CN114007632A - 抗纤溶酶剂 - Google Patents
抗纤溶酶剂 Download PDFInfo
- Publication number
- CN114007632A CN114007632A CN202080043706.XA CN202080043706A CN114007632A CN 114007632 A CN114007632 A CN 114007632A CN 202080043706 A CN202080043706 A CN 202080043706A CN 114007632 A CN114007632 A CN 114007632A
- Authority
- CN
- China
- Prior art keywords
- plant
- citrus
- extract
- curcuma
- family
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000284 extract Substances 0.000 claims abstract description 75
- 241000196324 Embryophyta Species 0.000 claims abstract description 68
- 241000736199 Paeonia Species 0.000 claims abstract description 19
- 235000014375 Curcuma Nutrition 0.000 claims abstract description 17
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims abstract description 17
- 241000207199 Citrus Species 0.000 claims abstract description 16
- 241000207929 Scutellaria Species 0.000 claims abstract description 15
- 235000004789 Rosa xanthina Nutrition 0.000 claims abstract description 12
- 241000220222 Rosaceae Species 0.000 claims abstract description 12
- 241001093501 Rutaceae Species 0.000 claims abstract description 12
- 241000234299 Zingiberaceae Species 0.000 claims abstract description 12
- 235000020971 citrus fruits Nutrition 0.000 claims abstract description 12
- 241000220485 Fabaceae Species 0.000 claims abstract description 11
- 241000207923 Lamiaceae Species 0.000 claims abstract description 11
- 241001106477 Paeoniaceae Species 0.000 claims abstract description 11
- 241001106462 Ulmus Species 0.000 claims abstract description 8
- 239000000504 antifibrinolytic agent Substances 0.000 claims abstract description 4
- 241000488874 Sonchus Species 0.000 claims abstract description 3
- 229940012957 plasmin Drugs 0.000 claims description 32
- 239000003795 chemical substances by application Substances 0.000 claims description 29
- 244000173853 Sanguisorba officinalis Species 0.000 claims description 19
- 235000008282 Sanguisorba officinalis Nutrition 0.000 claims description 17
- 235000015203 fruit juice Nutrition 0.000 claims description 17
- 235000008733 Citrus aurantifolia Nutrition 0.000 claims description 13
- 244000089742 Citrus aurantifolia Species 0.000 claims description 12
- 235000011941 Tilia x europaea Nutrition 0.000 claims description 12
- 244000163122 Curcuma domestica Species 0.000 claims description 11
- 235000003373 curcuma longa Nutrition 0.000 claims description 10
- 244000164480 Curcuma aromatica Species 0.000 claims description 9
- 239000004571 lime Substances 0.000 claims description 9
- 235000008598 Paeonia lactiflora Nutrition 0.000 claims description 8
- 244000236658 Paeonia lactiflora Species 0.000 claims description 8
- 235000006484 Paeonia officinalis Nutrition 0.000 claims description 8
- 235000017089 Scutellaria baicalensis Nutrition 0.000 claims description 8
- 240000004534 Scutellaria baicalensis Species 0.000 claims description 8
- 240000000560 Citrus x paradisi Species 0.000 claims description 6
- 240000002319 Citrus sinensis Species 0.000 claims description 5
- 235000005976 Citrus sinensis Nutrition 0.000 claims description 5
- 241001337999 Citrus iyo Species 0.000 claims description 4
- 235000005979 Citrus limon Nutrition 0.000 claims description 4
- 244000131522 Citrus pyriformis Species 0.000 claims description 4
- 235000003398 Curcuma aromatica Nutrition 0.000 claims description 4
- 235000003405 Curcuma zedoaria Nutrition 0.000 claims description 4
- 240000009138 Curcuma zedoaria Species 0.000 claims description 4
- 235000017317 Fortunella Nutrition 0.000 claims description 4
- 244000179970 Monarda didyma Species 0.000 claims description 4
- 235000010672 Monarda didyma Nutrition 0.000 claims description 4
- 241000915604 Scutellaria barbata Species 0.000 claims description 4
- 241000054078 Citrus depressa Species 0.000 claims description 3
- 241001672694 Citrus reticulata Species 0.000 claims description 3
- 241000555678 Citrus unshiu Species 0.000 claims description 3
- 241000632296 Scutellaria lateriflora Species 0.000 claims description 3
- 239000003527 fibrinolytic agent Substances 0.000 claims description 3
- 241000273649 Citrus hassaku Species 0.000 claims description 2
- 240000004307 Citrus medica Species 0.000 claims description 2
- 229930184510 Mallotus Natural products 0.000 claims description 2
- 241001060384 Mallotus <angiosperm> Species 0.000 claims description 2
- 235000015359 salad burnet Nutrition 0.000 claims description 2
- 240000006909 Tilia x europaea Species 0.000 claims 1
- 244000273928 Zingiber officinale Species 0.000 claims 1
- 235000006886 Zingiber officinale Nutrition 0.000 claims 1
- 235000008397 ginger Nutrition 0.000 claims 1
- 239000001841 zingiber officinale Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 33
- 235000011389 fruit/vegetable juice Nutrition 0.000 abstract description 26
- 241000407170 Curcuma Species 0.000 abstract 1
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 21
- 108010088842 Fibrinolysin Proteins 0.000 description 21
- 238000000605 extraction Methods 0.000 description 20
- 235000019441 ethanol Nutrition 0.000 description 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 14
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 13
- 239000002904 solvent Substances 0.000 description 13
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 12
- 235000019437 butane-1,3-diol Nutrition 0.000 description 12
- 239000012488 sample solution Substances 0.000 description 12
- 244000008991 Curcuma longa Species 0.000 description 11
- 239000000419 plant extract Substances 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 230000001567 anti-fibrinolytic effect Effects 0.000 description 9
- 108090000790 Enzymes Proteins 0.000 description 8
- 102000004190 Enzymes Human genes 0.000 description 8
- 229940088598 enzyme Drugs 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 235000003392 Curcuma domestica Nutrition 0.000 description 7
- 150000001298 alcohols Chemical class 0.000 description 7
- 235000011187 glycerol Nutrition 0.000 description 7
- 108010001014 Plasminogen Activators Proteins 0.000 description 6
- 102000001938 Plasminogen Activators Human genes 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 229940127126 plasminogen activator Drugs 0.000 description 6
- 235000013976 turmeric Nutrition 0.000 description 6
- YPFDHNVEDLHUCE-UHFFFAOYSA-N Trimethylene glycol Natural products OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 239000011159 matrix material Substances 0.000 description 5
- 239000011259 mixed solution Substances 0.000 description 5
- 239000002798 polar solvent Substances 0.000 description 5
- 235000013772 propylene glycol Nutrition 0.000 description 5
- 239000002994 raw material Substances 0.000 description 5
- 150000005846 sugar alcohols Polymers 0.000 description 5
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 4
- 244000183685 Citrus aurantium Species 0.000 description 4
- 235000007716 Citrus aurantium Nutrition 0.000 description 4
- 235000001759 Citrus maxima Nutrition 0.000 description 4
- 244000276331 Citrus maxima Species 0.000 description 4
- 102000013566 Plasminogen Human genes 0.000 description 4
- 108010051456 Plasminogen Proteins 0.000 description 4
- 241000907663 Siproeta stelenes Species 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 230000003078 antioxidant effect Effects 0.000 description 4
- 238000006911 enzymatic reaction Methods 0.000 description 4
- 239000012046 mixed solvent Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 244000007853 Sarothamnus scoparius Species 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 229930195729 fatty acid Natural products 0.000 description 3
- -1 fatty acid esters Chemical class 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- 239000002797 plasminogen activator inhibitor Substances 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 235000013211 Adiantum capillus veneris Nutrition 0.000 description 2
- 241001148501 Adiantum pedatum Species 0.000 description 2
- 235000012984 Aspalathus linearis Nutrition 0.000 description 2
- 240000006914 Aspalathus linearis Species 0.000 description 2
- 235000000228 Citrus myrtifolia Nutrition 0.000 description 2
- 235000016646 Citrus taiwanica Nutrition 0.000 description 2
- 244000301850 Cupressus sempervirens Species 0.000 description 2
- 235000005205 Pinus Nutrition 0.000 description 2
- 241000218602 Pinus <genus> Species 0.000 description 2
- 241000234314 Zingiber Species 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- 230000003266 anti-allergic effect Effects 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000011550 stock solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 235000020240 turmeric extract Nutrition 0.000 description 2
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 1
- 241000589291 Acinetobacter Species 0.000 description 1
- 241001219293 Aspalathus Species 0.000 description 1
- 235000003884 Aspalathus contaminatus Nutrition 0.000 description 1
- 244000274847 Betula papyrifera Species 0.000 description 1
- 235000009113 Betula papyrifera Nutrition 0.000 description 1
- 235000009109 Betula pendula Nutrition 0.000 description 1
- 235000010928 Betula populifolia Nutrition 0.000 description 1
- 235000002992 Betula pubescens Nutrition 0.000 description 1
- 241000468081 Citrus bergamia Species 0.000 description 1
- 235000002320 Citrus hystrix Nutrition 0.000 description 1
- 240000000981 Citrus hystrix Species 0.000 description 1
- 241000951471 Citrus junos Species 0.000 description 1
- 235000017727 Citrus sudachi Nutrition 0.000 description 1
- 240000008701 Citrus sudachi Species 0.000 description 1
- 241001140724 Citrus tachibana Species 0.000 description 1
- 235000000882 Citrus x paradisi Nutrition 0.000 description 1
- 241001512940 Curcuma amada Species 0.000 description 1
- 235000018453 Curcuma amada Nutrition 0.000 description 1
- 229920000832 Cutin Polymers 0.000 description 1
- 108050001049 Extracellular proteins Proteins 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- STECJAGHUSJQJN-USLFZFAMSA-N LSM-4015 Chemical compound C1([C@@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-USLFZFAMSA-N 0.000 description 1
- 241001093152 Mangifera Species 0.000 description 1
- 235000003889 Paeonia suffruticosa Nutrition 0.000 description 1
- 240000005001 Paeonia suffruticosa Species 0.000 description 1
- 241000287127 Passeridae Species 0.000 description 1
- 244000202052 Poncirus trifoliata Species 0.000 description 1
- 235000000404 Poncirus trifoliata Nutrition 0.000 description 1
- 239000010404 Scutellaria baicalensis extract Substances 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 241000712689 Velutina Species 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 229960002684 aminocaproic acid Drugs 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000019552 anatomical structure morphogenesis Effects 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000001153 anti-wrinkle effect Effects 0.000 description 1
- 239000000043 antiallergic agent Substances 0.000 description 1
- 229940082620 antifibrinolytics Drugs 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 230000012292 cell migration Effects 0.000 description 1
- 229940119217 chamomile extract Drugs 0.000 description 1
- 235000020221 chamomile extract Nutrition 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 239000001812 curcuma zedoaria berg. rosc. Substances 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000001877 deodorizing effect Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 239000010696 ester oil Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 230000020764 fibrinolysis Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000002806 plasmin inhibitor Substances 0.000 description 1
- 230000033885 plasminogen activation Effects 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- KVLPXRKIIFWZLM-DPZBCOQUSA-N tert-butyl n-[(2s)-1-[[(2s)-1-[[(2s)-6-amino-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxohexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate Chemical compound CC1=CC(=O)OC2=CC(NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)CC(C)C)=CC=C21 KVLPXRKIIFWZLM-DPZBCOQUSA-N 0.000 description 1
- 108010081072 tertiary butyloxycarbonylvalyl-leucyl-lysinyl-4-methylcoumarin-7-amide Proteins 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- 229960000401 tranexamic acid Drugs 0.000 description 1
- 239000008513 turmeric extract Substances 0.000 description 1
- 229940052016 turmeric extract Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 235000019509 white turmeric Nutrition 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/739—Sanguisorba (burnet)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019-205931 | 2019-11-14 | ||
| JP2019205931A JP2021080173A (ja) | 2019-11-14 | 2019-11-14 | 抗プラスミン剤 |
| PCT/JP2020/042104 WO2021095775A1 (ja) | 2019-11-14 | 2020-11-11 | 抗プラスミン剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114007632A true CN114007632A (zh) | 2022-02-01 |
Family
ID=75912704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080043706.XA Pending CN114007632A (zh) | 2019-11-14 | 2020-11-11 | 抗纤溶酶剂 |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP2021080173A (ja) |
| CN (1) | CN114007632A (ja) |
| WO (1) | WO2021095775A1 (ja) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1232692A (zh) * | 1998-02-24 | 1999-10-27 | 株式会社资生堂 | 抗纤溶酶剂 |
| CN101584721A (zh) * | 2009-07-06 | 2009-11-25 | 江苏泰灵生物科技有限公司 | 中药抗菌止血贴剂 |
| CN109276318A (zh) * | 2018-10-12 | 2019-01-29 | 安徽迈德普斯医疗科技有限公司 | 一种手术洞巾 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111096936A (zh) * | 2019-12-30 | 2020-05-05 | 柳州两面针股份有限公司 | 半枝莲提取物在制备口腔护理用品中的应用 |
-
2019
- 2019-11-14 JP JP2019205931A patent/JP2021080173A/ja active Pending
-
2020
- 2020-11-11 CN CN202080043706.XA patent/CN114007632A/zh active Pending
- 2020-11-11 WO PCT/JP2020/042104 patent/WO2021095775A1/ja active Application Filing
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1232692A (zh) * | 1998-02-24 | 1999-10-27 | 株式会社资生堂 | 抗纤溶酶剂 |
| CN101584721A (zh) * | 2009-07-06 | 2009-11-25 | 江苏泰灵生物科技有限公司 | 中药抗菌止血贴剂 |
| CN109276318A (zh) * | 2018-10-12 | 2019-01-29 | 安徽迈德普斯医疗科技有限公司 | 一种手术洞巾 |
Non-Patent Citations (1)
| Title |
|---|
| 王永奇: "八种黄芩属植物中黄芩甙含量的比较及凝血活性的观察" * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2021080173A (ja) | 2021-05-27 |
| WO2021095775A1 (ja) | 2021-05-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7362833B2 (ja) | ミノキシジル含有の育毛組成物 | |
| JP7439020B2 (ja) | 育毛組成物 | |
| DE69913035T2 (de) | Kosmetische Zusammensetzung mit antiradikalischer synergistischer Wirkung | |
| KR101964809B1 (ko) | No 활성 억제제, 이를 포함하는 항염증 제제, 이를 포함하는 화장품 및 이의 제조방법 | |
| KR101189344B1 (ko) | 자가-보존성 스킨케어 조성물 | |
| CN105078826A (zh) | 一种口腔护理液 | |
| JP2003252745A (ja) | マトリックスメタロプロテアーゼ（ＭＭＰｓ）阻害剤 | |
| CN106132385B (zh) | 洁齿剂组合物 | |
| BR112020003023A2 (pt) | composições e métodos para inibir patógenos de plantas | |
| CN114007632A (zh) | 抗纤溶酶剂 | |
| JP2009203184A (ja) | 抗老化性の化粧料組成物 | |
| CN111936116B (zh) | 含有腺苷磷酸和凝血酸的外用组合物的变色抑制方法 | |
| JP4643800B2 (ja) | プロテアーゼ阻害剤 | |
| WO2015064681A1 (ja) | 外用組成物 | |
| JP3645990B2 (ja) | コラゲナーゼ阻害剤 | |
| WO2010018385A3 (en) | Chemical composition for skin care formulations | |
| JP5746807B2 (ja) | 皮膚用化粧品の組成物 | |
| Wardhana et al. | Formulation of Toothpaste gel containing mixture of aloe vera (Aloe barbadensis mill.) and red betel (Piper crocatum) extract in prevention of dental caries | |
| JP2020100570A (ja) | 皮膚外用剤 | |
| Yanti et al. | Evaluating the Sapindusrarak DC Chemical compounds for their ability to inhibit the growth of Fusobacterium nucleatum In vitro | |
| KR20010094747A (ko) | 화장료 | |
| JP2009046428A (ja) | エラスターゼ阻害剤 | |
| JP2022100901A (ja) | 美白用組成物 | |
| KR20180130074A (ko) | 땀 악취증 증상 개선효과를 가지는 조성물 | |
| Roy et al. | Screening of Anti-inflammatory Potential of Berberis coriaceae Leaves by HRBC Membrane Stabilization |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20220201 |
|
| WD01 | Invention patent application deemed withdrawn after publication |