CN108852869B - Skin care composition for resisting blue light pollution and application thereof - Google Patents
Skin care composition for resisting blue light pollution and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Abstract
The invention discloses a skin care composition for resisting blue light pollution and application thereof. The skin care composition resisting blue light pollution comprises the following components: cell growth factor, diguanosine tetraphosphate, water-soluble fullerene, echinacea angustifolia leaf extract, lily bulbus extract, ectoin, ascorbyl glucoside and small molecule humectant. The skin care composition is designed aiming at various skin problems caused by blue light pollution, is reasonable in component collocation and scientific in proportioning, can effectively relieve the phenomena of collagen loss, pigmentation, skin sensitivity and the like caused under the blue light pressure, and has a good blue light resistant protection and repair effect.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a skin care composition capable of resisting blue light pollution and application thereof.
Background
The 'blue light' is really a common name of 'high-energy short-wave blue light', is light with relatively high energy at a wavelength of 400-480 nm, exists in sunlight, and also commonly exists in bathroom heaters, computers, projectors, laser pens, LED displays, fluorescent lamps, mobile phones, outdoor lamp boxes, LED lamps and movie screens. Modern life is inseparable from the electronic products, so that people are in the environment polluted by excessive artificial blue light generated by the electronic products for a long time.
The harm of blue light pollution to human body is not only reflected on eyesight, but also on skin. A large number of research experiments show that blue light is the largest invisible killer of skin. Compared with the ultraviolet pollution of the sun, the white light pollution of a glass curtain wall and the color pollution of a neon lamp, the blue light pollution is the deepest light source influencing the human health at present, and the damage to the skin is very strong. The blue light can completely penetrate the dermis and the epidermis of the skin, and is one of the most important factors for the loss of collagen of the skin basal layer while inducing the skin pigmentation.
According to scientific experiments, the energy of short-wave blue light with the wavelength of 410nm is equal to one third of UVA with the wavelength of 380nm, a screen continuously used for 3 hours is equal to the screen exposed to the sun for 1 hour, the blue light stimulates the skin to continuously secrete and generate melanine brown pigment, and the melanine turns into dirt to peel off after the melanine erodes the ultraviolet rays of the sun, and stays on the surface layer of the skin to form yellow spots and freckles. In addition, blue light can completely penetrate the epidermis and the dermis of the skin, serious damage is caused to mitochondria in epithelial cells, the activity of the mitochondria, namely a human skin cell 'generator', is reduced, the reduction of the activity of the mitochondria directly causes the abnormal activity of oxygen radicals in the skin, and the oxygen radicals continuously release a large amount of Matrix Metalloproteinases (MMPs) in the continuous proliferation process, and the Matrix Metalloproteinases (MMPs) are the root cause of the loss of human collagen and the root cause of skin aging and wrinkles. In addition, high-intensity blue light can stimulate cerebral cortex, inhibit melatonin secretion, improve the excitability of a human body, stimulate and improve the generation of adrenocortical hormone, and the adrenocortical hormone directly causes the rapid decline of human immunity and the occurrence of endocrine dyscrasia, thereby causing allergic phenomena of redness, red swelling, dryness, desquamation, tightness, itching, blister, pimple, small red spot and the like of skin. In conclusion, the damage of blue light to the skin is greatly influenced, and the blue light not only accelerates the oxidation and causes aging, is fragile, dry and lack of water; it also disturbs melatonin secretion, causing problems of pigmentation, free radicals increase, even blackening and spots and wrinkles. At present, the skin care products on the market are various in types, wherein most of the products for whitening, removing freckles, removing wrinkles and resisting aging are mainly ultraviolet rays, but not designed aiming at the root of blue light pollution, and the repair effect on skin problems caused by the blue light pollution is not obvious.
Chinese patent application with publication number CN 107397714A discloses an essence emulsion with blue light pollution resistance and fine line fading effects, which contains BlumilightTMBiofunctional, hypecoum culture filtrate, yeast lysate extract, hydrolyzed vegetable protein and other components can promote skin to resist blue light rays, reduce mitochondrial active oxygen caused by blue light pressure, and has effects of resisting blue light pollution and fading skin fine lines. At present, skin care products designed for blue light pollution are relatively few, and a skin care composition with blue light pollution resistance is needed to meet the market demand.
Disclosure of Invention
The invention aims to provide a skin care composition for resisting blue light pollution and application thereof. The skin care composition has super strong free radical scavenging capability, can remarkably relieve the phenomena of collagen loss, pigmentation, skin sensitivity and the like caused by blue light pressure, and has better blue light resistant protection and repair effects.
The invention is realized by the following technical scheme:
the skin care composition for resisting blue light pollution comprises the following components in parts by weight: 0.00005-0.001 part of cell growth factor, 0.5-2 parts of diguanosine tetraphosphate, 2-6 parts of water-soluble fullerene, 1-4 parts of echinacea angustifolia leaf extract, 2-4 parts of lily bulbus extract, 0.5-2 parts of ectoin and 0.5-1.5 parts of ascorbyl glucoside.
Preferably, the skin care composition resisting blue light pollution comprises the following components in parts by weight: 0.0001-0.001 part of cell growth factor, 1-2 parts of diguanosine tetraphosphate, 3-5 parts of water-soluble fullerene, 2-3 parts of echinacea angustifolia leaf extract, 3-4 parts of lily of white flower bulb extract, 1-2 parts of ectoin and 0.5-1.5 parts of ascorbyl glucoside.
Preferably, the skin care composition capable of resisting blue light pollution further comprises 2-4 parts of a small molecular humectant.
More preferably, the small molecule humectant is at least one of tocopherol, squalane, ceramide, pantethine, arginine, hydroxyproline, dipropylene glycol, and panthenol.
Preferably, the cell growth factor is at least one of a recombinant human basic fibroblast growth factor, a recombinant human acidic fibroblast growth factor and a recombinant human keratinocyte growth factor.
Preferably, the water-soluble fullerene is an acetyl chitosamine-fullerene compound, and the mass percentage of fullerene in the acetyl chitosamine-fullerene compound is 85-90%.
The water-soluble fullerene is prepared by the following method, and the method comprises the following steps:
(1) reacting fullerene C60Adding the powder into a jet mill pulverizer, carrying out jet milling under the protection of high-purity inert gas, allowing the fully ground micro powder to pass through gaps of a sorting wheel along with the air flow, and allowing the non-fully ground micro powder not to pass through, continuing jet milling until the particle size of the powder is 0.2-1 mu m, and collecting to obtain the fullerene C60Ultrafine powder;
(2) to fullerene C60Adding deionized water into the superfine powder, wherein the fullerene C60The mass ratio of the ultrafine powder to water is 1: 10000-100000, ultrasonic treatment is carried out for 60-120 min under the conditions that the power is 100-200W and the temperature is 50-60 ℃, cooling is carried out to the room temperature, and acetyl chitosamine is added, wherein the acetyl chitosamine and fullerene C60Carrying out ultrasonic treatment on the superfine powder for 1 to 6-9 mass ratio under the conditions that the power is 50-60W and the temperature is 35-40 ℃ for 1-2 hours to obtain a water-soluble fullerene solution;
(3) and (3) drying the water-soluble fullerene solution under vacuum reduced pressure to obtain the water-soluble fullerene.
The skin care composition capable of resisting blue light pollution provided by the invention can be used for preparing skin care products or cosmetics capable of resisting blue light pollution; the skin care product for resisting blue light pollution comprises, but is not limited to, toner, lotion, essence, cream or facial mask.
The water-soluble fullerene in the formula of the skin care composition has super strong free radical scavenging capability, can obviously scavenge mitochondrial active oxygen caused by blue light pressure, and has excellent antioxidant effect. The water-soluble fullerene is prepared by a specific process by the inventor, contains the fullerene component and the acetyl chitosamine, solves the problem that the fullerene is difficult to dissolve in water and the problem that the fullerene is difficult to be absorbed by skin, and is suitable for preparing the skin care product or the cosmetic with blue light pollution resistance.
In addition, the formula is compounded with cell growth factors, diguanosine tetraphosphate, echinacea angustifolia leaf extract, lily bulbus extract, ectoin and ascorbyl glucoside, all the components are reasonably compounded, the composition has obvious synergistic effect, the problems of collagen loss, fine line hyperplasia, sensitive, dry and water-deficient skin, pigment precipitation, color spot formation and the like caused by blue light pollution are comprehensively prevented, and various skin care effects of reducing fine lines, delaying senescence, replenishing water and moisturizing, whitening and removing freckles are achieved.
Wherein, the diguanosine tetraphosphate (GP4G) is an energy substance extracted from marine plankton extract, can 'wake up' cells which are 'dormant' due to aging or environmental influence, supplement cell energy, activate various physiological activities and metabolism of skin cells, has the functions of DNA protection and repair, and has better protective effect on cell damage caused by blue light. The skin collagen powder is compounded with cell growth factors, so that the skin collagen powder can promote the regeneration of skin collagen and the recombination of fibrous tissues, enhance the skin elasticity, reduce the skin sensitivity, make the thick, flushed and dilated capillaries become thin and shallow, has the effects of moistening the skin, enhancing the skin elasticity, reducing skin wrinkles and preventing skin aging, and has a good repairing effect on the skin collagen loss caused by blue light. In addition, the ectoin has a better mitochondrion protection effect, can effectively inhibit the mitochondrion variation, resist the damage of blue light to the mitochondrion, improve the protection capability of the cell against the blue light, and increase the self-repair capability of the cell. The echinacea angustifolia leaf extract can effectively improve the immune protection capability of skin cells, so that the skin can effectively resist the invasion of microorganisms and allergens, relieve various pressures born by the skin and relieve various sensitive reactions caused by blue light to the skin. The Lilium Candidum bulb extract can be used for preventing immune disorder caused by skin aging, preventing skin aging caused by external irritation, preventing and treating skin or mucosa pathological changes such as skin atrophy, sagging, pruritus, pachylosis, etc., and delaying skin aging caused by blue light. In addition, the ascorbic acid glucoside is added, so that the formation of melanin can be blocked, the pigmentation can be effectively relieved, and a certain inhibiting effect on the formation of color spots caused by blue light can be realized.
Compared with the prior art, the invention has the following beneficial effects:
(1) the skin care composition capable of resisting blue light pollution provided by the invention is designed aiming at various skin problems caused by blue light pollution, is reasonable in component matching and scientific in proportion, can effectively relieve the phenomena of collagen loss, pigmentation, skin sensitivity and the like caused under the blue light pressure, and has a better blue light resisting protection and repair effect.
(2) The blue light pollution resistant skin care composition provided by the invention is mild in property, has no toxic or side effect, has a certain conditioning effect on skin, and has various skin care effects of fading fine wrinkles, delaying senescence, replenishing water and moisturizing, whitening and removing freckles and the like.
Detailed Description
The following examples are further illustrative of the present invention and are not intended to be limiting thereof. The components of the formulations in the following examples, unless otherwise specified, are conventional commercial products in which diguanosine tetraphosphate is available from International Special products corporation (ISP) in the United states; ectoin was purchased from Wuhan Hill science and technology, Inc.; echinacea angustifolia leaf extract was obtained from Achilles technologies (Active Concepts) in USA; the lilium albo bulb extract is purchased from Shaanxi forest Freund Natural products, Inc.; ascorbyl glucoside was purchased from carbofuran technologies ltd.
Example 1 preparation of Water-soluble Fullerene
(1) Reacting fullerene C60Adding the powder into a jet mill pulverizer, carrying out jet milling under the protection of high-purity inert gas, allowing the fully ground micro powder to pass through gaps of a sorting wheel along with the air flow, and allowing the non-fully ground micro powder not to pass through, continuing jet milling until the particle size of the powder is 0.2-1 mu m, and collecting to obtain the fullerene C60Ultrafine powder;
(2) to fullerene C60Adding deionized water into the superfine powder, wherein the fullerene C60The mass ratio of the superfine powder to water is 1:100000, ultrasonic treatment is carried out for 60min under the conditions of 200W power and 60 ℃, cooling to room temperature is carried out, and acetyl chitosamine is added, wherein the acetyl chitosamine and fullerene C60Performing ultrasonic treatment on the superfine powder for 1h at the power of 60W and the temperature of 40 ℃ at the mass ratio of 1:9 to obtain a water-soluble fullerene solution;
(3) and (3) drying the water-soluble fullerene solution under vacuum reduced pressure to obtain the water-soluble fullerene.
Example 2 preparation of Water-soluble Fullerene
(1) Reacting fullerene C60Adding the powder into a jet mill pulverizer, carrying out jet milling under the protection of high-purity inert gas, allowing the fully ground micro powder to pass through gaps of a sorting wheel along with the air flow, and allowing the non-fully ground micro powder not to pass through, continuing jet milling until the particle size of the powder is 0.2-1 mu m, and collecting to obtain the fullerene C60Ultrafine powder;
(2) to fullerene C60Adding deionized water into the superfine powder, wherein the fullerene C60The mass ratio of the superfine powder to water is 1:10000, ultrasonic treatment is carried out for 120min under the conditions that the power is 100W and the temperature is 50 ℃, cooling is carried out to the room temperature, and the acetyl chitosamine is added, wherein the acetyl chitosamine and the fullerene C60Performing ultrasonic treatment on the ultrafine powder for 2 hours at the power of 50W and the temperature of 35 ℃ at the mass ratio of 1:6 to obtain a water-soluble fullerene solution;
(3) and (3) drying the water-soluble fullerene solution under vacuum reduced pressure to obtain the water-soluble fullerene.
Comparative example 1 preparation of Water-soluble Fullerene
(1) Reacting fullerene C60Adding the powder into a jet mill pulverizer, carrying out jet milling under the protection of high-purity inert gas, allowing the fully ground micro powder to pass through gaps of a sorting wheel along with the air flow, and allowing the non-fully ground micro powder not to pass through, continuing jet milling until the particle size of the powder is 0.2-1 mu m, and collecting to obtain the fullerene C60Ultrafine powder;
(2) to fullerene C60Adding deionized water into the superfine powder, wherein the fullerene C60Performing ultrasonic treatment on the ultrafine powder and water at a mass ratio of 1:100000 for 60min under the conditions of 200W power and 60 ℃, and performing ultrasonic treatment for 1h under the conditions of 60W power and 40 ℃ to obtain a water-soluble fullerene solution;
(3) and (3) drying the water-soluble fullerene solution under vacuum reduced pressure to obtain the water-soluble fullerene.
Comparative example 1 differs from example 1 only in that acetyl chitosamine was not added during the preparation of the water-soluble fullerene, and the remaining steps and parameters were the same as those of example 1.
EXAMPLE 3 preparation of skin care compositions resistant to blue light pollution
The blue light pollution resistant skin care composition of this example was prepared to include the following components in the following table 1 in parts by weight:
TABLE 1 compositions of blue light pollution resistant skin care compositions
The preparation method comprises the following steps: and weighing the raw materials of the components of the formula according to the weight parts shown in the table, and uniformly mixing to obtain the blue light pollution resistant skin care composition.
Comparative example 1 preparation of skin care composition resistant to blue light pollution
The preparation of the blue light pollution resistant skin care composition of this comparative example comprises the following components in parts by weight as shown in table 2:
TABLE 2 composition of blue light pollution resistant skin care compositions
The preparation method comprises the following steps: and weighing the raw materials of the components of the formula according to the weight parts shown in the table, and uniformly mixing to obtain the blue light pollution resistant skin care composition.
Example 4 skin lotion preparation against blue light pollution
(1) The formula is as follows:
(2) the preparation method comprises the following steps: adding the blue light pollution resisting skin care composition of the formula 1 in the embodiment 3, disodium EDTA, citric acid, sodium citrate and phenoxyethanol into deionized water, stirring until the materials are completely dissolved, and subpackaging to obtain the skin care lotion.
Skin lotions containing the blue-light pollution resistant skin care compositions of formulations 2 to 4 of example 3 and formulations 5 to 9 of comparative example 1 were prepared as described above, and the amount of the blue-light pollution resistant skin care composition added in each test example was 15 wt%.
Example 5 anti-blue-light-staining essence preparation:
(1) the formula is as follows:
(2) the preparation method comprises the following steps: adding the blue light pollution resisting skin care composition prepared in the formula 1 in the embodiment 3, disodium EDTA and glycerol into deionized water, heating to 37 ℃, stirring and mixing uniformly, wherein the stirring speed is 100 revolutions per minute; and (3) after uniformly mixing, cooling to 28 ℃, adding the acryloyl dimethyl ammonium taurate/VP copolymer and the ethylhexyl glycerol, uniformly mixing, and subpackaging to obtain the essence.
Essence preparation containing blue-light pollution resistant skin care compositions according to formulations 2 to 4 of example 3 and formulations 5 to 9 of comparative example 1 referring to the above, the blue-light pollution resistant skin care compositions were added in an amount of 15 wt% in each test example.
Test example I, patch test on human skin
The skin moisturizers containing the blue light pollution resisting skin care compositions according to formulas 1 to 4 in example 3 and formulas 5 to 9 in comparative example 1 are tested according to related requirements and determination methods of a human skin patch test in 2015 edition of cosmetic hygiene code issued by the ministry of health, skin reactions are observed at 0h, 6h, 12h, 24h and 48h respectively, and the experimental results of all volunteer subjects are negative results and do not have adverse skin reactions. The skin care lotion containing the blue light pollution resisting skin care composition provided by the invention is free of irritation and high in safety.
Test example two, antioxidant Activity test
(1) Free radical scavenging ability test: blue light radiation causes the body to generate a large number of free radicals. Free radicals are active chemical substances with extremely strong oxidizing capability, and a large number of free radicals generated in a body can damage the skin and accelerate the formation of color spots and melanin. DPPH is a stable long-lived radical whose light absorption is diminished by pairing with its single electron when a radical scavenger is present, thereby evaluating the ability of a substance to scavenge free radicals and thus assess its antioxidant ability. The present inventors determined the absorbance of skin care lotions containing blue light contamination resistant skin care compositions of formulas 1-4 of example 3 and formulas 5-9 of comparative example 1 by DPPH radical neutralization test to determine the removal rate of DPPH radicals to evaluate the ability of the blue light contamination resistant skin care compositions provided by the present invention to remove radicals, and the results are shown in Table 3.
TABLE 3 DPPH radical scavenging ratio of skin lotions of each group
The results show that the skin moisturizer containing the blue light pollution resistant skin care composition of formulas 1 to 4 of example 3 can effectively remove DPPH free radicals, the removal rate is more than 82%, and the skin moisturizer is obviously superior to the skin moisturizer containing the blue light pollution resistant skin care composition of formulas 5 to 9 of comparative example 1, and the skin moisturizer has the advantages that all components of the blue light pollution resistant skin care composition are reasonably compounded and coordinated with each other, so that the free radicals generated by blue light irradiation can be effectively removed, and the damage of the free radicals to the skin can be reduced.
(2) Inhibiting cellular reactive oxygen species production
100 healthy Kunming mice with the weight of 20-25 g and female bodies are selected and randomly divided into 10 groups, namely a test group 1-5 and a control group 1-5, and each group comprises 10 mice. The mice were dehaired on their backs to an area of approximately 2X 2cm at 425nm (3 mW/cm) of LED blue light2Lasting 18min), smearing tested samples on the naked skin of the mice, wherein test groups 1-4 are respectively smeared with skin care solution containing the skin care composition for resisting blue light pollution of formulas 1-4 of example 3, control groups 1-5 are respectively smeared with skin care solution containing the skin care composition for resisting blue light pollution of formulas 5-9 of comparative example 1, the smearing amount of each group is 1mL/cm, after 24h, the skin care solution is quantitatively analyzed by CellROX fluorescence intensity staining and Volocity image software, the higher the value of the cell active oxygen indicates that the blue light resistance of the tested samples is poorer, and the change condition of the cell active oxygen of the mice is shown in table 4 within 1 month of continuous use.
TABLE 4 Effect of skin lotions on active oxygen in mouse skin cells
The result shows that the skin care lotion containing the skin care compositions for resisting blue light pollution in the formulas 1 to 4 in the example 3 can effectively inhibit the increase of the active oxygen level of the skin cells of mice under the blue light pressure, and the skin care lotion containing the skin care compositions for resisting blue light pollution in the formula 1 in the example 3 has the best effect and has the effect obviously superior to that of the skin care lotion containing the skin care compositions for resisting blue light pollution in the formulas 5 to 9 in the comparative example 1, so that the skin care composition for resisting blue light pollution provided by the invention has the advantages of reasonable compounding and mutual coordination of all components, and has.
Test example three, test of the Using Effect of skin lotion containing the skin care composition for preventing blue light pollution
120 female volunteers were obtained daily in the same blue-light contaminated environment, in good health, and without lactation or pregnancy. All female volunteers had more fine lines, dark skin, more mottle, and large pores in the triangular region of the nose and dry skin in the cheek region between 25 and 40 years of age. The volunteers signed a comprehensive informed consent document.
Female volunteers were randomly divided into 6 groups, test group 1 and control groups 1-5, each group containing 20 persons, the skin care lotion containing the blue light pollution resistant skin care composition of formula 1 of example 3 was used for test group 1, the skin care lotion containing the blue light pollution resistant skin care composition of formulas 5-9 of comparative example 1 was used for control groups 1-5, the skin improvement of volunteers of each group was evaluated for 1 time in the morning and evening and for 1 month in succession, and the results are shown in table 5.
TABLE 5 evaluation results of skin-improving effects of skin lotions of each group
The results show that the skin moisturizer of the test group 1 can effectively improve the phenomena of increase of fine lines, dark skin color, color spots, large pores, dryness and the like of the skin caused by blue light pollution, the effective rate is higher than 90%, and the skin moisturizer is obviously superior to that of a control group 1-5, and shows that the skin moisturizer containing the blue light pollution resistant skin moisturizer of the formula 1 of the embodiment 3 has a good repairing effect on various skin problems caused by blue light pollution, and the blue light pollution resistant effect of the skin can be enhanced.
The above is only a preferred embodiment of the present invention, and it should be noted that the above preferred embodiment should not be considered as limiting the present invention, and the protection scope of the present invention should be subject to the scope defined by the claims. It will be apparent to those skilled in the art that various modifications and adaptations can be made without departing from the spirit and scope of the invention, and these modifications and adaptations should be considered within the scope of the invention.
Claims (7)
1. The skin care composition for resisting blue light pollution is characterized by comprising the following components in parts by weight: 0.00005-0.001 part of cell growth factor, 0.5-2 parts of diguanosine tetraphosphate, 2-6 parts of water-soluble fullerene, 1-4 parts of echinacea angustifolia leaf extract, 2-4 parts of lily bulbus extract, 0.5-2 parts of ectoin and 0.5-1.5 parts of ascorbyl glucoside; the water-soluble fullerene is an acetyl chitosamine-fullerene compound, and the mass percentage of fullerene in the acetyl chitosamine-fullerene compound is 85-90%;
the preparation of the water-soluble fullerene comprises the following steps:
(1) reacting fullerene C60Adding the powder into a jet mill pulverizer, carrying out jet milling under the protection of high-purity inert gas, allowing the fully ground micro powder to pass through gaps of a sorting wheel along with the air flow, and allowing the non-fully ground micro powder not to pass through, continuing jet milling until the particle size of the powder is 0.2-1 mu m, and collecting to obtain the fullerene C60Ultrafine powder;
(2) to fullerene C60Adding deionized water into the superfine powder, wherein the fullerene C60The mass ratio of the ultrafine powder to water is 1: 10000-100000, ultrasonic treatment is carried out for 60-120 min under the conditions that the power is 100-200W and the temperature is 50-60 ℃, cooling is carried out to the room temperature, and acetyl chitosamine is added, wherein the acetyl chitosamine and fullerene C60Carrying out ultrasonic treatment on the superfine powder for 1 to 6-9 mass ratio under the conditions that the power is 50-60W and the temperature is 35-40 ℃ for 1-2 hours to obtain a water-soluble fullerene solution;
(3) and (3) drying the water-soluble fullerene solution under vacuum reduced pressure to obtain the water-soluble fullerene.
2. The blue light pollution resistant skin care composition according to claim 1, comprising the following components in parts by weight: 0.0001-0.001 part of cell growth factor, 1-2 parts of diguanosine tetraphosphate, 3-5 parts of water-soluble fullerene, 2-3 parts of echinacea angustifolia leaf extract, 3-4 parts of lily of white flower bulb extract, 1-2 parts of ectoin and 0.5-1.5 parts of ascorbyl glucoside.
3. The blue light pollution resistant skin care composition according to claim 1 or 2, further comprising 2-4 parts of a small molecule humectant; the micromolecule humectant is at least one of tocopherol, squalane, ceramide, pantethine, arginine, hydroxyproline, dipropylene glycol and panthenol.
4. The blue-light pollution resistant skin care composition according to claim 1 or 2, wherein the cell growth factor is at least one of a recombinant human basic fibroblast growth factor, a recombinant human acidic fibroblast growth factor and a recombinant human keratinocyte growth factor.
5. Use of the blue-light pollution resistant skin care composition according to any one of claims 1 to 4 for preparing a blue-light pollution resistant skin care or cosmetic.
6. A blue light pollution resistant skin care product comprising the blue light pollution resistant skin care composition according to any one of claims 1 to 4.
7. The blue light pollution resistant skin care product according to claim 6, wherein the skin care product is a toner, a lotion, a essence, a cream or a mask.
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109106641A (en) * | 2018-09-20 | 2019-01-01 | 陈洁珍 | A kind of anti-blue light contamination sun screen and preparation method thereof |
| CN110742852A (en) * | 2019-11-15 | 2020-02-04 | 上海百好博化工有限公司 | Composition for multi-effect repair of sensitive skin and preparation method and application thereof |
| CN110721135A (en) * | 2019-11-29 | 2020-01-24 | 广州欧正化妆品技术研究院有限公司 | Fullerene-containing solid concentrated dry mask with moisturizing, repairing and anti-aging effects and preparation method thereof |
| CN111214427B (en) * | 2020-02-29 | 2022-04-01 | 宁波法迪曼生物工程有限公司 | Acid-free skin refreshing composition, preparation method thereof and essence containing composition |
Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005047858A (en) * | 2003-07-29 | 2005-02-24 | Ito:Kk | Photochemically cosmetic composition for skin care |
| CN1753968A (en) * | 2003-01-27 | 2006-03-29 | 三菱商事株式会社 | Antioxidative composition and composition for external use |
| CN1832719A (en) * | 2003-05-30 | 2006-09-13 | 奈尔·伯兰古洛夫 | Cosmetic compositions containing fullerene clusters |
| CN1906149A (en) * | 2003-12-15 | 2007-01-31 | Nano-C公司 | Higher fullerenes useful as radical scavengers |
| CN101926741A (en) * | 2010-04-02 | 2010-12-29 | 广东雅倩化妆品有限公司 | Skin refinishing essence and skin care product with same |
| CN103118652A (en) * | 2010-08-24 | 2013-05-22 | 荷兰联合利华有限公司 | Photoprotective personal care composition |
| CN103156784A (en) * | 2013-03-26 | 2013-06-19 | 深圳市通产丽星股份有限公司 | Chitosan-fullerol compound, preparation method thereof compound and moisture-preserving antioxidant |
| CN103756019A (en) * | 2013-12-19 | 2014-04-30 | 深圳市通产丽星股份有限公司 | Amphipathic chitosan-fullerene compound and preparation method thereof |
| CN105125580A (en) * | 2015-07-30 | 2015-12-09 | 北京大学深圳研究院 | Fullerene-macromolecule composite and preparation method thereof |
| CN106726975A (en) * | 2016-12-28 | 2017-05-31 | 广州环亚化妆品科技有限公司 | A kind of blue light protection component and preparation method thereof and the application in cosmetics |
| CN107375136A (en) * | 2017-07-31 | 2017-11-24 | 绵竹市天骄农业开发有限公司 | A kind of basic zirconium phosphate hand lotion |
| CN107397714A (en) * | 2017-07-19 | 2017-11-28 | 广东丸美生物技术股份有限公司 | With anti-blue light contamination and the elite breast of desalination microgroove effect and its preparation and application |
-
2018
- 2018-09-04 CN CN201811024506.0A patent/CN108852869B/en active Active
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1753968A (en) * | 2003-01-27 | 2006-03-29 | 三菱商事株式会社 | Antioxidative composition and composition for external use |
| CN1832719A (en) * | 2003-05-30 | 2006-09-13 | 奈尔·伯兰古洛夫 | Cosmetic compositions containing fullerene clusters |
| JP2005047858A (en) * | 2003-07-29 | 2005-02-24 | Ito:Kk | Photochemically cosmetic composition for skin care |
| CN1906149A (en) * | 2003-12-15 | 2007-01-31 | Nano-C公司 | Higher fullerenes useful as radical scavengers |
| CN101926741A (en) * | 2010-04-02 | 2010-12-29 | 广东雅倩化妆品有限公司 | Skin refinishing essence and skin care product with same |
| CN103118652A (en) * | 2010-08-24 | 2013-05-22 | 荷兰联合利华有限公司 | Photoprotective personal care composition |
| CN103156784A (en) * | 2013-03-26 | 2013-06-19 | 深圳市通产丽星股份有限公司 | Chitosan-fullerol compound, preparation method thereof compound and moisture-preserving antioxidant |
| CN103756019A (en) * | 2013-12-19 | 2014-04-30 | 深圳市通产丽星股份有限公司 | Amphipathic chitosan-fullerene compound and preparation method thereof |
| CN105125580A (en) * | 2015-07-30 | 2015-12-09 | 北京大学深圳研究院 | Fullerene-macromolecule composite and preparation method thereof |
| CN106726975A (en) * | 2016-12-28 | 2017-05-31 | 广州环亚化妆品科技有限公司 | A kind of blue light protection component and preparation method thereof and the application in cosmetics |
| CN107397714A (en) * | 2017-07-19 | 2017-11-28 | 广东丸美生物技术股份有限公司 | With anti-blue light contamination and the elite breast of desalination microgroove effect and its preparation and application |
| CN107375136A (en) * | 2017-07-31 | 2017-11-24 | 绵竹市天骄农业开发有限公司 | A kind of basic zirconium phosphate hand lotion |
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|---|---|
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