CN111150673A - Anti-ultraviolet and anti-blue-light composition and application thereof - Google Patents
Anti-ultraviolet and anti-blue-light composition and application thereof Download PDFInfo
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- CN111150673A CN111150673A CN202010039572.6A CN202010039572A CN111150673A CN 111150673 A CN111150673 A CN 111150673A CN 202010039572 A CN202010039572 A CN 202010039572A CN 111150673 A CN111150673 A CN 111150673A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention provides an anti-ultraviolet and anti-blue-light composition, wherein the composition at least comprises any three of troxerutin, ferulic acid, resveratrol and baicalin; preferably, the composition comprises troxerutin, ferulic acid, resveratrol, baicalin; preferably, the content of the troxerutin is 9-40 wt%, preferably 14-30 wt%, based on the total weight of the composition; the content of the ferulic acid is 5-30 wt%, preferably 6-20 wt%; the content of the resveratrol is 0.8-20 wt%, preferably 2-10 wt%; the content of baicalin is 0.8-10 wt%, preferably 2-8 wt%; wherein the sum of all the components is one hundred percent. The invention also provides the application of the anti-ultraviolet and anti-blue light composition in cosmetics. The composition of the invention can resist ultraviolet rays and blue light with wide-range wave bands; the composition disclosed by the invention has the effects of eliminating inflammatory factors, inhibiting allergic reaction, relieving and repairing skin and resisting oxidation.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to an anti-ultraviolet and anti-blue-light composition and application of the composition in cosmetics.
Background
Sunlight is a resource given to the earth by the sun, and due to the irradiation of the sunlight, all things can grow and lives can be multiplied. Sunlight shines on our skin, which can expand subcutaneous blood vessels, promote blood flow, increase excretion and resistance to toxic substances, increase secretion of saliva and gastric juice, enhance gastrointestinal peristalsis, promote appetite and digestion, and make our body grow healthier.
Ultraviolet rays are classified into three types according to the wavelength of sunlight:
UVA: the ultraviolet ray with the longest wavelength, the wavelength of 320-400nm, is not absorbed by the ozone layer at the top of the atmospheric layer, can penetrate the dermis and can penetrate into the skin more deeply than UVB, so that the skin is tanned, lipid and collagen are damaged, the photoaging of the skin and even skin cancer are caused, and UVA not only can excite pigment synthesis to blacken the skin color, but also is the main reason for the skin aging and fine lines. UVB: the medium-wave ultraviolet ray with the wavelength of 290-320nm can reach the epidermal layer, so that the phenomena of skin sunburn, erythema, suntan and the like can be caused, and the maximum damage (visible damage) can be caused to the upper layer of the skin. UVC: the wavelength is 200-290 nm, UVC can be almost completely absorbed by the atmosphere, and only few cases can be met.
When the skin is subjected to excessive exposure to ultraviolet rays, epidermal cells can be damaged; activating tyrosinase, accelerating pigment synthesis, destroying skin moisture retention function, drying skin, damaging elastic fiber in dermis layer, generating fine lines, and causing skin inflammation and burn under strong irradiation. In the case of an abnormal condition, the skin cancer becomes a pigment-type skin cancer.
Blue light: the light with the wavelength of 400nm-480nm and relatively high energy can penetrate through crystalline lens to reach retina, and atrophy and even death of retinal pigment epithelial cells are caused. For the skin, up to 3 months of melanin pigmentation is caused, and particularly pigmentation is easily generated in the epidermal granular layer and deeper skin layers. Can penetrate deeper into the skin to cause oxidative damage to cellular DNA. Studies have now demonstrated that blue light alters the structure of epidermal cells and also reduces collagen and elastin production. The blue light exists in LED lamps, computer displays (including CCFL and LED), mobile phones, digital products, liquid crystal display screens, bath heaters and other light rays in a large amount, and the harm to human bodies is gradually increased.
Current products for protection against sunlight are mainly chemically synthesized organic sunscreens and physical sunscreens. Most of the chemical sunscreen agents play a role in sunscreen, and can cause damage to skin due to degradation. Some components have poor product compatibility, and stability is easy to cause when the cosmetic is used. The physical sun-screening agent is generally used for shielding ultraviolet rays, and is mostly nano titanium dioxide and nano zinc dioxide, and the particle size of the particle is small, so that the particle is easy to enter skin pores and is not easy to clean.
The plant product has the characteristics of pure nature and safety. In recent years, the protection of plant products from sunlight is increasingly studied. However, at present, the plant products with sunlight protection in the market are relatively lacked, and the plant products only have the protection effect on a single wave band, so the protection effect is not ideal.
In addition, blue light protection is also needed for people with short outdoor activities and long-term indoor work, especially for people who adopt computers to work for a long time. Currently, there is no such product on the market.
Disclosure of Invention
Aiming at the damage of ultraviolet rays and blue light to the skin, the invention provides a composition capable of resisting ultraviolet rays and blue light.
In one aspect, the invention provides an anti-ultraviolet and anti-blue light composition, which is characterized in that the composition at least comprises any three of troxerutin, ferulic acid, resveratrol and baicalin; preferably, the composition comprises troxerutin, ferulic acid, resveratrol, baicalin; preferably, the content of the troxerutin is 9-40 wt%, preferably 14-30 wt%, based on the total weight of the composition; the content of the ferulic acid is 5-30 wt%, preferably 6-20 wt%; the content of the resveratrol is 0.8-20 wt%, preferably 2-10 wt%; the content of baicalin is 0.8-10 wt%, preferably 2-8 wt%; wherein the sum of all the components is one hundred percent.
In another aspect, the present invention provides the use of the above-described UV and blue light resistant composition in cosmetics.
Compared with the prior art, the invention has the following advantages and effects:
1. the composition provided by the invention can resist ultraviolet rays and blue light in a wide range of wave bands (280-440nm wave band), and has a broad-spectrum protection effect; therefore, the damage of UVB, UVA and blue light to the skin can be resisted at the same time, and the requirement of most people on sunlight protection is met.
2. The composition provided by the invention not only can protect light, but also can eliminate inflammatory factors, inhibit allergic reaction, relieve and repair skin and resist oxidation; therefore, can promote the repair after sunburn and has the function of anti-aging.
3. In a preferred embodiment, the compositions of the present invention have natural, safe properties, reduced side effects due to organic synthetic compound sunscreens and physical sunscreens, and are well adapted to the increasing number of people with sensitive skin.
Drawings
Fig. 1 is a uv detection spectrum of the composition provided in example 1.
Fig. 2 is a uv detection spectrum of the composition provided in example 2.
Fig. 3 is a uv detection spectrum of the composition provided in example 3.
Fig. 4 is a uv detection spectrum of the composition provided in example 4.
Fig. 5 is a uv detection spectrum of the composition provided in example 5.
Fig. 6 is a uv detection spectrum of the composition provided in example 6.
Fig. 7 is a uv detection spectrum of the composition provided in example 7.
FIG. 8 is a chart of UV detection of the creams provided in examples 8-11.
FIG. 9 is a graph of light transmittance in the blue band for various concentrations of the composition provided in example 1.
Fig. 10 is a protective test dose distribution.
Figure 11 is a graph of the sun protection effect of low SPF standard P7(SPF ≈ 4.4).
FIG. 12 is a graph of the sunscreen effect of the cream prepared in example 8.
FIG. 13 is a graph of the sunscreen effect of the cream prepared in example 9.
FIG. 14 is a graph of the effect of the cream prepared in example 8 on pre-sun protection and post-sun erythema repair.
FIG. 15 is a graph of the restoration of pre-sun protection and post-sun skin elasticity of the cream prepared in example 8.
FIG. 16 is a graph showing the effect of the cream prepared in example 8 on the restoration of post-sun skin roughness.
Detailed Description
The invention provides an anti-ultraviolet and anti-blue-light composition, which is characterized by at least comprising any three of troxerutin, ferulic acid, resveratrol and baicalin.
Preferably, the content of said troxerutin in said composition may be from 12 to 40% by weight, preferably from 15 to 30% by weight; the ferulic acid may be present in the composition in an amount of 7-30 wt%, preferably 8-20 wt%; the resveratrol may be present in the composition in an amount of 1-20 wt%, preferably 2-10 wt%; the baicalin may be contained in the composition in an amount of 1-10 wt%, preferably 2-8 wt%.
The inventor finds that the composition has better ultraviolet resistance and blue light resistance.
In order to further enhance the anti-uv and anti-blue light effects, preferably, the composition comprises troxerutin, ferulic acid, resveratrol, baicalin; preferably, the content of the troxerutin is 9-40 wt%, preferably 14-30 wt%, based on the total weight of the composition; the content of the ferulic acid is 5-30 wt%, preferably 6-20 wt%; the content of the resveratrol is 0.8-20 wt%, preferably 2-10 wt%; the content of baicalin is 0.8-10 wt%, preferably 2-8 wt%; wherein the sum of all the components is one hundred percent.
In order to further enhance the anti-UV and anti-blue light effect, in a preferred embodiment, the composition further comprises one or more of quercetin, 4-hydroxy-3-butylphyllolide, emodin and baicalein.
In order to further enhance the anti-uv and anti-blue light effects, in a preferred embodiment, the composition further comprises quercetin, 4-hydroxy-3-butylphilin, emodin and baicalein; preferably, the content of quercetin is 1-10 wt% of the troxerutin, the content of 4-hydroxy-3-butyl-dense lactone is 1-10 wt% of the ferulic acid, the content of emodin is 1-10 wt% of the resveratrol, and the content of baicalein is 1-10 wt% of the baicalin.
In order to further enhance the anti-uv and anti-blue light effects, in a preferred embodiment, the troxerutin is derived from sophora flower bud extract, the ferulic acid is derived from ligusticum chuanxiong hort extract, the resveratrol is derived from polygonum cuspidatum extract, and the baicalin is derived from scutellaria baicalensis extract.
In one embodiment, the sophora flower bud extract is present in an amount of 10-45 wt%, preferably 15-30 wt%, based on the total weight of the composition; the content of the ligusticum chuanxiong hort extract is 7-35 wt%, and preferably 10-25 wt%; the content of the giant knotweed extract is 1-25%, preferably 2-20% by weight; the content of the scutellaria baicalensis extract is 1-15 wt%, preferably 2-10 wt%.
The flos Sophorae Immaturus extract mainly contains troxerutin (rutin), quercetin, etc. The flos Sophorae Immaturus extract has effects of scavenging free radicals, enhancing skin vessel wall elasticity and toughness, reducing permeability, relieving red blood streak, and resisting bacteria and inflammation.
The rhizoma Ligustici Chuanxiong extract mainly contains ferulic acid, 4-hydroxy-3-butyl-dense lactone, etc. The rhizoma Ligustici Chuanxiong extract has antioxidant activity, can promote the generation of free radical scavenging enzyme, relieve radiation injury, inhibit tyrosinase activity, and has antibacterial and antiinflammatory effects.
The rhizoma Polygoni Cuspidati extract mainly contains resveratrol and emodin. The rhizoma Polygoni Cuspidati extract has effects of inhibiting lipid peroxidation, inhibiting melanin generation, promoting collagen synthesis, and resisting inflammation.
The Scutellariae radix extract mainly contains baicalin, baicalein, etc. The Scutellariae radix extract has effects in resisting inflammation and anaphylaxis, inhibiting bacteria, and scavenging free radicals.
The flos Sophorae Immaturus extract, rhizoma Ligustici Chuanxiong extract, rhizoma Polygoni Cuspidati extract, and Scutellariae radix extract can be obtained commercially.
In order to promote the dissolution of the ligusticum chuanxiong hort extract, the polygonum cuspidatum extract or the scutellaria baicalensis extract in the composition, in a preferred embodiment, the ligusticum chuanxiong hort extract, the polygonum cuspidatum extract or the scutellaria baicalensis extract is present in the form of microcapsules. Microcapsules of these extracts can be prepared according to the prior art, wherein the capsule material can be any material from which microcapsules are prepared, preferably hydroxypropyl cyclodextrin and/or chitosan.
In a preferred embodiment, the scutellaria baicalensis extract is in the form of microcapsule, and the capsule material is hydroxypropyl cyclodextrin and/or chitosan.
In a preferred embodiment, the microcapsule containing scutellaria baicalensis extract comprises the following ingredients: based on the total weight of the microcapsule containing the scutellaria baicalensis extract, the content of baicalin is 10-20 wt%, the content of capsule wall material is 80-90 wt%, the content of acid is 0.3-0.7 wt%, and the total weight of each component is one hundred percent. The capsule wall material can be hydroxypropyl cyclodextrin and chitosan; the acid may be organic and inorganic acids such as acetic acid, hydrochloric acid, sulfuric acid, phosphoric acid, and the like. In a preferred embodiment, the acid is arginine.
In a preferred embodiment, the microcapsule containing the scutellaria baicalensis extract is prepared by the following method: dispersing Scutellariae radix extract in solvent, adding acid to adjust pH to 6-7.5, preferably 6.5-7, heating to 45-60 deg.C, preferably 50-60 deg.C, adding capsule wall material, stirring to dissolve completely, cooling, filtering, and drying.
The solvent is various solvents that can dissolve the scutellaria baicalensis extract, but is preferably water, and more preferably deionized water.
The inventors found that the dissolution effect of the scutellaria baicalensis extract is very good when the pH of the solution is 6 to 7.5.
The temperature of cooling may be room temperature, but is preferably 5-10 deg.C, for example 6 deg.C.
The temperature of drying may be 50-80 ℃ but is preferably 50-60 ℃.
The capsule wall material can be any material for preparing microcapsules, preferably hydroxypropyl cyclodextrin and/or chitosan; preferably, the capsule wall material is hydroxypropyl cyclodextrin and/or chitosan.
The acid may be any organic and inorganic acid, such as acetic acid, hydrochloric acid, sulfuric acid, phosphoric acid, and the like. In a preferred embodiment, the acid is arginine.
In one embodiment, the composition further comprises a solvent; preferably, the composition is prepared by the steps of: heating solvent to 40-50 deg.C, adding flos Sophorae Immaturus extract, rhizoma Ligustici Chuanxiong extract and rhizoma Polygoni Cuspidati extract, stirring for 5-10 min, adding microcapsule containing Scutellariae radix extract, and stirring to dissolve completely.
In one embodiment, the composition comprises 10-17 wt% of sophora flower bud extract, 7-11 wt% of ligusticum chuanxiong hort extract, 1-5 wt% of polygonum cuspidatum extract, 10-22 wt% of microcapsule containing scutellaria baicalensis extract, 27-33 wt% of ethoxydiglycol, and 20-25 wt% of water.
The solvent may be any solvent used in cosmetics, and in a preferred embodiment, the solvent is ethoxydiglycol and water; when ethoxydiglycol and water are used as solvents, the sophora flower bud extract, the ligusticum chuanxiong hort extract, the polygonum cuspidatum extract and the microcapsule containing the scutellaria baicalensis extract are very well dissolved. In a preferred embodiment, the ethoxydiglycol is present in an amount of 25 to 35 wt.%, and the water is present in an amount of 20 to 25 wt.%, based on the total weight of the composition.
The composition may also contain antiseptic, which may be one or more of phenoxyethanol, ethyl hexyl glycerol, methyl paraben, p-hydroxyacetophenone, pentanediol, caprylyl glycol, hexanediol, etc. at any ratio. The preservative may be present in an amount of 0.1 to 1% by weight, for example, 0.5% by weight, based on the total weight of the composition.
The invention also relates to the use of the above composition in cosmetics.
In a preferred embodiment, the composition is present in the cosmetic product in an amount of from 2 to 20% by weight, preferably from 2 to 10% by weight.
The cosmetic may be a lotion, cream product.
In the cosmetic, lecithin, glyceryl stearate, ceteareth-25 may be used as an emulsifier; isononyl isononanoate can be used as an oil; glycerin and hydroxyethyl urea can be used as moisturizers; tocopherol acetate can also be added as an antioxidant; an ammonium acryloyldimethyltaurate/VP copolymer may be used as the thickener.
The present invention also provides an anti-uv and anti-blue cream, wherein the cream contains 2-20 wt% of the anti-uv and anti-blue composition.
In order to facilitate a better understanding of the invention, reference is made to the following examples. These examples belong to the scope of protection of the present invention, but do not limit the scope of protection of the present invention.
Examples 1 to 7: preparation of anti-UV and anti-blue light composition
1. Preparing microcapsules containing scutellaria baicalensis extracts: dispersing 15 g of scutellaria baicalensis extract powder (14 g of baicalin) into a proper amount of deionized water, adding 0.5 g of arginine to adjust the pH value of the solution to be 6.5, heating the solution to 60 ℃, adding 84.5 g of hydroxypropyl cyclodextrin, stirring until the hydroxypropyl cyclodextrin is completely dissolved, and cooling at 6 ℃ to obtain the microcapsule containing the scutellaria baicalensis extract. Filtering, and rotary evaporating at 60 deg.C to obtain dry powder;
2. preparation of uv-and blue-light-resistant compositions: mixing 30 g of ethoxydiglycol and 23 g of water uniformly, heating to 45 ℃, keeping the temperature constant and stirring, slowly adding 15 g of sophora flower bud extract powder (14 g of troxerutin), 9 g of ligusticum chuanxiong hort extract powder (8 g of ferulic acid) and 3 g of polygonum cuspidatum extract powder (2.7 g of resveratrol), stirring for 5 minutes, adding 20 g of microcapsule containing scutellaria baicalensis extract (2.7 g of baicalin), and continuously stirring until the components are completely dissolved.
Example 2
1. Preparing microcapsules containing scutellaria baicalensis extracts: dispersing 15 g of scutellaria baicalensis extract powder (14 g of baicalin) into a proper amount of deionized water, adding 0.5 g of arginine to adjust the pH value of the solution to be 6.5, heating the solution to 60 ℃, adding 84.5 g of hydroxypropyl cyclodextrin, stirring until the hydroxypropyl cyclodextrin is completely dissolved, and cooling at 6 ℃ to obtain the microcapsule containing the scutellaria baicalensis extract. Filtering, and rotary evaporating at 60 deg.C to obtain dry powder;
2. preparation of uv-and blue-light-resistant compositions: mixing 38 g of ethoxydiglycol and 26 g of water, heating to 45 ℃, keeping the temperature constant, stirring, slowly adding 12 g of sophora flower bud extract powder (11 g of troxerutin), 7 g of ligusticum chuanxiong hort extract powder (6 g of ferulic acid) and 2 g of polygonum cuspidatum extract powder (1.8 g of resveratrol), stirring for 10 minutes, adding 15 g of microcapsules containing scutellaria baicalensis extracts (2 g of baicalin), and continuously stirring until the microcapsules are completely dissolved.
Example 3
1. Preparing microcapsules containing scutellaria baicalensis extracts: dispersing 15 g of scutellaria baicalensis extract powder (14 g of baicalin) into a proper amount of deionized water, adding 0.5 g of arginine to adjust the pH value of the solution to be 6.5, heating the solution to 60 ℃, adding 84.5 g of hydroxypropyl cyclodextrin, stirring until the hydroxypropyl cyclodextrin is completely dissolved, and cooling at 6 ℃ to obtain the microcapsule containing the scutellaria baicalensis extract. Filtering, and rotary evaporating at 60 deg.C to obtain dry powder;
2. preparation of uv-and blue-light-resistant compositions: mixing 42 g of ethoxydiglycol and 32 g of water uniformly, heating to 45 ℃, keeping the temperature constant, stirring, slowly adding 10 g of sophora flower bud extract powder (9 g of troxerutin), 5 g of ligusticum chuanxiong hort extract powder (6 g of ferulic acid) and 1 g of polygonum cuspidatum extract powder (0.9 g of resveratrol), stirring for 10 minutes, adding 10 g of microcapsule containing scutellaria baicalensis extract (1.4 g of baicalin), and continuously stirring until the components are completely dissolved.
Example 4
Preparation of uv-and blue-light-resistant compositions: mixing 41 g of ethoxydiglycol and 31 g of water uniformly, heating to 45 ℃, keeping the temperature constant and stirring, slowly adding 20 g of sophora flower bud extract powder (18 g of troxerutin), 5 g of ligusticum chuanxiong hort extract powder (6 g of ferulic acid) and 3 g of polygonum cuspidatum extract powder (2.7 g of resveratrol), stirring for 10 minutes, and continuing stirring until the materials are completely dissolved.
Example 5
1. Preparing microcapsules containing scutellaria baicalensis extracts: dispersing 15 g of scutellaria baicalensis extract powder (14 g of baicalin) into a proper amount of deionized water, adding 0.5 g of arginine to adjust the pH value of the solution to be 6.5, heating the solution to 60 ℃, adding 84.5 g of hydroxypropyl cyclodextrin, stirring until the hydroxypropyl cyclodextrin is completely dissolved, and cooling at 6 ℃ to obtain the microcapsule containing the scutellaria baicalensis extract. Filtering, and rotary evaporating at 60 deg.C to obtain dry powder;
2. preparation of uv-and blue-light-resistant compositions: mixing 33 g of ethoxydiglycol and 20 g of water uniformly, heating to 45 ℃, keeping the temperature and stirring, slowly adding 15 g of sophora flower bud extract powder (13 g of troxerutin) and 12 g of ligusticum chuanxiong hort extract powder (11 g of ferulic acid), stirring for 10 minutes, adding 10 g of microcapsule containing scutellaria baicalensis extract (1.4 g of baicalin), and continuously stirring until the mixture is completely dissolved.
Example 6
1. Preparing microcapsules containing scutellaria baicalensis extracts: dispersing 15 g of scutellaria baicalensis extract powder (14 g of baicalin) into a proper amount of deionized water, adding 0.5 g of arginine to adjust the pH value of the solution to be 6.5, heating the solution to 60 ℃, adding 84.5 g of hydroxypropyl cyclodextrin, stirring until the hydroxypropyl cyclodextrin is completely dissolved, and cooling at 6 ℃ to obtain the microcapsule containing the scutellaria baicalensis extract. Filtering, and rotary evaporating at 60 deg.C to obtain dry powder;
2. preparation of uv-and blue-light-resistant compositions: mixing 36 g ethoxydiglycol and 24 g water, heating to 45 deg.C, stirring at constant temperature, slowly adding flos Sophorae Immaturus extract powder 15 g (troxerutin 13 g) and rhizoma Polygoni Cuspidati extract powder 5 g (resveratrol 4.5 g), stirring for 10 min, adding microcapsule containing Scutellariae radix extract 20 g (baicalin 2.7 g), and stirring to dissolve completely.
Example 7
1. Preparing microcapsules containing scutellaria baicalensis extracts: dispersing 15 g of scutellaria baicalensis extract powder (14 g of baicalin) into a proper amount of deionized water, adding 0.5 g of arginine to adjust the pH value of the solution to be 6.5, heating the solution to 60 ℃, adding 84.5 g of hydroxypropyl cyclodextrin, stirring until the hydroxypropyl cyclodextrin is completely dissolved, and cooling at 6 ℃ to obtain the microcapsule containing the scutellaria baicalensis extract. Filtering, and rotary evaporating at 60 deg.C to obtain dry powder;
2. preparation of uv-and blue-light-resistant compositions: mixing 35 g ethoxydiglycol and 21 g water, heating to 45 deg.C, stirring at constant temperature, slowly adding rhizoma Ligustici Chuanxiong extract powder 9 g (ferulic acid 8 g) and rhizoma Polygoni Cuspidati extract powder 5 g (resveratrol 4.5 g), stirring for 10 min, adding microcapsule containing Scutellariae radix extract 20 g (baicalin 2.7 g), and stirring to dissolve completely.
Examples 8 to 11: cream containing 5%, 10%, 15% and 20% of the composition prepared in example 1 was prepared
Preparing a cream base: lecithin (1.8 wt%), glycerol stearate (1.35 wt%), emulsifier ceteareth-25 (1.25 wt%), isononyl isononanoate (5 wt%), glycerol (5 wt%), humectant hydroxyethyl urea (0.8 wt%), antioxidant tocopherol acetate (2 wt%), thickener ammonium acryloyldimethyltaurate/VP copolymer (1.3 wt%), water (81.5 wt%) were mixed well.
The compositions prepared in example 1 were mixed uniformly with 95 parts by weight, 90 parts by weight, 85 parts by weight and 80 parts by weight of the cream bases prepared above, to obtain creams of examples 8 to 11, respectively 5 parts by weight, 10 parts by weight, 15 parts by weight and 20 parts by weight.
And (3) performance testing:
examples 12 to 18: UV detection spectra of UV and blue light resistant compositions prepared in examples 1-7
1. Instruments and materials
An ultraviolet/visible spectrophotometer; an analytical balance; quartz pool
2. Experimental procedure
(1) Taking a solution of ethylhexyl methoxycinnamate (MC80) with the concentration of 0.01 per mill prepared by using a proper amount of ethanol as a control group;
(2) taking a proper amount of water, preparing 0.02 per mill, 0.04 per mill and 0.06 per mill of solutions of the anti-ultraviolet and anti-blue light compositions prepared in the examples 1 to 7 respectively as an experimental group;
(2) switching on a power supply of an ultraviolet spectrophotometer instrument and preheating, and setting a detection wavelength: 280 nm-400 nm;
(3) placing the quartz cuvette filled with the solvent in a photometer, and adjusting the zero point of the instrument;
(4) and sequentially detecting ultraviolet absorption peak images of a control group and an experimental group with prepared gradient concentration content.
3. Results of the experiment
The results of the UV detection spectra of the compositions prepared in examples 1-7 are shown in FIGS. 1-7, respectively: the compositions prepared in examples 1-7 all have higher absorption at 280 nm-400 nm, especially after 340nm, the absorption value is obviously higher than that of the standard sample.
Examples 19 to 22: detection of ultraviolet detection spectra and ultraviolet absorbance values of the creams prepared in examples 8 to 11
1. Instruments and materials
An ultraviolet/visible spectrophotometer; an analytical balance; a quartz cell; medical adhesive tape manufactured by American 3M company
2. Experimental procedure
(1) Cutting a medical latex tape produced by 3M company into a rectangle of 1cm X4 cm, and pasting a pasting surface on the surface of the light-transmitting side of a quartz cell;
(2) switching on a power supply of an ultraviolet spectrophotometer instrument and preheating, and setting a detection wavelength: 280 nm-400 nm (280, 290, 300, 310, 320 … …);
(3) placing the quartz cuvette pasted with the adhesive tape in a photometer, and adjusting the zero point of the photometer;
(4) a cream sample prepared in example 8 to 11 was applied to the surface of a quartz cell to which an adhesive tape was attached, to be precisely weighed (8X 0.2 mg) with a glass rod, and the sample was applied uniformly after being fitted with a medical latex finger cot. Weighing five parallel samples;
(5) placing the cuvette coated with the sample under sunlight for 30min and 60min at room temperature to be detected;
(6) measuring ultraviolet absorbance value A of 280 nm-400 nm (280, 290, 300, 310, 320 … …) wavelength in a cuvette photometer coated with a sample to be measurediThe measured values are arithmetically averaged to
(7) Five parallel samples are sequentially measured, and
calculating the arithmetic average value, namely the ultraviolet absorbance of the sample
3. Data processing
The test results of the raw materials for UVB band protection are calculated as follows:
the test results of the raw materials for UVA band protection are calculated as follows:
in the formula: a. theiThe ultraviolet absorbance values measured at each wavelength for sample No. i.
Evaluation of sample test results:
if it is
If the sun protection effect is less than 0.5, judging that the sun protection effect of the sample is lower than the minimum protection effect or no protection effect; if it is
If not less than 0.5, the sample is judged to have the effect of preventingAnd (4) protecting.
4. Test results and analysis
The results of the measurement are shown in FIG. 8, and the values of ultraviolet absorbance are shown in Table 1
TABLE 1 UV absorbance values of protective creams for samples of examples 8-11
According to the evaluation method of the sunscreen effect of the UVB region of QB/T2410-1998 sunscreen cosmetic, 10% of the protective cream of the sample in the example 1 is added, the average value of the absorbance of the protective cream in the UVB wave band exceeds 0.5, the minimum protective ultraviolet light effect is achieved, and the protective cream is suitable for being used in winter sunlight, summer sunlight in the morning and evening and cloudy environment.
Example 23: in vitro blue light protection efficacy of the UV and blue light resistant compositions prepared in example 1 were tested
1. Instruments and materials
An ultraviolet/visible spectrophotometer; an analytical balance; quartz pool
2. Experimental procedure
(1) Taking a proper amount of deionized water, and preparing 0.1%, 0.25%, 0.7%, 2% and 5% concentration of aqueous solution of the ultraviolet-resistant and blue-light-resistant composition prepared in the example 1;
(2) switching on a power supply of an ultraviolet spectrophotometer instrument and preheating, and setting a detection wavelength: 400 nm-500 nm;
(3) placing the quartz cuvette filled with deionized water in a photometer, and adjusting the zero point of the photometer;
(4) the transmittance of the aqueous solution of the sample of the ultraviolet and blue light resistant composition prepared in example 1 having the configured gradient concentration content was sequentially measured.
3. The detection results are shown in fig. 9.
As can be seen from fig. 9, when the concentration of the uv and blue light resistant composition prepared in example 1 was 0.25%, the transmittance at a wavelength of 400nm was zero and the effect of preventing damage to blue light began to be achieved; when the concentration of the uv and blue light resistant composition prepared in example 1 was 5%, the light transmittance at a wavelength of 440nm was nearly zero, and the blue light was substantially completely absorbed, and the blue light was substantially completely protected in the wavelength range where damage to the skin occurred.
Example 24: the in vitro photoprotective efficacy of the creams prepared in examples 8-9 was tested
1. Testing method for SPF value according to cosmetic safety technical Specification of 2015 edition
a. In the evaluation test of sun protection efficacy of human body, the following are defined:
(1) left arm test zones ① through ④ are unprotected zones that are not treated;
(2) right arm test areas ⑥ through ⑩ are applied sunscreen (2 mg/cm)2) A rear zone of protection;
and after the tested areas are irradiated by ultraviolet rays with different doses, the minimum erythema dose is observed within 16-24 hours.
b. In the post-sun repair efficacy evaluation test, the following are defined:
(1) region ④ is the UVB-only radiation group (natural metabolome);
(2) area ⑤ is post-UVB irradiation + cream repair prepared in examples 8-9 (repair group);
(3) area ⑨ is post-protection + UVB radiation for creams prepared in examples 8-9 (protection group);
data (a x, R2, SEr) were measured for each test area of volunteers after 1 day, 1 week and 2 weeks of testing.
Note: the instrument is a sigma SH-1B type ultraviolet therapeutic instrument (UVB peak value is 311nm, and irradiation intensity is 13 mW/cm)2)
The protective test dose profile 10 is shown.
2. Analysis of results
2.1 evaluation of the Sun protection efficacy of Low SPF Standard P7(SPF ≈ 4.4)
The detection results are shown in fig. 11: the red frame of the left arm is a slightly reddish area which is irradiated by UVB for 69 seconds and appears on the next day after being not treated; the red frame of the right arm is filled with 2mg/cm2After the sunscreen cream is smeared, a slightly reddened area appears on the next day after UVB irradiation for 253 seconds; thus, the low SPF label P7 is resistant to about 3.67Multiple doses of UVB irradiation without severe tanning.
2.2 evaluation results of sunscreen efficacy in human of the cream prepared in example 8
The detection results are shown in fig. 12: the red frame of the left arm is a slightly reddish area which is irradiated by UVB for 23 seconds and appears on the next day after being not treated; the red frame of the right arm is filled with 2mg/cm2After the sunscreen cream is smeared, a slightly reddened area appears on the next day after UVB irradiation for 69 seconds; thus, 5% of the samples of example 1 were resistant to approximately 3 times the dose of UVB radiation without severe tanning.
2.3 evaluation results of sunscreen efficacy in human of the cream prepared in example 9
The detection results are shown in fig. 13: the red frame of the left arm is a slightly reddish area which is irradiated by UVB for 46 seconds and appears on the next day after being not treated; the red frame of the right arm is filled with 2mg/cm2After the sunscreen cream is applied, the slightly reddened area appears on the next day after UVB irradiation for 230 seconds; thus, 10% of the samples of example 1 were resistant to approximately 5 times the dose of UVB radiation without severe tanning.
2.4 Effect of the cream samples prepared in example 8 on redness of skin after UV irradiation
The detection results are shown in fig. 14.
The cream samples prepared in example 8 were applied before UVB irradiation, and the generation of erythema was reduced by 101.52% the next day.
The cream samples prepared in example 8 were applied after UVB irradiation, and the generation of erythema was reduced by 19.29% the next day; after 1 week, the generation of 19.54% of erythema can be reduced; after 2 weeks, the production of erythema dose was reduced by 35.82%.
2.5 Effect of cream samples prepared in example 8 on the elasticity of skin after UV irradiation
The detection results are shown in fig. 15.
The next day when the cream samples prepared in example 8 were applied before UVB irradiation, 103.43% of the skin elastic damage was reduced.
The next day the cream samples prepared in example 8 were applied after UVB irradiation to reduce skin elastic damage by 39.57%; after 1 week, 66.19% of skin elastic damage can be reduced; after 2 weeks, 67.51% of the skin elastic damage was reduced.
2.6 Effect of the cream samples prepared in example 8 on skin roughening after UV irradiation
The detection results are shown in fig. 16.
After 1 week, the cream samples prepared in example 8 were applied and improved in skin roughness by 95.56% after 2 weeks and 107.14% after UVB irradiation.
Claims (10)
1. An anti-ultraviolet and anti-blue light composition, characterized in that the composition at least comprises any three of troxerutin, ferulic acid, resveratrol and baicalin; preferably, the composition comprises troxerutin, ferulic acid, resveratrol, baicalin; preferably, the content of the troxerutin is 9-40 wt%, preferably 14-30 wt%, based on the total weight of the composition; the content of the ferulic acid is 5-30 wt%, preferably 6-20 wt%; the content of the resveratrol is 0.8-20 wt%, preferably 2-10 wt%; the content of baicalin is 0.8-10 wt%, preferably 2-8 wt%; wherein the sum of all the components is one hundred percent.
2. The composition of claim 1, wherein said composition further comprises one or more of quercetin, 4-hydroxy-3-butyl-dense lactone, emodin and baicalein.
3. The composition of claim 2, wherein said composition further comprises quercetin, 4-hydroxy-3-butyl-dense lactone, emodin and baicalein; preferably, the content of quercetin is 1-10 wt% of the troxerutin, the content of 4-hydroxy-3-butyl-dense lactone is 1-10 wt% of the ferulic acid, the content of emodin is 1-10 wt% of the resveratrol, and the content of baicalein is 1-10 wt% of the baicalin.
4. The composition according to any one of claims 1-3, wherein the troxerutin is derived from sophora flower bud extract, the ferulic acid is derived from ligusticum chuanxiong hort extract, the resveratrol is derived from polygonum cuspidatum extract, and the baicalin is derived from scutellaria baicalensis extract.
5. The composition of any one of claims 4, wherein the Ligusticum chuanxiong Hort extract, the Polygonum cuspidatum extract, or the Scutellaria baicalensis extract is in the form of microcapsules.
6. The composition according to any one of claim 4, wherein the Scutellariae radix extract is in the form of microcapsule, and the capsule material is hydroxypropyl cyclodextrin and/or chitosan.
7. The composition according to any one of claims 6, wherein the microcapsule containing Scutellaria baicalensis Georgi extract is prepared by the following method: dispersing Scutellariae radix extract in solvent, adding acid to adjust pH to 6-7.5, heating to 45-60 deg.C, adding capsule wall material, stirring to dissolve completely, cooling, filtering, and drying; preferably, the capsule wall material is hydroxypropyl cyclodextrin and/or chitosan; preferably, the acid is arginine; preferably, the solvent is water.
8. The composition according to any one of claim 6, wherein the composition further comprises a solvent, preferably the solvent is ethoxydiglycol and water; preferably, the content of the ethoxy diglycol is 25-35 wt%, and the content of the water is 20-25 wt%; preferably the composition is prepared by the steps of: heating solvent to 40-50 deg.C, adding flos Sophorae Immaturus extract, rhizoma Ligustici Chuanxiong extract and rhizoma Polygoni Cuspidati extract, stirring for 5-10 min, adding microcapsule containing Scutellariae radix extract, and stirring to dissolve completely.
9. Use of a composition according to any one of claims 1 to 8 in cosmetics.
10. Use according to claim 9, wherein the composition is present in the cosmetic product in an amount of from 2 to 20% by weight.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113925809A (en) * | 2021-10-08 | 2022-01-14 | 广州葆妍生物科技有限公司 | Blue light resistant composition and preparation method and application thereof |
| KR102389476B1 (en) * | 2021-08-30 | 2022-04-25 | 김준석 | Organic compound for blocking blue light |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101244022A (en) * | 2008-03-21 | 2008-08-20 | 江苏隆力奇生物科技股份有限公司 | Chinese medicine combination with whitening function and uses thereof |
| CN101467938A (en) * | 2007-12-27 | 2009-07-01 | 天津天阜康生物技术发展有限公司 | Chinese medicine sun cream and preparation method thereof |
| EP2522329A1 (en) * | 2011-05-09 | 2012-11-14 | DSM IP Assets B.V. | Use of resveratrol and arbutin |
| CN105407720A (en) * | 2012-10-12 | 2016-03-16 | 莱雅公司 | Cosmetic compositions containing at least one flavonoid and ferulic acid |
| CN107157823A (en) * | 2017-04-07 | 2017-09-15 | 浙江工业大学 | A kind of nano liposomes ultra light sun block lotion and preparation method thereof |
| CN108904316A (en) * | 2018-08-17 | 2018-11-30 | 江西中医药大学 | Natural whiting antioxidant composition and nanogel cosmetics prepared therefrom |
| CN109689012A (en) * | 2016-03-31 | 2019-04-26 | 莱雅公司 | Photo-stable composition and application method |
| CN110403871A (en) * | 2019-08-29 | 2019-11-05 | 北昊干细胞与再生医学研究院有限公司 | It is a kind of to have effects that anti-blue light, the composition repaired and the preparation method and application thereof |
-
2020
- 2020-01-15 CN CN202010039572.6A patent/CN111150673B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101467938A (en) * | 2007-12-27 | 2009-07-01 | 天津天阜康生物技术发展有限公司 | Chinese medicine sun cream and preparation method thereof |
| CN101244022A (en) * | 2008-03-21 | 2008-08-20 | 江苏隆力奇生物科技股份有限公司 | Chinese medicine combination with whitening function and uses thereof |
| EP2522329A1 (en) * | 2011-05-09 | 2012-11-14 | DSM IP Assets B.V. | Use of resveratrol and arbutin |
| CN105407720A (en) * | 2012-10-12 | 2016-03-16 | 莱雅公司 | Cosmetic compositions containing at least one flavonoid and ferulic acid |
| CN109689012A (en) * | 2016-03-31 | 2019-04-26 | 莱雅公司 | Photo-stable composition and application method |
| CN107157823A (en) * | 2017-04-07 | 2017-09-15 | 浙江工业大学 | A kind of nano liposomes ultra light sun block lotion and preparation method thereof |
| CN108904316A (en) * | 2018-08-17 | 2018-11-30 | 江西中医药大学 | Natural whiting antioxidant composition and nanogel cosmetics prepared therefrom |
| CN110403871A (en) * | 2019-08-29 | 2019-11-05 | 北昊干细胞与再生医学研究院有限公司 | It is a kind of to have effects that anti-blue light, the composition repaired and the preparation method and application thereof |
Non-Patent Citations (3)
| Title |
|---|
| 冯娇等: "具有防晒功能的植物源成分研究进展", 《日用化学品科学》 * |
| 吴骏等: "双黄槐防晒乳膏的研制", 《中国药师》 * |
| 戚秀中等: "具有抗紫外线皮肤损伤作用的常用中药", 《中国美容医学》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102389476B1 (en) * | 2021-08-30 | 2022-04-25 | 김준석 | Organic compound for blocking blue light |
| CN113925809A (en) * | 2021-10-08 | 2022-01-14 | 广州葆妍生物科技有限公司 | Blue light resistant composition and preparation method and application thereof |
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