CN111150673B - Ultraviolet-resistant and blue-light-resistant composition and application thereof - Google Patents
Ultraviolet-resistant and blue-light-resistant composition and application thereof Download PDFInfo
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- CN111150673B CN111150673B CN202010039572.6A CN202010039572A CN111150673B CN 111150673 B CN111150673 B CN 111150673B CN 202010039572 A CN202010039572 A CN 202010039572A CN 111150673 B CN111150673 B CN 111150673B
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention provides an ultraviolet-resistant and blue-light-resistant composition, wherein the composition at least comprises any three of troxerutin, ferulic acid, resveratrol and baicalin; preferably, the composition comprises troxerutin, ferulic acid, resveratrol and baicalin; preferably, the troxerutin is present in an amount of 9-40% by weight, preferably 14-30% by weight, based on the total weight of the composition; the ferulic acid content is 5-30wt%, preferably 6-20wt%; the resveratrol content is 0.8-20 wt%, preferably 2-10 wt%; the content of baicalin is 0.8-10wt%, preferably 2-8wt%; wherein the sum of the components is one hundred percent. The invention also provides application of the ultraviolet-resistant and blue-light-resistant composition in cosmetics. The composition of the invention can resist ultraviolet light and blue light in a wide range of wave bands; the composition provided by the invention can eliminate inflammatory factors, inhibit allergic reaction, relieve and repair skin and resist oxidation.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to an ultraviolet-resistant and blue-light-resistant composition and application of the composition in cosmetics.
Background
Sunlight is a resource given to the earth by the sun, and due to the irradiation of sunlight, everything grows, and life is multiplied. When sunlight irradiates on our skin, subcutaneous blood vessels are dilated, blood flow is vigorous, excretion and resistance to toxic substances are increased, secretion of saliva and gastric juice is increased, gastrointestinal peristalsis is enhanced, appetite and digestion are promoted, and our body can grow healthier.
Ultraviolet rays are classified into three types according to the wavelength of solar light:
UVA: the ultraviolet rays with the longest wavelength, 320-400nm, are not absorbed by the ozone layer at the top end of the atmosphere, can penetrate through the dermis layer, can penetrate deeper into the skin than UVB, make the skin sunk, cause lipid and collagen damage, cause photoaging of the skin and even skin cancer, so UVA not only can excite pigment synthesis to cause skin color to be 'blackened', but also is a main cause of skin 'aging' and fine wrinkles. UVB: medium wave ultraviolet rays with the wavelength of 290-320nm can reach the epidermis layer, cause phenomena of sun burn, erythema, tanning and the like of the skin, and cause the maximum damage (visible damage) to the upper layer of the skin. UVC: the UVC is almost completely absorbed by the atmosphere at wavelengths of 200-290 nm, and only a few cases are met.
When the skin is exposed to ultraviolet rays excessively, the skin cells are damaged; activating tyrosinase, accelerating pigment synthesis, destroying skin moisturizing function, drying skin, damaging elastic fiber in dermis layer, generating fine lines, and causing skin inflammation and burn under intense irradiation. In the case of abnormality, a skin cancer with a pigmentary nature is caused.
Blue light: light with a wavelength of 400-480 nm and relatively high energy can penetrate the lens to reach the retina, causing atrophy and even death of retinal pigment epithelial cells. For skin, melanin pigmentation can occur for up to 3 months, and pigmentation is particularly likely to occur in the epidermis granule layer and deeper skin layers. Can penetrate into skin deeper to cause oxidative damage to cellular DNA. There have been studies to date that blue light alters the structure of epidermal cells and also reduces the production of collagen and elastin. Blue light exists in a large amount in light rays of LED lamps, computer displays (comprising CCFLs and LEDs), mobile phones, digital products, liquid crystal display screens, bath heaters and the like, and the harm to human bodies is gradually increased.
Current sun protection products are mainly chemically synthesized organic sunscreens and physical sunscreens. Most of the chemical sunscreens exert a sun-screening effect, and simultaneously, the chemical sunscreens themselves can be degraded to cause damage to skin. Some components have poor product compatibility, and are easy to cause stability problems when used in cosmetics. The physical sun-screening agent is generally used for shielding ultraviolet rays, and is mostly used as nano titanium dioxide and nano zinc dioxide, and the particle size of the physical sun-screening agent is small, so that the physical sun-screening agent is easy to enter skin pores and is not easy to clean.
The plant products have the characteristics of pure nature and safety. In recent years, the protection of plant products against sunlight has been increasingly studied. However, plant products on the market which have protection against sunlight are relatively lacking, and often only have protection against a single band, and the protection effect is not ideal.
In addition, for people who have less outdoor activity time and work indoors for a long time, especially for people who work by adopting computers for a long time, blue light protection is also required. Currently, there are no such products on the market.
Disclosure of Invention
The invention provides a composition capable of resisting ultraviolet rays and blue light, aiming at the damage of ultraviolet rays and blue light to skin.
In one aspect, the invention provides an ultraviolet-resistant and blue-light-resistant composition, which is characterized by at least comprising any three of troxerutin, ferulic acid, resveratrol and baicalin; preferably, the composition comprises troxerutin, ferulic acid, resveratrol and baicalin; preferably, the troxerutin is present in an amount of 9-40% by weight, preferably 14-30% by weight, based on the total weight of the composition; the ferulic acid content is 5-30wt%, preferably 6-20wt%; the resveratrol content is 0.8-20 wt%, preferably 2-10 wt%; the content of baicalin is 0.8-10wt%, preferably 2-8wt%; wherein the sum of the components is one hundred percent.
In another aspect, the present invention provides the use of the above-described uv and blue light resistant composition in cosmetics.
Compared with the prior art, the invention has the following advantages and effects:
1. the composition provided by the invention can resist ultraviolet rays and blue light in a wide range of wave bands (280-440 nm wave bands), and has a broad-spectrum protection effect; therefore, the skin protection device can resist the damage of UVB, UVA and blue light to the skin at the same time, and meets the requirements of most people on sunlight protection.
2. The composition provided by the invention not only can realize photoprotection, but also can eliminate inflammatory factors, inhibit allergic reaction, relieve and repair skin and resist oxidation; therefore, the composition can promote repair after sun exposure and has anti-aging effect.
3. In a preferred embodiment, the composition of the invention has natural and safe properties, reduces the side effects of sunscreens and physical sunscreens due to organic and synthetic compounds, and has very good adaptability to the current increasing population of sensitive skin.
Drawings
FIG. 1 is a UV spectrum of the composition provided in example 1.
Fig. 2 is a uv detection spectrum of the composition provided in example 2.
FIG. 3 is a UV spectrum of the composition provided in example 3.
Fig. 4 is an ultraviolet detection spectrum of the composition provided in example 4.
Fig. 5 is a uv detection spectrum of the composition provided in example 5.
FIG. 6 is a UV detection spectrum of the composition provided in example 6.
Fig. 7 is an ultraviolet detection spectrum of the composition provided in example 7.
FIG. 8 is an ultraviolet spectrum of the cream provided in examples 8-11.
Fig. 9 is a graph of transmittance in the blue wavelength band for the compositions provided in example 1 at different concentrations.
Fig. 10 is a guard test dose distribution.
Fig. 11 is a sunscreen effect graph of low SPF standard P7 (spf≡4.4).
Fig. 12 is a sun protection effect diagram of the cream prepared in example 8.
Fig. 13 is a sun protection effect diagram of the cream prepared in example 9.
Figure 14 is a graph of the restoration effect of the cream prepared in example 8 on pre-sun protection and post-sun erythema.
Fig. 15 is a graph showing the restoration effect of the cream prepared in example 8 on the protection before sun and the skin elasticity after sun.
Fig. 16 is a graph showing the restoration effect of the cream prepared in example 8 on the roughness of skin after sun.
Detailed Description
The invention provides an ultraviolet-resistant and blue-light-resistant composition which is characterized by at least comprising any three of troxerutin, ferulic acid, resveratrol and baicalin.
Preferably, the troxerutin may be present in the composition in an amount of from 12 to 40% by weight, preferably from 15 to 30% by weight; the ferulic acid may be present in the composition in an amount of 7-30 wt%, preferably 8-20 wt%; the resveratrol may be present in the composition in an amount of from 1 to 20 wt%, preferably from 2 to 10 wt%; the baicalin may be present in the composition in an amount of 1-10 wt%, preferably 2-8 wt%.
The inventor finds that the composition has better ultraviolet resistance and blue light resistance.
In order to further improve the ultraviolet and blue light resistant effects, preferably, the composition comprises troxerutin, ferulic acid, resveratrol and baicalin; preferably, the troxerutin is present in an amount of 9-40% by weight, preferably 14-30% by weight, based on the total weight of the composition; the ferulic acid content is 5-30wt%, preferably 6-20wt%; the resveratrol content is 0.8-20 wt%, preferably 2-10 wt%; the content of baicalin is 0.8-10wt%, preferably 2-8wt%; wherein the sum of the components is one hundred percent.
In order to further enhance the anti-ultraviolet and anti-blue light effect, in a preferred embodiment, the composition further comprises one or more of quercetin, 4-hydroxy-3-butyl-lactone, emodin and baicalein.
In order to further enhance the anti-UV and anti-blue light effect, in a preferred embodiment, the composition further comprises quercetin, 4-hydroxy-3-butyl-lactone, emodin and baicalein; preferably, the quercetin is present in an amount of 1-10 wt% of the troxerutin, the 4-hydroxy-3-butyl-senlactone is present in an amount of 1-10 wt% of the ferulic acid, the emodin is present in an amount of 1-10 wt% of the resveratrol, and the baicalein is present in an amount of 1-10 wt% of the baicalin.
In order to further improve the ultraviolet and blue light resistant effects, in a preferred embodiment, the troxerutin is derived from pagodatree flower bud extract, the ferulic acid is derived from ligusticum chuanxiong hort extract, the resveratrol is derived from polygonum cuspidatum extract, and the baicalin is derived from scutellaria baicalensis extract.
In one embodiment, the pagodatree flower bud extract is present in an amount of 10 to 45% by weight, preferably 15 to 30% by weight, based on the total weight of the composition; the content of the ligusticum chuanxiong hort extract is 7-35 wt%, preferably 10-25 wt%; the content of the polygonum cuspidatum extract is 1-25%, preferably 2-20% by weight; the content of the Scutellariae radix extract is 1-15 wt%, preferably 2-10 wt%.
The flos Sophorae Immaturus extract contains troxerutin (rutin), quercetin, etc. The flos Sophorae Immaturus extract has effects of scavenging free radicals, enhancing skin vascular wall elasticity and toughness, reducing permeability, relieving red blood streak, resisting bacteria, and relieving inflammation.
The main components of the ligusticum chuanxiong hort extract comprise ferulic acid, 4-hydroxy-3-butyl-lactone and the like. The rhizoma Ligustici Chuanxiong extract has antioxidant activity, and has effects of promoting free radical enzyme generation, relieving radiation injury, inhibiting tyrosinase activity, resisting bacteria, and relieving inflammation.
The main components of the giant knotweed extract are resveratrol, emodin and the like. The rhizoma Polygoni Cuspidati extract has effects of inhibiting lipid peroxidation, inhibiting melanin generation, promoting collagen synthesis, and relieving inflammation.
The main components of the radix Scutellariae extract are baicalin, baicalein, etc. The Scutellariae radix extract has effects of resisting inflammation and anaphylaxis, inhibiting bacteria in a broad spectrum, and scavenging free radicals.
The pagodatree flower bud extract, the ligusticum chuanxiong hort extract, the polygonum cuspidatum extract and the scutellaria baicalensis extract can be obtained commercially.
In order to promote dissolution of the ligusticum chuanxiong hort extract, the polygonum cuspidatum extract or the scutellaria baicalensis extract in the composition, in a preferred embodiment, the ligusticum chuanxiong hort extract, the polygonum cuspidatum extract or the scutellaria baicalensis extract is present in the form of microcapsules. The microcapsules of these extracts can be prepared according to the prior art, wherein the encapsulate material can be any material from which the microcapsules are made, preferably hydroxypropyl cyclodextrin and/or chitosan.
In a preferred embodiment, the scutellaria baicalensis extract is in the form of microcapsules, and the capsule wall material is hydroxypropyl cyclodextrin and/or chitosan.
In a preferred embodiment, the microcapsule containing the scutellaria baicalensis extract comprises the following components: based on the total weight of the microcapsule containing the baicalin extract, the content of baicalin is 10-20 wt%, the content of the capsule wall material is 80-90 wt%, the content of acid is 0.3-0.7 wt%, and the total weight of all the components is hundred percent. The capsule wall material can be hydroxypropyl cyclodextrin or chitosan; the acid may be an organic acid and an inorganic acid, such as acetic acid, hydrochloric acid, sulfuric acid, phosphoric acid, and the like. In a preferred embodiment, the acid is arginine.
In a preferred embodiment, the microcapsules containing the scutellaria baicalensis extract are prepared by the following method: dispersing Scutellariae radix extract in solvent, adding acid to adjust pH to 6-7.5, preferably 6.5-7, heating to 45-60deg.C, preferably 50-60deg.C, adding capsule wall material, stirring to dissolve completely, cooling, filtering, and drying.
The solvent is various solvents that can dissolve the scutellaria baicalensis extract, but is preferably water, more preferably deionized water.
The inventors found that the dissolution effect of the baikal skullcap root extract was very good when the pH of the solution was 6-7.5.
The temperature of cooling may be room temperature, but is preferably 5-10 ℃, for example 6 ℃.
The drying temperature may be 50-80℃but is preferably 50-60 ℃.
The capsule wall material may be any material from which microcapsules are prepared, preferably hydroxypropyl cyclodextrin and/or chitosan; preferably, the capsule wall material is hydroxypropyl cyclodextrin and/or chitosan.
The acid may be any of organic and inorganic acids, such as acetic acid, hydrochloric acid, sulfuric acid, phosphoric acid, and the like. In a preferred embodiment, the acid is arginine.
In one embodiment, the composition further comprises a solvent; preferably, the composition is prepared by the steps of: heating the solvent to 40-50deg.C, adding flos Sophorae Immaturus extract, rhizoma Ligustici Chuanxiong extract, and rhizoma Polygoni Cuspidati extract, stirring for 5-10 min, adding microcapsule containing Scutellariae radix extract, and stirring to dissolve completely.
In one embodiment, the composition comprises 10-17 wt% of pagodatree flower bud extract, 7-11 wt% of ligusticum chuanxiong hort extract, 1-5 wt% of polygonum cuspidatum extract, 10-22 wt% of microcapsule containing scutellaria baicalensis extract, 27-33 wt% of ethoxydiglycol and 20-25 wt% of water.
The solvent may be any solvent used in cosmetics, in a preferred embodiment, ethoxydiglycol and water; when ethoxydiglycol and water are used as solvents, the pagodatree flower bud extract, the ligusticum chuanxiong hort extract, the polygonum cuspidatum extract and the microcapsule containing the scutellaria baicalensis extract are very well dissolved. In a preferred embodiment, the ethoxydiglycol is present in an amount of 25 to 35% by weight and the water is present in an amount of 20 to 25% by weight, based on the total weight of the composition.
The composition can also contain a preservative, wherein the preservative can be one or a mixture of more than two of phenoxyethanol, ethylene-level hexylglycerol, methyl hydroxybenzoate, p-hydroxyacetophenone, pentanediol, octanediol, hexanediol and the like in any proportion. The above-mentioned preservative may be contained in an amount of 0.1 to 1% by weight, for example, 0.5% by weight, based on the total weight of the composition.
The invention also relates to the use of the above composition in cosmetics.
In a preferred embodiment, the composition is present in the cosmetic in an amount of from 2 to 20% by weight, preferably from 2 to 10% by weight.
The cosmetic product may be an emulsion or a cream product.
In the cosmetic, lecithin, glyceryl stearate, cetostearyl ether-25 may be used as an emulsifier; isononyl isononanoate can be used as a grease; glycerin, hydroxyethyl urea may be used as a humectant; tocopheryl acetate may also be added as an antioxidant; ammonium acryloyldimethyl taurate/VP copolymer may be used as a thickener.
The invention also provides an ultraviolet and blue light resistant cream, wherein the cream contains 2-20 wt% of the ultraviolet and blue light resistant composition.
In order that the invention may be better understood, it is illustrated by the following examples. These examples are included in the scope of the invention, but are not intended to limit the scope of the invention.
Examples 1 to 7: preparation of UV and blue light resistant compositions
1. Preparing microcapsule containing Scutellariae radix extract: 15 g of baicalin extract powder (14 g of baicalin) is dispersed in a proper amount of deionized water, 0.5 g of arginine is added to adjust the pH value of the solution to 6.5, the solution is heated to 60 ℃, 84.5 g of hydroxypropyl cyclodextrin is added to be stirred until the solution is completely dissolved, and the solution is placed at 6 ℃ to be cooled, so that the microcapsule containing the baicalin extract is obtained. Filtering, and rotary evaporating at 60deg.C to obtain dry powder;
2. preparation of an ultraviolet and blue light resistant composition: mixing 30 g of ethoxydiglycol and 23 g of water uniformly, heating to 45 ℃ and keeping constant temperature stirring, slowly adding 15 g of pagodatree flower bud extract powder (14 g of troxerutin), 9 g of ligusticum chuanxiong hort extract powder (8 g of ferulic acid) and 3 g of polygonum cuspidatum extract powder (2.7 g of resveratrol), stirring for 5 minutes, adding 20 g of microcapsule containing scutellaria baicalensis extract (2.7 g of baicalin), and continuously stirring until complete dissolution.
Example 2
1. Preparing microcapsule containing Scutellariae radix extract: 15 g of baicalin extract powder (14 g of baicalin) is dispersed in a proper amount of deionized water, 0.5 g of arginine is added to adjust the pH value of the solution to 6.5, the solution is heated to 60 ℃, 84.5 g of hydroxypropyl cyclodextrin is added to be stirred until the solution is completely dissolved, and the solution is placed at 6 ℃ to be cooled, so that the microcapsule containing the baicalin extract is obtained. Filtering, and rotary evaporating at 60deg.C to obtain dry powder;
2. preparation of an ultraviolet and blue light resistant composition: mixing 38 g of ethoxydiglycol and 26 g of water uniformly, heating to 45 ℃ and keeping constant temperature stirring, slowly adding 12 g of pagodatree flower bud extract powder (troxerutin is 11 g), 7 g of ligusticum chuanxiong hort extract powder (ferulic acid is 6 g) and 2 g of polygonum cuspidatum extract powder (resveratrol is 1.8 g), stirring for 10 minutes, adding 15 g of microcapsule containing scutellaria baicalensis extract (baicalin is 2 g), and continuously stirring until complete dissolution.
Example 3
1. Preparing microcapsule containing Scutellariae radix extract: 15 g of baicalin extract powder (14 g of baicalin) is dispersed in a proper amount of deionized water, 0.5 g of arginine is added to adjust the pH value of the solution to 6.5, the solution is heated to 60 ℃, 84.5 g of hydroxypropyl cyclodextrin is added to be stirred until the solution is completely dissolved, and the solution is placed at 6 ℃ to be cooled, so that the microcapsule containing the baicalin extract is obtained. Filtering, and rotary evaporating at 60deg.C to obtain dry powder;
2. preparation of an ultraviolet and blue light resistant composition: mixing 42 g of ethoxydiglycol and 32 g of water uniformly, heating to 45 ℃ and keeping constant temperature stirring, slowly adding 10 g of pagodatree flower bud extract powder (9 g of troxerutin), 5 g of ligusticum chuanxiong hort extract powder (6 g of ferulic acid) and 1 g of polygonum cuspidatum extract powder (0.9 g of resveratrol), stirring for 10 minutes, adding 10 g of microcapsule containing scutellaria baicalensis extract (1.4 g of baicalin), and continuously stirring until complete dissolution.
Example 4
Preparation of an ultraviolet and blue light resistant composition: mixing 41 g of ethoxydiglycol and 31 g of water uniformly, heating to 45 ℃ and keeping constant temperature stirring, slowly adding 20 g of pagodatree flower bud extract powder (troxerutin is 18 g), 5 g of ligusticum chuanxiong hort extract powder (ferulic acid is 6 g) and 3 g of polygonum cuspidatum extract powder (resveratrol is 2.7 g), stirring for 10 minutes, and continuing stirring until the materials are completely dissolved.
Example 5
1. Preparing microcapsule containing Scutellariae radix extract: 15 g of baicalin extract powder (14 g of baicalin) is dispersed in a proper amount of deionized water, 0.5 g of arginine is added to adjust the pH value of the solution to 6.5, the solution is heated to 60 ℃, 84.5 g of hydroxypropyl cyclodextrin is added to be stirred until the solution is completely dissolved, and the solution is placed at 6 ℃ to be cooled, so that the microcapsule containing the baicalin extract is obtained. Filtering, and rotary evaporating at 60deg.C to obtain dry powder;
2. preparation of an ultraviolet and blue light resistant composition: mixing 33 g of ethoxydiglycol and 20 g of water uniformly, heating to 45 ℃ and keeping constant temperature stirring, slowly adding 15 g of pagodatree flower bud extract powder (13 g of troxerutin) and 12 g of ligusticum chuanxiong hort extract powder (11 g of ferulic acid), stirring for 10 minutes, adding 10 g of microcapsule containing scutellaria baicalensis extract (1.4 g of baicalin), and continuously stirring until complete dissolution.
Example 6
1. Preparing microcapsule containing Scutellariae radix extract: 15 g of baicalin extract powder (14 g of baicalin) is dispersed in a proper amount of deionized water, 0.5 g of arginine is added to adjust the pH value of the solution to 6.5, the solution is heated to 60 ℃, 84.5 g of hydroxypropyl cyclodextrin is added to be stirred until the solution is completely dissolved, and the solution is placed at 6 ℃ to be cooled, so that the microcapsule containing the baicalin extract is obtained. Filtering, and rotary evaporating at 60deg.C to obtain dry powder;
2. preparation of an ultraviolet and blue light resistant composition: mixing 36 g of ethoxydiglycol and 24 g of water uniformly, heating to 45 ℃ and keeping constant temperature stirring, slowly adding 15 g of pagodatree flower bud extract powder (13 g of troxerutin) and 5 g of polygonum cuspidatum extract powder (4.5 g of resveratrol), stirring for 10 minutes, adding 20 g of microcapsule containing baicalin extract (2.7 g of baicalin), and continuously stirring until complete dissolution.
Example 7
1. Preparing microcapsule containing Scutellariae radix extract: 15 g of baicalin extract powder (14 g of baicalin) is dispersed in a proper amount of deionized water, 0.5 g of arginine is added to adjust the pH value of the solution to 6.5, the solution is heated to 60 ℃, 84.5 g of hydroxypropyl cyclodextrin is added to be stirred until the solution is completely dissolved, and the solution is placed at 6 ℃ to be cooled, so that the microcapsule containing the baicalin extract is obtained. Filtering, and rotary evaporating at 60deg.C to obtain dry powder;
2. preparation of an ultraviolet and blue light resistant composition: mixing 35 g of ethoxydiglycol and 21 g of water uniformly, heating to 45 ℃ and keeping constant temperature stirring, slowly adding 9 g of ligusticum chuanxiong hort extract powder (8 g of ferulic acid) and 5 g of polygonum cuspidatum extract powder (4.5 g of resveratrol), stirring for 10 minutes, adding 20 g of microcapsule containing the scutellaria baicalensis extract (2.7 g of baicalin), and continuously stirring until complete dissolution.
Examples 8 to 11: preparation of creams containing 5%, 10%, 15% and 20% of the composition prepared in example 1
Preparing a cream matrix: lecithin (1.8 wt%), glycerol stearate (1.35 wt%), emulsifier cetostearyl alcohol polyether-25 (1.25 wt%), isononyl isononanoate (5 wt%), glycerol (5 wt%), humectant hydroxyethyl urea (0.8 wt%), antioxidant tocopheryl acetate (2 wt%), thickener acrylamide/VP copolymer (1.3 wt%), water (81.5 wt%) were mixed well.
The compositions prepared in example 1 were uniformly mixed with 95 parts by weight, 90 parts by weight, 85 parts by weight and 80 parts by weight of the above-formulated cream base, respectively, 5 parts by weight, 10 parts by weight, 15 parts by weight and 20 parts by weight, to obtain the creams of examples 8 to 11.
Performance test:
examples 12 to 18: UV detection spectra of UV and blue light resistant compositions prepared in examples 1-7
1. Instrument and materials
An ultraviolet/visible spectrophotometer; an analytical balance; quartz pool
2. Experimental procedure
(1) Preparing ethylhexyl methoxycinnamate (MC 80) solution with concentration of 0.01%o by using a proper amount of ethanol as a control group;
(2) Taking a proper amount of water, and respectively preparing solutions of the ultraviolet-resistant and blue-light-resistant compositions prepared in examples 1-7 with concentrations of 0.02 permillage, 0.04 permillage and 0.06 permillage as experimental groups;
(2) After the power supply of the ultraviolet spectrophotometer instrument is connected and preheated, the detection wavelength is set: 280 nm-400 nm;
(3) Placing a quartz cuvette filled with a solvent in a photometer, and adjusting the zero point of the photometer;
(4) The ultraviolet absorption peak patterns of the control group and the experimental group with the prepared gradient concentration content are sequentially detected.
3. Experimental results
The results of the ultraviolet detection spectra of the compositions prepared in examples 1 to 7 are shown in FIGS. 1 to 7, respectively: the compositions prepared in examples 1-7 have higher absorption at 280nm to 400nm, especially after 340nm, which is significantly higher than the standard sample.
Examples 19 to 22: ultraviolet detection spectrograms for detecting the creams prepared in examples 8-11 and ultraviolet absorbance values thereof
1. Instrument and materials
An ultraviolet/visible spectrophotometer; an analytical balance; a quartz pool; medical adhesive tape produced by 3M company in America
2. Experimental procedure
(1) Cutting a medical emulsion tape produced by 3M company into a rectangle with the length of 1cm X4 cm, and attaching an adhesive surface to the surface of the light-transmitting side of the quartz pool;
(2) After the power supply of the ultraviolet spectrophotometer instrument is connected and preheated, the detection wavelength is set: 280nm to 400nm (280, 290, 300, 310, 320, … …);
(3) Placing the quartz cuvette with the adhesive tape in a photometer, and adjusting the zero point of the photometer;
(4) The cream samples prepared in examples 8 to 11 were taken with a glass rod on the surface of a quartz cell with an adhesive tape, precisely weighed (8.2 mg) and coated with a medical latex fingerstall. Five parallel samples were weighed;
(5) Placing the cuvette coated with the sample under sunlight for 30min and 60min at room temperature, and measuring;
(6) Measuring ultraviolet absorbance A of each wavelength of 280 nm-400 nm (280, 290, 300, 310, 320 and … …) in a cuvette photometer coated with a sample to be measured i The measured value is calculated as arithmetic mean value
(7) Five parallel samples were measured sequentially and the
Arithmetically averaging the ultraviolet absorbance +.>
3. Data processing
The test results of the raw materials on UVB band protection are calculated as follows:
the test results of the raw materials on UVA band protection are calculated as follows:
wherein: a is that i -the ultraviolet absorbance value measured at each wavelength for sample i.
Sample test result evaluation:
if it is
If the sun-screening effect of the sample is less than 0.5, judging that the sun-screening effect of the sample is lower than the minimum protection effect or no protection effect; if->
And if the value is not less than 0.5, judging that the sample has a protective effect.
4. Detection results and analysis
The results of the detection are shown in FIG. 8, and the UV absorbance values are shown in Table 1
TABLE 1 UV absorbance values for example 8-11 sample protective creams
According to the evaluation method of the UVB region sun protection effect of the QB/T2410-1998 sun protection cosmetics, 10% of the protection cream of the example 1 sample is added, the absorbance average value of the protection cream in the UVB wave band exceeds 0.5, the minimum ultraviolet light protection effect is achieved, and the protection cream is suitable for sunlight in winter, sunlight in the morning and evening in summer and environment conditions in the shade.
Example 23: in vitro blue light protection efficacy of the UV and blue light resistant compositions prepared in example 1 was tested
1. Instrument and materials
An ultraviolet/visible spectrophotometer; an analytical balance; quartz pool
2. Experimental procedure
(1) Taking a proper amount of deionized water, and preparing an aqueous solution of the ultraviolet-resistant and blue-light-resistant composition prepared in the example 1 with the concentration of 0.1%,0.25%,0.7%,2% and 5%;
(2) After the power supply of the ultraviolet spectrophotometer instrument is connected and preheated, the detection wavelength is set: 400 nm-500 nm;
(3) Placing a quartz cuvette filled with deionized water in a photometer, and adjusting the zero point of the photometer;
(4) The aqueous solutions of the UV and blue light resistant composition samples prepared in example 1 were tested for their prepared graded concentration levels in sequence for light transmittance.
3. The detection results are shown in FIG. 9.
As can be seen from fig. 9, when the concentration of the ultraviolet and blue light resistant composition prepared in example 1 was 0.25%, the light transmittance at 400nm wavelength was zero, and the blue light injury was started to be resisted; when the concentration of the ultraviolet and blue light resistant composition prepared in example 1 was 5%, the transmittance at 440nm wavelength was nearly zero, at which time blue light was substantially completely absorbed and the wavelength range of blue light damaging the skin reached a substantially complete resistance.
Example 24: in vitro solar protection efficacy of the creams prepared in examples 8-9 was tested
1. SPF value test method in 2015 edition of cosmetic safety technical Specification
a. In the human sunscreen efficacy evaluation test, define:
(1) The left arm test areas (1) to (4) are unprotected areas which are not subjected to any treatment;
(2) The right arm test area (6) to the area (gamma) are coated with sun cream (2 mg/cm) 2 ) A rear protection area;
the minimum erythema dose is observed within 16-24 h after the tested area is irradiated by ultraviolet rays with different doses.
b. In the post-sun repair efficacy evaluation test, define:
(1) Region (4) is the UVB-only radiation group (natural metabolome);
(2) Region (5) was the repair of the cream prepared in examples 8-9 (repair group) after UVB irradiation;
(3) Region (9) is post-protection +uvb radiation for the creams prepared in examples 8-9 (protection group);
data for each test area of volunteers were measured 1 day after, 1 week after and 2 weeks after testing (a, R2, SEr).
Note that: the instrument is a sigma SH-1B type ultraviolet therapeutic instrument (UVB peak value is 311nm, irradiation intensity is 13 mW/cm) 2 )
The guard test dose profile 10 is shown.
2. Analysis of results
2.1 evaluation results of human Sun-screening efficacy of Low SPF Standard P7 (SPF. Apprxeq.4.4)
The detection results are shown in fig. 11: the left arm red frame is irradiated by UVB for 69 seconds after being not treated, and a slightly reddish area appears in the next day; the right arm is in the red frame according to 2mg/cm 2 After the sun cream is smeared, the sun cream is irradiated by UVB for 253 seconds, and a slightly reddish area appears in the next day; therefore, the low SPF marker P7 was able to withstand UVB radiation at about 3.67 doses without significant redness.
2.2 evaluation results of human sunscreen efficacy of the cream prepared in example 8
The detection results are shown in fig. 12: the red frame of the left arm is a region which is slightly reddish in the next day after being irradiated by UVB for 23 seconds without any treatmentThe method comprises the steps of carrying out a first treatment on the surface of the The right arm is in the red frame according to 2mg/cm 2 After the sun cream is smeared, the sun cream is irradiated by UVB for 69 seconds, and a slightly reddish area appears in the next day; thus, 5% of the example 1 samples were able to withstand approximately 3-fold doses of UVB radiation without significant redness.
2.3 results of evaluation of human sunscreen efficacy of the cream prepared in example 9
The detection results are shown in fig. 13: the red frame of the left arm is irradiated by UVB for 46 seconds after no treatment, and a slightly reddish area appears in the next day; the right arm is in the red frame according to 2mg/cm 2 After the sun cream is smeared, the sun cream is irradiated by UVB for 230 seconds, and a slightly reddish area appears in the next day; thus, 10% of the example 1 samples were able to withstand approximately 5-fold doses of UVB radiation without significant redness.
2.4 Effect of the cream sample prepared in example 8 on redness of skin after UV irradiation
The detection results are shown in FIG. 14.
The cream samples prepared in example 8 were coated prior to UVB irradiation, and the next day reduced the production of 101.52% erythema.
After UVB irradiation, the cream sample prepared in the example 8 is coated, and the generation of the red spot amount can be reduced by 19.29% in the next day; after 1 week, the generation of the red spot quantity can be reduced by 19.54%; after 2 weeks, the production of 35.82% erythema can be reduced.
2.5 Effect of the cream sample prepared in example 8 on skin elasticity after UV irradiation
The detection results are shown in FIG. 15.
The cream samples prepared in example 8 were applied prior to UVB irradiation, and the next day reduced 103.43% skin elasticity damage.
After uv b irradiation, the cream sample prepared in example 8 was coated, and the next day could reduce skin elasticity damage by 39.57%; after 1 week, the skin elasticity damage can be reduced by 66.19%; after 2 weeks, 67.51% skin elasticity damage can be reduced.
2.6 Effect of roughening the skin of the cream sample prepared in example 8 after ultraviolet irradiation
The detection results are shown in FIG. 16.
The cream samples prepared in example 8 were applied after UVB irradiation, and after 1 week, improved by 95.56% and after 2 weeks, improved by 107.14% skin roughness.
Claims (4)
1. An ultraviolet-resistant and blue-light-resistant composition is characterized by comprising troxerutin, ferulic acid, resveratrol and baicalin; the content of troxerutin is 9-40 wt% based on the total weight of the composition, and the content of ferulic acid is 5-30 wt%; the resveratrol content is 0.8-20wt%; the content of baicalin is 0.8-10wt%; wherein the composition further comprises quercetin, 4-hydroxy-3-butyl-lactone, emodin and baicalein; the content of the quercetin is 1-10% of the troxerutin, the content of the 4-hydroxy-3-butyl-lactone is 1-10% of the ferulic acid, the content of the emodin is 1-10% of the resveratrol, and the content of the baicalein is 1-10% of the baicalin; the sum of the components is hundred percent; wherein the troxerutin is derived from flos Sophorae Immaturus extract, the ferulic acid is derived from rhizoma Ligustici Chuanxiong extract, the resveratrol is derived from rhizoma Polygoni Cuspidati extract, and the baicalin is derived from Scutellariae radix extract; the scutellaria baicalensis extract exists in a microcapsule form, and the capsule wall material of the microcapsule is hydroxypropyl cyclodextrin and/or chitosan; wherein the composition is prepared by the steps of: heating ethoxydiglycol and water to 40-50deg.C, adding flos Sophorae Immaturus extract, rhizoma Ligustici Chuanxiong extract, and rhizoma Polygoni Cuspidati extract, stirring for 5-10 min, adding microcapsule containing Scutellariae radix extract, and stirring to dissolve completely; the ethoxydiglycol is used in an amount of 25 to 35% by weight and the water is used in an amount of 20 to 25% by weight, based on the total weight of the composition; wherein, the microcapsule of the baical skullcap root extract is prepared by the following method: dispersing Scutellariae radix extract in water, adding arginine to adjust pH to 6-7.5, heating to 45-60deg.C, adding capsule wall material, stirring to dissolve completely, cooling, filtering, and drying.
2. The composition according to claim 1, wherein the troxerutin is present in an amount of 14-30% by weight; the content of ferulic acid is 6-20wt%; the resveratrol content is 2-10wt%; the content of baicalin is 2-8wt%.
3. Use of a composition according to any one of claims 1-2 for the preparation of cosmetics.
4. Use according to claim 3, wherein the composition is present in the cosmetic in an amount of 2-20% by weight.
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