齿上。
目前，市场上很少有这一类的可起泡的口腔用组合物。CN101815499A公开了一种泡沫组合物，但其泡沫持续时间、稳定性情况、成型性等并不理想，而且保存条件较为严格。
发明内容
本发明目的在于提供一种可起泡沫的口腔用组合物。本发明提供的可起泡沫的口腔用组合物稳定性好，泡沫成型性好，泡沫丰富细腻，泡沫持续时间长。
本发明的目的通过以下措施实现：
本发明提供了一种可起泡沫的口腔用组合物，以质量百分比计，包括以下组分：0.01～1％的组分A，0.01～5％的组分B，0.1～5％的组分C，3～30％的组分D和0.1～10％的表面活性剂；
所述组分A包括O-伞花烃-5-醇、尼泊金甲酯、苯氧乙醇、氯己定、西吡氯铵、三氯生、尿囊素、氨甲环酸、丁香酚、百里香酚、叶绿素铜钠盐和冰片中的一种或多种；
所述组分B包括聚乙烯吡咯烷酮、月桂酰基肌氨酸钠、烷基糖苷和椰油酰胺丙基甜菜碱中的一种或多种；
所述组分C包括纤维素胶、卡拉胶和羟丙基瓜尔胶中的一种或多种；
所述组分D包括甘油、山梨醇、聚乙二醇和丙二醇中的一种或多种。
优选的，所述表面活性剂包括离子型表面活性剂、非离子型表面活性剂和两性表面活性剂中的一种或几种。
优选的，所述表面活性剂包括泊洛沙姆和/或月桂醇硫酸钠。
优选的，所述可起泡沫的口腔用组合物还包括pH调节剂。
优选的，所述pH调节剂包括柠檬酸、苹果酸、酒石酸、碳酸氢钠、碳酸氢钾、磷酸二氢钠/磷酸钠/磷酸氢二钠酸碱缓冲剂、柠檬酸钠/柠檬酸酸碱缓冲剂中的一种或多种。
优选的，所述pH调节剂的质量为可起泡沫的口腔用组合物的0.01～1％。
优选的，以质量百分比计，所述可起泡沫的口腔用组合物还包括0.01～2％的甜味剂、0.1～5％的香精和10～99％的水。
优选的，所述甜味剂包括糖精钠、三氯蔗糖、甜蜜素、甜菊糖苷、木糖醇、赤藓糖醇和异麦芽酮糖中的一种或几种；
所述香精包括草莓、香橙、苹果和薄荷中的一种或几种。
在本发明中，所述可起泡沫的口腔用组合物还包括粘结剂以及抗敏、去渍、美白、清新口气，缓解牙龈肿痛、出血等一种或多种功效成分和其它口腔护理中常用辅料。
优选的，所述可起泡沫的口腔用组合物的pH值为5.5～10.0。本发明得到的可起泡沫的口腔用组合物在常温和高温下pH能持续稳定在该范围内，长达三个月以上。
优选的，所述可起泡沫的口腔用组合物的泡沫持续时间不低于150s。
本发明中，未特别提出的，其涉及的百分比以重量百分比计。
在本发明中，所述组分A有效提高了泡沫组合物的稳定性，并兼具抑菌清洁作用；且保存方便，各性能持久保持。在本发明中，所述组分B能够进一步提高组合物的稳定性，并同时增效泡沫，使泡沫更加丰富细腻。在本发明中，所述组分C能够使组合物泡沫成型性较好，泡沫持续时间增长。在本发明中，所述组分D能够进一步提高各组分的相容性，使泡沫组合物更加稳定，防止结晶析出现象的发生。
本发明人基于市面上特殊人群刷牙的现状，特提出了该款泡沫丰富，安全性高，无刺激和使用方便的液体口腔组合物。
有益效果
1.本发明的可起泡沫的口腔用组合物，泡沫丰富细腻，成型性好、泡沫持续时间长并可超过150s，能充分接触口腔的各个角落，有很好的抑菌清洁力。
2.本发明选材考究，安全性高，对口腔、皮肤和人体无刺激。
3.本发明使用简单、方便，口感舒适，可作为使用、携带方便的液体洁牙泡沫，易于保存，各优异性能能较长时间保持。
4.本发明保质期长，在常温以及加速试验45℃条件三个月，依然能呈现出无析出的透明液体，并且不影响其稳定性，透明度以及泡沫丰富程度。
附图说明
图1实施例及对比例泡沫丰富性和成型性试验结果；
图2抑菌试验图。
具体实施方式
下面通过实施例对本发明进行具体的描述，有必要在此指出的是本实施例只能用于对本发明进行进一步说明，不能理解为对本发明保护范围的限制，该领域的技术熟练人员可以根据上述本发明的内容作出一些非本质的改进和调整。
按照表1-3中的配方比例制备可起泡沫的口腔用组合物，按以下步骤：
(1)按照配方比例，称取大部分(60-80％)组分D，以及组分A、组分B、表面活性剂、pH调节剂，甜味剂和水，或根据需要加入的功效成分，搅拌至完全溶解；
(2)再称取组分C，溶解在剩余的组分D中，直接加入步骤(1)溶液中，快速搅拌，至充分溶解；
(3)最后加入香精，搅拌混合均匀，制得所述液体口腔组合物。
表1
表2
表3
表4
实施例和对比实施例中，O-伞花烃-5-醇可以被尼泊金甲酯、苯氧乙醇、氯己定、西吡氯铵、三氯生、尿囊素、氨甲环酸、丁香酚、百里香酚、叶绿素铜钠盐、冰片中的一种或多种替代，效果与O-伞花烃-5-醇的效果一致。K30可被月桂酰基肌氨酸钠、烷基糖苷、椰油酰胺丙基甜菜碱或它们的混合物替代。纤维素胶可被纤维素胶、卡拉胶、羟丙基瓜尔胶或它们的混合物替代。
甜味剂可替换为糖精钠，三氯蔗糖、甜蜜素、甜菊糖苷，木糖醇，赤藓糖醇、异麦芽酮糖，氯化钠或其混合物，效果与添加三氯蔗糖一致。香精可以使用草莓，香橙，苹果，薄荷等多种香精中的一种或者多种混合物。上述实施例和对比实施例还可以选择性加入一些抗敏、去渍、美白、清新口气，缓解牙龈肿痛、出血等一种或多种功效成分。
实验结果：
1.抑菌试验结果：
*评判标准：细菌总数从初始到14天的细菌数对数减少值不能小于2.0，并且从14天到28天细菌数不能增加，霉菌和酵母菌总数从初始到14天和28天，数量不能增加。
实施例1的抑菌实验数据
对比例1的抑菌实验数据
实施例4的抑菌实验数据
对比例2的抑菌实验数据
实施例7的抑菌试验数据
对比例3的抑菌试验数据
对比例1、2和3没有通过抑菌试验。
2.稳定性实验组：
*45℃条件下能加速产品的老化情况。本产品分别在常温和45℃两种条件观察三个月，主要测定其pH值，变化范围越小并在上述规范产品的pH范围内，视为产品的稳定性，试验通过和保质期较长。如果超出这个范围，就视为不稳定和不能经过较长的保质期。不稳定情况主要是pH值不断降低，超出了5.5-10.0的范围，视为不稳定。
实施例1稳定性试验
对比例4的稳定性试验
实施例4的稳定性试验
对比实施例5的稳定性试验
实施例7的稳定性试验
对比例6的稳定性试验
对比例和实验组的稳定性试验可看出，对比例4、5和6都是不稳定的。
3.泡沫持续时间试验：
*主要通过秒表记录泡沫挤出后直到消失殆尽的时间
对比实施例8-10中，持续时间分别比实施例1、4和7少很多。
4.抑菌试验效果
*在其他条件相同的条件下，加入相同的抑菌清洁成分，并在相同的处理条件下，实施例样品，漱口水，牙膏溶液分别对口腔常见菌(变异链球菌)的生长影响情况，采用吸光光度法，以ΔOD值记数，其值越低，表明抑菌效果越明显。
图2可以看出，实施例抑菌效果明显优于牙膏和漱口水对变异链球菌的生长抑制作用。
5.泡沫丰富性和成型性试验：
*通过视觉直接观察泡沫的多少，丰富的泡沫组白色并且厚，成型性好的泡沫能保持一定形状，不会很快液化。
从图1可以得出，本发明实施例中各组分相互配合，使液体泡沫组合物产品稳定、成型性好，泡沫丰富，泡沫的持续性时间长。
尽管上述实施例对本发明做出了详尽的描述，但它仅仅是本发明一部分实施例，而不是全部实施例，还可以根据本实施例在不经创造性前提下获得其他实施例，这些实施例都属于本发明保护范围。
Claims (10)
1.一种可起泡沫的口腔用组合物，其特征在于，以质量百分比计，包括以下组分：0.01～1％的组分A，0.01～5％的组分B，0.1～5％的组分C，3～30％的组分D、0.1～10％的表面活性剂和10～99％的水；
所述组分A包括O-伞花烃-5-醇、尼泊金甲酯、苯氧乙醇、氯己定、西吡氯铵、三氯生、尿囊素、氨甲环酸、丁香酚、百里香酚、叶绿素铜钠盐和冰片中的一种或多种；
所述组分B包括聚乙烯吡咯烷酮、月桂酰基肌氨酸钠、烷基糖苷和椰油酰胺丙基甜菜碱中的一种或多种；
所述组分C包括纤维素胶、卡拉胶和羟丙基瓜尔胶中的一种或多种；
所述组分D包括甘油、山梨醇、聚乙二醇和丙二醇中的一种或多种。
2.根据权利要求1所述的可起泡沫的口腔用组合物，其特征在于，所述表面活性剂包括离子型表面活性剂、非离子型表面活性剂和两性表面活性剂中的一种或几种。
3.根据权利要求2所述的可起泡沫的口腔用组合物，其特征在于，所述表面活性剂包括泊洛沙姆和/或月桂醇硫酸钠。
4.根据权利要求1所述的可起泡沫的口腔用组合物，其特征在于，所述可起泡沫的口腔用组合物还包括pH调节剂。
5.根据权利要求1所述的可起泡沫的口腔用组合物，其特征在于，所述pH调节剂包括柠檬酸、苹果酸、酒石酸、碳酸氢钠、碳酸氢钾、磷酸二氢钠/磷酸钠/磷酸氢二钠酸碱缓冲剂、柠檬酸钠/柠檬酸酸碱缓冲剂中的一种或多种。
6.根据权利要求5所述的可起泡沫的口腔用组合物，其特征在于，所述pH调节剂的质量为可起泡沫的口腔用组合物的0.01～1％。
7.根据权利要求4所述的可起泡沫的口腔用组合物，其特征在于，以质量百分比计，所述可起泡沫的口腔用组合物还包括0.01～2％的甜味剂和0.1～5％的香精。
8.根据权利要求7所述的可起泡沫的口腔用组合物，其特征在于，所述甜味剂包括糖精钠、三氯蔗糖、甜蜜素、甜菊糖苷、木糖醇、赤藓糖醇和异麦芽酮糖中的一种或几种；
所述香精包括草莓、香橙、苹果和薄荷中的一种或几种。
9.根据权利要求7所述的可起泡沫的口腔用组合物，其特征在于，所述可起泡沫的口腔用组合物的pH值为5.5～10.0。
10.根据权利要求9所述的可起泡沫的口腔用组合物，其特征在于，所述可起泡沫的口腔用组合物的泡沫持续时间不低于150s。
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