CN114214192A - 用于处理细胞的设备 - Google Patents

用于处理细胞的设备 Download PDF

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Publication number
CN114214192A
CN114214192A CN202111185751.1A CN202111185751A CN114214192A CN 114214192 A CN114214192 A CN 114214192A CN 202111185751 A CN202111185751 A CN 202111185751A CN 114214192 A CN114214192 A CN 114214192A
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reactor
fixed bed
cells
container
compartment
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Pending
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CN202111185751.1A
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Chinese (zh)
Inventor
苏雷什·普鲁少塔曼
何塞·安东尼奥·卡斯蒂略冈萨雷斯
让-克里斯托弗·德吕格曼
维希沃思·佩泽
德里克·彭德尔伯里
法比安·蒙考贝格
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Pall Atlas Co ltd
Pall Life Science Belgium BVBA
Pall Technology UK Ltd
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Pall Atlas Co ltd
Pall Life Science Belgium BVBA
Pall Technology UK Ltd
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Publication of CN114214192A publication Critical patent/CN114214192A/zh
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    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/26—Constructional details, e.g. recesses, hinges flexible
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/34—Internal compartments or partitions
    • C—CHEMISTRY; METALLURGY
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    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/16—Particles; Beads; Granular material; Encapsulation
    • C12M25/18—Fixed or packed bed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/02—Stirrer or mobile mixing elements
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    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/10—Rotating vessel
    • C12M27/12—Roller bottles; Roller tubes
    • C—CHEMISTRY; METALLURGY
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    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/16—Vibrating; Shaking; Tilting
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/14—Pressurized fluid
    • C—CHEMISTRY; METALLURGY
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    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/04—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by injection or suction, e.g. using pipettes, syringes, needles
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    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/08—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by vibration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/12—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by pressure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/14—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus with filters, sieves or membranes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/18—Rollers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
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    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
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    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/04—Cell isolation or sorting

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  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
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  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN202111185751.1A 2012-12-11 2013-12-11 用于处理细胞的设备 Pending CN114214192A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261735841P 2012-12-11 2012-12-11
US61/735,841 2012-12-11
PCT/US2013/074298 WO2014093439A1 (en) 2012-12-11 2013-12-11 System and method for detachment of cells in fixed bed reactors
CN201380064957.6A CN104903435A (zh) 2012-12-11 2013-12-11 用于固定床反应器中的细胞分离的系统和方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201380064957.6A Division CN104903435A (zh) 2012-12-11 2013-12-11 用于固定床反应器中的细胞分离的系统和方法

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CN114214192A true CN114214192A (zh) 2022-03-22

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CN202111185751.1A Pending CN114214192A (zh) 2012-12-11 2013-12-11 用于处理细胞的设备
CN201380064957.6A Pending CN104903435A (zh) 2012-12-11 2013-12-11 用于固定床反应器中的细胞分离的系统和方法
CN201380064887.4A Active CN105229139B (zh) 2012-12-11 2013-12-11 用于细胞培养的器皿

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Application Number Title Priority Date Filing Date
CN201380064957.6A Pending CN104903435A (zh) 2012-12-11 2013-12-11 用于固定床反应器中的细胞分离的系统和方法
CN201380064887.4A Active CN105229139B (zh) 2012-12-11 2013-12-11 用于细胞培养的器皿

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US (2) US10781417B2 (https=)
EP (2) EP2931871B1 (https=)
JP (2) JP2016501525A (https=)
CN (3) CN114214192A (https=)
SG (2) SG11201504219QA (https=)
WO (2) WO2014093439A1 (https=)

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US20150299634A1 (en) 2015-10-22
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EP2931870A4 (en) 2016-07-20
US20150322399A1 (en) 2015-11-12
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