CN101244022A - Chinese medicine combination with whitening function and uses thereof - Google Patents
Chinese medicine combination with whitening function and uses thereof Download PDFInfo
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- CN101244022A CN101244022A CNA2008100244119A CN200810024411A CN101244022A CN 101244022 A CN101244022 A CN 101244022A CN A2008100244119 A CNA2008100244119 A CN A2008100244119A CN 200810024411 A CN200810024411 A CN 200810024411A CN 101244022 A CN101244022 A CN 101244022A
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Abstract
The invention discloses a Chinese herbal medicine composition with whitening function and the application, comprising extracts of scutellaria, polygonum cuspidate, and cortex moutan. The Chinese herbal medicine composition can be used as skin whitening preparation for external application, and has the advantages of inhibiting the formation of melanogenesis, improving pigmentation, and whitening skin.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and application thereof, relate in particular to a kind of Chinese medicine composition and application thereof of Pear Power function.
Background technology
The color of skin depends primarily in the skin contained how much melanic.Melanin is generated by the melanocyte in the epidermis, and its synthetic influence that is subjected to plurality of enzymes in the cell comprises tryrosinase, dopachrome isomerase, 5,6-dihydroxy indole-2-carboxylic acid (DHICA) oxidase etc.Wherein tryrosinase is main rate-limiting enzyme, and this enzymatic activity size is determining the quantity that melanin forms.In addition, the melanic synthetic influence that also is subjected to factors such as ultraviolet, free radical.
Current whitening product great majority are based on restraint of tyrosinase.These existing medicaments, also unsatisfactory at aspects such as stability, side effect, effects.For example, the hydroquinone use that is under an embargo owing to side effect is excessive, kojic acid and derivant whitening function thereof are strong, but meet light, heat is easily decomposed.The natural product of plant is used for cosmetics can play good treatment and skin protection double effects, and have function many, widely applicable, safe, have no side effect or characteristic such as side effect is little substantially, thereby in the day chemical industry, more and more paid attention to.
Summary of the invention
Technical problem to be solved by this invention provides a kind of natural Chinese medicine composition to the high and effective whitening function of human safety that is derived from.
Another technical problem to be solved by this invention provides the application of above-mentioned Chinese medicine composition.
For solving the problems of the technologies described above, the technical solution adopted in the present invention is as follows:
A kind of Chinese medicine composition of Pear Power function is characterized in that it comprises the component of following percentage by weight:
Radix Scutellariae extract 10～50%
Rhizoma Polygoni Cuspidati extract 10～50%
Cortex Moutan extract 10～50%
Above-mentioned Chinese medicine extract can obtain by conventional solvent extraction method, for example can with above-mentioned plant rhizome etc. with extract that solvent soaks or reflux after, filter, concentrate and obtain.Unqualified about the extraction solvent that uses among the present invention, can use so long as be generally used for the solvent of plant extract, for example water, methanol, ethanol, aqueous alcohols, acetone etc.Also be not particularly limited for extracting operation, can only use solvent slightly to carry, or carry out further separation and purification treatment, for example the extracting solution former state that above-mentioned solvent extraction is obtained or concentrate after extracting solution remove impurity by resin.
The application of above-mentioned Chinese medicine composition on the preparation skin-whitening agents.
With respect to the total amount of external agent, the use level of above-mentioned plant extract in the skin-whitening agents of the present invention in dry thing, is 0.05～20% (w/w), and preferable amount is 0.5～5% (w/w).
In Dermatologic preparation for beautifying of the present invention, except that above-mentioned essential composition, can suitably cooperate the composition that in cosmetics, uses usually as required, for example, matrix components such as other whitening agent, wetting agent, antioxidant, surfactant, alcohols, water.
The dosage form of skin-whitening agents is not particularly limited, and can be solution, suspension, emulsion, paste, gel, milk, skin care liquid, powder, fancy soap, oil, dry powder, foundation emulsion, wet-milling or spray.
Beneficial effect: the Chinese medicine composition of Pear Power function of the present invention has restraint of tyrosinase, free radical resisting and anti-ultraviolet effect, can effectively suppress melanin and generate, desalination pigmentation, senile plaque, freckle etc.Compare with other whitening agents, said composition can suppress melanic synthetic from different approach comprehensively, has excellent whitening effect, and simultaneously, said composition does not contain the chemosynthesis material, has no side effect, and skin irritation is little, stable in properties.Except that whitening effect, because said composition contains the plurality of Chinese active component, have functions such as blood circulation promoting and blood stasis dispelling, antiinflammatory be antibacterial, can promote the metabolism of skin, the nutrition that improves skin makes skin pure white naturally tender with healthy.
The specific embodiment:
The present invention will be described in more detail to enumerate embodiment below, but technical scope of the present invention is not limited by these embodiment.Below all proportional quantities all by weight percentage.
Embodiment 1: experimental technique and whitening effect evaluation
1, sample preparation
The Chinese medicine crude drug spends the night in oven drying, pulverizes the back and crosses 40 mesh sieves, adds 10 times 50% ethanol, heating and refluxing extraction 3 times, each 1 hour.Merge extractive liquid,, sucking filtration while hot.Decompression filtrate recycling ethanol is placed.The centrifugal precipitation of removing, supernatant is collected 70% ethanol elution by D101 macroporous resin eluting, and reduced vacuum concentrates, and obtains Chinese medicine extract.Extract is dissolved in the dimethyl sulfoxide, is made into concentration and is 1% solution, carry out following experiment.
2, the mensuration of free radical scavenging effect
Diphenyl picryl phenylhydrazine (DPPH) the solution 2mL that gets extracts of Chinese herbal medicine 2mL and concentration and be 100umol/L successively adds in the same tool plug test tube, shakes up; Left standstill working sample absorbance under the 517nm wavelength under the room temperature 30 minutes.
Suppression ratio: k%=[1-(A
i-A
j)/A
c] * 100%
A
i: the absorbance of 2ml DPPH solution+2ml extracting solution
A
j: the absorbance of 2ml extracting solution+2ml solvent
A
c: the absorbance of 2ml DPPH solution+2ml solvent
3, anti-ultraviolet property is measured
In 280～400nm wave-length coverage, scan every 10nm, determine the light transmittance of Chinese medicine extraction liquid under each wavelength, calculate the average absorption rate of wave-length coverage.
4, suppress tryrosinase vitality test in the mouse melanin cell
The B16 melanocyte is inoculated in 96 orifice plates, every hole 100uL, put in the incubator cultivate educate 24h after, add Chinese medicine extraction liquid.Behind the drug effect 3d, abandoning supernatant, with pH 6.8 poly butylene succinates (PBS) flushing twice, every hole adds the PBS that 90uL contains 1% (volume fraction) Triton X-100.Ultrasonication in the ice bath, every hole add the L-DOPA (L-dopa) of 10uL 10mmoL/L, hatch 60min for 37 ℃, and in 475nm place colorimetric, each hole absorbance is surveyed in the blank well zeroing.
Suppression ratio=(1-medicine group mean light absorbency value ÷ matched group mean light absorbency value) * 100%.
5, suppress melanocyte synthetic test in the mouse melanin cell
Will be from the B16 melanoma cells of mice with 1 * 10
5The density of individual/mL is inoculated in culture dish, at 37 ℃, 5%CO
2Condition under cultivated 2 days.Abandon supernatant, add Chinese medicine extraction liquid, behind the drug effect 3d, abandon supernatant, the PBS washing, every hole adds 0.5mL trypsin digestion cell 3min, and every hole adds 2ml and keeps liquid termination digestion.Behind the piping and druming mixing, every kind of concentration is taken out 0.5mL and is done the cell counting.All the other cell suspension are abandoned supernatant with the centrifugal 5min of 2500r/min, add NaOH solution in precipitation, and heating makes the melanin dissolving, select the 490nm wavelength to survey absorbance on enzyme-linked immunosorbent assay instrument.
Melanin synthesizes suppression ratio=[1-(medicine hole absorbance ÷ medicine porocyte density) ÷ (control wells absorbance ÷ control wells cell density)] * 100%
6, experimental result
Table 1 experimental result
| Suppression ratio (%) | |
| The free radical scavenging effect | 87.1 |
| Anti-ultraviolet property | 46.9 |
| The restraint of tyrosinase vigor | 54.7 |
| It is synthetic to suppress melanocyte | 62.3 |
Experiment shows that Chinese medicine composition of the present invention effectively restraint of tyrosinase activity, inhibition melanocyte generates, and has the free radical of removing and anti-ultraviolet function simultaneously.
Embodiment 2: Chinese medicine composition
(I) is composed as follows for the Chinese medicine composition of Pear Power function:
Radix Scutellariae extract 10%
Rhizoma Polygoni Cuspidati extract 50%
Cortex Moutan extract 40%
(II) is composed as follows for the Chinese medicine composition of Pear Power function:
Radix Scutellariae extract 50%
Rhizoma Polygoni Cuspidati extract 10%
Cortex Moutan extract 40%
(III) is composed as follows for the Chinese medicine composition of Pear Power function:
Radix Scutellariae extract 45%
Rhizoma Polygoni Cuspidati extract 45%
Cortex Moutan extract 10%
(IV) is composed as follows for the Chinese medicine composition of Pear Power function:
Radix Scutellariae extract 30%
Rhizoma Polygoni Cuspidati extract 20%
Cortex Moutan extract 50%
Embodiment 3: skin whitener
Component w/%
The sweet ester 6.00 of A monostearate
Propylene glycol 5.50
Stearic acid 4.00
Triethanolamine 0.70
Slab oil 10.00
Methyl hydroxybenzoate 1.50
Isopropyl myristate 10.00
Polydimethylsiloxane 2.00
B Chinese medicine composition (I) 1.00
Deionized water 59.30
Preparation: stir down A and B component are heated to 70 ℃ respectively, to whole dissolving mix homogeneously.70 ℃, stir down B added in the A component, to forming W/Q type Emulsion.After stirring, cool to room temperature promptly.
Embodiment 4: sunlight lotion
Component w/%
A: sodium lactate (70%) 0.30
Deionized water 75.65
Chinese medicine composition (II) 1.00
Sorbitan laurate 5.50
B: HANSHENGJIAO 0.20
Aluminium-magnesium silicate 0.80
C: Palmic acid sad 5.00
16 octadecanol caprylates 5.00
Dimethicone 3.00
Propylene glycol 0.05
Cera alba 3.50
Preparation: heating is also stirred A to 80 ℃.B is mixed mutually, add the A phase.It is even until system to continue stirring, remains on 75～80 ℃.Heating C to 75～80 ℃, mix homogeneously slowly adds the A/B mixed phase, high speed homogenization.Continue to stir and be cooled to 30 ℃, the moisture of replenish lost, homogenizing gets final product again.
Embodiment 5: the elite of preserving moisture is revealed
Component w/%
1,3 butylene glycol 1.60
Glycerol 1.00
Polyethylene Glycol ether in the last of the ten Heavenly stems 0.70
Polyoxyethylene oleyl ether 1.30
Ethyl oleate 0.50
Oleyl alcohol 0.40
Citric acid 0.35
Disodium hydrogen phosphate 0.65
Methyl parahydroxybenzoate 0.10
Chinese medicine composition (III) 1.00
Deionized water adds to 100.00
Preparation: mix mentioned component successively to evenly getting final product.
Embodiment 6: cleawhite pack
Component w/%
Polyvinyl alcohol 12.0
Vinyl acetate emulsion 14.0
Propylene glycol 5.0
Polysorbate60 0.5
Silicone oil emulsion 1.5
Ethanol 6.0
Chinese medicine composition (IV) 2.0
Deionized water 59.0
Preparation:, be added in the water of polysorbate60 and silicone emulsion the polyvinyl alcohol moistening with ethanol, be heated to 70 ℃, stir simultaneously, make it mix homogeneously, again other remaining raw material is all added, stir evenly and get final product.
Claims (2)
1, a kind of Chinese medicine composition of Pear Power function is characterized in that it comprises the component of following percentage by weight:
Radix Scutellariae extract 10～50%
Rhizoma Polygoni Cuspidati extract 10～50%
Cortex Moutan extract 10～50%
2, the application of the described Chinese medicine composition of claim 1 on the preparation skin-whitening agents.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810024411A CN100588389C (en) | 2008-03-21 | 2008-03-21 | Chinese medicine combination with whitening function and uses thereof |
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|---|---|---|---|
| CN200810024411A CN100588389C (en) | 2008-03-21 | 2008-03-21 | Chinese medicine combination with whitening function and uses thereof |
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| Publication Number | Publication Date |
|---|---|
| CN101244022A true CN101244022A (en) | 2008-08-20 |
| CN100588389C CN100588389C (en) | 2010-02-10 |
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| CN200810024411A Active CN100588389C (en) | 2008-03-21 | 2008-03-21 | Chinese medicine combination with whitening function and uses thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406577A (en) * | 2011-11-28 | 2012-04-11 | 广东轻工职业技术学院 | Chinese medicine composite with sun-screening function and preparation method and application of extract thereof |
| CN103876989A (en) * | 2014-04-23 | 2014-06-25 | 上海相宜本草化妆品股份有限公司 | Application of tree peony bark extract to preparation of skin whitening composition for external use and preparation method of tree peony bark extract |
| CN107206039A (en) * | 2014-06-30 | 2017-09-26 | 株式会社爱茉莉太平洋 | The composition for skin whitening of the Baical Skullcap root P.E containing high mountain |
| CN111150673A (en) * | 2020-01-15 | 2020-05-15 | 北京贝丽莱斯生物化学有限公司 | Anti-ultraviolet and anti-blue-light composition and application thereof |
| CN111228200A (en) * | 2020-04-15 | 2020-06-05 | 南京思兰森生物科技有限公司 | Whitening composition, whitening essence containing whitening composition and preparation method of whitening essence |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1166961A (en) * | 1997-05-26 | 1997-12-10 | 邱兵 | Traditional Chinese medicinal buauty liquid capable of eliminating acne and whitening skin |
| CN1257745C (en) * | 2004-04-27 | 2006-05-31 | 涂冲林 | Chinese medicinal composition for treating typhoid |
-
2008
- 2008-03-21 CN CN200810024411A patent/CN100588389C/en active Active
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406577A (en) * | 2011-11-28 | 2012-04-11 | 广东轻工职业技术学院 | Chinese medicine composite with sun-screening function and preparation method and application of extract thereof |
| CN102406577B (en) * | 2011-11-28 | 2013-06-05 | 广东轻工职业技术学院 | Chinese medicine composite with sun-screening function and preparation method and application of extract thereof |
| CN103876989A (en) * | 2014-04-23 | 2014-06-25 | 上海相宜本草化妆品股份有限公司 | Application of tree peony bark extract to preparation of skin whitening composition for external use and preparation method of tree peony bark extract |
| CN107206039A (en) * | 2014-06-30 | 2017-09-26 | 株式会社爱茉莉太平洋 | The composition for skin whitening of the Baical Skullcap root P.E containing high mountain |
| CN111150673A (en) * | 2020-01-15 | 2020-05-15 | 北京贝丽莱斯生物化学有限公司 | Anti-ultraviolet and anti-blue-light composition and application thereof |
| CN111150673B (en) * | 2020-01-15 | 2023-07-04 | 北京贝丽莱斯生物科技有限公司 | Ultraviolet-resistant and blue-light-resistant composition and application thereof |
| CN111228200A (en) * | 2020-04-15 | 2020-06-05 | 南京思兰森生物科技有限公司 | Whitening composition, whitening essence containing whitening composition and preparation method of whitening essence |
| CN111228200B (en) * | 2020-04-15 | 2022-06-17 | 南京思兰森生物科技有限公司 | Whitening composition, whitening essence containing whitening composition and preparation method of whitening essence |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100588389C (en) | 2010-02-10 |
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Effective date of registration: 20200515 Address after: 215500 Xinzhuang section, provincial road 227, Changshu City, Suzhou City, Jiangsu Province Patentee after: Suzhou Crowley Cosmetics Co., Ltd. Address before: 215555 long nilfisk bio Industrial Park, Xinzhuang Town, Jiangsu, Changshou City Patentee before: JIANGSU LONGRICH BIOTECH Co.,Ltd. |
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Address after: 215500 Xinzhuang section of 227 provincial road, Changshu City, Suzhou City, Jiangsu Province Patentee after: Crowley Cosmetics Co.,Ltd. Address before: 215500 Xinzhuang section of 227 provincial road, Changshu City, Suzhou City, Jiangsu Province Patentee before: Suzhou Crowley Cosmetics Co.,Ltd. |
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