CN101926741A - Skin refinishing essence and skin care product with same - Google Patents
Skin refinishing essence and skin care product with same Download PDFInfo
- Publication number
- CN101926741A CN101926741A CN2010101441978A CN201010144197A CN101926741A CN 101926741 A CN101926741 A CN 101926741A CN 2010101441978 A CN2010101441978 A CN 2010101441978A CN 201010144197 A CN201010144197 A CN 201010144197A CN 101926741 A CN101926741 A CN 101926741A
- Authority
- CN
- China
- Prior art keywords
- skin
- skin care
- essence
- care item
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
The invention belongs to the field of cosmetics, relating to an active component of a skin care product used for improving skin water content, increasing elasticity and whitening, comprising 0.5-10 parts of tetraphosphate guanosine diphosphate, 0.1-8 parts of nicotinamide, 0.1-3 parts of sodium hyaluronate. The invention provides the skin care product which can be directly used for caring skin such as cleansing milk, moisturizer, eye cream, facial treatment milk, skin care lotion and the like; and the mass percent of the tetraphosphate guanosine diphosphate is 0.5-10%, the mass percent of the nicotinamide is 0.1-8% and the mass percent of the sodium hyaluronate is 0.1-3%. The skin care product achieves the effect of improving the moisture content of intercellular substance of keratoderma, can obviously improve the softness and the elasticity of the skin layer, prompt the updating and falling-off speed of melanophore and has particularly remarkable effect on whitening after solarization.
Description
Technical field
The invention belongs to cosmetic field, be specifically related to a kind of skin care item with active component and contain the skin care item of this component.
Background technology
Liking to be beautiful is women's nature, and along with the development of society, skin-protection product has become indispensable daily necessities gradually for modern female.The aesthetic conceptions of China are tended to the pale of skin.Present existing skin-protection product usually with whiten, moisturizing, crease-resistant etc. be major function.Though the total class of different on the market skin-protection products is various, its effect is many can not be satisfactory.
At first, present skin care item poor effect.With the moisturizing is example, and most moisturizing skin care item only can replenish the outer moisture of epidermis, increases the content of water, oil outside skin surface, and can't deeply improve the moisture of cortex, and this also fails fundamentally to improve the xerosis cutis sense.Secondly, though have the skin-protection product of multiple becoming " multi-efficiency " at present, actual research effect shows, their many effects that possess simple superposition do not have the obvious effect of improving to a plurality of skin problems.Such as, there is a whitening product of preserving moisture to adopt hyaluronic acid and vitamin C as main component, hyaluronic acid has very strong hygroscopicity to be used to preserve moisture, and vitamin C is used to prevent melanic precipitation.But this compositions has only simply been utilized the single effect of each composition, evidence its preserve moisture, whitening effect is all not ideal enough.Remove this, some skin-protection products are more arranged, added harmful materials such as heavy metal in order to reach whitening effect for the moment.These potential harm constitute serious threat to women's health.
Under this background, along with the recovery of economy and the expansion of the skin care item market demand, be adapted to Chinese women moisturizing, whiten, support the developmental research and the quality improvement of the skin-protection product of skin, become the major issue in this field.
Summary of the invention
The objective of the invention is at the deficiencies in the prior art, a kind of cosmetic composition that can improve moisture of skin, elasticity and fairness effectively simultaneously is provided.
Above-mentioned purpose of the present invention is achieved by the following technical programs:
The invention provides a kind of composite skin care product, wherein contain the material of following parts by weight simultaneously: four di(2-ethylhexyl)phosphate guanosine 0.5-10 parts, nicotiamide 0.1-8 part, hyaluronate sodium 0.1-3 part.Four di(2-ethylhexyl)phosphate guanosines wherein are extracts of the artemia (Artemia Salina) that comes from salt lake and marine site.It is 100-3000Kda's that hyaluronate sodium is selected molecular weight for use.
Said composition can be applicable in the preparation of skin-protection product, as one of its composite parts.
Said composition can further be configured as the following product that can directly apply to skin nursing, wherein contains this skin-active essence of 1g in the skin care item of every 100g.
Said composition contains hyaluronic acid, can form a non-Sealed lock water mucous layer at epidermis, has kept the moistening degree of epidermis, forms a supracutaneous water-oils and fats barrier film, reduces the further dry sensation of skin.Hyaluronic acid is the polymer of a kind of linear glycosaminoglycan (GAGs), be distributed widely in the partes corporis humani position, the intercellular substance of skin surface contains a large amount of hyaluronic acids especially, this polymer with network structure firm in conjunction with large quantity of moisture, it is the most important retention agent of moisture of top layer skin, with the testing in vitro result is example, all the other 98% the moisture of reservation that contain 2% aqueous solution of sodium hyaluronate can be very firm.The sodium salt of hyaluronic acid preferably clear matter of the present invention acid, when helping the technology preparation, the complete dispersing and dissolving in water.The hyaluronan molecule amount determines according to application target that normally its transdermal ability of low-molecular-weight hyaluronic acid is stronger, can continue to improve the moisture of cortex; The supracutaneous again water holding capacity of high-molecular weight hyaluronic acid is better, can improve the dry sensation of skin sooner, but can't transdermal.It is 500-1000KDa that the present invention more selects hyaluronic molecular weight, and it promptly imitates the ability that changes drying capacity and lasting change cortex moisture is best.
Simultaneously, the present invention has adopted a kind of energy matter---and four di(2-ethylhexyl)phosphate guanosines preferably come from the extract of artemia (Artemia Salina).Carry out the G albumen that information is transmitted in the direct active cell of four di(2-ethylhexyl)phosphate guanosines, the outer signals that enhancing receives by cell-membrane receptor is to intracytoplasmic transmission, thereby cause stronger cell biological chain reflex, activate more relevant enzyme or albumen at last, allow epidermis cell show stronger vitality.Four di(2-ethylhexyl)phosphate guanosines can increase ATP, and the content of GTP strengthens the transmission of information many-sidedly, strengthen the vigor of cell; Thereby four the di(2-ethylhexyl)phosphate guanosine can activate the various physiological activities of Skin Cell and new become metabolism, quickens various proteic synthetic (cutin fibril gathering albumen, keratin, collagen protein, the fibronectins etc.) that the skin health state plays a key effect that remain in.It is the sign of human keratinous cell maturation and ability power that the cutin fibril is assembled albumen, the horn cell at initial stage contains less cutin fibril and assembles albumen, maturation along with horn cell, wherein the cutin fibril assemble proteic content can be more and more higher, indicate that horn cell has more and more stronger physiological function; The cutin fibril is assembled the precursor that albumen is NMF in the human keratinous layer, and is constantly ripe at epidermal keratinocyte, is divided at last in the cuticular process, and the fragment that the degraded of four di(2-ethylhexyl)phosphate guanosines produces has constituted the NMF of human body.Therefore, the cutin fibril is assembled the increase of protein content in the skin keratin cell, just means that skin can become more moistening, more soft.Fibronectin is the connection albumen that connects between human body fibroblast and the collagen protein, the various collagen protein of human body are played the effect of very important maintenance and reparation, the collagen protein of human body is all sustaining damage because of ultraviolet rays, heat, aging, environmental pollution etc. or is running off all the time, if collagen protein impaired or that run off can not be repaired timely or be replenished, the outside of skin will show wrinkle to be increased, lax following the string, therefore, fibronectin has very crucial effect for the maintenance of collagen protein and skin health situation.Four di(2-ethylhexyl)phosphate guanosines also have unique DNA protection and the function of repairing, and have magical defying age skin-care effect.
Remove this, nicotiamide also is a kind of requisite material in the present composition.Nicotiamide CAS98-92-0, molecular formula is C6H6N2O, fusing point 128-131 ℃.Nicotiamide also is vitamin B3, be the biological activity state of vitamin B3, nicotiamide can keep the skin energy balance, can recover cellular energy simultaneously, the acceleration collagen is synthetic, thereby avoids the melanin that skin is low because of fat content, stratum corneum gets thinner causes excessively calm.
Except above-mentioned these three kinds of materials, these skin care item also contain deionized water, and the deionized water electrical conductivity is less than 5 μ S/CM, total plate count 100CFU/g.
Simultaneously, in order to guarantee the good efficacy of these skin care item, this composite skin care product pH value should remain on 5.0-7.0, total plate count 500CFU/g, mycete and yeast total plate count 100CFU/g, excrement colibacillus group 10CFU/g, staphylococcus aureus 10CFU/g, Pseudomonas aeruginosa 10CFU/g.
The present invention also can contain acrylate copolymer, and its content in skin care item is mass fraction 0.05-5.0%, is used to provide the best product fluidised form of skin-active essence, makes things convenient for taking of user.Can be for selecting for use but being not limited to Carbopol 940, Carbopol 941, Carbopol ETD 2020, Carbopol AQUASF-1, Carbopol Ultrez 21, Carbopol Ultrez 20, Pemulen TR-1, Pemulen TR-2.Preferred Carbopol Ultrez 21.
The present invention can also comprise other optional components, comprises metal ion intercalating agent, pH regulator agent, essence, pigment etc.The non-limiting example of described metal ion intercalating agent has: ethylenediaminetetraacetic acid, disodiumedetate, tetrasodium ethylenediamine tetraacetate, citric acid and salt thereof, phosphoric acid and salt thereof etc., preferred tetrasodium ethylenediamine tetraacetate; The non-limiting example of described pH regulator agent has: citric acid and salt thereof, phosphoric acid and salt thereof etc., optimization citric acid and salt thereof, the pH of regulation system are 5.0 to 7.0, and preferred 5.5 to 6.0; Choosing of described essence, pigment meets relevant laws and regulations and the standard of country about hygienic standards for cosmetics.The content of citric acid or citrate is mass fraction 0.1-3%.
Composite skin care product of the present invention can be used in the various skin care product, in facial milk cleanser, emollient cream, eye cream, facial treatment milk, surfactant, has purposes widely in skin protection.
Three kinds of chemical compound hyaluronate sodiums, four di(2-ethylhexyl)phosphate guanosines, the nicotiamide that invention is adopted is the existing material that adopts in the present skin care field.Had the research report to show that hyaluronate sodium can further be converted into hyaluronic acid, is a kind of multi-functional substrate, is good wetting agent, hyaluronate sodium can provide the lifting of moisture of skin in skin care item; Four di(2-ethylhexyl)phosphate guanosines are cellular energy factors, cell protecting factor, and the precursor of energy element ATP can provide the cell viability of skin, strengthens the accretion rate of skin; Nicotiamide promotes that by quickening skin containing melanic horn cell comes off.
Though these three kinds of materials are respectively applied in the skin care item, proved to have above-mentioned effect.But, the present invention with these three kinds of materials according to the characteristics mixed after, found to mutually promote between it and the collaborative effect of improving cortex health, out of original imagination, the result verification of its experiment this point, specific as follows:
Invention has designed following four basic schemes (as table 1), and as the testing research that the skin-active essence promotes the skin health sense, test index has keratodermatitis water content, skin elasticity and dermal melanin minimizing degree:
Table 1: for the reference substance solution and the tabulation of experimental solutions composition of test
| ? | Contrast solution 1 | Contrast solution 2 | Contrast solution 3 | Experimental solutions |
| Hyaluronate sodium | 2.0? | -? | -? | 1.5? |
| Four di(2-ethylhexyl)phosphate guanosines | -? | 4.0? | -? | 3.0? |
| Nicotiamide | -? | -? | 4.0? | 3.0? |
| Carbopol Ultrez?21 | 0.3? | 0.3? | 0.3? | 0.3? |
| Deionized water | 97.7? | 95.7? | 95.7? | 92.7? |
(1) test result of keratodermatitis water content
Adopt Callegari Soft5.5, test 120 25-35 year women triers, be coated with the position is the skin of the inboard 3.0*3.0cm area of upper arm, testing time is for being coated with trial target after 10 minutes, 30 minutes, 60 minutes, test is coated with the keratodermatitis moisture in the area, average, test result is as shown in table 2.
Table 2. is coated with the water content with skin behind different solutions, the certain interval of time
| ? | Contrast solution 1 | Contrast solution 2 | Contrast solution 3 | Experimental solutions |
| 10 minutes | 45? | 30? | 25? | 75? |
| 30 minutes | 30? | 22? | 20? | 60? |
| 60 minutes | 15? | 10? | 8? | 40? |
The result shows, contains the skin activating water of skin-active essence simultaneously, and is obvious to the change of the horny layer moisture content of skin, still obviously is better than the effect that three kinds of components are used separately after 60 minutes.
(2) test of skin elasticity
Adopt Callegari Soft5.5, test 110 25-35 year women triers, be coated with the position is the skin of the inboard 3.0*3.0cm area of upper arm, testing time is used trial target morning and evening every day respectively once for being coated with, be coated with continuously with after 1 week, 2 weeks, 3 weeks, 4 weeks, 8 weeks, the improvement value of test skin elasticity, test result is averaged, and the result is as shown in table 3.
Table 3. is coated with the skin elasticity improvement value behind the different solutions
| ? | Contrast solution 1 | Contrast solution 2 | Contrast solution 3 | Experimental solutions |
[0032]?
| 1 week | 2.8? | 3.2? | 2.4? | 4.3? |
| 2 weeks | 3.6? | 3.7? | 3.3? | 5.2? |
| 3 weeks | 4.3? | 4.5? | 3.6? | 5.8? |
| 4 weeks | 5.1? | 5.6? | 4.0? | 8.1? |
| 8 weeks | 5.6? | 6.5? | 4.2? | 14.6? |
The result shows, contains the skin activating water of facial treatment essence skin-active essence, single and accumulative total be coated with after, the improvement of skin elasticity all is better than the effect of any one-component.
(3) dermal melanin test
Adopt Callegari Soft5.5, test 150 20-35 year women triers, be coated with the position is the skin of left cheek side 1.5*2.0cm area, testing time is used trial target morning and evening every day respectively once for being coated with, be coated with continuously with after 1 week, 2 weeks, 3 weeks, 4 weeks, 8 weeks, test dermal melanin minimizing degree, test result is averaged, and the result is as shown in table 4.
Table 4. is coated with the dermal melanin minimizing degree behind the different solutions
| ? | Contrast solution 1 | Contrast solution 2 | Contrast solution 3 | Experimental solutions |
| 1 week | 1.8? | 2.1? | 2.2? | 2.5? |
| 2 weeks | 2.2? | 2.6? | 2.6? | 3.6? |
| 3 weeks | 2.3? | 2.8? | 3.0? | 4.4? |
| 4 weeks | 2.6? | 3.1? | 3.2? | 5.2? |
| 8 weeks | 3.5? | 5.2? | 5.6? | 8.0? |
The result shows, contains the skin activating water of facial treatment essence skin-active essence, single and accumulative total be coated with after, the minimizing of dermal melanin improves the effect that all is better than any one-component.
What should also be pointed out that is, proportioning between these three kinds of materials also has the influence of outbalance to the skin nursing effect, infer that this is because between this three classes material, and have complicated organic connections between they and the human body skin metabolism, though being proved as nicotiamide has good facilitation to skin metabolism, but the present invention finds, if its too high levels in compositions, then can not preserve moisture and the effect of additional moisture of skin reaches synergistic effect with hyaluronic, this may be because hyaluronic acid must just can be brought into play effect more than certain threshold value, and if this moment is the too high levels of nicotiamide, may will influence the activity of some enzyme in the cortex again, reduce the absorption metabolism of the vigor and the nutrient substance of skin on the contrary.
The present invention confirms through test, in being applied directly to the finished product of skin nursing, contain the compositions that 1g should contain four di(2-ethylhexyl)phosphate guanosines, nicotiamide and the hyaluronate sodium of fixed mixing ratio in the skin care item of every 100g, proportioning between its each active component is coordinated, absolute content is suitable for the absorption and the conversion of human body skin, and the experimental subject of majority is all being improved skin moisture content, improving skin elasticity and promote and significant effect is arranged aspect the whiteness of skin.
Compared with prior art, the present invention has following beneficial effect:
(1) the present invention is improving aspect the skin moisture content, has reached the effect that promotes the intercellular substance water content of keratodermatitis, and this is the effect that at present few skin-protection product can reach.
(2) these three kinds of combination of compounds of adopting of the present invention can significantly be improved the pliability and the elasticity of skin surface, and this is the new breakthrough that never was in the news in crease-resistant field.
(3) compositions of the present invention has reached synergitic facilitation aspect the melanin deposition improving, and the renewal falling speed of melanocyte has reached further lifting, is applied to whitening after the Exposure to Sunlight and has effect especially significantly.
The specific embodiment
Below further specify technical scheme of the present invention by specific embodiment.
Embodiment 1 surfactant
The surfactant prescription is as follows:
Raw material weight percentage ratio %
Four di(2-ethylhexyl)phosphate guanosines 5.5
Nicotiamide 3.0
Hyaluronate sodium 1.2
1,3 butylene glycol 5.0
1,2-pentanediol 5.0
Carbopol?Ultrez?21 0.5
PPG-26-butylol polyether-26 1.5
Citric acid 0.3
Essence 0.1
Tetrasodium ethylenediamine tetraacetate 0.05
The deionized water surplus
Preparation method: the weight of having calculated required various materials according to the composition proportion of prescription, getting hyaluronate sodium by result of calculation fully is dissolved in the deionized water, proportionally add other the various formula components except that citric acid successively, at normal temperatures, vacuum stirring 30 minutes, adjust pH value to 5.5 with citric acid at last, get final product discharging.On inspection, total plate count 500CFU/g, mycete and yeast total plate count 100CFU/g, excrement colibacillus group 10CFU/g, staphylococcus aureus 10CFU/g, Pseudomonas aeruginosa 10CFU/g, qualified after, can be packed as bottled product.
Above-mentioned prescription uses through 100 triers, and the age is 25-35 year women.Its result shows that skin elasticity promoted 4.3% after the horny layer moisture promoted for 42.8%, one week after the horny layer moisture promoted 64.6%, 60 minute after the horny layer moisture promoted 75%, 30 minute after 10 minutes, and melanin reduces 2.3%; Two week back skin elasticity liftings 5.6%, melanin reduces 3.5%; Three week back skin elasticity liftings 8.2, melanin reduces 4.6%; The back skin elasticity promotes 8.6% all around, and skin elasticity promoted 15.3% after melanin reduced by 5.2%, eight week, and melanin reduces 8.2%.
Embodiment 2 facial treatment milk
The facial treatment milk prescription is as follows:
Raw material weight percentage ratio %
Four di(2-ethylhexyl)phosphate guanosines 5.5
Nicotiamide 3.2
Hyaluronate sodium 1.5
1,3 butylene glycol 4.0
1,2-pentanediol 5.0
Carbopol?Ultrez?21 0.8
PEMULEN?TR?1 0.2
Tocopherol 0.3
Citric acid 0.2
Essence 0.15
Tetrasodium ethylenediamine tetraacetate 0.05
The deionized water surplus
Preparation method: the weight of having calculated required various materials according to the composition proportion of prescription, getting hyaluronate sodium by result of calculation fully is dissolved in the deionized water, proportionally add other the various formula components except that citric acid successively, at normal temperatures, vacuum stirring 30 minutes, at last, adjust pH value to 5.5, get final product discharging with citric acid.On inspection, total plate count 500CFU/g, mycete and yeast total plate count 100CFU/g, excrement colibacillus group 10CFU/g, staphylococcus aureus 10CFU/g, Pseudomonas aeruginosa 10CFU/g, qualified after, can be packed as bottled product.
Above-mentioned prescription uses through 80 triers, and the age is 20-35 year women.Its result shows that skin elasticity promoted 4.8% after the horny layer moisture promoted for 48.3%, one week after the horny layer moisture promoted 65.4%, 60 minute after the horny layer moisture promoted 85%, 30 minute after 10 minutes, and melanin reduces 2.5%; Two week back skin elasticity liftings 6.1%, melanin reduces 3.6%; Three week back skin elasticity liftings 8.7, melanin reduces 5.1%; The back skin elasticity promotes 9.5% all around, and skin elasticity promoted 16.5% after melanin reduced by 5.6%, eight week, and melanin reduces 8.7%.
Embodiment 3 eye creams
The eye cream prescription is as follows:
Raw material weight percentage ratio %
Four di(2-ethylhexyl)phosphate guanosines 6.0
Nicotiamide 1.5
Hyaluronate sodium 1.5
1,3 butylene glycol 5.0
1,2-pentanediol 3.0
Carbopol?ETD?2020?2.0
Tocopherol 0.3
PEMULEN?TR?1 0.3
Citric acid 0.3
Essence 0.1
Tetrasodium ethylenediamine tetraacetate 0.05
The deionized water surplus
Preparation method: the weight of having calculated required various materials according to the composition proportion of prescription, getting hyaluronate sodium by result of calculation fully is dissolved in the deionized water, proportionally add other the various formula components except that citric acid successively, at normal temperatures, vacuum stirring 30 minutes, at last, adjust pH value to 5.5, get final product discharging with citric acid.On inspection, total plate count 500CFU/g, mycete and yeast total plate count 100CFU/g, excrement colibacillus group 10CFU/g, staphylococcus aureus 10CFU/g, Pseudomonas aeruginosa 10CFU/g, qualified after, can be packed as bottled product.
Above-mentioned prescription uses through 60 triers, and the age is 20-35 year women.Its result shows that skin elasticity promoted 4.7% after the horny layer moisture promoted for 45.6%, one week after the horny layer moisture promoted 62.3%, 60 minute after the horny layer moisture promoted 83%, 30 minute after 10 minutes, and melanin reduces 2.8%; Two week back skin elasticity liftings 6.6%, melanin reduces 3.3%; Three week back skin elasticity liftings 8.4, melanin reduces 5.4%; The back skin elasticity promotes 9.1% all around, and skin elasticity promoted 16.2% after melanin reduced by 5.6%, eight week, and melanin reduces 8.6%.
Embodiment 4 emollient cream
Emollient cream prescription is as follows:
Raw material weight percentage ratio %
Four di(2-ethylhexyl)phosphate guanosines 3.8
Nicotiamide 2.5
Hyaluronate sodium 2.0
1,3 butylene glycol 5.0
1,2-pentanediol 5.0
Semen Tritici aestivi germ oil 3.0
Carbopol?ETD?2020 2.0
PEMULEN?TR?1 0.5
Tocopherol 0.3
Citric acid 0.25
Essence 0.2
Tetrasodium ethylenediamine tetraacetate 0.05
The deionized water surplus
Preparation method: the weight of having calculated required various materials according to the composition proportion of prescription, getting hyaluronate sodium by result of calculation fully is dissolved in the deionized water, proportionally add other the various formula components except that citric acid successively, at normal temperatures, vacuum stirring 30 minutes, at last, adjust pH value to 5.5, get final product discharging with citric acid.On inspection, total plate count 500CFU/g, mycete and yeast total plate count 100CFU/g, excrement colibacillus group 10CFU/g, staphylococcus aureus 10CFU/g, Pseudomonas aeruginosa 10CFU/g, qualified after, can be packed as bottled product.
Above-mentioned prescription uses through 150 triers, and the age is 20-35 year women.Its result shows that skin elasticity promoted 5.1% after the horny layer moisture promoted for 48.8%, one week after the horny layer moisture promoted 66.4%, 60 minute after the horny layer moisture promoted 87%, 30 minute after 10 minutes, and melanin reduces 2.9%; Two week back skin elasticity liftings 6.9%, melanin reduces 3.7%; Three week back skin elasticity liftings 8.8, melanin reduces 5.4%; The back skin elasticity promotes 10.2% all around, and skin elasticity promoted 17.2% after melanin reduced by 5.8%, eight week, and melanin reduces 9.1%.
Embodiment 5 facial milk cleanser
The facial milk cleanser prescription is as follows:
Prescription:
Raw material weight percentage ratio %
Four di(2-ethylhexyl)phosphate guanosines 6.0
Nicotiamide 2.5
Hyaluronate sodium 2.0
Sodium lauroyl glutamate 10.0
Cocos nucifera oil acyl both sexes sodium acetate 6.0
The sweet Lay alkali 5.0 of cocamidopropyl propyl amide
1,3 butylene glycol 3.0
1,2-pentanediol 6.0
Carbopol?Ultrez?21 2.0
PEMULEN?TR?1 0.3
Tocopherol 0.3
Citric acid 0.5
Essence 0.2
Tetrasodium ethylenediamine tetraacetate 0.1
The deionized water surplus
Preparation method: the weight of having calculated required various materials according to the composition proportion of prescription, getting hyaluronate sodium by result of calculation fully is dissolved in the deionized water, proportionally add other the various formula components except that citric acid successively, at normal temperatures, vacuum stirring 30 minutes, at last, adjust pH value to 5.5, get final product discharging with citric acid.On inspection, total plate count 500CFU/g, mycete and yeast total plate count 100CFU/g, excrement colibacillus group 10CFU/g, staphylococcus aureus 10CFU/g, Pseudomonas aeruginosa 10CFU/g, qualified after, can be packed as bottled product.
Above-mentioned prescription uses through 50 triers, and the age is 20-35 year women.Its result shows that skin elasticity promoted 4.3% after the horny layer moisture promoted for 30.8%, one week after the horny layer moisture promoted 50.4%, 60 minute after the horny layer moisture promoted 79%, 30 minute after 10 minutes, and melanin reduces 2.2%; Two week back skin elasticity liftings 5.8%, melanin reduces 3.4%; Three week back skin elasticity liftings 7.8, melanin reduces 5.1%; The back skin elasticity promotes 8.6% all around, and skin elasticity promoted 16.2% after melanin reduced by 5.6%, eight week, and melanin reduces 8.3%.
Claims (9)
1. a skin-active essence is characterized in that being made up of the material of following weight proportion: four di(2-ethylhexyl)phosphate guanosine 0.5-10 parts, nicotiamide 0.1-8 part, hyaluronate sodium 0.1-3 part.
2. skin-active essence as claimed in claim 1 is characterized in that described hyaluronic molecular weight is 500-1000Kda.
3. skin-active essence as claimed in claim 1 is characterized in that described four di(2-ethylhexyl)phosphate guanosines are extracts of the artemia (Artemia Salina) that comes from salt lake and marine site.
4. the application of skin-active essence as claimed in claim 1 on preparation facial milk cleanser, emollient cream, eye cream, facial treatment milk, surfactant.
5. skin care item is characterized in that containing skin-active essence as claimed in claim 1.
6. skin care item as claimed in claim 5 is characterized in that every parts by weight are to contain 1 part of skin-active essence as claimed in claim 1 in 100 parts the skin care item.
7. skin care item as claimed in claim 5 is characterized in that also containing the acrylate copolymer that weight is 0.05-3%, and weight is 0.1-3% citric acid or citrate.
8. skin care item as claimed in claim 7 is characterized in that described acrylate copolymer is Carbopol Ultrez 21.
9. as the described skin care item of the arbitrary claim of claim 5 ~ 8, it is characterized in that its pH value is 5.0-7.0.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101441978A CN101926741B (en) | 2010-04-02 | 2010-04-02 | Skin refinishing essence and skin care product with same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101441978A CN101926741B (en) | 2010-04-02 | 2010-04-02 | Skin refinishing essence and skin care product with same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101926741A true CN101926741A (en) | 2010-12-29 |
| CN101926741B CN101926741B (en) | 2012-09-19 |
Family
ID=43366355
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010101441978A Active CN101926741B (en) | 2010-04-02 | 2010-04-02 | Skin refinishing essence and skin care product with same |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101926741B (en) |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102362846A (en) * | 2011-11-14 | 2012-02-29 | 广州孕肤宝日用品有限公司 | Skin radiation-preventing composition |
| CN102362845A (en) * | 2011-11-14 | 2012-02-29 | 广州孕肤宝日用品有限公司 | External preparation for promoting active circulation of skin |
| CN103006524A (en) * | 2012-11-28 | 2013-04-03 | 西安泰科迈医药科技有限公司 | Anti-wrinkle anti-aging eye cream for pregnant women and preparation method thereof |
| CN103494754A (en) * | 2013-08-27 | 2014-01-08 | 星彤（上海）化妆品科技有限公司 | Anti-hair loss and hair-regeneration shampoo prepared from herbal essence and biochemical components and preparation method thereof |
| CN104984406A (en) * | 2015-06-24 | 2015-10-21 | 苏州乔纳森新材料科技有限公司 | Skin epidermis repairing material and preparation method thereof |
| CN105168040A (en) * | 2015-08-18 | 2015-12-23 | 广东轻工职业技术学院 | Composite anti-ageing skin-care composition and manufacturing method |
| CN105193694A (en) * | 2015-10-29 | 2015-12-30 | 桂林华诺威基因药业有限公司 | Skin care product with whitening and freckle-removing functions |
| CN107468625A (en) * | 2016-06-08 | 2017-12-15 | 浙江润和生物科技有限公司 | A kind of EGF for medical cosmetology imports liquid |
| CN108079309A (en) * | 2018-02-02 | 2018-05-29 | 福建龙生生物科技有限公司 | A kind of promotion transdermal absorbing composition and its application |
| CN108852870A (en) * | 2018-09-04 | 2018-11-23 | 广东科玮生物技术股份有限公司 | A kind of anti-radiation sun screen and preparation method thereof |
| CN108852869A (en) * | 2018-09-04 | 2018-11-23 | 广东科玮生物技术股份有限公司 | The skin care compositions of anti-blue light contamination and its application |
| CN111789937A (en) * | 2020-07-06 | 2020-10-20 | 江苏艾特美科技有限公司 | Bacteriostatic tablet with vagina tightening effect |
| CN114795996A (en) * | 2022-04-08 | 2022-07-29 | 广东先强药业有限公司 | Composition containing nucleoside components and application thereof |
| CN115813803A (en) * | 2022-12-14 | 2023-03-21 | 广州时光之城科技有限公司 | Composition capable of improving skin anti-wrinkle, moisturizing and whitening effects on cell layer |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1304305A (en) * | 1998-01-29 | 2001-07-18 | 科蒂股份有限公司 | Cosmetic product based on artemia salina extracts for regenerating anmd stimulating skin cells |
| US20040228884A1 (en) * | 2003-05-15 | 2004-11-18 | Gupta Shyam K. | Ion-pair delivery system for cosmetic and pharmaceutical compositions |
| CN1731973A (en) * | 2002-12-30 | 2006-02-08 | 吉恩-诺埃尔·托雷尔 | Cutanceous metabolic bio-activator |
-
2010
- 2010-04-02 CN CN2010101441978A patent/CN101926741B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1304305A (en) * | 1998-01-29 | 2001-07-18 | 科蒂股份有限公司 | Cosmetic product based on artemia salina extracts for regenerating anmd stimulating skin cells |
| CN1731973A (en) * | 2002-12-30 | 2006-02-08 | 吉恩-诺埃尔·托雷尔 | Cutanceous metabolic bio-activator |
| US20040228884A1 (en) * | 2003-05-15 | 2004-11-18 | Gupta Shyam K. | Ion-pair delivery system for cosmetic and pharmaceutical compositions |
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102362846A (en) * | 2011-11-14 | 2012-02-29 | 广州孕肤宝日用品有限公司 | Skin radiation-preventing composition |
| CN102362845A (en) * | 2011-11-14 | 2012-02-29 | 广州孕肤宝日用品有限公司 | External preparation for promoting active circulation of skin |
| CN102362846B (en) * | 2011-11-14 | 2013-01-23 | 广州孕肤宝日用品有限公司 | Skin radiation-preventing composition |
| CN102362845B (en) * | 2011-11-14 | 2013-01-23 | 广州孕肤宝日用品有限公司 | External preparation for promoting active circulation of skin |
| CN103006524A (en) * | 2012-11-28 | 2013-04-03 | 西安泰科迈医药科技有限公司 | Anti-wrinkle anti-aging eye cream for pregnant women and preparation method thereof |
| CN103494754A (en) * | 2013-08-27 | 2014-01-08 | 星彤（上海）化妆品科技有限公司 | Anti-hair loss and hair-regeneration shampoo prepared from herbal essence and biochemical components and preparation method thereof |
| CN103494754B (en) * | 2013-08-27 | 2015-09-23 | 星彤（上海）化妆品科技有限公司 | Hair-loss preventing and hair-restoring shampoo of herbal essences and biochemical component formula and preparation method thereof |
| CN104984406A (en) * | 2015-06-24 | 2015-10-21 | 苏州乔纳森新材料科技有限公司 | Skin epidermis repairing material and preparation method thereof |
| CN105168040A (en) * | 2015-08-18 | 2015-12-23 | 广东轻工职业技术学院 | Composite anti-ageing skin-care composition and manufacturing method |
| CN105193694A (en) * | 2015-10-29 | 2015-12-30 | 桂林华诺威基因药业有限公司 | Skin care product with whitening and freckle-removing functions |
| CN107468625A (en) * | 2016-06-08 | 2017-12-15 | 浙江润和生物科技有限公司 | A kind of EGF for medical cosmetology imports liquid |
| CN108079309A (en) * | 2018-02-02 | 2018-05-29 | 福建龙生生物科技有限公司 | A kind of promotion transdermal absorbing composition and its application |
| CN108079309B (en) * | 2018-02-02 | 2021-04-20 | 福建龙生生物科技有限公司 | Composition for promoting transdermal absorption and application thereof |
| CN108852870A (en) * | 2018-09-04 | 2018-11-23 | 广东科玮生物技术股份有限公司 | A kind of anti-radiation sun screen and preparation method thereof |
| CN108852869A (en) * | 2018-09-04 | 2018-11-23 | 广东科玮生物技术股份有限公司 | The skin care compositions of anti-blue light contamination and its application |
| CN108852869B (en) * | 2018-09-04 | 2021-05-14 | 广东科玮生物技术股份有限公司 | Skin care composition for resisting blue light pollution and application thereof |
| CN111789937A (en) * | 2020-07-06 | 2020-10-20 | 江苏艾特美科技有限公司 | Bacteriostatic tablet with vagina tightening effect |
| CN114795996A (en) * | 2022-04-08 | 2022-07-29 | 广东先强药业有限公司 | Composition containing nucleoside components and application thereof |
| CN114795996B (en) * | 2022-04-08 | 2023-08-29 | 广东先强药业有限公司 | Composition containing nucleoside components and application thereof |
| CN115813803A (en) * | 2022-12-14 | 2023-03-21 | 广州时光之城科技有限公司 | Composition capable of improving skin anti-wrinkle, moisturizing and whitening effects on cell layer |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101926741B (en) | 2012-09-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101926741B (en) | Skin refinishing essence and skin care product with same | |
| CN104736136B (en) | Beauty and make-up is used or medicinal moisturizing ingredient | |
| US20060165644A1 (en) | Cosmetics | |
| CN109381363A (en) | A kind of amino acid shampoo and preparation method thereof | |
| CN104083291A (en) | Application of N-acetylneuraminic acid monomer or its hydrate in cosmetics | |
| KR20050105461A (en) | SKIN PREPARATION FOR EXTERNAL USE CHARACTERIZED BY CONTAINING SUGAR DERIVATIVE OF α,α-TREHALOSE | |
| CN101744757A (en) | Preservative-free moisturizing firming cosmetic containing natural and organic ingredients | |
| CN105496938B (en) | α-bisabolol shin moisturizer | |
| CN107714559A (en) | One kind is without anti-corrosion deep water supplement skin care item | |
| CN106420482A (en) | Skin energy activating sparkling essence | |
| CN107303253A (en) | It is a kind of to be used to be damaged renovation agent of skin and preparation method thereof | |
| JPWO2019021988A1 (en) | External composition | |
| US20050153003A1 (en) | Anti-aging cosmetic composition and method of application | |
| CN105640867A (en) | Facial mask for replenishing moisture intensively with pearl essence and preparation method of facial mask | |
| CN107822945A (en) | One kind is matched unartificial yeast composition, preparation method and applied in cosmetics | |
| CN102988230B (en) | Mineral ion shampoo and preparation method thereof | |
| AU2002324634B2 (en) | Method of skin exfoliation | |
| CN105534815B (en) | A kind of skin care compositions and preparation method thereof containing lotus active constituent | |
| KR20180069487A (en) | Hydrogel comprising spicule and use thereof | |
| CN110496069A (en) | A kind of poly- peptide stoste of small molecule and preparation method thereof | |
| KR102530481B1 (en) | External composition for antiaging comprising osthole | |
| CN103893097A (en) | Seaweed fiber care type mascara | |
| CN113368003A (en) | Composition with overnight muscle repairing effect and preparation method and application thereof | |
| CN109330917B (en) | Essential oil composition with whitening, anti-aging and moisturizing effects and application thereof | |
| CN108852977B (en) | Crystal moistening essence |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |