CN114450407A - 包含抗-间质表皮转化因子抗体或其抗原结合片段的嵌合抗原受体及其用途 - Google Patents
包含抗-间质表皮转化因子抗体或其抗原结合片段的嵌合抗原受体及其用途 Download PDFInfo
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- CN114450407A CN114450407A CN202080067658.8A CN202080067658A CN114450407A CN 114450407 A CN114450407 A CN 114450407A CN 202080067658 A CN202080067658 A CN 202080067658A CN 114450407 A CN114450407 A CN 114450407A
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- A61K40/31—Chimeric antigen receptors [CAR]
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- A61K40/4209—Hepatocyte growth factor receptor [HGFR] or c-met]
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C12N5/0602—Vertebrate cells
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- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- General Chemical & Material Sciences (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2019-0119148 | 2019-09-26 | ||
| KR1020190119148A KR102685211B1 (ko) | 2019-09-26 | 2019-09-26 | 항-c-Met 항체 또는 그의 항원 결합 단편을 포함하는 키메라 항원 수용체, 및 이의 용도 |
| PCT/KR2020/013127 WO2021060932A1 (ko) | 2019-09-26 | 2020-09-25 | 항-c-met 항체 또는 그의 항원 결합 단편을 포함하는 키메라 항원 수용체, 및 이의 용도 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114450407A true CN114450407A (zh) | 2022-05-06 |
Family
ID=75164878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080067658.8A Pending CN114450407A (zh) | 2019-09-26 | 2020-09-25 | 包含抗-间质表皮转化因子抗体或其抗原结合片段的嵌合抗原受体及其用途 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US12570719B2 (https=) |
| EP (1) | EP4039703A4 (https=) |
| JP (1) | JP7373242B2 (https=) |
| KR (1) | KR102685211B1 (https=) |
| CN (1) | CN114450407A (https=) |
| WO (1) | WO2021060932A1 (https=) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106008721A (zh) * | 2016-08-09 | 2016-10-12 | 安徽未名细胞治疗有限公司 | 一种c-Met特异性嵌合抗原受体及其应用 |
| CN107108737A (zh) * | 2014-08-07 | 2017-08-29 | 药物抗体公司 | c‑met特异性人抗体及其制备方法 |
| CN108601834A (zh) * | 2016-02-05 | 2018-09-28 | 百疗医株式会社 | 抗间质-上皮细胞转化因子抗体及其用途 |
| CN109422815A (zh) * | 2017-08-28 | 2019-03-05 | 复旦大学 | 双特异性嵌合抗原受体c-Met/PD-1 scFv-CAR-T及其构建方法和应用 |
| US20210130456A1 (en) * | 2019-11-01 | 2021-05-06 | East Tennessee State University Research Foundation | Single-chain variable fragment of met monoclonal antibody and methods of use in car t cell therapy |
| CN113166244A (zh) * | 2018-11-14 | 2021-07-23 | 赫利世弥斯株式会社 | 稳定性得到提高的抗c-肝细胞生长因子受体抗体或其抗原结合片段 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
| KR20000006334A (ko) | 1998-06-26 | 2000-01-25 | 이선경 | 바이러스코딩염기서열이전혀없는고효율레트로바이러스벡터 |
| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| KR102042174B1 (ko) * | 2013-03-29 | 2019-11-08 | 삼성전자주식회사 | 인간화 및 친화도 성숙된 항 c-Met 항체 및 그의 용도 |
| CN109153975A (zh) * | 2015-12-28 | 2019-01-04 | 诺华股份有限公司 | 制备嵌合抗原受体表达细胞的方法 |
| US20180257300A1 (en) | 2017-03-09 | 2018-09-13 | Applied Materials, Inc. | Additive manufacturing with energy delivery system having rotating polygon and adjustment of angle of light path |
| CN108341881B (zh) | 2018-01-31 | 2020-08-18 | 深圳市默赛尔生物医学科技发展有限公司 | 带安全开关的嵌合抗原受体及其表达基因、其修饰的nk细胞及应用 |
| CN108707198A (zh) | 2018-06-28 | 2018-10-26 | 李永海 | 识别人c-Met蛋白的人源单链抗体、诊断试剂及其CAR-T细胞制剂 |
| KR102077987B1 (ko) * | 2018-12-19 | 2020-02-17 | 주식회사 헬릭스미스 | 신장 질환 진단용 바이오 마커 |
-
2019
- 2019-09-26 KR KR1020190119148A patent/KR102685211B1/ko active Active
-
2020
- 2020-09-25 JP JP2022519423A patent/JP7373242B2/ja active Active
- 2020-09-25 EP EP20868836.6A patent/EP4039703A4/en active Pending
- 2020-09-25 US US17/763,712 patent/US12570719B2/en active Active
- 2020-09-25 CN CN202080067658.8A patent/CN114450407A/zh active Pending
- 2020-09-25 WO PCT/KR2020/013127 patent/WO2021060932A1/ko not_active Ceased
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107108737A (zh) * | 2014-08-07 | 2017-08-29 | 药物抗体公司 | c‑met特异性人抗体及其制备方法 |
| CN108601834A (zh) * | 2016-02-05 | 2018-09-28 | 百疗医株式会社 | 抗间质-上皮细胞转化因子抗体及其用途 |
| CN106008721A (zh) * | 2016-08-09 | 2016-10-12 | 安徽未名细胞治疗有限公司 | 一种c-Met特异性嵌合抗原受体及其应用 |
| CN109422815A (zh) * | 2017-08-28 | 2019-03-05 | 复旦大学 | 双特异性嵌合抗原受体c-Met/PD-1 scFv-CAR-T及其构建方法和应用 |
| CN113166244A (zh) * | 2018-11-14 | 2021-07-23 | 赫利世弥斯株式会社 | 稳定性得到提高的抗c-肝细胞生长因子受体抗体或其抗原结合片段 |
| US20210130456A1 (en) * | 2019-11-01 | 2021-05-06 | East Tennessee State University Research Foundation | Single-chain variable fragment of met monoclonal antibody and methods of use in car t cell therapy |
Non-Patent Citations (2)
| Title |
|---|
| LIU B等: "Development of c‑MET‑specific chimeric antigen receptor‑engineered natural killer cells with cytotoxic effects on human liver cancer HepG2 cells", 《MOLECULAR MEDICINE REPORTS》 * |
| 黄骁辰: "c-Met CAR-T细胞的制备及对肝癌细胞的杀伤作用", 《中国优秀硕士学位论文全文数据库(电子期刊)医药卫生科技辑》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021060932A1 (ko) | 2021-04-01 |
| EP4039703A1 (en) | 2022-08-10 |
| EP4039703A4 (en) | 2023-07-19 |
| KR102685211B1 (ko) | 2024-07-16 |
| KR20210036742A (ko) | 2021-04-05 |
| US12570719B2 (en) | 2026-03-10 |
| JP7373242B2 (ja) | 2023-11-02 |
| JP2022550120A (ja) | 2022-11-30 |
| US20220362298A1 (en) | 2022-11-17 |
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