JP4343272B2 - ポリオール組成物 - Google Patents

ポリオール組成物 Download PDF

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Publication number
JP4343272B2
JP4343272B2 JP53767397A JP53767397A JP4343272B2 JP 4343272 B2 JP4343272 B2 JP 4343272B2 JP 53767397 A JP53767397 A JP 53767397A JP 53767397 A JP53767397 A JP 53767397A JP 4343272 B2 JP4343272 B2 JP 4343272B2
Authority
JP
Japan
Prior art keywords
mannitol
sorbitol
polyols
weight
polyol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP53767397A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000508668A (ja
JP2000508668A5 (cg-RX-API-DMAC7.html
Inventor
シュヴァルツ，オイゲン
メーシュル，ゲルノット
マウル，カリン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7791693&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP4343272(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of JP2000508668A publication Critical patent/JP2000508668A/ja
Publication of JP2000508668A5 publication Critical patent/JP2000508668A5/ja
Application granted granted Critical
Publication of JP4343272B2 publication Critical patent/JP4343272B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/16—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by suspending the powder material in a gas, e.g. in fluidised beds or as a falling curtain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/18—Polyhydroxylic acyclic alcohols
    • C07C31/26—Hexahydroxylic alcohols

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pulleys (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
JP53767397A 1996-04-22 1997-04-10 ポリオール組成物 Expired - Lifetime JP4343272B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19615418.9 1996-04-22
DE19615418A DE19615418A1 (de) 1996-04-22 1996-04-22 Polyol-Zusammensetzung
PCT/EP1997/001787 WO1997039739A2 (de) 1996-04-22 1997-04-10 Polyol-zusammensetzung

Publications (3)

Publication Number Publication Date
JP2000508668A JP2000508668A (ja) 2000-07-11
JP2000508668A5 JP2000508668A5 (cg-RX-API-DMAC7.html) 2004-12-09
JP4343272B2 true JP4343272B2 (ja) 2009-10-14

Family

ID=7791693

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53767397A Expired - Lifetime JP4343272B2 (ja) 1996-04-22 1997-04-10 ポリオール組成物

Country Status (16)

Country Link
US (1) US6165511A (cg-RX-API-DMAC7.html)
EP (1) EP0896528B1 (cg-RX-API-DMAC7.html)
JP (1) JP4343272B2 (cg-RX-API-DMAC7.html)
CN (1) CN1147290C (cg-RX-API-DMAC7.html)
AT (1) ATE210971T1 (cg-RX-API-DMAC7.html)
CA (1) CA2252609C (cg-RX-API-DMAC7.html)
CZ (1) CZ291589B6 (cg-RX-API-DMAC7.html)
DE (2) DE19615418A1 (cg-RX-API-DMAC7.html)
DK (1) DK0896528T3 (cg-RX-API-DMAC7.html)
ES (1) ES2169385T3 (cg-RX-API-DMAC7.html)
ID (1) ID17384A (cg-RX-API-DMAC7.html)
MY (1) MY116890A (cg-RX-API-DMAC7.html)
PT (1) PT896528E (cg-RX-API-DMAC7.html)
RU (1) RU2184535C2 (cg-RX-API-DMAC7.html)
TW (1) TWI237567B (cg-RX-API-DMAC7.html)
WO (1) WO1997039739A2 (cg-RX-API-DMAC7.html)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0000279A3 (en) 1996-11-15 2002-07-29 Merck Patent Gmbh Method for producing shaped and unshaped polyol masses
US20030203036A1 (en) 2000-03-17 2003-10-30 Gordon Marc S. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
GB9716432D0 (en) 1997-08-05 1997-10-08 Cerestar Holding Bv Tableting of erythritol
FI107732B (fi) 1998-03-18 2001-09-28 Xyrofin Oy Laktitolin kiteyttäminen, kiteinen laktitolituote ja sen käyttö
DE19943491B4 (de) 1999-09-10 2010-04-01 Südzucker AG Mannheim/Ochsenfurt Verbesserte Komprimate
US6872414B1 (en) 1999-09-20 2005-03-29 Xyrofin Oy Anhydrous lactitol crystals, a product containing the same and a process for the preparation thereof as well as use thereof
US7575761B2 (en) 2000-06-30 2009-08-18 Novartis Pharma Ag Spray drying process control of drying kinetics
AU2001291721A1 (en) * 2000-08-25 2002-03-04 Merck Patent G.M.B.H Powdered mannitol and mannitol-containing compositions
JP4446463B2 (ja) * 2000-10-16 2010-04-07 第一三共株式会社 口腔内速崩壊性医薬組成物およびその製造方法
TW200300696A (en) 2001-11-01 2003-06-16 Inhale Therapeutic Syst Spray drying methods and related compositions
CA2363528A1 (en) * 2001-11-19 2003-05-19 Merck Patent Gesellschaft Mit Beschraenkter Haftung Immediate release tablet containing naproxen sodium
DE60138494D1 (de) * 2001-11-29 2009-06-04 Rettenmaier & Soehne Gmbh & Co Verfahren zum co-sprühtrocknen flüssiger kräuterextrakte mit trockener silifizierter mcc
DE10161402A1 (de) † 2001-12-13 2003-06-18 Merck Patent Gmbh Verfahren zur Herstellung von direkt tablettierbarem beta-Mannit
US7118765B2 (en) * 2001-12-17 2006-10-10 Spi Pharma, Inc. Co-processed carbohydrate system as a quick-dissolve matrix for solid dosage forms
FI20021312A7 (fi) 2002-07-03 2004-01-04 Danisco Sweeteners Oy Polyolikoostumusten kiteyttäminen, kiteinen polyolikoostumustuote ja sen käyttö
DE10240778A1 (de) * 2002-08-30 2004-03-11 Merck Patent Gmbh Verfahren zur Herstellung von direkt tablettierbarem a-Mannit
RU2334762C2 (ru) * 2002-11-26 2008-09-27 Геркулес Инкорпорейтед Растворимая ассоциативная карбоксиметилцеллюлоза, содержащие ее композиции, способ ее получения и применения
JP2004285052A (ja) * 2003-03-06 2004-10-14 Lion Corp 化粧料組成物
WO2004095942A2 (de) * 2003-04-30 2004-11-11 Ipc Prozess Center Gmbh & Co. Coffein enthaltende tablette
US7862834B2 (en) * 2003-05-28 2011-01-04 Novartis Pharma Ag Pharmaceutical formulation comprising a water-insoluble active agent
KR101324898B1 (ko) * 2006-03-31 2013-11-04 루비콘 리서치 피브이티. 엘티디. 구강 붕해 정제
WO2008079342A2 (en) * 2006-12-21 2008-07-03 Mallinckrodt Inc. Composition of and method for preparing orally disintegrating tablets
DE102008014237A1 (de) * 2008-03-14 2009-09-17 J. Rettenmaier & Söhne Gmbh + Co. Kg Direktverpressbares Tablettierhilfsmittel
BRPI0914164B1 (pt) * 2008-06-20 2019-04-30 Merck Patent Gmbh Comistura para produção de comprimidos de desintegração rápida em um processo de formação de comprimido direto, seus usos, e formulações de comprimido
ES2720626T3 (es) * 2008-06-20 2019-07-23 Merck Patent Gmbh Combinación de poliol compresible directamente
JP5806124B2 (ja) * 2009-03-09 2015-11-10 エスピーアイ ファーマ，インコーポレイテッド 高度に圧密可能かつ耐久性のある直接圧縮賦形剤および賦形剤系
ES2425373T3 (es) * 2009-03-12 2013-10-15 Ferton Holding Sa Uso de un polvo o de una mezcla de polvos para la producción de un agente para la limpieza por chorro de polvo de superficies dentales
DK2238974T3 (da) 2009-04-09 2013-08-26 E Pharma Trento Spa Granulat til formulering af smeltetabletter
US8551529B2 (en) * 2009-07-10 2013-10-08 Merck Patent Gmbh Composition for the production of tablets, and method for the production of said composition
JP5753842B2 (ja) * 2009-07-10 2015-07-22 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 水分含量の低い打錠補助剤およびその調製方法
US20110027445A1 (en) * 2009-07-28 2011-02-03 Heartland Sweeteners, LLC No-calorie sweetener compositions
US20110027446A1 (en) * 2009-07-28 2011-02-03 Heartland Sweeteners, LLC No-calorie sweetener compositions
US20110027444A1 (en) * 2009-07-28 2011-02-03 Heartland Sweeteners, LLC No-calorie sweetener compositions
MX2012001893A (es) 2009-08-18 2012-03-16 Cargill Inc Tableteado de eritritol e isomaltosa.
EP2384742A1 (en) 2010-05-03 2011-11-09 The Jordanian Pharmaceutical Manufacturing Co. Pharmaceutical excipient, method for its preparation and use thereof
MX2013002326A (es) 2010-09-07 2013-03-18 Cargill Inc Mezcla solidificada de alcohol de azucar.
HUE054747T2 (hu) * 2010-12-17 2021-09-28 Merck Patent Gmbh Eljárás közvetlenül tablettázható delta-mannit elõállítására
EP2683365A1 (de) * 2011-03-09 2014-01-15 Basf Se Pharmazeutische formulierung für die herstellung von schnell zerfallenden tabletten
CN104095184B (zh) * 2014-07-15 2016-03-30 浙江华康药业股份有限公司 一种粒状复合糖醇及其制备方法
US10463620B2 (en) 2014-10-16 2019-11-05 Cargill, Incorporated Process for preparing a directly compressible erythritol and uses thereof
CN104447898B (zh) * 2014-11-06 2017-03-29 山东绿健生物技术有限公司 一种固体乳糖醇及其制备方法与应用
EP4183389A1 (en) 2021-11-18 2023-05-24 KRKA, d.d., Novo mesto Pharmaceutical composition comprising apremilast

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3245170A1 (de) * 1982-12-07 1984-06-07 Merck Patent Gmbh, 6100 Darmstadt Verbesserter sorbit, verfahren zur herstellung und verwendung
DE69022861T2 (de) * 1989-01-24 1996-04-04 Spi Polyols Inc Kryoschützende kristalline Sorbitolkügelchen.
FR2670398B1 (fr) * 1990-12-14 1995-02-17 Roquette Freres Composition pulverulente directement compressible et procede d'obtention.
US5158789A (en) * 1991-08-09 1992-10-27 Ici Americas Inc. Melt cocrystallized sorbitol/xylitol compositions
US5876754A (en) * 1992-01-17 1999-03-02 Alfatec-Pharma Gmbh Solid bodies containing active substances and a structure consisting of hydrophilic macromolecules, plus a method of producing such bodies
FR2710637B1 (fr) * 1993-09-28 1995-12-08 Roquette Freres Mannitol pulvérulent de friabilité modérée et son procédé de préparation.

Also Published As

Publication number Publication date
RU2184535C2 (ru) 2002-07-10
MY116890A (en) 2004-04-30
WO1997039739A2 (de) 1997-10-30
TWI237567B (en) 2005-08-11
WO1997039739A3 (de) 1997-11-27
CA2252609A1 (en) 1997-10-30
CN1147290C (zh) 2004-04-28
EP0896528B1 (de) 2001-12-19
CZ291589B6 (cs) 2003-04-16
ATE210971T1 (de) 2002-01-15
DK0896528T3 (da) 2002-04-08
HK1019202A1 (en) 2000-01-28
PT896528E (pt) 2002-06-28
DE59705894D1 (de) 2002-01-31
DE19615418A1 (de) 1997-10-23
CA2252609C (en) 2007-01-30
ES2169385T3 (es) 2002-07-01
CN1216466A (zh) 1999-05-12
EP0896528A2 (de) 1999-02-17
US6165511A (en) 2000-12-26
JP2000508668A (ja) 2000-07-11
ID17384A (id) 1997-12-24

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