JP5548969B2 - 歯磨組成物 - Google Patents
歯磨組成物 Download PDFInfo
- Publication number
- JP5548969B2 JP5548969B2 JP2008234662A JP2008234662A JP5548969B2 JP 5548969 B2 JP5548969 B2 JP 5548969B2 JP 2008234662 A JP2008234662 A JP 2008234662A JP 2008234662 A JP2008234662 A JP 2008234662A JP 5548969 B2 JP5548969 B2 JP 5548969B2
- Authority
- JP
- Japan
- Prior art keywords
- fatty acid
- weight
- dentifrice composition
- lauryl sulfate
- amidopropyl betaine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- -1 alpha Substances 0.000 claims description 42
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 35
- 239000000194 fatty acid Substances 0.000 claims description 35
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- 150000004665 fatty acids Chemical class 0.000 claims description 32
- 229960003237 betaine Drugs 0.000 claims description 24
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 claims description 22
- 229940043264 dodecyl sulfate Drugs 0.000 claims description 22
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 17
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- 229940097043 glucuronic acid Drugs 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
- 239000001685 glycyrrhizic acid Substances 0.000 description 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 230000000774 hypoallergenic effect Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 239000000832 lactitol Substances 0.000 description 1
- 235000010448 lactitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 1
- 229960003451 lactitol Drugs 0.000 description 1
- 239000010501 lemon oil Substances 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000001683 mentha spicata herb oil Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960001047 methyl salicylate Drugs 0.000 description 1
- 229940116837 methyleugenol Drugs 0.000 description 1
- PRHTXAOWJQTLBO-UHFFFAOYSA-N methyleugenol Natural products COC1=CC=C(C(C)=C)C=C1OC PRHTXAOWJQTLBO-UHFFFAOYSA-N 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 231100000017 mucous membrane irritation Toxicity 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 235000015205 orange juice Nutrition 0.000 description 1
- 239000010502 orange oil Substances 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 229940116257 pepper extract Drugs 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 229920003124 powdered cellulose Polymers 0.000 description 1
- 235000019814 powdered cellulose Nutrition 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- ROSDSFDQCJNGOL-UHFFFAOYSA-N protonated dimethyl amine Natural products CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 1
- 229940070687 psyllium Drugs 0.000 description 1
- 235000019423 pullulan Nutrition 0.000 description 1
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 239000010668 rosemary oil Substances 0.000 description 1
- 229940058206 rosemary oil Drugs 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 239000010670 sage oil Substances 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- AQMNWCRSESPIJM-UHFFFAOYSA-M sodium metaphosphate Chemical compound [Na+].[O-]P(=O)=O AQMNWCRSESPIJM-UHFFFAOYSA-M 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- URLJMZWTXZTZRR-UHFFFAOYSA-N sodium myristyl sulfate Chemical compound CCCCCCCCCCCCCCOS(O)(=O)=O URLJMZWTXZTZRR-UHFFFAOYSA-N 0.000 description 1
- 229950005425 sodium myristyl sulfate Drugs 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 1
- 229910052911 sodium silicate Inorganic materials 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000019721 spearmint oil Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 150000008054 sulfonate salts Chemical class 0.000 description 1
- 235000010491 tara gum Nutrition 0.000 description 1
- 239000000213 tara gum Substances 0.000 description 1
- 239000000892 thaumatin Substances 0.000 description 1
- 235000010436 thaumatin Nutrition 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- 229960000401 tranexamic acid Drugs 0.000 description 1
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 description 1
- 125000000647 trehalose group Chemical group 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 229960001939 zinc chloride Drugs 0.000 description 1
- 150000003752 zinc compounds Chemical class 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 229960001296 zinc oxide Drugs 0.000 description 1
- GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
本発明に用いるラウリル硫酸塩は、0.2〜0.7重量%で配合できる。0.2重量%を下回ると刺激性は低いものの充分な発泡性が得られず、0.7重量%を超えると刺激の低減が難しくなる。特に制限するものではないが、ラウリル硫酸塩は、アルカリ金属塩が好ましく、ナトリウム塩が特に好ましい。
表1に示した処方にて、発泡性、苦味、刺激性に関する官能試験、及び舌細胞の変性を確認するためにジュース効果の評価を行った。それらの結果を表1に示す。表1に示した処方に従い、常法で各歯磨組成物を調製した。
歯磨剤専門パネル5名が2分間歯磨きを行い、その発泡性及び苦味を5点満点で評価した。5名の平均点を表1に示す。発泡性は、点数が高いほど発泡性が高く、低いほど発泡性が低いことを示す。苦味は、点数が高いほど苦味が少なく、点数が低いほど苦味が高いことを示す。
歯磨剤専門パネル5名が、粘膜の感受性を上げるために20%エタノール水溶液で10秒間含嗽し吐き出した後、歯磨きを2分間行い、その刺激性を5点満点で評価した。点数が高いほど刺激が低く、点数が低いほど刺激が高いこと示す。
歯磨剤専門パネル5名が2分間歯磨きを行った後、市販の100%果汁オレンジジュースを口に含み、その苦味を5点満点で評価した。点数が高いほど、ジュース効果が低いため苦味がなく、点数が低いほどジュース効果が高いため苦味が強いことを示す。
発泡性、苦味、刺激性、ジュース効果のすべての点数が3.0以上である場合は○、一つでも3.0未満の項目がある場合は×とした。
次の処方により、常法に従って練歯磨を調製した。
成分 配合量(%)
研磨性シリカ 13.0
増粘性シリカ 7.0
酸化チタン 0.3
70%ソルビット液 40.0
グリセリン 15.0
トルナーレ 1.0
フッ化ナトリウム 0.2
キサンタンガム 0.5
カルボキシメチルセルロースナトリウム 1.0
サッカリンナトリウム 0.1
ラウリル硫酸ナトリウム 0.3
ヤシ油脂肪酸アミドプロピルベタイン 0.3
ポリオキシエチレン(60)硬化ヒマシ油 0.5
香料[ペパーミントオイル40%、 0.5
ハーブ系アクセント60%(l−メントール含量18%)]
水 残部
計 100.0
頭頚部の放射線療法、造血幹細胞移植、化学療法によるがん治療に伴う口腔粘膜炎により、一般的な歯磨剤での口腔清掃が困難な口腔がん治療患者6名が、実施例5に示す歯磨組成物(練歯磨)を2日間使用した。使用前に口腔外科医による口腔内所見調査をおこなった。使用後、味、刺激性、泡立ち、清涼感(スッキリ感)、今まで使用した一般的な歯磨剤との比較に関して、5段階の使用評価を行なった。各評価項目の詳細は表2に示す。評価結果を表3に示す。
次の処方により、常法に従って練歯磨を調製した。
成分 配合量(%)
炭酸カルシウム 30.0
増粘性シリカ 3.0
無水ケイ酸 3.0
70%ソルビット液 30.0
トルナーレ 1.0
カルボキシメチルセルロースナトリウム 0.8
カラギーナン 0.2
ラウリル硫酸ナトリウム 0.5
ヤシ油脂肪酸アミドプロピルベタイン 0.7
ポリオキチエチレン(40)硬化ヒマシ油 0.2
トリクロサン 0.02
イソプロピルメチルフェノール 0.02
モノフルオロリン酸ナトリウム 0.7
フルーツタイプ香料(メントール含量50%) 0.6
サッカリンナトリウム 0.1
ステビアエキス(ステビオサイド70%配合) 0.04
水 残部
計 100.0
次の処方により、常法に従って練歯磨を調製した。
成分 配合量(%)
研磨性シリカ 15.0
増粘性シリカ 5.0
酸化チタン 0.3
70%ソルビット液 40.0
トルナーレ 1.0
グリセリン 10.0
カルボキシメチルセルロースナトリウム 0.7
キサンタンガム 0.5
ラウリル硫酸ナトリウム 0.3
ヤシ油脂肪酸アミドプロピルベタイン 0.5
ポリオキチエチレン(60)硬化ヒマシ油 0.5
パラオキシ安息香酸メチル 0.1
フッ化ナトリウム 0.2
ハーブタイプ香料(メントール含量40%) 0.5
サッカリンナトリウム 0.1
水 残部
計 100.0
次の処方により、常法に従って透明ジェル歯磨を調製した。
成分 配合量(%)
研磨性シリカ 10.0
増粘性シリカ 10.0
70%ソルビット液 62.0
グリセリン 10.0
トルナーレ 5.0
ポリエチレングリコール400 3.0
プロピレングリコール 1.0
カルボキシメチルセルロースナトリウム 1.0
ラウリル硫酸ナトリウム 0.3
ヤシ油脂肪酸アミドプロピルベタイン 0.4
ポリオキシエチレン(60)硬化ヒマシ油 0.5
フッ化ナトリウム 0.2
酢酸トコフェロール 0.05
フローラル系香料(メントール含量60%) 0.5
サッカリンナトリウム 0.1
水 残部
計 100.0
次の処方により、常法に従って練歯磨を調製した。
成分 配合量(%)
歯磨用リン酸水素カルシウム 25.0
結晶セルロース 5.0
トルナーレ 15.0
グリセリン 30.0
ポリエチレングリコール400 3.0
1,3−ブチレングリコール 2.0
カルボキシメチルセルロースナトリウム 1.0
ラウリル硫酸ナトリウム 0.7
ヤシ油脂肪酸アミドプロピルベタイン 0.7
ポリオキシエチレン(60)硬化ヒマシ油 0.5
ペパーミント系香料(メントール含量50%) 0.5
サッカリンナトリウム 0.1
水 残部
計 100.0
次の処方により、常法に従って練歯磨を調製した。
成分 配合量(%)
歯磨用リン酸水素カルシウム 25.0
アロエエキス 0.5
結晶セルロース 5.0
トルナーレ 15.0
グリセリン 30.0
ポリエチレングリコール400 3.0
1,3−ブチレングリコール 2.0
カルボキシメチルセルロースナトリウム 1.0
ラウリル硫酸ナトリウム 0.7
ヤシ油脂肪酸アミドプロピルベタイン 0.7
ポリオキシエチレン(60)硬化ヒマシ油 0.5
ペパーミント系香料(メントール含量50%) 0.5
サッカリンナトリウム 0.1
水 残部
計 100.0
Claims (4)
- (A)0.2〜0.7重量%のラウリル硫酸塩及び(B)0.2〜0.7重量%の脂肪酸アミドプロピルベタインを含むものであって、ラウリル硫酸塩と脂肪酸アミドプロピルベタインとの配合比率が、(A):(B)=1:0.5〜1:2であり、かつ粘膜保湿剤として、α,α−トレハロースの糖質誘導体を含むことを特徴とする歯磨組成物。
- 脂肪酸アミドプロピルベタインが、ヤシ油脂肪酸アミドプロピルベタインであることを特徴とする請求項1に記載の歯磨組成物。
- ポリオキシエチレン硬化ヒマシ油を配合することを特徴とする請求項1又は2に記載の歯磨組成物。
- 頭頚部の放射線療法、造血幹細胞移植、化学療法によるがん治療中またはがん治療後の患者のための請求項1〜3のいずれかに記載の歯磨組成物。
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US9636284B2 (en) | 2010-03-31 | 2017-05-02 | Johnson & Johnson Consumer Inc. | Oral care compositions |
US8906348B2 (en) * | 2010-03-31 | 2014-12-09 | Mcneil-Ppc, Inc. | Oral care compositions |
JP2012140379A (ja) * | 2011-01-04 | 2012-07-26 | Korea Eisei Center Co Ltd | 歯磨き剤組成物 |
MX349621B (es) * | 2011-02-04 | 2017-08-07 | Colgate Palmolive Co | Composiciones para el cuidado oral. |
JP2013155169A (ja) * | 2012-01-05 | 2013-08-15 | Nippon Eisei Center:Kk | 歯磨き剤組成物 |
JP5834921B2 (ja) * | 2012-01-10 | 2015-12-24 | ライオン株式会社 | 歯磨組成物 |
JP5924010B2 (ja) * | 2012-02-09 | 2016-05-25 | ライオン株式会社 | 歯磨剤組成物 |
DE102012220154A1 (de) * | 2012-11-06 | 2014-05-08 | Henkel Ag & Co. Kgaa | Mund- und Zahnpflege- und -reinigungsmittel mit Vitamin E |
JP6358255B2 (ja) * | 2013-08-02 | 2018-07-18 | ライオン株式会社 | ポンプディスペンサーを有する容器充填用歯磨剤組成物及び歯磨製品 |
MY180536A (en) * | 2014-03-03 | 2020-12-01 | Lion Corp | Toothpaste composition |
CN110709049A (zh) * | 2017-05-31 | 2020-01-17 | 株式会社Lg生活健康 | 泵压式牙膏组合物 |
WO2020190872A1 (en) | 2019-03-18 | 2020-09-24 | Sunstar Americas, Inc. | Oral care composition |
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JP4846079B2 (ja) * | 1999-07-21 | 2011-12-28 | 日本ゼトック株式会社 | 口腔用組成物 |
JP2002047157A (ja) * | 2000-07-28 | 2002-02-12 | Lion Corp | 口腔用組成物 |
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JPWO2007069429A1 (ja) * | 2005-12-15 | 2009-05-21 | ライオン株式会社 | 歯磨組成物 |
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