CN114712446A - Traditional Chinese medicine composition and preparation for treating stomach diseases and preparation method thereof - Google Patents
Traditional Chinese medicine composition and preparation for treating stomach diseases and preparation method thereof Download PDFInfo
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- CN114712446A CN114712446A CN202110009341.5A CN202110009341A CN114712446A CN 114712446 A CN114712446 A CN 114712446A CN 202110009341 A CN202110009341 A CN 202110009341A CN 114712446 A CN114712446 A CN 114712446A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating stomach illness, a preparation and a preparation method thereof, wherein the traditional Chinese medicine composition comprises the following components: atractylodis rhizoma, Poria, rhizoma Pinelliae Preparada, fructus Aurantii Immaturus and cortex Magnolia officinalis; pretreating the above Chinese medicinal materials, mixing, and making into preparation. The invention treats based on the diagnosis and treatment of the traditional Chinese medicine, achieves the aim of treating diseases on the basis of restoring the physique of a patient, and obtains outstanding clinical effect.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating stomach illness, a preparation and a preparation method thereof.
Background
The main physiological functions of the stomach are to accept and digest food, the stomach functions to descend as a sum and to communicate with the spleen. Gastropathy often occurs between 30 and 50 years old, and clinically, the gastropathy is mainly gastritis, gastric ulcer, gastric acid excess, duodenal ulcer and the like. At present, most of the Chinese patent medicines in clinic can treat one or two diseases or distinguish typing treatment, but the treatment time is long, the symptoms are not treated, the root causes are not treated, the side effects are large, the human body is easy to be damaged, and the effect of conditioning the physique of a patient cannot be achieved.
Disclosure of Invention
Aiming at the defects of the prior problems, the invention aims to provide a traditional Chinese medicine composition for treating gastropathy, a preparation and a preparation method thereof. The invention has the effects of harmonizing the stomach, relieving pain, invigorating the stomach and promoting digestion, and achieves the purpose of treating diseases on the basis of conditioning the physique of patients; the traditional Chinese medicine composition is clinically used for treating gastritis, gastric ulcer, excessive gastric acid, duodenal ulcer and other diseases, and has quick curative effect and no toxic or side effect.
The technical scheme adopted by the invention for solving the technical problems is as follows:
a traditional Chinese medicine composition for treating gastropathy comprises the following components: rhizoma Atractylodis Macrocephalae, Poria, rhizoma Pinelliae Preparatum, fructus Aurantii Immaturus preparatum, and cortex Magnoliae officinalis.
Preferably, the weight parts of the components are as follows: 50-70 parts of bighead atractylodes rhizome, 30-50 parts of poria cocos, 10-30 parts of ginger processed pinellia, 20-30 parts of green-skin immature bitter orange and 5-20 parts of mangnolia officinalis.
More preferably, the following components are also included: medicated leaven, malt, ligusticum chuanxiong hort, rhizoma cyperi, scutellaria baicalensis, cuttlebone, areca-nut and liquorice.
More preferably, the mass parts of the components are as follows: 50-70 parts of bighead atractylodes rhizome, 30-50 parts of poria cocos, 10-30 parts of ginger processed pinellia, 20-30 parts of green-coated immature bitter orange, 5-20 parts of mangnolia officinalis, 20-50 parts of medicated leaven, 30-50 parts of malt, 10-20 parts of ligusticum wallichii, 10-20 parts of rhizoma cyperi, 10-20 parts of scutellaria baicalensis, 10-20 parts of cuttlebone, 10-20 parts of betel nut and 10-20 parts of liquorice.
More preferably, each agent comprises the following raw materials in weight ratio: 50 parts of bighead atractylodes rhizome, 40 parts of poria cocos, 10 parts of ginger processed pinellia tuber, 30 parts of green-coat immature bitter orange, 20 parts of mangnolia officinalis, 50 parts of medicated leaven, 50 parts of malt, 10 parts of ligusticum chuanxiong hort, 10 parts of rhizoma cyperi, 10 parts of scutellaria baicalensis, 10 parts of cuttlebone, 10 parts of betel nut and 10 parts of liquorice.
More preferably, each agent comprises the following raw materials in weight ratio: 50 parts of largehead atractylodes rhizome, 30 parts of tuckahoe, 30 parts of ginger processed pinellia tuber, 20 parts of green-coat immature bitter orange, 10 parts of officinal magnolia bark, 20 parts of medicated leaven, 30 parts of malt, 20 parts of szechuan lovage rhizome, 20 parts of nutgrass galingale rhizome, 20 parts of baical skullcap root, 20 parts of cuttlebone, 20 parts of betel nut and 20 parts of liquoric root.
More preferably, each agent comprises the following raw materials in weight ratio: 70 parts of bighead atractylodes rhizome, 50 parts of poria cocos, 10 parts of ginger processed pinellia tuber, 20 parts of green-coat immature bitter orange, 5 parts of mangnolia officinalis, 35 parts of medicated leaven, 30 parts of malt, 15 parts of ligusticum chuanxiong hort, 15 parts of rhizoma cyperi, 15 parts of scutellaria baicalensis, 15 parts of cuttlebone, 15 parts of betel nut and 15 parts of liquorice.
A Chinese medicinal preparation for treating gastropathy comprises the Chinese medicinal composition for treating gastropathy and pharmaceutically or health food acceptable adjuvants.
A preparation method of a traditional Chinese medicine preparation for treating gastropathy specifically comprises the following steps:
(1) pulverizing, sieving and uniformly mixing the bighead atractylodes rhizome, the poria cocos, the ginger processed pinellia tuber, the green-coat immature bitter orange, the mangnolia officinalis, the malt, the ligusticum chuanxiong hort, the rhizoma cyperi, the scutellaria baicalensis, the cuttlebone, the betelnut and the liquorice in parts by weight;
(2) decocting the medicated leaven in parts by weight with water, filtering to remove residues, collecting liquid medicine, and concentrating to obtain clear paste; (3) and (3) uniformly mixing the powder obtained in the step (1) and the clear paste obtained in the step (2) to prepare a preparation.
Wherein, the processes of crushing, sieving, mixing, filtering, concentrating, preparing into preparation and the like do not provide specific process parameters, are all the prior art, and can be completed by routine adjustment according to the prior art by a person skilled in the art.
Preferably, the preparation method of the traditional Chinese medicine preparation for treating gastropathy comprises the following steps:
(1) pulverizing, sieving and uniformly mixing the bighead atractylodes rhizome, the poria cocos, the ginger processed pinellia tuber, the green-coat immature bitter orange, the mangnolia officinalis, the malt, the ligusticum chuanxiong hort, the rhizoma cyperi, the scutellaria baicalensis, the cuttlebone, the betelnut and the liquorice in parts by weight;
(2) decocting the medicated leaven in 8 times of water for 2-3 hours, filtering to remove residues, collecting liquid medicine, and concentrating to obtain clear paste with the relative density of 1-1.10 g/mL;
(3) and (3) uniformly mixing the powder obtained in the step (1) and the clear paste obtained in the step (2) to obtain wet medicinal powder, and carrying out boiling drying to prepare the traditional Chinese medicine preparation.
Preferably, the traditional Chinese medicine preparation is pills, tablets, capsules and powder.
Wherein, the preparation of pills, tablets, capsules and powders is the prior art.
The invention also protects the application of the traditional Chinese medicine preparation in preparing the medicine for treating gastropathy.
The application method of the preparation comprises the following steps: making into various dosage forms of traditional Chinese medicine 3-4 times a day. The composition is administered for 7 days as 1 course of treatment, and is administered for 5 courses. During the period, the patient should not eat easily-fermented food, and should not avoid smoking, wine, pepper, raw garlic and the like; it is forbidden for pregnant women, teenagers and children.
The raw materials of the invention have the following effects:
white atractylodes rhizome: it enters spleen and stomach meridians. Invigorate spleen, replenish qi, dry dampness, induce diuresis, stop sweating, prevent abortion. Can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm retention, dizziness, palpitation, edema, spontaneous perspiration, and threatened abortion.
Tuckahoe, poria cocos: it enters heart, lung, spleen and kidney meridians. Induce diuresis and drain dampness, invigorate spleen and calm heart. Can be used for treating edema, oliguria, phlegm and fluid retention, dizziness, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia.
Ginger processed pinellia tuber: it enters spleen, stomach and lung meridians. Dry dampness and resolve phlegm, check adverse rise of qi and arrest vomiting, relieve stuffiness and dissipate nodulation. Can be used for treating cough with asthma due to excessive phlegm, dizziness and palpitation due to phlegm and fluid retention, dizziness due to wind-phlegm, headache due to phlegm syncope, emesis, regurgitation, chest and gastric fullness, and globus hystericus; unprocessed for treating abscess and phlegm nodule. Jiang ban Xia is mostly used for checking adverse rise of qi and arresting vomiting.
Green-coating immature bitter orange: it enters spleen and stomach meridians. Break qi and remove food retention, resolve phlegm and disperse distention and fullness. Can be used for treating stagnation, abdominal distention, pain, dysentery, constipation, phlegm stagnation, qi obstruction of chest, and thoracic obstruction; gastroptosis, rectocele, uterine prolapse.
Magnolia officinalis: it enters spleen, lung, stomach and large intestine meridians. Dry dampness and resolve phlegm, descend qi and remove fullness. Can be used for treating damp stagnation, abdominal distention, vomiting, diarrhea, food stagnation, qi stagnation, abdominal distention, constipation, phlegm retention, asthma, and cough.
Medicated leaven: it enters spleen and stomach meridians. Promote digestion and harmonize stomach. Can be used for treating food stagnation.
Malt: it enters spleen, stomach and liver meridians. Move qi and promote digestion, invigorate spleen and stimulate appetite, remove milk and relieve distension. Can be used for treating dyspepsia, abdominal pain, spleen deficiency, anorexia, breast pain, and female hypogalactia.
Ligusticum wallichii: entering liver and gallbladder meridians. Move qi and relieve depression, dispel wind-dryness and dampness, activate blood and alleviate pain. It is indicated for wind-cold headache, dizziness, hypochondriac pain, abdominal pain, cold arthralgia, spasm of tendons, amenorrhea, dystocia, postpartum pain due to blood stasis, carbuncle, cellulitis, sore and ulcer. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal pain, pricking pain in chest and hypochondrium, traumatic injury, swelling and pain, headache, and rheumatalgia.
Rhizoma cyperi: it enters liver, spleen and triple energizer meridians. Move qi and relieve depression, regulate menstruation and alleviate pain. Can be used for treating stagnation of qi due to stagnation of liver-qi, chest pain, hypochondrium pain, abdominal distention and pain, dyspepsia, chest and abdominal distention and fullness, hernia due to cold, abdominal pain, breast pain, menoxenia, amenorrhea, and dysmenorrhea.
Scutellaria baicalensis: it enters lung, gallbladder, spleen, large intestine and small intestine meridians. Clear heat and dry dampness, purge fire and remove toxicity, stop bleeding, prevent abortion. Can be used for treating chest distress, nausea, damp-heat, dysentery, jaundice, cough due to lung heat, hyperpyrexia, polydipsia, hematemesis, carbuncle, swelling, sore, and threatened abortion.
Cuttlebone: it enters liver and kidney meridians. Astringe to stop bleeding, astringe essence to stop leucorrhea, relieve hyperacidity, heal wound. Can be used for treating gastralgia, acid regurgitation, hematemesis, epistaxis, metrorrhagia, hematochezia, spermatorrhea, and leucorrhea with red and white discharge; and (3) ulcer disease. It is used externally to treat wound bleeding, sore with pus.
Betel nut: it enters stomach and large intestine meridians. Expel parasites, remove food retention, direct qi downward and promote water circulation. Can be used for treating tapeworm, ascariasis, fasciolopsiasis, abdominal pain due to parasitic infestation, stagnation, dysentery, tenesmus, edema, tinea pedis, and malaria.
Licorice root: it enters heart, lung, spleen and stomach meridians. Invigorating spleen and replenishing qi, clearing away heat and toxic material, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the drugs. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature.
In the invention, the bighead atractylodes rhizome, the poria cocos, the ginger processed pinellia tuber, the spleen strengthening and the dampness eliminating are monarch drugs; the immature bitter orange of green coating and the officinal magnolia bark are used as ministerial drugs for warming the middle-jiao and regulating the flow of qi; medicated leaven, malt, rhizoma ligustici wallichii, rhizoma cyperi, radix scutellariae, cuttlebone and betel nut are used as adjuvant drugs for relieving food stagnation, dampness, qi, blood, phlegm, fire, insect and other food stagnation; licorice root, radix Glycyrrhizae is used to regulate the effects of the other drugs in the recipe and to tonify the middle energizer.
Advantageous effects
Compared with the prior art, the invention uses the medicated leaven, the malt, the ligusticum wallichii, the rhizoma cyperi, the scutellaria baicalensis, the cuttlebone and the betel nut in a synergistic way according to the treatment based on the disease differentiation of the traditional Chinese medicine, has the effects of relieving food, dampness, qi, blood, phlegm, fire, insects and the like, achieves the aim of treating diseases on the basis of repairing the physique of a patient, and obtains outstanding clinical effect. The traditional Chinese medicine composition is clinically used for treating gastritis, gastric ulcer, excessive gastric acid, duodenal ulcer and other diseases, and has quick curative effect and no toxic or side effect.
Drawings
FIG. 1 is a diagram of a stomach anatomy; wherein A is a blank group; b is a molding set; c is a group of Sanjiuweitai (positive medicine); d is the low dose group of the present application; e is the dose group in the present application; f is the high dose group of the present application;
FIG. 2 shows the ulcer score (A) and the ulcer area (B) ((A))
n＝5，####P<0.0001,*P<0.05,**P<0.01)；
FIG. 3 is a stomach wall longitudinal cut HE pathology (scale bar 100 μm); wherein A is a blank group; b is a molding set; c is the Sanjiuweitai group (positive medicine); d is the low dose group of the present application; e is the dose group in the present application; f is the high dose group of the present application;
FIG. 4 shows the MPO content (A) and the SOD content (B) of stomach tissues; (
n＝5，####P<0.0001,*P<0.05,***P<0.001,****P<0.0001)。
Detailed Description
The present invention will be described in further detail with reference to examples. The reagents or instruments used are not indicated by manufacturers, and are regarded as conventional products which can be purchased in the market.
Example 1
A Chinese medicinal composition for treating gastropathy comprises the following raw materials by weight: 50 parts of bighead atractylodes rhizome, 50 parts of poria cocos, 10 parts of ginger processed pinellia tuber, 20 parts of green-skin immature bitter orange and 10 parts of mangnolia officinalis.
The preparation method of the traditional Chinese medicine composition for treating the stomach illness comprises the following steps:
(1) pulverizing, sieving and uniformly mixing the bighead atractylodes rhizome, the poria cocos, the ginger processed pinellia tuber, the green-coat immature bitter orange, the mangnolia officinalis, the malt, the ligusticum chuanxiong hort, the rhizoma cyperi, the scutellaria baicalensis, the cuttlebone, the betelnut and the liquorice in parts by weight;
(2) boiling and drying the powder obtained in the step (1), and preparing into pills, tablets, capsules or powder.
Example 2
A Chinese medicinal composition for treating gastropathy comprises the following raw materials by weight: 70 parts of bighead atractylodes rhizome, 40 parts of poria cocos, 20 parts of rhizoma pinelliae preparata, 30 parts of green-coated immature bitter orange and 20 parts of mangnolia officinalis.
The preparation method of the traditional Chinese medicine composition for treating the stomach illness is the same as that of the example 1.
Example 3
A Chinese medicinal composition for treating gastropathy comprises the following raw materials by weight: 60 parts of bighead atractylodes rhizome, 30 parts of poria cocos, 30 parts of ginger processed pinellia tuber, 25 parts of green-coated immature bitter orange and 5 parts of mangnolia officinalis.
The preparation method of the traditional Chinese medicine composition for treating the stomach illness is the same as that in example 1.
Example 4
A Chinese medicinal composition for treating gastropathy comprises the following raw materials by weight: 50 parts of bighead atractylodes rhizome, 40 parts of poria cocos, 10 parts of ginger processed pinellia tuber, 30 parts of green-coat immature bitter orange, 20 parts of mangnolia officinalis, 50 parts of medicated leaven, 50 parts of malt, 10 parts of ligusticum chuanxiong hort, 10 parts of rhizoma cyperi, 10 parts of scutellaria baicalensis, 10 parts of cuttlebone, 10 parts of betel nut and 10 parts of liquorice.
The preparation method of the traditional Chinese medicine composition for treating the stomach illness comprises the following steps:
(1) pulverizing, sieving and uniformly mixing the bighead atractylodes rhizome, the poria cocos, the ginger processed pinellia tuber, the green-coat immature bitter orange, the mangnolia officinalis, the malt, the ligusticum chuanxiong hort, the rhizoma cyperi, the scutellaria baicalensis, the cuttlebone, the betelnut and the liquorice in parts by weight;
(2) decocting the medicated leaven in 8 times of water for 2-3 hours, filtering to remove residues, collecting liquid medicine, and concentrating to the relative density of 1-1.10g/mL to obtain clear paste;
(3) and (3) uniformly mixing the powder obtained in the step (1) and the clear paste obtained in the step (2) to obtain wet medicinal powder, and carrying out boiling drying to prepare the traditional Chinese medicine preparation.
Example 5
A Chinese medicinal composition for treating gastropathy comprises the following raw materials by weight: 50 parts of largehead atractylodes rhizome, 30 parts of tuckahoe, 30 parts of ginger processed pinellia tuber, 20 parts of green-coat immature bitter orange, 10 parts of officinal magnolia bark, 20 parts of medicated leaven, 30 parts of malt, 20 parts of szechuan lovage rhizome, 20 parts of nutgrass galingale rhizome, 20 parts of baical skullcap root, 20 parts of cuttlebone, 20 parts of betel nut and 20 parts of liquoric root.
The preparation method of the traditional Chinese medicine composition for treating the stomach illness comprises the following steps:
(1) pulverizing, sieving and uniformly mixing the bighead atractylodes rhizome, the poria cocos, the ginger processed pinellia tuber, the green-coat immature bitter orange, the mangnolia officinalis, the malt, the ligusticum chuanxiong hort, the rhizoma cyperi, the scutellaria baicalensis, the cuttlebone, the betelnut and the liquorice in parts by weight;
(2) decocting the medicated leaven in 8 times of water for 2-3 hours, filtering to remove residues, collecting liquid medicine, and concentrating to obtain clear paste with the relative density of 1-1.10 g/mL;
(3) and (3) uniformly mixing the powder obtained in the step (1) and the clear paste obtained in the step (2) to obtain wet medicinal powder, and carrying out boiling drying to prepare the traditional Chinese medicine preparation.
Example 6
A Chinese medicinal composition for treating gastropathy comprises the following raw materials by weight: 70 parts of bighead atractylodes rhizome, 50 parts of poria cocos, 10 parts of ginger processed pinellia tuber, 20 parts of green-coat immature bitter orange, 5 parts of mangnolia officinalis, 35 parts of medicated leaven, 30 parts of malt, 15 parts of ligusticum chuanxiong hort, 15 parts of rhizoma cyperi, 15 parts of scutellaria baicalensis, 15 parts of cuttlebone, 15 parts of betel nut and 15 parts of liquorice.
The preparation method of the traditional Chinese medicine composition for treating the stomach illness comprises the following steps:
(1) pulverizing, sieving and uniformly mixing the bighead atractylodes rhizome, the poria cocos, the ginger processed pinellia tuber, the green-coat immature bitter orange, the mangnolia officinalis, the malt, the ligusticum chuanxiong hort, the rhizoma cyperi, the scutellaria baicalensis, the cuttlebone, the betelnut and the liquorice in parts by weight;
(2) decocting the medicated leaven in 8 times of water for 2-3 hours, filtering to remove residues, collecting liquid medicine, and concentrating to the relative density of 1-1.10g/mL to obtain clear paste;
(3) and (3) uniformly mixing the powder obtained in the step (1) and the clear paste obtained in the step (2) to obtain wet medicinal powder, and carrying out boiling drying to obtain the traditional Chinese medicine preparation.
Example 7
A Chinese medicinal composition for treating gastropathy comprises the following raw materials by weight: 50 parts of largehead atractylodes rhizome, 30 parts of tuckahoe, 30 parts of ginger processed pinellia tuber, 20 parts of green-coat immature bitter orange, 10 parts of officinal magnolia bark, 20 parts of medicated leaven, 30 parts of malt, 20 parts of szechuan lovage rhizome, 20 parts of nutgrass galingale rhizome, 20 parts of baical skullcap root, 20 parts of cuttlebone, 20 parts of betel nut and 20 parts of liquoric root.
The preparation method of the traditional Chinese medicine composition for treating the stomach illness comprises the following steps:
(1) pulverizing, sieving and uniformly mixing the bighead atractylodes rhizome, the poria cocos, the ginger processed pinellia tuber, the green-coat immature bitter orange, the mangnolia officinalis, the malt, the ligusticum chuanxiong hort, the rhizoma cyperi, the scutellaria baicalensis, the cuttlebone, the betelnut and the liquorice in parts by weight;
(2) decocting the medicated leaven in 8 times of water for 2-3 hours, filtering to remove residues, collecting liquid medicine, and concentrating to obtain clear paste with the relative density of 1-1.10 g/mL;
(3) and (3) uniformly mixing the powder obtained in the step (1) and the clear paste obtained in the step (2), and preparing the mixture into pills, tablets, capsules or powder.
Example 8 acute toxicity test
The medicine comprises the following components: the traditional Chinese medicine preparation is dissolved.
② testing animals: mice, weighing about 50g, were randomly male and female.
③ method and results: taking 50 mice, dividing into 5 groups, feeding 10 mice each group after starvation for about 15 hours, feeding the drugs according to 20mL of each drug, and feeding the drugs for the 1 st, 2 nd, 3 rd, 4 th and 5 th groups for 1, 2 nd, 3 rd, 4 th and 5 th times within 24 hours respectively, observing for 5 days, wherein the mice normally move, have no toxic reaction and die. Wherein, the dosage of the white mouse is calculated according to the dosage of kilogram body weight, which shows that the preparation has no acute toxicity and safe clinical dosage.
Example 9
In order to explore whether the traditional Chinese medicine preparation has a protection effect on the acute gastric ulcer, a mouse acute gastric ulcer model is established by adopting absolute ethyl alcohol, and the protection effect of the traditional Chinese medicine preparation on the acute gastric ulcer is evaluated by measuring indexes such as the area and index of the mouse gastric ulcer, the content of Myeloperoxidase (MPO) and superoxide dismutase (SOD) in gastric tissues and the like.
1 Material
1.1 medicaments
The positive medicine used in the experiment is the Sanjiuweitai, and the tested medicine is the traditional Chinese medicine preparation in the embodiment 5 of the application.
1.2 reagents
Sodium chloride injection, TMB color development solution, superoxide dismutase (SOD) kit and 4% paraformaldehyde.
1.3 animals
ICR mice, SPF grade males, body weight (28.0 ± 1.0) grams, 6 weeks of age.
2 method
2.1 animal acute gastric ulcer model establishment
1. The mice administration group is continuously administered by intragastric administration for 2 weeks, and the blank group and the model group are administered with physiological saline with the same intragastric administration dosage. Before the last administration, mice in each group are fasted for 24 hours without water prohibition, and after the last administration for 1.5 hours, the mice in the administration group and the model group are injected with absolute ethyl alcohol according to the ratio of 10ml/kg to cause an acute gastric ulcer model (Schleina, Wangxufei, and the like; toxicity of single administration of effective parts of pomegranate bark polyphenol and protection effect on the gastric ulcer of rats caused by the absolute ethyl alcohol [ J ] Chinese pharmacological report, 2015,31(5): 709-15); the blank group of mice is administered with 10ml/kg of normal saline by gastric lavage; all mice were sacrificed after fasting for 4h without water.
2.2 grouping and administration
After receiving the animals, the animals are firstly placed in an animal room for one week to be adapted, and then are randomly divided into 6 groups, 5 animals in each group are respectively a blank group, a modeling group, a positive medicine group (Sanjiuweitai), a low-dose group in the application, a medium-dose group in the application and a high-dose group in the application. Each administration group is administrated by intragastric administration according to the dose of 10ml/kg, and the administration concentrations are respectively the Sanjiuweitai (2000mg/kg), the low dose (62.5mg/kg) of the application, the dose (125mg/kg) of the application and the high dose (250mg/kg) of the application; the blank group and the model group were administered with physiological saline by gavage at a dose of 10 ml/kg. Oral administration was given 1 time per day for 2 weeks.
2.3 detection of gastric ulcer disease index
After the animal euthanizes, the stomach tissue is taken out, a small opening is cut at the cardia and then the scissors are cut along the greater curvature of the stomachAfter the contents were washed clean with physiological saline, the contents were spread on a clean petri dish to take a picture, and the number of bleeding points was counted. The degree of injury is represented by ulcer score, ulcer area and ulcer inhibition rate. Ulcer scoring criteria were as follows: normal stomach color, 0; red, 0.5; punctate ulcer, 1.0; striated bleeding, 1.5; deep ulcer, 2.0; gastric perforation, 3.0; the ulcer index was calculated as follows: UI ═ 10 (UN + US + UP) ×－1Wherein UN refers to the average number of ulcers per mouse, US refers to the average number of severe ulcers scored, UP refers to the percentage of gastric ulcer mice[3](ii) a The area of gastric ulcer was calculated from the photographs taken using the software Image J.
2.4 Biochemical index detection and pathological examination of stomach tissue
2.4.1 stomach tissue MPO enzyme Activity and SOD enzyme Activity detection
40mg of stomach tissue from the same site of each mouse was taken into an EP tube, and pre-cooled physiological saline, 400. mu.l, was added at a concentration of 10ml/g, and the tissue was minced with scissors in ice and then ground with an electric tissue grinder to obtain a tissue homogenate. Centrifuging the obtained tissue homogenate at 12000r/min for 10min (4 ℃), collecting supernatant, and performing MPO and SOD enzyme activity detection according to the kit instructions.
2.5.2 histopathological evaluation
The stomach tissue of the same part of each mouse was taken, similar in size, and was spread on tin foil paper, fixed with 4% paraformaldehyde for 24 hours, embedded, sectioned, and stained with hematoxylin-eosin (HE). Histopathological evaluation was performed after photographing by observation using an inverted microscope.
2.6 statistical methods
Statistical analysis of the data was performed using GraphPad Prism 8.0 software. T test is adopted between the blank control group and the model building group, and one-way ANOVA test is adopted between the model building group and the drug administration group.
3 results of
3.1 Effect of dosing and modeling on mouse status
The status of the mice was examined by their body weight and behavioral performance. After the administration for 14 days, the weight average of mice in the administration group and the normal saline administration group is not obviously reduced, and the mice have no symptoms of shrugging, depilation, lassitude and the like. Suggesting that neither the present application nor the Sanjiuweitai has obvious drug toxicity.
After the ethanol molding, the model group mice have the problems of unstable pace, lethargy, listlessness, intolerance to cold and the like, and the mice with positive medicines, the dosage in the application and the high dosage in the application are more clear-headed and more active compared with the mice with the model group. The low dose group of the present application showed no significant difference from the model group.
3.2 detection results of gastric ulcer-related indices
3.2.1 anatomical examination of mouse stomach tissue
Visible to the naked eye after stomach tissue dissection (fig. 1): the stomach tissue of the blank control group is in a meat pink color, and the stomach wall is intact without bleeding points; compared with the blank group, the color of the stomach wall of the ethanol-making group is red, and large-area ulcer and bleeding appear; the bleeding points of the positive medicine group are obviously reduced compared with those of the model group, and a large area is in a pink color; the stomach tissue of the low-dose group is red, and bleeding and ulcer appear in a larger area; the dose group tissue in this application was slightly red with bleeding and ulceration in small areas; the high dose group tissue of this application is in a meat pink color, with sporadic bleeding spots. Meanwhile, the ulcer index results suggest that the ulcer index of the high dose group of the present application is lower and statistically significantly different (fig. 2) compared to the model group, and the ulcer index of the positive drug group and the ulcer index of the low and medium dose group of the present application are lower but statistically not significantly different compared to the model group. In addition, the ulcer areas of the sanjiuweitai group, the doses in this application, and the high dose group of this application were all lower than the modeling group and were statistically significantly different, as were the ulcer areas of the low dose group of this application (fig. 2).
3.2.2 histopathological changes in the stomach of mice
As shown in figure 3, the glands of the stomach tissues of the mice in the blank group are arranged regularly, the structures of the mucous membrane, the submucosa and the muscular layer are complete, the layers are clear, and edema and inflammatory cell infiltration are not seen. The normal tissue structure of the model building group disappears, the apical gland cells drop off greatly, the mucosa layer is seriously damaged, and the infiltration of inflammatory cells is obvious. The submucosa develops a widening phenomenon, i.e., edema. Compared with the modeling group, the submucosa of the mucosa of the positive drug group has the phenomenon of broadening partially, and the cells of the apical gland drop less; the apical gland cells of the low-dose group are more shed, a large amount of inflammatory cells infiltrate, and the protective effect is not shown; in the dosage group, a small amount of apical gland cells infiltrate, part of inflammatory cells infiltrate, and the protective effect is not obvious; the structure of the stomach tissue of the high-dose group is completed, the edema phenomenon is obviously improved, and no glandular cell shedding phenomenon exists at the top end, so that the high-dose group has a certain protective effect on gastric ulcer.
3.3 Effect on Biochemical indicators of stomach tissue in mice with acute gastric ulcer
As shown in fig. 4, compared with the blank control group, the activity of peroxidase mainly containing MPO in the stomach tissue of the molding group was significantly increased, and the SOD content was significantly decreased, suggesting that ethanol causes oxidative damage to the body. Compared with a molding group, the peroxidase activity of the high-dose group is obviously reduced, and the SOD content is increased, so that the medicine ensures that an organism metabolically produces more SOD to resist against the increased peroxidase, and the application has certain antioxidant capacity.
4 conclusion
The result shows that the application can obviously reduce the ulcer score and the ulcer area of the alcoholic gastric ulcer of the mouse, and has a certain ulcer inhibition rate. Biochemical index analysis suggests that the administration of the composition can significantly reduce the peroxidase level in the stomach tissue and increase the SOD content, suggesting that the composition has a protective effect on gastric ulcer caused by ethanol, and plays a role in protecting mucosa from damage mainly by relieving inflammation and resisting oxidation, and the effect has dose dependence. Therefore, a certain dosage of the application can be used for preventing the alcoholic gastric ulcer.
EXAMPLE 10 typical cases
Case 1
The male is 38 years old, likes to eat pungent food such as sour and spicy food, and has hidden pain in stomach in recent months, and is diagnosed as gastric ulcer through examination, after taking the medicament of the embodiment 5 of the invention for 4 courses, the symptoms are basically eliminated, and after continuing to take the medicament of the embodiment 5 of the invention for 2 courses, the clinical symptoms are completely eliminated.
Case 2
For women with the age of 33, pain in the abdomen for one year, worsening on fasting condition, with some relief after meals with occasional acid return. After the 6 medicaments of the invention are taken for 2 courses, each symptom is obviously relieved, and the clinical symptoms are eliminated after the 6 medicaments are taken for 1 course.
The protection of the present invention is not limited to the above embodiments. Variations and advantages that may occur to those skilled in the art may be incorporated into the invention without departing from the spirit and scope of the inventive concept and the scope of the appended claims is intended to be protected.
Claims (10)
1. A traditional Chinese medicine composition for treating gastropathy is characterized by comprising the following components: rhizoma Atractylodis Macrocephalae, Poria, rhizoma Pinelliae Preparatum, fructus Aurantii Immaturus preparatum, and cortex Magnoliae officinalis.
2. The traditional Chinese medicine composition for treating gastropathy according to claim 1, which is characterized by further comprising the following components: medicated leaven, malt, ligusticum chuanxiong hort, rhizoma cyperi, scutellaria baicalensis, cuttlebone, areca-nut and liquorice.
3. The traditional Chinese medicine composition for treating gastropathy according to claim 1, which is characterized by comprising the following components in parts by mass: 50-70 parts of bighead atractylodes rhizome, 30-50 parts of poria cocos, 10-30 parts of ginger processed pinellia tuber, 20-30 parts of green-coating immature bitter orange, 5-20 parts of mangnolia officinalis, 20-50 parts of medicated leaven, 30-50 parts of malt, 10-20 parts of ligusticum wallichii, 10-20 parts of rhizoma cyperi, 10-20 parts of scutellaria baicalensis, 10-20 parts of cuttlebone, 10-20 parts of betel nut and 10-20 parts of liquorice.
4. The traditional Chinese medicine composition for treating gastropathy according to any one of claims 2 or 3, wherein the mass parts of the components are as follows: 50 parts of bighead atractylodes rhizome, 40 parts of poria cocos, 10 parts of ginger processed pinellia tuber, 30 parts of green-coat immature bitter orange, 20 parts of mangnolia officinalis, 50 parts of medicated leaven, 50 parts of malt, 10 parts of ligusticum chuanxiong hort, 10 parts of rhizoma cyperi, 10 parts of scutellaria baicalensis, 10 parts of cuttlebone, 10 parts of betel nut and 10 parts of liquorice.
5. The traditional Chinese medicine preparation for treating gastropathy according to any one of claims 2 or 3, which is characterized by comprising the following components in parts by weight: 50 parts of largehead atractylodes rhizome, 30 parts of tuckahoe, 30 parts of ginger processed pinellia tuber, 20 parts of green-coat immature bitter orange, 10 parts of officinal magnolia bark, 20 parts of medicated leaven, 30 parts of malt, 20 parts of szechuan lovage rhizome, 20 parts of nutgrass galingale rhizome, 20 parts of baical skullcap root, 20 parts of cuttlebone, 20 parts of betel nut and 20 parts of liquoric root.
6. The traditional Chinese medicine composition for treating gastropathy according to any one of claims 1 or 2, which is characterized by comprising the following components in parts by weight: 70 parts of bighead atractylodes rhizome, 50 parts of poria cocos, 10 parts of ginger processed pinellia tuber, 20 parts of green-coat immature bitter orange, 5 parts of mangnolia officinalis, 35 parts of medicated leaven, 30 parts of malt, 15 parts of ligusticum chuanxiong hort, 15 parts of rhizoma cyperi, 15 parts of scutellaria baicalensis, 15 parts of cuttlebone, 15 parts of betel nut and 15 parts of liquorice.
7. The Chinese medicinal composition for treating gastropathy according to any one of claims 1-6, wherein the medicated leaven is used after extraction.
8. A Chinese medicinal preparation for treating gastropathy, which is characterized by comprising the Chinese medicinal composition for treating gastropathy according to any one of claims 1 to 7 and auxiliary materials acceptable in medicines or health-care foods.
9. The preparation method of the traditional Chinese medicine preparation for treating gastropathy as claimed in claim 8, which is characterized by comprising the following specific steps:
(1) pulverizing, sieving and uniformly mixing the bighead atractylodes rhizome, the poria cocos, the ginger processed pinellia tuber, the green-coat immature bitter orange, the mangnolia officinalis, the malt, the ligusticum chuanxiong hort, the rhizoma cyperi, the scutellaria baicalensis, the cuttlebone, the betelnut and the liquorice in parts by weight;
(2) decocting the medicated leaven in parts by weight with water, filtering to remove residues, collecting liquid medicine, and concentrating to obtain clear paste;
(3) uniformly mixing the powder obtained in the step (1) and the clear paste obtained in the step (2) to prepare a preparation; preferably, the formulation is a pill, tablet, capsule, or powder.
10. The preparation method of the traditional Chinese medicine preparation for treating gastropathy as claimed in claim 9, is characterized by comprising the following specific steps:
(1) pulverizing, sieving and uniformly mixing the bighead atractylodes rhizome, the poria cocos, the ginger processed pinellia tuber, the green-coat immature bitter orange, the mangnolia officinalis, the malt, the ligusticum chuanxiong hort, the rhizoma cyperi, the scutellaria baicalensis, the cuttlebone, the betelnut and the liquorice in parts by weight;
(2) decocting the medicated leaven in 8 times of water for 2-3 hours, filtering to remove residues, collecting liquid medicine, and concentrating to obtain clear paste with the relative density of 1-1.10 g/mL;
(3) and (3) uniformly mixing the powder obtained in the step (1) and the clear paste obtained in the step (2) to obtain wet medicinal powder, and carrying out boiling drying to prepare the traditional Chinese medicine preparation.
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