CN114107212A - 细胞 - Google Patents

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Publication number
CN114107212A
CN114107212A CN202111208410.1A CN202111208410A CN114107212A CN 114107212 A CN114107212 A CN 114107212A CN 202111208410 A CN202111208410 A CN 202111208410A CN 114107212 A CN114107212 A CN 114107212A
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Prior art keywords
car
ser
nucleic acid
gly
leu
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Pending
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CN202111208410.1A
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Chinese (zh)
Inventor
M.普勒
S.科多巴
S.奥诺哈
S.托马斯
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Autolus Ltd
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Autolus Ltd
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55066668&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN114107212(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Autolus Ltd filed Critical Autolus Ltd
Publication of CN114107212A publication Critical patent/CN114107212A/zh
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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    • A61K2039/80—Vaccine for a specifically defined cancer
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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  • Hematology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Plant Pathology (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Developmental Biology & Embryology (AREA)
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CN202111208410.1A 2014-12-24 2015-12-23 细胞 Pending CN114107212A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1423172.4 2014-12-24
GB201423172 2014-12-24
CN201580065695.4A CN107002045B (zh) 2014-12-24 2015-12-23 细胞

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201580065695.4A Division CN107002045B (zh) 2014-12-24 2015-12-23 细胞

Publications (1)

Publication Number Publication Date
CN114107212A true CN114107212A (zh) 2022-03-01

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Application Number Title Priority Date Filing Date
CN201580065695.4A Active CN107002045B (zh) 2014-12-24 2015-12-23 细胞
CN202111208410.1A Pending CN114107212A (zh) 2014-12-24 2015-12-23 细胞

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Application Number Title Priority Date Filing Date
CN201580065695.4A Active CN107002045B (zh) 2014-12-24 2015-12-23 细胞

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US (8) US11091532B2 (enExample)
EP (3) EP3237442B1 (enExample)
JP (5) JP6633081B2 (enExample)
KR (6) KR102376242B1 (enExample)
CN (2) CN107002045B (enExample)
AU (5) AU2015370679C1 (enExample)
BR (1) BR112017013690A2 (enExample)
CA (2) CA3224507A1 (enExample)
CL (3) CL2017001314A1 (enExample)
DK (2) DK3560953T5 (enExample)
ES (2) ES2744910T3 (enExample)
FI (1) FI3560953T3 (enExample)
HR (1) HRP20240357T1 (enExample)
HU (2) HUE046262T2 (enExample)
IL (4) IL301458A (enExample)
LT (1) LT3560953T (enExample)
MX (1) MX2017006233A (enExample)
PL (2) PL3560953T3 (enExample)
PT (2) PT3237442T (enExample)
RS (1) RS65343B1 (enExample)
RU (2) RU2768019C2 (enExample)
SG (2) SG11201704084VA (enExample)
SI (1) SI3560953T1 (enExample)
SM (1) SMT202400134T1 (enExample)
WO (1) WO2016102965A1 (enExample)
ZA (1) ZA201703381B (enExample)

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SG11201706236SA (en) 2015-02-06 2017-08-30 Nat Univ Singapore Methods for enhancing efficacy of therapeutic immune cells
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GB201507115D0 (en) * 2015-04-27 2015-06-10 Ucl Business Plc Nucleic Acid Construct
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WO2018108106A1 (zh) * 2016-12-13 2018-06-21 科济生物医药（上海）有限公司 抗cd19的人源化抗体以及靶向cd19的免疫效应细胞
WO2018124766A2 (ko) * 2016-12-28 2018-07-05 주식회사 녹십자랩셀 키메라 항원 수용체 및 이를 발현하는 자연 살해 세포
US12473343B2 (en) 2017-01-10 2025-11-18 The General Hospital Corporation Targeted t cells with cytotoxicity toward immunosuppressive cells
CN110612119B (zh) 2017-02-07 2024-10-29 西雅图儿童医院（Dba西雅图儿童研究所） 磷脂醚(ple)car t细胞肿瘤靶向(ctct)剂
US11850262B2 (en) 2017-02-28 2023-12-26 Purdue Research Foundation Compositions and methods for CAR T cell therapy
JP2020511136A (ja) 2017-03-17 2020-04-16 フレッド ハッチンソン キャンサー リサーチ センター 免疫調節性融合タンパク質およびその使用
EP3609914A4 (en) * 2017-04-14 2021-04-14 The General Hospital Corporation CHIMERIC ANTIGEN RECEPTOR T-CELLS AGAINST TUMOR MICRO ENVIRONMENT
ES2905377T3 (es) * 2017-04-18 2022-04-08 Autolus Ltd Célula
CN110753555A (zh) * 2017-04-19 2020-02-04 得克萨斯州大学系统董事会 表达工程化抗原受体的免疫细胞
CN110650975B (zh) * 2017-05-15 2024-04-05 美国卫生和人力服务部 双顺反子嵌合抗原受体及其用途
CN118853581A (zh) 2017-06-21 2024-10-29 美商生物细胞基因治疗有限公司 嵌合抗原受体(CARs)、组合物及其使用方法
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