CN114315801B - 血管紧张素ii受体拮抗剂代谢产物与nep抑制剂的复合物及其制备方法 - Google Patents
血管紧张素ii受体拮抗剂代谢产物与nep抑制剂的复合物及其制备方法 Download PDFInfo
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- FKENQMMABCRJMK-RITPCOANSA-N sulbactam Chemical compound O=S1(=O)C(C)(C)[C@H](C(O)=O)N2C(=O)C[C@H]21 FKENQMMABCRJMK-RITPCOANSA-N 0.000 description 1
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- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
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- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract
Description
编号 | 2θ(°,±0.2) | 相对强度(%) |
1 | 4.35 | 70.97 |
2 | 5.15 | 100.00 |
3 | 5.90 | 32.67 |
4 | 9.00 | 2.80 |
5 | 10.15 | 3.40 |
6 | 12.80 | 5.21 |
7 | 15.02 | 5.59 |
8 | 15.85 | 8.27 |
9 | 16.81 | 2.57 |
10 | 20.27 | 2.39 |
11 | 22.09 | 2.48 |
12 | 23.79 | 1.34 |
13 | 26.22 | 1.87 |
编号 | 2θ(°,±0.2) | 相对强度(%) |
1 | 4.40 | 77.30 |
2 | 5.19 | 100.00 |
3 | 5.96 | 19.78 |
4 | 15.82 | 5.11 |
5 | 26.34 | 3.44 |
编号 | 2θ(°,±0.2) | 相对强度(%) |
1 | 4.40 | 77.30 |
2 | 5.19 | 100.00 |
3 | 5.96 | 19.78 |
4 | 15.82 | 5.11 |
5 | 26.34 | 3.44 |
Claims (6)
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CN2016104302480 | 2016-06-16 | ||
CN201610430248 | 2016-06-16 | ||
CN202210026536.5A CN114315801B (zh) | 2016-01-20 | 2017-01-19 | 血管紧张素ii受体拮抗剂代谢产物与nep抑制剂的复合物及其制备方法 |
PCT/CN2017/071625 WO2017125031A1 (zh) | 2016-01-20 | 2017-01-19 | 血管紧张素ii受体拮抗剂代谢产物与nep抑制剂的复合物及其制备方法 |
CN201780004975.3A CN108473474B (zh) | 2016-01-20 | 2017-01-19 | 血管紧张素ii受体拮抗剂代谢产物与nep抑制剂的复合物及其制备方法 |
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CN (2) | CN114315801B (zh) |
AU (1) | AU2017209250B2 (zh) |
CA (1) | CA3016258A1 (zh) |
MX (1) | MX2018008531A (zh) |
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TW (1) | TWI657826B (zh) |
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US20220226285A1 (en) * | 2019-05-30 | 2022-07-21 | Shenzhen Salubris Pharmaceuticals Co., Ltd. | Treatment Method Using A Complex of Angiotensin II Receptor Antagonist Metabolite and NEP Inhibitor |
CN114452287B (zh) * | 2019-05-30 | 2023-05-12 | 深圳信立泰药业股份有限公司 | 血管紧张素ii受体拮抗剂代谢产物与nep抑制剂的复合物的新用途 |
WO2021052441A1 (zh) * | 2019-09-20 | 2021-03-25 | 深圳信立泰药业股份有限公司 | 血管紧张素ii受体拮抗剂代谢产物与nep抑制剂的复合物治疗心衰的用途 |
WO2021093697A1 (zh) * | 2019-11-11 | 2021-05-20 | 深圳信立泰药业股份有限公司 | 血管紧张素ii受体拮抗剂与nep抑制剂的复合物及其制备方法 |
WO2021143898A1 (zh) * | 2020-01-19 | 2021-07-22 | 深圳信立泰药业股份有限公司 | Arb代谢产物与nep抑制剂的复合物新晶型及其制备方法 |
WO2021254409A1 (zh) * | 2020-06-18 | 2021-12-23 | 深圳信立泰药业股份有限公司 | 一种复合物的药物组合物及其制备方法 |
CN115443272B (zh) * | 2020-08-17 | 2023-11-17 | 深圳信立泰药业股份有限公司 | 血管紧张素ii受体拮抗剂代谢产物与nep抑制剂的复合物的心衰应用 |
TW202228671A (zh) * | 2020-11-25 | 2022-08-01 | 大陸商深圳信立泰藥業股份有限公司 | Arb代謝產物與nep抑制劑的複合物在製備用於預防和/或治療腎病的藥物中的用途 |
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WO2024027779A1 (zh) * | 2022-08-04 | 2024-02-08 | 深圳信立泰药业股份有限公司 | ARNi化合物新晶型及其制备方法与应用 |
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