CN1147290C - 多醇组合物 - Google Patents

多醇组合物

Info

Publication number
CN1147290C
CN1147290C CNB97194024XA CN97194024A CN1147290C CN 1147290 C CN1147290 C CN 1147290C CN B97194024X A CNB97194024X A CN B97194024XA CN 97194024 A CN97194024 A CN 97194024A CN 1147290 C CN1147290 C CN 1147290C
Authority
CN
China
Prior art keywords
mannitol
sorbitol
weight
polyols
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB97194024XA
Other languages
English (en)
Chinese (zh)
Other versions
CN1216466A (zh
Inventor
E
E·施瓦茨
G·默施尔
K·摩尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7791693&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1147290(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of CN1216466A publication Critical patent/CN1216466A/zh
Application granted granted Critical
Publication of CN1147290C publication Critical patent/CN1147290C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/16—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by suspending the powder material in a gas, e.g. in fluidised beds or as a falling curtain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/18—Polyhydroxylic acyclic alcohols
    • C07C31/26—Hexahydroxylic alcohols

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Pulleys (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNB97194024XA 1996-04-22 1997-04-10 多醇组合物 Expired - Lifetime CN1147290C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19615418.9 1996-04-22
DE19615418A DE19615418A1 (de) 1996-04-22 1996-04-22 Polyol-Zusammensetzung

Publications (2)

Publication Number Publication Date
CN1216466A CN1216466A (zh) 1999-05-12
CN1147290C true CN1147290C (zh) 2004-04-28

Family

ID=7791693

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB97194024XA Expired - Lifetime CN1147290C (zh) 1996-04-22 1997-04-10 多醇组合物

Country Status (16)

Country Link
US (1) US6165511A (cg-RX-API-DMAC7.html)
EP (1) EP0896528B1 (cg-RX-API-DMAC7.html)
JP (1) JP4343272B2 (cg-RX-API-DMAC7.html)
CN (1) CN1147290C (cg-RX-API-DMAC7.html)
AT (1) ATE210971T1 (cg-RX-API-DMAC7.html)
CA (1) CA2252609C (cg-RX-API-DMAC7.html)
CZ (1) CZ291589B6 (cg-RX-API-DMAC7.html)
DE (2) DE19615418A1 (cg-RX-API-DMAC7.html)
DK (1) DK0896528T3 (cg-RX-API-DMAC7.html)
ES (1) ES2169385T3 (cg-RX-API-DMAC7.html)
ID (1) ID17384A (cg-RX-API-DMAC7.html)
MY (1) MY116890A (cg-RX-API-DMAC7.html)
PT (1) PT896528E (cg-RX-API-DMAC7.html)
RU (1) RU2184535C2 (cg-RX-API-DMAC7.html)
TW (1) TWI237567B (cg-RX-API-DMAC7.html)
WO (1) WO1997039739A2 (cg-RX-API-DMAC7.html)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ID24271A (id) 1996-11-15 2000-07-13 Merck Patent Gmbh Proses untuk memproduksi bahan-bahan poliol yang dibentuk atau tidak dibentuk
US20030203036A1 (en) 2000-03-17 2003-10-30 Gordon Marc S. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
GB9716432D0 (en) * 1997-08-05 1997-10-08 Cerestar Holding Bv Tableting of erythritol
FI107732B (fi) * 1998-03-18 2001-09-28 Xyrofin Oy Laktitolin kiteyttäminen, kiteinen laktitolituote ja sen käyttö
DE19943491B4 (de) * 1999-09-10 2010-04-01 Südzucker AG Mannheim/Ochsenfurt Verbesserte Komprimate
US6872414B1 (en) 1999-09-20 2005-03-29 Xyrofin Oy Anhydrous lactitol crystals, a product containing the same and a process for the preparation thereof as well as use thereof
US7575761B2 (en) 2000-06-30 2009-08-18 Novartis Pharma Ag Spray drying process control of drying kinetics
AU2001291721A1 (en) * 2000-08-25 2002-03-04 Merck Patent G.M.B.H Powdered mannitol and mannitol-containing compositions
EP1334716A4 (en) * 2000-10-16 2009-04-29 Daiichi Seiyaku Co MEDICAL COMPOSITIONS THAT CAN RAPIDLY DISINTEGRATE IN ORAL CAVITY AND METHOD OF PRODUCING THE SAME
JP4837892B2 (ja) 2001-11-01 2011-12-14 ネクター セラピューティクス 粉末バッチを製造する方法
CA2363528A1 (en) * 2001-11-19 2003-05-19 Merck Patent Gesellschaft Mit Beschraenkter Haftung Immediate release tablet containing naproxen sodium
EP1481211B1 (en) * 2001-11-29 2009-04-22 J. Rettenmaier & Söhne GmbH + Co. KG Process for co-spray drying liquid herbal extracts with dry silicified mcc
DE10161402A1 (de) † 2001-12-13 2003-06-18 Merck Patent Gmbh Verfahren zur Herstellung von direkt tablettierbarem beta-Mannit
US7118765B2 (en) 2001-12-17 2006-10-10 Spi Pharma, Inc. Co-processed carbohydrate system as a quick-dissolve matrix for solid dosage forms
FI20021312A7 (fi) 2002-07-03 2004-01-04 Danisco Sweeteners Oy Polyolikoostumusten kiteyttäminen, kiteinen polyolikoostumustuote ja sen käyttö
DE10240778A1 (de) * 2002-08-30 2004-03-11 Merck Patent Gmbh Verfahren zur Herstellung von direkt tablettierbarem a-Mannit
AU2003298762A1 (en) * 2002-11-26 2004-06-18 Hercules Incorporated Soluble, associative carboxymethylcellulose, method of making, and uses thereof
JP2004285052A (ja) * 2003-03-06 2004-10-14 Lion Corp 化粧料組成物
WO2004095942A2 (de) * 2003-04-30 2004-11-11 Ipc Prozess Center Gmbh & Co. Coffein enthaltende tablette
JP2007500234A (ja) * 2003-05-28 2007-01-11 ネクター セラピューティクス 水に不溶な活性剤を含む医薬的成形
CN101460150B (zh) * 2006-03-31 2014-02-12 鲁比康研究私人有限公司 用于口腔崩解片剂的可直接压片复合物
US20100092564A1 (en) * 2006-12-21 2010-04-15 Jae Han Park Composition of and Method for Preparing Orally Disintegrating Tablets
DE102008014237A1 (de) * 2008-03-14 2009-09-17 J. Rettenmaier & Söhne Gmbh + Co. Kg Direktverpressbares Tablettierhilfsmittel
WO2009152921A1 (de) * 2008-06-20 2009-12-23 Merck Patent Gmbh Direkt verpressbare polyolkombination
WO2009152922A1 (de) 2008-06-20 2009-12-23 Merck Patent Gmbh Direkt verpressbare und schnell zerfallende tablettenmatirx
CA2753685C (en) * 2009-03-09 2017-09-12 Spi Pharma, Inc. Highly compactable and durable direct compression excipients and excipient systems
EP2228175B1 (de) 2009-03-12 2013-06-19 Ferton Holding SA Verwendung eines Pulvers oder Pulvergemisches zur Herstellung eines Mittels zur Pulverstrahlreinigung von Zahnoberflächen
DK2238974T3 (da) 2009-04-09 2013-08-26 E Pharma Trento Spa Granulat til formulering af smeltetabletter
WO2011003603A2 (de) * 2009-07-10 2011-01-13 Merck Patent Gmbh Zusammensetzung für die tablettenherstellung und verfahren zu deren herstellung
JP5753842B2 (ja) * 2009-07-10 2015-07-22 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 水分含量の低い打錠補助剤およびその調製方法
US20110027446A1 (en) * 2009-07-28 2011-02-03 Heartland Sweeteners, LLC No-calorie sweetener compositions
US20110027444A1 (en) * 2009-07-28 2011-02-03 Heartland Sweeteners, LLC No-calorie sweetener compositions
US20110027445A1 (en) * 2009-07-28 2011-02-03 Heartland Sweeteners, LLC No-calorie sweetener compositions
EP2467029A1 (en) 2009-08-18 2012-06-27 Cargill, Incorporated Tabletting of erythritol and isomalt
EP2384742A1 (en) 2010-05-03 2011-11-09 The Jordanian Pharmaceutical Manufacturing Co. Pharmaceutical excipient, method for its preparation and use thereof
EP2613645A1 (en) 2010-09-07 2013-07-17 Cargill, Incorporated Solidified sugar alcohol mixture
CN103429229A (zh) * 2010-12-17 2013-12-04 默克专利股份有限公司 可直接压片的δ-甘露糖醇的制备方法
BR112013022017A2 (pt) * 2011-03-09 2016-11-29 Basf Se formulação farmacêutica, comprimido, e, método para produzir uma formulação farmacêutica
CN104095184B (zh) * 2014-07-15 2016-03-30 浙江华康药业股份有限公司 一种粒状复合糖醇及其制备方法
EP3206671B1 (en) 2014-10-16 2024-06-12 Cargill, Incorporated Process for preparing a directly compressible erythritol and uses thereof
CN104447898B (zh) * 2014-11-06 2017-03-29 山东绿健生物技术有限公司 一种固体乳糖醇及其制备方法与应用
EP4183389A1 (en) 2021-11-18 2023-05-24 KRKA, d.d., Novo mesto Pharmaceutical composition comprising apremilast

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3245170A1 (de) * 1982-12-07 1984-06-07 Merck Patent Gmbh, 6100 Darmstadt Verbesserter sorbit, verfahren zur herstellung und verwendung
DE69022861T2 (de) * 1989-01-24 1996-04-04 Spi Polyols Inc Kryoschützende kristalline Sorbitolkügelchen.
FR2670398B1 (fr) * 1990-12-14 1995-02-17 Roquette Freres Composition pulverulente directement compressible et procede d'obtention.
US5158789A (en) * 1991-08-09 1992-10-27 Ici Americas Inc. Melt cocrystallized sorbitol/xylitol compositions
US5876754A (en) * 1992-01-17 1999-03-02 Alfatec-Pharma Gmbh Solid bodies containing active substances and a structure consisting of hydrophilic macromolecules, plus a method of producing such bodies
FR2710637B1 (fr) * 1993-09-28 1995-12-08 Roquette Freres Mannitol pulvérulent de friabilité modérée et son procédé de préparation.

Also Published As

Publication number Publication date
CA2252609A1 (en) 1997-10-30
HK1019202A1 (en) 2000-01-28
RU2184535C2 (ru) 2002-07-10
DE19615418A1 (de) 1997-10-23
CN1216466A (zh) 1999-05-12
JP4343272B2 (ja) 2009-10-14
ES2169385T3 (es) 2002-07-01
CA2252609C (en) 2007-01-30
ATE210971T1 (de) 2002-01-15
TWI237567B (en) 2005-08-11
DE59705894D1 (de) 2002-01-31
WO1997039739A3 (de) 1997-11-27
MY116890A (en) 2004-04-30
PT896528E (pt) 2002-06-28
JP2000508668A (ja) 2000-07-11
DK0896528T3 (da) 2002-04-08
EP0896528B1 (de) 2001-12-19
EP0896528A2 (de) 1999-02-17
CZ291589B6 (cs) 2003-04-16
WO1997039739A2 (de) 1997-10-30
US6165511A (en) 2000-12-26
ID17384A (id) 1997-12-24

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