CN114344185B - Oil-in-water skin care emulsion containing sialic acid salt and preparation method thereof - Google Patents
Oil-in-water skin care emulsion containing sialic acid salt and preparation method thereof Download PDFInfo
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- CN114344185B CN114344185B CN202111501671.2A CN202111501671A CN114344185B CN 114344185 B CN114344185 B CN 114344185B CN 202111501671 A CN202111501671 A CN 202111501671A CN 114344185 B CN114344185 B CN 114344185B
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Abstract
The invention provides an oil-in-water skin care emulsion containing sialic acid salt and a preparation method thereof. The invention applies sialic acid salt to an oil-in-water system, and solves the problem of reduced viscosity of thickening bodies (particularly thickening bodies containing carbomers) caused by degradation of sialic acid. According to the invention, through a great deal of researches on the emulsifier and the thickener of the skin care emulsion, the sialic acid salt can be stably present in the obtained oil-in-water system, and the obtained skin care emulsion has excellent physical and chemical stability, and the quality of cosmetics is obviously improved.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to an oil-in-water skin care emulsion containing sialic acid salt and a preparation method thereof.
Background
Sialic acid (Sialic acid) is an acidic amino sugar containing 9 carbon atoms and having a pyranose structure, also called N-acetylneuraminic acid, nidus Collocaliae acid and nidus Collocaliae, widely existing in various biological tissues, is an important part forming cell surface complex carbohydrate, and has physiological effects of promoting brain development, improving memory, resisting inflammation and virus, resisting tumor, improving intestinal absorption of vitamins and minerals, etc. With the intensive research and understanding of sialic acid, sialic acid can also inhibit oxidation reaction of tyrosine, reduce melanin deposition, and thereby improve the appearance of skin. Therefore, sialic acid can be widely used in the cosmetic field.
The oil-in-water (O/W) system is one of the most commonly used emulsifying systems for topical cream emulsions, being an emulsifying system in which oil is dispersed in water, which is the internal phase, and water is the continuous external phase. The oil-in-water system has the advantages of simple operation, fresh skin feel and the like, and is the most commonly used formulation of cosmetics.
However, the applicant found that when sialic acid is applied to an oil-in-water system, the thickening body (especially a thickening body containing carbomer) has the problems of gravity delamination, particle flocculation and aggregation due to compatibility with part of auxiliary materials, and meanwhile, the sialic acid has the degradation reaction in the oil-in-water system, so that the sialic acid content in the system is reduced, and meanwhile, the produced byproducts cause the system to have the problem of color change, so that the quality of the cosmetic product is seriously reduced.
In view of this, the present invention has been made.
Disclosure of Invention
In order to solve the problems in the prior art, the invention aims to provide an oil-in-water type skin care emulsion containing sialic acid salt, which has excellent physical and chemical stability and can remarkably improve the quality of cosmetics. The invention also provides a preparation method of the oil-in-water skin care emulsion containing sialic acid salt.
To achieve the above object, according to a first aspect of the present invention, there is provided an oil-in-water skin care cream containing sialic acid salt, wherein the sialic acid salt is the only active ingredient or one of the active ingredients.
The invention discovers that the stability of sialic acid salt formed by neutralizing sialic acid by alkali to acid, heat, light and the like is obviously improved, and when the sialic acid salt is added into an oil-in-water system by using only one effective component or one of the effective components, the problem that the viscosity of the sialic acid to a thickening body (particularly a thickening body containing carbomer) is reduced can be effectively solved, and the stability of skin care cream is improved.
In some specific embodiments, the oil-in-water skin care emulsion comprises a sialic acid salt and an emulsifier.
Further, the weight percentage of the sialic acid salt in the oil-in-water skin care emulsion is 0.1-2%; the weight percentage of the emulsifier in the oil-in-water skin care emulsion is 4-13%.
In some specific embodiments, the sialic acid salt is selected from one or more of sodium sialic acid, potassium sialic acid, calcium sialic acid, magnesium sialic acid.
Further, the emulsifier comprises the following components in parts by weight (2-5): (1-5): stearyl polyether-21, stearyl polyether-2 and cetostearyl alcohol of (1-3). The invention further discovers that the skin care emulsion adopting the emulsifier does not have layering phenomenon, is more beneficial to improving the physical stability of a system, and meanwhile, the sialate is stable and is not easy to generate degradation reaction, so that the chemical stability of the system is more beneficial to improving.
In some specific embodiments, the oil-in-water skin care emulsion further comprises 0.15-6% by weight of a thickener.
Further, the thickener comprises the following components in percentage by weight (0.05-1): (0.1-5) carbomers and polyacrylamides. Carbomers are commonly used as thickeners in cosmetics, are also very important rheology modifiers, and can form gel to achieve good stability and use feeling, so the carbomers are widely applied to the preparation of creams and emulsions. However, in the course of the present invention, it was found that flocculation reaction occurred when carbomers were compatible with sialic acid. The present invention employs sialic acid salts to avoid this phenomenon. The skin care emulsion using the thickener has excellent physical and chemical stability, and meanwhile, the obtained skin care emulsion has better skin feel so as to further meet the requirements of consumers.
In some specific embodiments, the oil-in-water skin care emulsion further comprises 10-40% by weight of a lipid emollient selected from one or more of isooctyl palmitate, polydimethylsiloxane, petrolatum, squalane. Wherein petrolatum is vaseline.
Further, the oil-in-water skin care emulsion further comprises the following components in percentage by weight: 0.1-5% of skin restoration agent, 0.1-20% of humectant, 0.1-1% of preservative, and/or 0.1-2% of acid-base regulator.
In some specific embodiments, the skin repair agent is allantoin;
and/or, the humectant is propylene glycol;
and/or, the preservative is p-hydroxyacetophenone;
and/or, the acid-base modifier is sodium carbonate.
In some specific embodiments, the oil-in-water skin care emulsion comprises the following raw materials in weight percent: 0.1-2% of sialic acid salt, 212-5% of stearyl alcohol polyether, 21-5% of stearyl alcohol, 1-3% of cetostearyl alcohol, 2-10% of isooctyl palmitate, 2-10% of polydimethylsiloxane, 5-10% of petrolatum, 1-10% of squalane, 0.1-20% of propylene glycol, 0.1-5% of allantoin, 0.05-1% of carbomer, 0.1-5% of polyacrylamide, 0.1-2% of sodium carbonate, 0.1-1% of p-hydroxyacetophenone and the balance of deionized water.
In a second aspect, the present invention provides a method for preparing the sialic acid salt-containing oil-in-water skin care emulsion, comprising the following steps:
(1) Weighing the components according to the weight percentage for standby;
(2) Sequentially adding a thickening agent, a moisturizing agent and deionized water into a vacuum emulsifying pot, heating to 75-85 ℃ in a water bath under the stirring condition, and preserving heat for 10-15min;
(3) Sequentially adding the emulsifier and the grease emollient into an oil phase pot, heating to 75-85 ℃ in a water bath under stirring condition, and preserving heat for 10-15min;
(4) Adding the materials of the oil phase pot into a vacuum emulsifying pot, homogenizing at 10000-15000rpm for 10-15min until uniform emulsion is formed, continuously stirring, cooling to 40-45deg.C, adding sialic acid salt, skin repairing agent, acid-base regulator and antiseptic, observing the uniformity of the materials, and cooling to room temperature to obtain the final product.
The invention has the following advantages:
the invention applies sialic acid salt to an oil-in-water system, and solves the problem that the system is unstable due to degradation of sialic acid and reduced viscosity of thickening bodies (especially thickening bodies containing carbomers). According to the invention, through a great deal of researches on the emulsifier and the thickener of the skin care emulsion, the sialic acid salt can be stably present in the obtained oil-in-water system, and the obtained skin care emulsion has excellent physical and chemical stability and good skin feel, and the quality of cosmetics is obviously improved.
Detailed Description
The following examples are illustrative of the invention and are not intended to limit the scope of the invention. The specific techniques or conditions are not identified in the examples and are described in the literature in this field or are carried out in accordance with the product specifications. The reagents or equipment used were conventional products available for purchase by regular vendors without the manufacturer's attention.
In the following examples and comparative examples, "%" means weight percent unless otherwise specified.
Example 1
The embodiment provides an oil-in-water skin care emulsion containing sialic acid salt, which comprises the following components in percentage by weight: 1% of sodium sialic acid, 4.2% of stearyl alcohol polyether-21, 21% of stearyl alcohol polyether-21%, 3% of cetostearyl alcohol, 5% of isooctyl palmitate, 2.2% of polydimethylsiloxane, 10% of petrolatum, 10% of squalane, 12% of propylene glycol, 1.5% of allantoin, 0.6% of carbomer, 2% of polyacrylamide, 0.5% of sodium carbonate, 0.5% of p-hydroxyacetophenone and the balance of deionized water.
The preparation method of the oil-in-water skin care emulsion comprises the following steps:
(1) Weighing the raw materials according to the weight percentage for standby;
(2) Sequentially adding carbomer, polyacrylamide, propylene glycol and deionized water into a vacuum emulsifying pot, heating to 80 ℃ in a water bath under stirring condition, and preserving heat for 12min;
(3) Sequentially adding stearyl alcohol polyether-21, stearyl alcohol polyether-2, glyceryl stearate, PEG-100 stearate, cetostearyl alcohol, isooctyl palmitate, polydimethylsiloxane, petrolatum and squalane into an oil phase pot, heating to 80 ℃ in a water bath under stirring condition, and preserving heat for 15min;
(4) Adding the materials of the oil phase pot into a vacuum emulsifying pot, homogenizing for 10min at 12000rpm until uniform emulsion is formed, continuously stirring, cooling to 40 ℃, adding sialic acid salt, allantoin, sodium carbonate and p-hydroxyacetophenone, observing the uniformity of the materials, and cooling to room temperature to obtain the product.
Example 2
The embodiment provides an oil-in-water skin care emulsion containing sialic acid salt, which comprises the following raw materials in percentage by weight: sodium sialic acid 0.5%, stearyl polyether-21.5%, stearyl polyether-21.6%, cetostearyl alcohol 2%, isooctyl palmitate 5%, polydimethylsiloxane 3%, petrolatum 9%, squalane 5%, propylene glycol 12%, allantoin 1.5%, carbomer 0.8%, polyacrylamide 2%, sodium carbonate 0.8%, p-hydroxyacetophenone 0.5%, and deionized water in balance.
The preparation method of the skin care cream of this example is the same as that of example 1.
Example 3
The embodiment provides an oil-in-water skin care emulsion containing sialic acid salt, which comprises the following raw materials in percentage by weight: 1.5% of sodium sialic acid, 2.5% of stearyl polyether-21, 23.2% of stearyl polyether-2.5% of cetostearyl alcohol, 5% of isooctyl palmitate, 3% of polydimethylsiloxane, 8% of petrolatum, 1% of squalane, 10% of propylene glycol, 1% of allantoin, 0.8% of carbomer, 2.5% of polyacrylamide, 1% of sodium carbonate, 0.5% of p-hydroxyacetophenone and the balance of deionized water.
The preparation method of the skin care cream of this example is the same as that of example 1.
Example 4
The embodiment provides an oil-in-water skin care emulsion containing sialic acid salt, which comprises the following raw materials in percentage by weight: sodium sialic acid 2%, stearyl alcohol polyether-21.8%, stearyl alcohol polyether-2 4%, cetostearyl alcohol 2%, isooctyl palmitate 6%, polydimethylsiloxane 7%, petrolatum 5%, squalane 5%, propylene glycol 12%, allantoin 1.2%, carbomer 0.5%, polyacrylamide 3%, sodium carbonate 0.6%, p-hydroxyacetophenone 0.5%, and deionized water in balance.
The preparation method of the skin care cream of this example is the same as that of example 1.
Example 5
The embodiment provides an oil-in-water skin care emulsion containing sialic acid salt, which comprises the following raw materials in percentage by weight: 1% of sodium sialic acid, 21% of stearyl alcohol polyether, 2.5% of stearyl alcohol polyether, 1.5% of cetostearyl alcohol, 3% of isooctyl palmitate, 8% of polydimethylsiloxane, 4% of petrolatum, 2% of squalane, 10% of propylene glycol, 1.8% of allantoin, 1% of carbomer, 3% of polyacrylamide, 0.8% of sodium carbonate, 0.5% of p-hydroxyacetophenone and the balance of deionized water.
The preparation method of the skin care cream of this example is the same as that of example 1.
Example 6
This example differs from example 1 only in that the thickener used is different, and the oil-in-water skin care cream of this example comprises carbomer 2% and polyacrylamide 0.6%.
The preparation method of the skin care cream of this example is the same as that of example 1.
Comparative example 1
This comparative example differs from example 1 only in that the emulsifier used, the steareth-21 of example 1 was replaced with an equivalent amount of PEG-100 stearate.
The skin care cream of this comparative example was prepared in the same manner as in example 1.
Comparative example 2
This comparative example differs from example 1 only in that the emulsifier used, the steareth-21 of example 1 was replaced by an equivalent amount of glycerol stearate.
The skin care cream of this comparative example was prepared in the same manner as in example 1.
Comparative example 3
The oil-in-water skin care emulsion of this comparative example differs from example 1 only in the emulsifier used, and includes stearyl polyether-210.6%, stearyl polyether-25%, cetostearyl alcohol 2.5%
The skin care cream of this comparative example was prepared in the same manner as in example 1.
Comparative example 4
This comparative example differs from example 1 only in that the thickener used was changed to the same amount of xanthan gum as the polyacrylamide in example 1.
The skin care cream of this comparative example was prepared in the same manner as in example 1.
Test example 1
The oil-in-water skin care milk of the present invention was tested for high temperature stability and long term stability.
High temperature stability: the skin care milks of examples 1 to 6 and comparative examples 1 to 4 were placed in a suitable container, placed in a constant temperature oven at 50℃for 10 days, and sampled at 0, 5 and 10 days, respectively, and the properties, sialic acid salt content and pH value of the skin care milks were examined.
Long-term stability: the skin care milks of examples 1 to 6 and comparative examples 1 to 4 were placed in a suitable container, placed in a constant temperature oven at (28.+ -. 2) ℃ for 12 months, and sampled at the end of each of the 0 th, 3 rd, 6 th, 9 th and 12 th months, and the properties, sialic acid content and pH of the skin care milks were examined.
The test results of high temperature stability and long term stability are shown in table 1.
TABLE 1
The results show that: the oil-in-water skin care emulsion of the present invention has excellent physical and chemical stability, whether in an accelerated test or a long-term test.
Test example 2
Sanitary microbiological and sanitary chemical tests on the oil-in-water skin care emulsions of the present invention
The results of the sanitary microorganism test and sanitary chemistry test of the skin care cream prepared in example 1 of the present invention are shown in Table 2.
TABLE 2
The results of the hygienic microbiological and hygienic chemical tests for the skin care milks of examples 2-6 were not significantly different from example 1.
The results show that: the oil-in-water skin care emulsion meets the specification of cosmetic safety technical Specification.
Test example 3
The feel of use of the oil-in-water skin care cream of the present invention was evaluated.
30 subjects were randomly selected, 2 pumps of the oil-in-water skin care cream prepared in the invention example 1, example 6 and comparative example 4 were respectively smeared on the face after 5min of face cleaning, a questionnaire was filled in after 30min, and the results were obtained through statistics and are shown in Table 3.
TABLE 3 Table 3
The results show that: the texture, feel, and skin feel of the oil-in-water skin care cream of example 1 are more satisfactory to consumers than those of example 6 and comparative example 4.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention, and are not limiting; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present invention.
Claims (6)
1. An oil-in-water skin care cream containing sialic acid salt, characterized in that the oil-in-water skin care cream comprises the following components in percentage by weight: 0.1-2% of sialic acid salt, 2-5% of stearyl alcohol polyether-21, 21-5% of stearyl alcohol, 1-3% of cetostearyl alcohol, 10-40% of grease emollient, 0.1-20% of humectant, 0.1-5% of skin repair agent, 0.05-1% of carbomer, 0.1-5% of polyacrylamide, 0.1-2% of acid-base regulator, 0.1-1% of preservative and the balance of deionized water.
2. The sialate-containing oil-in-water skin care emulsion according to claim 1, wherein the sialate is selected from one or more of sodium sialic acid, potassium sialic acid, calcium sialic acid, magnesium sialic acid.
3. The sialate-containing oil-in-water skin care emulsion of claim 1, wherein the oil emollient is selected from one or more of isooctyl palmitate, polydimethylsiloxane, petrolatum, squalane.
4. The sialate-containing oil-in-water skin care emulsion of claim 1, wherein the skin repair agent is allantoin;
and/or, the humectant is propylene glycol;
and/or, the preservative is p-hydroxyacetophenone;
and/or, the acid-base modifier is sodium carbonate.
5. The sialate-containing oil-in-water skin care emulsion according to claim 1, characterized in that it comprises the following components in weight percent: 0.1-2% of sialic acid salt, 212-5% of stearyl alcohol polyether, 21-5% of stearyl alcohol, 1-3% of cetostearyl alcohol, 2-10% of isooctyl palmitate, 2-10% of polydimethylsiloxane, 5-10% of petrolatum, 1-10% of squalane, 0.1-20% of propylene glycol, 0.1-5% of allantoin, 0.05-1% of carbomer, 0.1-5% of polyacrylamide, 0.1-2% of sodium carbonate, 0.1-1% of p-hydroxyacetophenone and the balance of deionized water.
6. A method of preparing a sialate-containing oil-in-water skin care emulsion according to any one of claims 1 to 5, comprising the steps of:
(1) Weighing the components according to the weight percentage for standby;
(2) Sequentially adding carbomer, polyacrylamide, humectant and deionized water into a vacuum emulsifying pot, heating to 75-85deg.C in water bath under stirring, and maintaining for 10-15min;
(3) Sequentially adding stearyl alcohol polyether-21, stearyl alcohol polyether-2, cetostearyl alcohol and oil emollient into an oil phase pot, heating to 75-85deg.C in water bath under stirring, and maintaining for 10-15min;
(4) Adding the materials of the oil phase pot into a vacuum emulsifying pot, homogenizing at 10000-15000rpm for 10-15min until uniform emulsion is formed, continuously stirring, cooling to 40-45deg.C, adding sialic acid salt, skin repairing agent, acid-base regulator and antiseptic, observing the uniformity of the materials, and cooling to room temperature to obtain the final product.
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