CN114667289B - 杂芳基血浆激肽释放酶抑制剂 - Google Patents

杂芳基血浆激肽释放酶抑制剂

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Publication number
CN114667289B
CN114667289B CN202080076489.4A CN202080076489A CN114667289B CN 114667289 B CN114667289 B CN 114667289B CN 202080076489 A CN202080076489 A CN 202080076489A CN 114667289 B CN114667289 B CN 114667289B
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China
Prior art keywords
methyl
pyridin
compound
mmol
nitrogen
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CN202080076489.4A
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Chinese (zh)
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CN114667289A (zh
Inventor
N·帕帕约安努
J·M·特拉维斯
S·J·芬克
J·M·埃拉德
A·雷
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN202080076489.4A 2019-09-18 2020-09-17 杂芳基血浆激肽释放酶抑制剂 Active CN114667289B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962902333P 2019-09-18 2019-09-18
US62/902,333 2019-09-18
PCT/US2020/051249 WO2021055589A1 (en) 2019-09-18 2020-09-17 Heteroaryl plasma kallikrein inhibitors

Publications (2)

Publication Number Publication Date
CN114667289A CN114667289A (zh) 2022-06-24
CN114667289B true CN114667289B (zh) 2025-08-26

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CN202080076489.4A Active CN114667289B (zh) 2019-09-18 2020-09-17 杂芳基血浆激肽释放酶抑制剂

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US (2) US11370803B2 (enExample)
EP (1) EP4031245A1 (enExample)
JP (2) JP7695232B2 (enExample)
CN (1) CN114667289B (enExample)
WO (1) WO2021055589A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4494698A3 (en) * 2017-08-04 2025-04-23 Takeda Pharmaceutical Company Limited Inhibitors of plasma kallikrein and uses thereof
CN112135825A (zh) 2018-03-13 2020-12-25 夏尔人类遗传性治疗公司 血浆激肽释放酶抑制剂及其用途
CN114728962B (zh) 2019-09-18 2025-09-19 武田药品工业有限公司 血浆激肽释放酶抑制剂及其用途
WO2021055589A1 (en) * 2019-09-18 2021-03-25 Shire Human Genetic Therapies, Inc. Heteroaryl plasma kallikrein inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112135825A (zh) * 2018-03-13 2020-12-25 夏尔人类遗传性治疗公司 血浆激肽释放酶抑制剂及其用途

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US11370803B2 (en) 2022-06-28
CN114667289A (zh) 2022-06-24
JP2025124882A (ja) 2025-08-26
US12065448B2 (en) 2024-08-20
JP2022549601A (ja) 2022-11-28
US20210079022A1 (en) 2021-03-18
WO2021055589A1 (en) 2021-03-25
EP4031245A1 (en) 2022-07-27
US20220298176A1 (en) 2022-09-22
JP7695232B2 (ja) 2025-06-18

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