CN114728952A - 一种鲁拉西酮盐酸盐的制备方法 - Google Patents

一种鲁拉西酮盐酸盐的制备方法 Download PDF

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Publication number
CN114728952A
CN114728952A CN202080081396.0A CN202080081396A CN114728952A CN 114728952 A CN114728952 A CN 114728952A CN 202080081396 A CN202080081396 A CN 202080081396A CN 114728952 A CN114728952 A CN 114728952A
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China
Prior art keywords
lurasidone
hydrochloric acid
acid solution
hydrochloride
ethanol
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CN202080081396.0A
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CN114728952B (zh
Inventor
张一凯
黄钧正
卢浩
郭效文
姜亚飞
高源海
黄鲁宁
陶安平
安建国
顾虹
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Shanghai Syncores Technologies Inc ltd
Zhejiang Huahai Pharmaceutical Co Ltd
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Shanghai Syncores Technologies Inc ltd
Zhejiang Huahai Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

本发明提供了一种盐酸鲁拉西酮的制备方法，包括在醇类溶剂和卤代烷类溶剂的混合溶剂中，鲁拉西酮游离碱与盐酸反应得到盐酸鲁拉西酮。本发明提供的方法，收率高，成本低，安全性高，残留溶剂低，非常适合工业化生产。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN202080081396.0A 2019-12-24 2020-12-07 一种鲁拉西酮盐酸盐的制备方法 Active CN114728952B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201911346683.5A CN113024535B (zh) 2019-12-24 2019-12-24 一种鲁拉西酮盐酸盐的制备方法
CN2019113466835 2019-12-24
PCT/CN2020/134285 WO2021129364A1 (zh) 2019-12-24 2020-12-07 一种鲁拉西酮盐酸盐的制备方法

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CN114728952A true CN114728952A (zh) 2022-07-08
CN114728952B CN114728952B (zh) 2024-08-20

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US (1) US20230037151A1 (zh)
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WO (1) WO2021129364A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115043830A (zh) * 2022-07-01 2022-09-13 浙江美诺华药物化学有限公司 一种鲁拉西酮二盐酸盐晶型的制备方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012123858A1 (en) * 2011-03-14 2012-09-20 Ranbaxy Laboratories Limited Amorphous lurasidone hydrochloride
WO2013132511A1 (en) * 2012-03-09 2013-09-12 Hetero Research Foundation Novel polymorph of lurasidone hydrochloride
CN104031041A (zh) * 2013-03-06 2014-09-10 江苏恩华药业股份有限公司 盐酸鲁拉西酮的新晶型及其制备方法
CN106397424A (zh) * 2016-03-30 2017-02-15 北京万全德众医药生物技术有限公司 盐酸鲁拉西酮氧化杂质的一种制备方法
CN106518729A (zh) * 2016-09-21 2017-03-22 北京万全德众医药生物技术有限公司 盐酸鲁拉西酮中间体的制备方法
CN106916151A (zh) * 2015-12-28 2017-07-04 苏州二叶制药有限公司 一种盐酸鲁拉西酮的制备方法
WO2017154021A1 (en) * 2016-03-09 2017-09-14 Zcl Chemicals Ltd. An improved process for the preparation of lurasidone base and its salt
CN110114063A (zh) * 2017-01-06 2019-08-09 广东东阳光药业有限公司 鲁拉西酮固体分散体及其制备方法

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012123858A1 (en) * 2011-03-14 2012-09-20 Ranbaxy Laboratories Limited Amorphous lurasidone hydrochloride
WO2013132511A1 (en) * 2012-03-09 2013-09-12 Hetero Research Foundation Novel polymorph of lurasidone hydrochloride
CN104031041A (zh) * 2013-03-06 2014-09-10 江苏恩华药业股份有限公司 盐酸鲁拉西酮的新晶型及其制备方法
CN109705112A (zh) * 2013-03-06 2019-05-03 江苏恩华药业股份有限公司 盐酸鲁拉西酮的新晶型的制备方法
CN106916151A (zh) * 2015-12-28 2017-07-04 苏州二叶制药有限公司 一种盐酸鲁拉西酮的制备方法
WO2017154021A1 (en) * 2016-03-09 2017-09-14 Zcl Chemicals Ltd. An improved process for the preparation of lurasidone base and its salt
CN106397424A (zh) * 2016-03-30 2017-02-15 北京万全德众医药生物技术有限公司 盐酸鲁拉西酮氧化杂质的一种制备方法
CN106518729A (zh) * 2016-09-21 2017-03-22 北京万全德众医药生物技术有限公司 盐酸鲁拉西酮中间体的制备方法
CN110114063A (zh) * 2017-01-06 2019-08-09 广东东阳光药业有限公司 鲁拉西酮固体分散体及其制备方法

Also Published As

Publication number Publication date
CN114728952B (zh) 2024-08-20
US20230037151A1 (en) 2023-02-02
WO2021129364A1 (zh) 2021-07-01
CN113024535B (zh) 2024-08-02
CN113024535A (zh) 2021-06-25

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