CN114642601A - Anti-aging blue light-resisting and wrinkle-removing composition and preparation method thereof - Google Patents
Anti-aging blue light-resisting and wrinkle-removing composition and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9722—Chlorophycota or Chlorophyta [green algae], e.g. Chlorella
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention discloses an anti-aging blue light and wrinkle-removing composition and a preparation method thereof, wherein the preparation method comprises the following steps: preparing tripeptide-3, carnosine and a blue light absorbent into a solution, then carrying out spray drying to obtain powder, and preparing starch pasting liquid by utilizing the characteristic that starch can be pasted at high temperature; preparing the powder into a solution, dropwise adding the solution into the starch pasting liquid to obtain a mixture, centrifuging, eluting, finally taking the solid, and drying to obtain the powdery anti-aging blue light and wrinkle-removing composition. The composition comprises the main functional components of tripeptide-3, carnosine scutellaria baicalensis root extract, ligusticum wallichii root extract, scenedesmus extract and marigold extract, can realize the synergistic effect through reasonable compatibility of the components, and has the effects of resisting blue light and resisting aging.
Description
Technical Field
The invention relates to the technical field of anti-aging and anti-blue-light skin care products, and in particular relates to an anti-aging and anti-blue-light wrinkle-removing composition and a preparation method thereof.
Background
The daily activities of human beings cannot be separated from light, and the light which can be sensed by eyes is part of a spectrum with the wavelength of 380 nm-760 nm, which is called visible light. Among them, high-energy short-wave visible light (400nm to 500nm) damages the outer segment of photoreceptor cells by photochemical action, and this damage is called blue light damage because the wavelength band belongs to the blue light region. In daily life, the main blue light damage comes from artificial light sources. Artificial light sources with high blue light are: arc lamps (searchlights), sun lamps, projection lamps, and the like, and in addition, screens of electronic products such as notebook computers, tablet computers, smart phones, and the like also generate blue light. As people become more and more unable to live these products, especially when they are often used in low-light areas, the blue light poses an increasing risk to skin health.
Blue-light absorbers are mostly used in the field of engineering and also contain small amounts of blue-light absorbers in plants, such as lutein, coffee beans, etc. The lutein contains a large amount of unsaturated conjugated double bonds, so that the lutein has extremely strong antioxidant activity, and the combination of carbon-carbon double bonds and free radicals can be accelerated by the existence of two hydroxyl groups at the long chain end, so that the lutein is beneficial to improving the self-immunity of an organism, slowing down the aging of cells and organism organs and protecting the health of skin. However, the lipid solubility of lutein makes it difficult to disperse it homogeneously in aqueous media. The instability and water insolubility of lutein limit its wide application in food, medicine, feed and other fields.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention aims to provide a preparation method of an anti-aging blue light and wrinkle-removing composition, which combines starch pasting liquid and blue light absorbent powder containing lutein components to improve the stability of the lutein and the dispersibility in an aqueous medium; the invention also aims to provide an anti-aging blue light and wrinkle-removing composition, which has strong stability and high activity of lutein, can be transdermally absorbed by skin, provides nutrition for the skin, and has the effects of resisting blue light and resisting aging.
One of the purposes of the invention is realized by adopting the following technical scheme:
a preparation method of an anti-aging blue light and wrinkle-removing composition comprises the following steps:
1) mixing tripeptide-3, carnosine and a blue light absorbent with water to obtain a dispersion liquid; wherein the blue-light absorber contains a xanthophyll component;
2) spray drying the dispersion to obtain powder;
3) weighing starch, adding water, mixing, heating while stirring until the starch is gelatinized to obtain starch gelatinized liquid for later use;
4) adding the powder obtained in the step 2) into a solvent for mixing to obtain a solution, and then dropwise adding the solution into the starch pasting solution while stirring to obtain a mixed solution;
5) and centrifuging the mixed solution, taking out the solid, continuously centrifuging after eluting, taking out the solid again, drying and dehydrating the solid, and sieving to obtain the powdery anti-aging blue light-resistant and wrinkle-removing composition.
The carnosine and the white powder are dissolved in water, so that glycosylation reaction can be inhibited, crosslinking and solidification of macromolecules causing wrinkle generation and elasticity loss in a dermis layer can be prevented, synthesis of collagen is stimulated, and skin aging is delayed.
Tripeptide-3 is capable of increasing the ATP content of cells, thus ensuring the ability of cells to balance metabolic expenditure of energy with the recovery of energy, which is rapidly and efficiently recovered during expenditure, which is particularly important in aged skin, by inducing an increase in ATP levels in human fibroblasts, increasing keratin expression and thus enhancing the barrier effect of the skin epidermis.
The key component in the blue light absorbent is lutein, and the blue light transmittance is reduced by absorbing blue light, so that the blue light protective effect is achieved. Lutein, a carotenoid without vitamin a activity, is believed to have stronger antioxidant property than carotene because its terminal has two more hydroxyl groups than carotene, and the strong electronegativity of oxygen ions makes unsaturated double bonds of lutein easier to open and combine with free radicals. The lutein mainly absorbs light with the wavelength of 400-500 nm which can not be captured by the chlorophyll, the spectrum range of photosynthesis is expanded, and the lutein plays a role in transferring electrons and protects cells from being damaged by excessive solar radiation by capturing free radicals. Free radicals are also generated in the metabolic process of a human body, and the rise of oxidation pressure induces chain oxidation reaction to cause cell damage and aging, so that the lutein is applied to cosmetics and health care products with the effects of resisting oxidation and preventing radiation. Lutein has no vitamin A activity, so that the lutein cannot generate the stimulation of vitamin A when being used in cosmetics.
Further, the blue-light absorber is one or more of radix Scutellariae extract, rhizoma Chuanxiong extract, scenedesmus extract, and flos Tagetis Erectae extract.
The Scutellariae radix extract has effects in inhibiting elastase, scavenging free radicals, improving skin metabolism, improving skin elasticity and wrinkle resistance, and resisting aging; promoting cerebral amide, improving sebum and softening skin; has effects in inhibiting dermatitis, enhancing skin resistance, and resisting inflammation; can neutralize released histamine, and has effect in preventing allergy.
The rhizoma Ligustici Chuanxiong root extract can inhibit the generation of free radicals, and effectively scavenge oxygen free radicals; at a lower concentration, the activity of melanocytes can be effectively inhibited, and the generation of melanin is reduced; it also has moisture absorption and moisture keeping effects.
Marigold is a traditional lutein source, most of lutein products on the market are extracted from marigold petals, and the lutein in marigold exists in a monoester or diester form. The lutein in microalgae (scenedesmus) is mostly free type lutein and has higher bioavailability than lutein ester. Therefore, the scenedesmus extract and the marigold extract have the effects of resisting blue light, preventing photoaging and damage of the skin and helping the skin to relieve the premature senility symptoms.
Still further, in the step 1), the dispersion liquid comprises the following raw materials in percentage by weight: 5-10 parts of tripeptide-3, 5-10 parts of carnosine and a blue light absorbent; wherein the blue light absorbent comprises 10-20 parts of scutellaria root extract, 10-20 parts of ligusticum wallichii root extract, 10-15 parts of scenedesmus extract and 5-10 parts of marigold extract.
Further, in the step 3), after the starch and the water are mixed, the container is placed into a boiling water bath for heating for 1-2 hours, and stirring is carried out at the speed of 200-300 r/min, so that the starch is completely gelatinized, and the starch gelatinized liquid is obtained.
Further, in the step 4), the solution also comprises a blue light reflecting agent, and the blue light reflecting agent comprises the following components in a mass ratio of (1-3): (2-3): 1 titanium dioxide, manganese dioxide and aluminum oxide.
Further, the mass ratio of the blue light reflecting agent to the powder is (0.1-0.5): 1.
further, in the step 4), the mass ratio of the powder to the starch pasting liquid is (0.1-0.5): 1; the starch pasting liquid contains 1-5% of starch.
Further, in the step 4), the solvent is ethanol.
Further, in the step 4), the solution is dripped twice, and in the process of dripping the solution into the starch pasting solution for the first time, the starch pasting solution is kept in a water bath and is kept at a temperature of 95-100 ℃; and cooling to 20-40 ℃ during the second dripping.
The second purpose of the invention is realized by adopting the following technical scheme:
an anti-aging blue light and wrinkle-removing composition is prepared by the preparation method of the anti-aging blue light and wrinkle-removing composition.
Compared with the prior art, the invention has the beneficial effects that:
(1) in order to form a stable dispersion system of the lutein in an aqueous medium, the composition is prepared by adopting a nano-sedimentation method, and the specific preparation method is as follows: preparing tripeptide-3, carnosine and a blue light absorbent into a solution, then carrying out spray drying to obtain powder, and preparing starch pasting liquid by utilizing the characteristic that starch swells and splits at high temperature to form a uniform pasty solution; and then preparing the powder and a non-aqueous solvent into a solution, then dropwise adding the solution into the starch pasting liquid to obtain a mixture, centrifuging and eluting the mixture, finally taking the solid, and drying the solid to obtain the powdery anti-aging blue light and wrinkle-removing composition which can form a uniformly dispersed suspension in an aqueous medium, so that the stability of the lutein is improved, and the lutein can better exert the anti-blue light and anti-aging effects.
(2) The main effective components of the anti-aging blue light-resisting and wrinkle-removing composition are tripeptide-3, carnosine and a blue light absorbent; the blue light absorbent is a composition of a scutellaria baicalensis root extract, a ligusticum wallichii root extract, a scenedesmus extract and a marigold extract, the components are reasonably compatible, the synergistic effect can be realized, the lutein stability is higher due to the optimized preparation method, the composition has the effects of reducing the generation of wrinkles and the elastic loss of skin, improving fine lines of the skin and resisting oxidation, the generation of melanin can be inhibited, the blue light can be resisted, the light-induced aging and damage of the skin can be prevented, the barrier effect of the skin can be enhanced, the skin-care matrix can be effectively absorbed by the skin through skin in a transdermal manner, the nutrition can be provided for the skin, and the effects of resisting the blue light and resisting the aging can be realized.
(3) The blue light reflecting agent is a composition of titanium dioxide, manganese dioxide and aluminum oxide, blocks, reflects or scatters the blue light by using reflective particles in a physical covering mode, so that the blue light reaching the skin is reduced to achieve the purpose of resisting the blue light.
(4) The composition can be used as one of raw materials, is applied to masks, essences, toner and face creams, and has the advantages of positive effect, safe use and wide application range.
Detailed Description
The present invention is further described below with reference to specific embodiments, and it should be noted that, without conflict, any combination between the embodiments or technical features described below may form a new embodiment.
Example 1
A composition with anti-aging, anti-blue light and wrinkle removing effects is prepared by pulverizing the effective components into powder, adding water to obtain solution, and adding dropwise into starch gelatinizing solution. The active ingredients comprise the following raw materials in parts by weight: 5 parts tripeptide-3, 5 parts carnosine and a blue light absorber; wherein the blue light absorber comprises 10 parts of radix Scutellariae extract, 10 parts of rhizoma Ligustici Chuanxiong extract, 10 parts of Scenedesmus obliquus extract and 5 parts of flos Tagetis Erectae extract. The starch is selected from corn starch.
The preparation method of the composition specifically comprises the following steps:
1) mixing tripeptide-3, carnosine and a blue light absorbent with water to obtain a dispersion liquid; wherein the blue-light absorber contains a xanthophyll component;
2) spray drying the dispersion to obtain powder;
3) weighing starch, dispersing in 50mL deionized water, putting the container into a boiling water bath, heating for 1h, stirring at the speed of 200r/min, and completely gelatinizing the starch to obtain starch gelatinized liquid.
4) Adding ethanol into the powder obtained in the step 2), mixing to obtain a solution, dropwise adding the solution twice, and keeping the solution under the conditions of water bath heat preservation at 95 ℃ and stirring at 200r/min in the process of dropwise adding the solution into the starch pasting solution for the first time; cooling to 20 ℃ in the second dripping process, and repeating the dripping operation to obtain a mixed solution; wherein the mass ratio of the powder to the starch pasting liquid is 0.1: 1; the content of starch in the starch pasting liquid is 1%.
5) Centrifuging the mixed solution, taking out the solid, eluting, continuing to centrifuge, taking out the solid, placing the solid in an electrothermal blowing drying oven at 35 deg.C for hot air drying for 2h, sieving to obtain powdery anti-aging blue light and wrinkle-removing composition, and storing at-20 deg.C.
Example 2
An anti-aging, blue light-resisting and wrinkle-removing composition is prepared by preparing effective components into powder, adding water to obtain solution, and dripping into starch gelatinizing solution. The active ingredients comprise the following raw materials in parts by weight: 10 parts tripeptide-3, 10 parts carnosine and a blue light absorber; wherein the blue light absorber comprises 20 parts of radix Scutellariae extract, 20 parts of rhizoma Ligustici Chuanxiong extract, 15 parts of Scenedesmus obliquus extract and 10 parts of flos Tagetis Erectae extract. The starch is selected from corn starch.
The preparation method of the composition specifically comprises the following steps:
1) mixing tripeptide-3, carnosine and a blue light absorbent with water to obtain a dispersion liquid; wherein the blue-light absorber contains a xanthophyll component;
2) spray drying the dispersion to obtain powder;
3) weighing starch, dispersing in 50mL deionized water, putting the container into a boiling water bath, heating for 2h, stirring at the speed of 300r/min, and completely gelatinizing the starch to obtain starch gelatinized liquid.
4) Adding ethanol into the powder obtained in the step 2), mixing to obtain a solution, dropwise adding the solution twice, and keeping the solution under the conditions of water bath heat preservation at 95 ℃ and stirring at 300r/min in the process of dropwise adding the solution into the starch pasting solution for the first time; cooling to 40 ℃ during the second dripping, and repeating the dripping operation to obtain a mixed solution; wherein the mass ratio of the powder to the starch gelatinization liquid is 0.5: 1; the starch content in the starch pasting liquid is 5%.
5) Centrifuging the mixed solution, taking out solid, eluting, continuing to centrifuge, taking out solid, drying the solid in electric heating air blowing drying oven at 35 deg.C for 4 hr with hot air, sieving to obtain powdery composition with anti-aging, blue light resisting and wrinkle removing effects, and storing at-20 deg.C.
Example 3
An anti-ageing, blue-light-resisting and wrinkle-removing composition is prepared through preparing powder from active components, adding water and blue-light absorbent, preparing solution, and dripping it in starch gelatinizing liquid. The active ingredients comprise the following raw materials in parts by weight: 8 parts tripeptide-3, 7 parts carnosine and a blue light absorber; wherein the blue light absorber comprises 15 parts of radix Scutellariae extract, 18 parts of rhizoma Ligustici Chuanxiong extract, 16 parts of Scenedesmus obliquus extract and 7 parts of flos Tagetis Erectae extract. The starch is selected from corn starch. The blue light reflecting agent comprises the following components in a mass ratio of 1: 2: 1 titanium dioxide, manganese dioxide and aluminum oxide. The mass ratio of the blue light reflecting agent to the powder is 0.1: 1.
the preparation method of the composition specifically comprises the following steps:
1) mixing tripeptide-3, carnosine and a blue light absorbent with water to obtain a dispersion liquid; wherein the blue-light absorber contains a xanthophyll component;
2) spray drying the dispersion to obtain powder;
3) weighing starch, dispersing in 50mL deionized water, putting the container into a boiling water bath, heating for 1h, stirring at the speed of 250r/min, and completely gelatinizing the starch to obtain starch gelatinized liquid.
4) Adding ethanol into the powder obtained in the step 2) and the blue light absorbent, mixing to obtain a solution, dropwise adding the solution twice, and keeping the solution under the conditions of 95 ℃ water bath heat preservation and 250r/min stirring in the process of dropwise adding the solution into the starch pasting liquid for the first time; cooling to 30 ℃ during the second dripping, and repeating the dripping operation to obtain a mixed solution; wherein the mass ratio of the powder to the starch gelatinization liquid is 0.3: 1; the content of starch in the starch pasting liquid is 3%.
5) Centrifuging the mixed solution, taking out solid, eluting, continuing to centrifuge, taking out solid, drying the solid in electric heating air blowing drying oven at 35 deg.C for 3 hr, sieving to obtain powdery composition with anti-aging, blue light resisting and wrinkle removing effects, and storing at-20 deg.C.
Example 4
An anti-ageing, blue-light-resisting and wrinkle-removing composition is prepared through preparing powder from active components, adding water and blue-light absorbent, preparing solution, and dripping it in starch gelatinizing liquid. The active ingredients comprise the following raw materials in parts by weight: 10 parts tripeptide-3, 8 parts carnosine and a blue light absorber; wherein the blue light absorber comprises 15 parts of radix Scutellariae extract, 18 parts of rhizoma Ligustici Chuanxiong extract, 14 parts of Scenedesmus obliquus extract and 8 parts of flos Tagetis Erectae extract. The starch is selected from corn starch. The blue light reflecting agent comprises the following components in a mass ratio of 2: 2: 1 titanium dioxide, manganese dioxide and aluminum oxide. The mass ratio of the blue light reflecting agent to the powder is 0.5: 1.
the preparation method of the composition specifically comprises the following steps:
1) mixing tripeptide-3, carnosine and a blue light absorbent with water to obtain a dispersion liquid; wherein the blue-light absorber contains a xanthophyll component;
2) spray drying the dispersion to obtain powder;
3) weighing starch, dispersing the starch in 50mL of deionized water, putting the container into a boiling water bath, heating for 1-2 h, and stirring at the speed of 200-300 r/min to completely gelatinize the starch to obtain starch gelatinization liquid.
4) Adding ethanol into the powder obtained in the step 2) and the blue light absorbent to mix to obtain a solution, dropwise adding the solution twice, and keeping the solution under the conditions of water bath heat preservation at 95 ℃ and stirring at 250r/min in the process of dropwise adding the solution into the starch pasting solution for the first time; cooling to 30 ℃ during the second dripping, and repeating the dripping operation to obtain a mixed solution; wherein the mass ratio of the powder to the starch gelatinization liquid is 0.3: 1; the starch content in the starch pasting liquid is 4%.
5) Centrifuging the mixed solution, taking out solid, eluting, continuing to centrifuge, taking out solid, drying the solid in electric heating air blowing drying oven at 35 deg.C for 3 hr, sieving to obtain powdery composition with anti-aging, blue light resisting and wrinkle removing effects, and storing at-20 deg.C.
Example 5
An anti-ageing, blue-light-resisting and wrinkle-removing composition is prepared through preparing powder from active components, adding water and blue-light absorbent, preparing solution, and dripping it in starch gelatinizing liquid. The active ingredients comprise the following raw materials in parts by weight: 6 parts of tripeptide-3, 10 parts of carnosine and a blue light absorber; wherein the blue light absorber comprises 13 parts of radix Scutellariae extract, 11 parts of rhizoma Ligustici Chuanxiong extract, 12 parts of Scenedesmus obliquus extract and 8 parts of flos Tagetis Erectae extract. The starch is selected from corn starch. The blue light reflecting agent comprises the following components in a mass ratio of 2: 3: 1 titanium dioxide, manganese dioxide and aluminum oxide. The mass ratio of the blue light reflecting agent to the powder is 0.2: 1.
the preparation method of the composition specifically comprises the following steps:
1) mixing tripeptide-3, carnosine and a blue light absorbent with water to obtain a dispersion liquid; wherein the blue-light absorber contains a xanthophyll component;
2) spray drying the dispersion to obtain powder;
3) weighing starch, dispersing in 50mL deionized water, putting the container into a boiling water bath, heating for 2h, and stirring at the speed of 250r/min to completely gelatinize the starch to obtain starch gelatinized liquid.
4) Adding ethanol into the powder obtained in the step 2) and the blue light absorbent to mix to obtain a solution, dropwise adding the solution twice, and keeping the solution under the conditions of water bath heat preservation at 95 ℃ and stirring at 250r/min in the process of dropwise adding the solution into the starch pasting solution for the first time; cooling to 30 ℃ during the second dripping, and repeating the dripping operation to obtain a mixed solution; wherein the mass ratio of the powder to the starch gelatinization liquid is 0.2: 1; the starch content in the starch pasting liquid is 2%.
5) Centrifuging the mixed solution, taking out the solid, eluting, continuing to centrifuge, taking out the solid, placing the solid in an electrothermal blowing drying oven at 35 deg.C, hot air drying for 3 hr, sieving to obtain powdery composition with antiaging, blue light resisting and wrinkle removing effects, and storing at-20 deg.C.
Comparative example 1
Comparative example 1 differs from example 3 in that: comparative example 1 the kinds and contents of the effective components used were the same as those of example 3, but they were not mixed with the starch-gelatinizing liquid, and only the respective extracts were mixed with ethanol to prepare an ethanol solution.
Comparative example 2
Comparative example 2 differs from example 3 in that: comparative example 2 no blue light absorber was added. The remaining components and preparation were the same as in example 3.
Comparative example 3
Comparative example 3 differs from example 3 in that: comparative example 3 tripeptide-3 was not added. The remaining components and preparation were the same as in example 3.
Comparative example 4
Comparative example 4 differs from example 3 in that: comparative example 4 no carnosine was added. The remaining components and preparation were the same as in example 3.
Performance testing
Whitening performance test
The preparation method of the solution to be detected comprises the following steps: weighing 1.0g of each sample (examples 1-5 and comparative examples 1-4), dispersing uniformly by distilled water, transferring into a 100mL volumetric flask for constant volume, and diluting to a solution to be tested with a concentration of 5.0 mg/mL.
The method for measuring the tyrosinase inhibition rate comprises the following steps: respectively preparing a Phosphate Buffer Solution (PBS) with the pH value of 6.83, a tyrosinase solution with the mass concentration of 0.07mg/mL and an L-tyrosinase solution with the mass concentration of 1.0 mg/mL. Accurately preparing a solution to be detected 1: 2.0mL of PBS +0.5mL of tyrosinase solution +0.5mL of L-tyrosine solution; and (3) liquid to be detected 2: 2.5mL PBS +0.5mL tyrosinase solution; solution to be tested 3: 0.5mL of a solution to be tested +1.5mL of PBS +0.5mL of tyrosinase solution +0.5mL of a solution of MLL-tyrosinase; and (4) a to-be-detected liquid: 0.5mL of the solution to be tested +2.0mL of LPBS +0.5mL of the tyrosinase solution. Placing in 37 deg.C water bath, keeping the temperature for 30min, immediately measuring absorbance at 475nm, and recording the absorbance as A1、A2、A3、A4. Tyrosinase inhibition was calculated according to formula (1). The data are shown in table 1.
I＝[(A1-A2)-(A3-A4)]/(A1-A2)×100％ (1)
Second, testing the oxidation resistance
The preparation method of the solution to be detected comprises the following steps: weighing 1.0g of each sample (examples 1-5 and comparative examples 1-4), dispersing uniformly by distilled water, transferring into a 100mL volumetric flask for constant volume, and diluting to a solution to be tested with a concentration of 5.0 mg/mL.
Method for measuring DPPH-radical inhibition ratio: adding 3mL of the solution to be detected and 3mL of 0.2mmol/L DPPH-ethanol solution into the same test tube with a plug, shaking, standing in the dark at room temperature for 30min, and measuring the absorbance A at the wavelength of 517nmi1The absorbance A of the mixture of the extractant and 3mL each of the DPPH and ethanol solutions was measured by the same method01And absorbance A of the mixture of the solution to be detected and 3mL of absolute ethyl alcoholj1The inhibition ratio P is calculated according to the formula (3). The data are shown in table 1.
P＝[1-(Ai1-Aj1)/A01]×100％。
Inhibition of tyrosinase and free radical by the compositions of Table 1
| Group of | I/％ | P/％ |
| Example 1 | 63.9 | 73.1 |
| Example 2 | 68.2 | 78.5 |
| Example 3 | 66.7 | 76.9 |
| Example 4 | 66.3 | 75.7 |
| Example 5 | 65.8 | 75.3 |
| Comparative example 1 | 58.3 | 70.5 |
| Comparative example 2 | 50.6 | 60.2 |
| Comparative example 3 | 56.7 | 64.3 |
| Comparative example 4 | 55.1 | 64.7 |
Third, anti-blue light test
1. Blue light absorption test
The composition powders of examples 1 to 5 and comparative examples 1 to 4 were each deionized and diluted to a 5% concentration composition solution, and the blue light spectrum was scanned within 400 to 500 nm. The absorbance values at 400nm, 420nm, 440nm, 460nm, 480nm and 500nm were recorded, as specified in Table 2.
2. Reflected blue light test
The composition powders of examples 1 to 5 and comparative examples 1 to 4 were diluted to 5% by deionization, and coated on a glass plate, and the blue light transmittance of a blue light visible (blue light) 450nm light source was measured using a fast-dray SDR852 blue light transmittance tester, the data of which are shown in table 3.
As can be seen from table 1, the antioxidant capacity and the whitening effect of example 2 are most effective in adding the effective components, and although the blue light absorbent is added in examples 3 to 5, the blue light absorbent has little influence on the antioxidant capacity and the whitening effect, and the blue light absorbent of comparative example 1 is not coated with starch, so that the blue light absorbent is difficult to be uniformly dispersed in an aqueous solution, and the antioxidant capacity and the whitening capacity are influenced. In comparative examples 2-4, the blue light absorbent, the tripeptide-3 and the carnosine are not added, so that the antioxidant effect and the whitening effect are greatly reduced, and the fact that the tripeptide-3, the carnosine and radix scutellariae extract, the ligusticum wallichii root extract, the scenedesmus extract and the marigold extract are compounded to play a role in synergistic whitening and antioxidant effects and improve the effect is shown.
As can be seen from Table 2, the absorbance values of each group were greater than 1 in both the 400nm and 420nm bands, indicating that the compositions of each group were capable of completely absorbing blue light in this band. The blue light absorbing agent of the comparative example 2 is not coated with starch, so that the blue light absorbing agent is difficult to be uniformly dispersed in an aqueous solution, and the blue light absorbing effect of the blue light absorbing agent is influenced.
As can be seen from Table 3, the blue light reflecting agent is added in the examples 3-5 and the comparative examples 1-4, so that the transmittance of the blue light is reduced, and the blue light can be effectively reflected and scattered, so that the damage of the blue light to the skin is reduced.
The above embodiments are only preferred embodiments of the present invention, and the protection scope of the present invention is not limited thereby, and any insubstantial changes and substitutions made by those skilled in the art based on the present invention are within the protection scope of the present invention.
Claims (10)
1. The preparation method of the anti-aging blue light-resisting and wrinkle-removing composition is characterized by comprising the following steps of:
1) mixing tripeptide-3, carnosine and a blue light absorbent with water to obtain a dispersion liquid; wherein the blue-light absorber contains a xanthophyll component;
2) spray drying the dispersion to obtain powder;
3) weighing starch, adding water, mixing, heating while stirring until the starch is gelatinized to obtain starch gelatinized liquid for later use;
4) adding the powder obtained in the step 2) into a solvent for mixing to obtain a solution, and then dropwise adding the solution into the starch pasting solution while stirring to obtain a mixed solution;
5) and centrifuging the mixed solution, taking out the solid, continuously centrifuging after eluting, taking out the solid again, drying and dehydrating the solid, and sieving to obtain the powdery anti-aging blue light-resistant and wrinkle-removing composition.
2. The method for preparing the anti-aging blue-light-resisting and wrinkle-removing composition as claimed in claim 1, wherein the blue-light absorber is one or more of scutellaria baicalensis root extract, ligusticum wallichii root extract, scenedesmus japonica extract and marigold extract.
3. The method for preparing the anti-aging blue light-resistant and wrinkle-removing composition according to claim 1, wherein in step 1), the dispersion comprises the following raw materials in percentage by weight: 5-10 parts of tripeptide-3, 5-10 parts of carnosine and a blue light absorbent; wherein the blue light absorbent comprises 10-20 parts of scutellaria root extract, 10-20 parts of ligusticum wallichii root extract, 10-15 parts of scenedesmus extract and 5-10 parts of marigold extract.
4. The preparation method of the anti-aging blue light-resistant and wrinkle-removing composition as claimed in claim 1, wherein in step 3), after the starch and the water are mixed, the container is placed into a boiling water bath to be heated for 1-2 hours, and stirring is carried out at a speed of 200-300 r/min, so that the starch is completely gelatinized, and the starch gelatinized liquid is obtained.
5. The method for preparing the anti-aging blue light and wrinkle-removing composition according to claim 1, wherein in the step 4), the solution further comprises a blue light reflecting agent, and the blue light reflecting agent comprises the following components in a mass ratio of (1-3): (2-3): 1 titanium dioxide, manganese dioxide and aluminum oxide.
6. The method for preparing the anti-aging blue light and wrinkle-removing composition according to claim 5, wherein the mass ratio of the blue light reflecting agent to the powder is (0.1-0.5): 1.
7. the method for preparing the anti-aging blue light-resisting and wrinkle-removing composition according to claim 1, wherein in the step 4), the mass ratio of the powder to the starch gelatinizing liquid is (0.1-0.5): 1; the starch pasting liquid contains 1-5% of starch.
8. The method for preparing the anti-aging blue-light and wrinkle-removing composition according to claim 1, wherein in step 4), the solvent is ethanol.
9. The preparation method of the anti-aging blue light-resisting and wrinkle-removing composition as claimed in claim 1, wherein in the step 4), the solution is dripped twice, and in the process of dripping the solution into the starch pasting solution for the first time, the starch pasting solution is kept in a water bath and kept at a temperature of 95-100 ℃; and cooling to 20-40 ℃ during the second dripping.
10. An anti-aging blue light and wrinkle-removing composition, which is prepared by the preparation method of the anti-aging blue light and wrinkle-removing composition as claimed in any one of claims 1 to 9.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB774549A (en) * | 1953-09-03 | 1957-05-08 | Corn Prod Refining Co | Improvements in or relating to the production of dispersions in starch |
| CN102802436A (en) * | 2010-03-29 | 2012-11-28 | 弗门尼舍有限公司 | Spray-dried crystalline active ingredient |
| CN107334686A (en) * | 2017-08-18 | 2017-11-10 | 广州丸美生物科技有限公司 | Skin matrix, preparation method and applications and cosmetics and preparation method thereof |
| WO2019026970A1 (en) * | 2017-08-02 | 2019-02-07 | ペトロユーロアジア株式会社 | Lutein-containing composition and method for manufacturing same |
| CN111743795A (en) * | 2020-07-29 | 2020-10-09 | 苏州讯如电子科技有限公司 | Repair skin cream with blue light resisting function and preparation method thereof |
| CN113730308A (en) * | 2021-09-26 | 2021-12-03 | 湖北省麦诗特生物科技有限公司 | Eye cream composition containing blue light resisting liposome and preparation method thereof |
-
2022
- 2022-02-17 CN CN202210145387.4A patent/CN114642601A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB774549A (en) * | 1953-09-03 | 1957-05-08 | Corn Prod Refining Co | Improvements in or relating to the production of dispersions in starch |
| CN102802436A (en) * | 2010-03-29 | 2012-11-28 | 弗门尼舍有限公司 | Spray-dried crystalline active ingredient |
| WO2019026970A1 (en) * | 2017-08-02 | 2019-02-07 | ペトロユーロアジア株式会社 | Lutein-containing composition and method for manufacturing same |
| CN107334686A (en) * | 2017-08-18 | 2017-11-10 | 广州丸美生物科技有限公司 | Skin matrix, preparation method and applications and cosmetics and preparation method thereof |
| CN111743795A (en) * | 2020-07-29 | 2020-10-09 | 苏州讯如电子科技有限公司 | Repair skin cream with blue light resisting function and preparation method thereof |
| CN113730308A (en) * | 2021-09-26 | 2021-12-03 | 湖北省麦诗特生物科技有限公司 | Eye cream composition containing blue light resisting liposome and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 中华人民共和国国家药品监督管理局: "《化妆品安全技术规范》", pages: 5 * |
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