CN114007632A - Antiplasmin agent - Google Patents
Antiplasmin agent Download PDFInfo
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- CN114007632A CN114007632A CN202080043706.XA CN202080043706A CN114007632A CN 114007632 A CN114007632 A CN 114007632A CN 202080043706 A CN202080043706 A CN 202080043706A CN 114007632 A CN114007632 A CN 114007632A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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Abstract
The purpose of the present invention is to provide a novel plant-derived component useful as an anti-fibrinolytic agent. Comprises extract of plant of Scutellaria of Labiatae, plant of Curcuma of Zingiberaceae, plant of Ulmus of Rosaceae, plant of Paeonia of Paeoniaceae, and/or plant of Sonchus of Leguminosae; and/or a juice of a plant of genus Citrus of family Rutaceae has an excellent antiplasmin effect.
Description
Technical Field
The present invention relates to a plant-derived component having antiplasmin activity.
Background
Plasmin is known as an enzyme that decomposes fibrin, which is a main component of thrombus, and is generally present in plasma in the form of plasminogen as a precursor. Plasminogen is activated by cleavage of peptide bonds using Plasminogen Activator (PA), freeing plasmin, which aids in the lysis of thrombi. Plasminogen activation is controlled by Plasminogen Activation Inhibitor (PAI), which maintains tissue constancy through a balance of PA and PAI.
Plasmin produced on the cell surface directly or indirectly decomposes extracellular proteins and participates in cell migration, tissue repair, and the like. In skin tissues, the plasminogen/plasmin system is also known to be involved in morphogenesis, disease onset, and the like, and PA is reported to be involved in the growth of epidermal cells (non-patent document 1).
Antiplasmin is an agent that inhibits activation of plasminogen by PA to prevent fibrinolysis and exert a hemostatic action, and is used to inhibit the action of plasmin. As examples of antiplasmin agents, synthetic plasmin inhibitors such as epsilon-aminocaproic acid and tranexamic acid have been known. Further, plant extracts such as a white birch extract (patent document 1), a hop extract and a chamomile extract (patent document 2) have been found.
Documents of the prior art
Non-patent document
Non-patent document 1: kirchheimer JC et at, Eur J Biochem,181, 103-one 107(1989)
Patent document
Patent document 1: japanese laid-open patent publication No. 10-338614
Patent document 2: japanese patent laid-open No. 2000-229833
Disclosure of Invention
Problems to be solved by the invention
Since plant-derived components constitute a complex multi-component system due to natural products, they may be various depending on the form of the preparation and other components coexisting, and may have different properties such as stability. Therefore, the formulation of increasingly diverse formulations cannot be flexibly coped with only with anti-plasmin agents containing plant extracts known to date.
Accordingly, an object of the present invention is to provide a novel plant-derived component useful as an anti-plasmin agent.
Means for solving the problems
The present inventors have conducted intensive studies and, as a result, have found that extracts of plants belonging to the genus Scutellaria of the family Labiatae, Curcuma of the family Zingiberaceae, Ulmus of the family Rosaceae, Paeonia of the family Paeoniaceae and Acinetobacter of the family Leguminosae, and fruit juices of plants belonging to the genus Citrus of the family Rutaceae have anti-plasmin activity. The present invention has been completed by further repeated studies based on this finding.
That is, the present invention provides the following embodiments.
An anti-plasmin agent comprising:
extract of plant of Scutellaria of Labiatae, plant of Curcuma of Zingiberaceae, plant of Ulmus of Rosaceae, plant of Paeonia of Paeoniaceae, and/or plant of Sonchus of Leguminosae; and/or
Fruit juice of plant of Citrus of Rutaceae.
Item 2 the anti-fibrinolytic agent according to item 1, wherein the plant of genus Scutellaria of family Labiatae is selected from the group consisting of Scutellaria baicalensis, Scutellaria lateriflora, and Scutellaria barbata.
Item 3 the anti-fibrinolytic agent according to item 1 or 2, wherein the plant of the genus curcuma of the family zingiberaceae is selected from the group consisting of curcuma longa, zingiber mangostana, curcuma aromatica, curcuma zedoary, and curcuma indonesia ("japanese text of curcuma indonesis: クスリウコン).
The antiplasmin agent according to any one of items 1 to 3, wherein the plant of genus Ulmus of family Rosaceae is sanguisorba officinalis and/or sanguisorba parvifolia.
Item 5 the antiplasmin agent according to any one of items 1 to 4, wherein the plant of the genus Paeonia of the family Paeoniaceae is selected from the group consisting of peony, Paeonia lactiflora and Paeonia lactiflora.
The antiplasmin agent according to any one of items 1 to 5, wherein the plant of the genus Mallotus of the family Leguminosae is Genistus tikoua.
The fibrinolytic agent according to any one of items 1 to 6, wherein the citrus plant of the rutaceae family is selected from the group consisting of lime, sweet orange, grapefruit, arrow leaf orange, fragrant orange, sour orange, stinky, mandarin, lemon, citron, bergamot, summer orange, navel orange, hassaku, Citrus depressa, Citrus trifoliata, Citrus iyo, Fortunella, Citrus unshiu, bergamot, and grapefruit.
Effects of the invention
According to the present invention, a novel plant-derived component useful as an anti-plasmin agent can be provided.
Drawings
FIG. 1 shows the results of measurement of the plasmin activity of each plant-derived component.
Detailed Description
The fibrinolytic agent of the present invention is characterized by comprising an extract of a plant belonging to the genus Scutellaria of the family Labiatae, a plant belonging to the genus Curcuma of the family Zingiberaceae, a plant belonging to the genus Ulmus of the family Rosaceae, a plant belonging to the genus Paeonia of the family Paeoniaceae and/or a plant belonging to the genus Songbus of the family Leguminosae; and/or juice of Citrus plant of Rutaceae as effective component. Hereinafter, the antiplasmin agent of the present invention is described in detail.
Extract of plant of Scutellaria of Labiatae
Extracts of plants belonging to the genus Scutellaria (Labiatae) are known to have antiallergic, antibacterial, astringent, and moisturizing effects. In the present invention, from the viewpoint of obtaining a more preferable antifibrinolytic enzyme activity, preferable examples of the extract of a plant belonging to the genus Scutellaria of the family labiatae include an extract of Scutellaria baicalensis (Scutellaria baicalensis Georgi), an extract of Scutellaria baicalensis (Scutellaria lateriflora Linne), and an extract of Scutellaria barbata (Scutellaria barbata D.Don.). These plant extracts may be used alone in 1 kind, or may be used in combination in 2 or more kinds.
Among the above plant extracts, from the viewpoint of obtaining a more preferable anti-fibrinolytic activity, an extract of scutellaria baicalensis is preferable. The extract of scutellaria baicalensis is expressed as a scutellaria baicalensis extract in the standard of quasi drug raw materials and the like. Specifically, the extract of scutellaria can be obtained from the root of scutellaria by extraction treatment using an extraction solvent. Examples of the extraction solvent used in the extraction treatment of scutellaria include water; lower alcohols such as ethanol and isopropanol; polyhydric alcohols such as 1, 3-butanediol, propylene glycol, and glycerin; examples of the polar solvent such as a mixed solution thereof include water, ethanol, 1, 3-butanediol, glycerin, and a mixed solvent thereof. The extract of scutellaria baicalensis can be obtained commercially from, for example, Yamadayaken co., ltd., ICHIMARU PHARCOS co., pillared pharmaceutical co.
The content of the extract of a plant belonging to the genus scutellaria of the family labiatae in the antiplasmin agent of the present invention is not particularly limited, and can be suitably determined in accordance with the antiplasmin effect to be given, and examples thereof include 0.00009 to 10% by weight, preferably 0.0009 to 5% by weight, more preferably 0.009 to 3% by weight, and still more preferably 0.09 to 0.9% by weight in terms of dry weight.
Extract of plant of Curcuma of Zingiberaceae
An extract of a plant belonging to the genus Curcuma (Curcuma) of the family Zingiberaceae (Zingiberaceae) is a known component having an antioxidant activity, an anti-aging activity, and the like. In the present invention, from the viewpoint of obtaining a more preferable antifibrinolytic enzyme activity, preferable examples of the extract of a plant belonging to the genus Curcuma of the family zingiberaceae include an extract of Curcuma longa (Curcuma longa line), an extract of zingiber mangifera (Curcuma amada Roxb.), an extract of Curcuma aromatica (Curcuma aromatica Salisb.), an extract of Curcuma zedoaria (Curcuma zedoaria Roscoe), and an extract of Curcuma indonesica (Curcuma domestica Valeton). These plant extracts may be used alone in 1 kind, or may be used in combination in 2 or more kinds.
Among the above plant extracts, from the viewpoint of obtaining a more preferable anti-fibrinolytic activity, an extract of turmeric is preferably used. The extract of turmeric is expressed as a turmeric extract in the standards for quasi drug raw materials and the like. Specifically, the extract of turmeric may be obtained by subjecting the rhizome of turmeric to extraction treatment using an extraction solvent. Examples of the extraction solvent used in the extraction treatment of turmeric include water; lower alcohols such as ethanol and isopropanol; polyhydric alcohols such as 1, 3-butanediol, propylene glycol, and glycerin; examples of the polar solvent such as a mixed solution thereof include water, ethanol, 1, 3-butanediol and a mixed solvent thereof. Turmeric extracts are commercially available from, for example, Yamadayaken co., ltd., ichimamar PHARCOS co., pillared pharmaceutical co., japan oil co.
The content of the extract of a plant belonging to the genus curcuma of the family zingiberaceae in the antiplasmin agent of the present invention is not particularly limited, and may be suitably determined in accordance with the antiplasmin effect to be imparted, and examples thereof include 0.00008 to 10% by weight, preferably 0.0008 to 5% by weight, more preferably 0.008 to 1% by weight, and further preferably 0.08 to 0.8% by weight in terms of dry weight.
Extract of plant of genus Ulmus of family Rosaceae
An extract of a plant belonging to genus Sanguisorba (Sanguisorba) of family Rosaceae (Rosaceae) is a known component having an astringent effect, an antibacterial effect, an antiallergic effect, an antiaging effect, a hair-growing effect, a deodorizing effect, etc. In the present invention, from the viewpoint of obtaining a more preferable antifibrinolytic enzyme activity, preferable examples of the extract of a plant belonging to the genus Sanguisorba of the family Rosaceae include an extract of Sanguisorba officinalis (Sanguisorba officinalis Linne) and an extract of Sanguisorba parvum (sanguisorb minor Scop). These plant extracts may be used alone in 1 kind, or in combination in 2 kinds.
Among the above plant extracts, from the viewpoint of obtaining a more preferable anti-plasmin activity, an extract of sanguisorba officinalis is preferable. The sanguisorba officinalis extract is expressed as a sanguisorba officinalis extract in the standards of quasi drug raw materials and the like. Specifically, the sanguisorba officinalis extract can be obtained by subjecting roots and rhizomes of sanguisorba officinalis to extraction treatment using an extraction solvent. Examples of the extraction solvent used in the extraction treatment of sanguisorba officinalis include water; lower alcohols such as ethanol and isopropanol; polyhydric alcohols such as 1, 3-butanediol, propylene glycol, and glycerin; examples of the polar solvent such as a mixed solution thereof include water, ethanol, 1, 3-butanediol and a mixed solvent thereof. Sanguisorba officinalis extract is commercially available from, for example, bolus pharmaceutical co.
The content of the extract of a plant belonging to the genus sanguisorba of the family rosaceae in the antiplasmin agent of the present invention is not particularly limited, and may be suitably determined depending on the antiplasmin effect to be imparted, and examples thereof include 0.00008 to 10 wt%, preferably 0.0008 to 5 wt%, more preferably 0.008 to 3 wt%, and further preferably 0.08 to 0.8 wt% in terms of dry weight.
Extract of plant of Paeonia of Paeoniaceae
The extract of a plant belonging to Paeonia of Paeoniaceae (Paeoniaceae) is known as a component having cell-activating, antibacterial, moisturizing/isolation-improving, anti-wrinkle, etc. effects. In the present invention, from the viewpoint of obtaining a more preferable antifibrinolytic enzyme activity, preferable examples of the extract of a plant belonging to genus Paeonia of family Paeoniaceae include an extract of Paeonia suffruticosa Andrews, an extract of Paeonia lactiflora Pall, and an extract of Paeonia lactiflora Pall. These plant extracts may be used alone in 1 kind, or may be used in combination in 2 or more kinds.
Among the above plant extracts, the extract of peony is preferable from the viewpoint of obtaining a more preferable anti-plasmin activity. The extract of peony is represented as a peony extract in quasi drug raw material standards and the like. Specifically, the extract of paeonia lactiflora can be obtained from roots of paeonia lactiflora by extraction treatment using an extraction solvent. Examples of the extraction solvent used in the extraction treatment of peony include water; lower alcohols such as ethanol and isopropanol; polyhydric alcohols such as 1, 3-butanediol, propylene glycol, and glycerin; examples of the polar solvent such as a mixed solution thereof include water, ethanol, 1, 3-butanediol and a mixed solvent thereof. The peony extract can be obtained commercially from, for example, Yamadayaken co., ltd., ICHIMARU pharos corporation, pillared pharmaceutical co.
The content of the extract of a plant belonging to the genus Paeonia of the family Paeoniaceae in the antiplasmin agent of the present invention is not particularly limited, and may be suitably determined depending on the antiplasmin effect to be administered, and examples thereof include 0.0001 to 10% by weight, preferably 0.001 to 5% by weight, more preferably 0.01 to 3% by weight, and still more preferably 0.1 to 1% by weight in terms of dry weight.
Extract of plant of genus Pinus of family Leguminosae
An extract of a plant belonging to the genus Aspalathus (Fabaceae) is known as an antiallergic agent, an antioxidant agent, etc. In the present invention, from the viewpoint of obtaining a more preferable antifibrinolytic enzyme activity, a preferable example of the extract of a plant belonging to the genus malachite of the family leguminosae is an extract of malachite pilosus (Aspalathus Linearis (burm.f.) r.dahlgren).
The extract of the maidenhair was expressed as maidenhair extract (Aspalathus Linearis extract) in the quasi drug raw material standard and the like. Specifically, the extract of the broom cypress can be obtained from the whole plant of the broom cypress by extraction treatment using an extraction solvent. Examples of the extraction solvent used in the extraction treatment of the sparrow velutina include water; lower alcohols such as ethanol and isopropanol; polyhydric alcohols such as 1, 3-butanediol, propylene glycol, and glycerin; as the polar solvent such as a mixed solution of these, 1, 3-butanediol is preferably used. The extract of broom of malachite can be obtained commercially from, for example, Bolus pharmaceuticals, Yamadayaken Co., Ltd., ICHIMARU PHARCOS, etc.
The content of the extract of the plant of the genus pinus of the family Leguminosae in the antiplasmin agent of the present invention is not particularly limited, and may be suitably determined depending on the antiplasmin effect to be given, and examples thereof include 0.0005 to 10% by weight, preferably 0.005 to 7.5% by weight, more preferably 0.05 to 6% by weight, and further preferably 0.5 to 5% by weight in terms of dry weight.
Juice of Citrus of Rutaceae
Juice of Citrus (Citrus) belonging to Rutaceae (Rutaceae) is a known component having an antioxidant action, a moisturizing action, an astringent action, an exfoliating (ピーリング) action, a cutin softening action, and the like. In the present invention, from the viewpoint of obtaining a more preferable antifibrinolytic enzyme activity, preferable examples of the extract of a Citrus plant belonging to the family Rutaceae include a fruit juice of lime (Citrus aurantifolia Swingle), a fruit juice of lime (Citrus aurantium Linne), a fruit juice of sweet orange (Citrus sinense (L.), Osbeck), a fruit juice of grapefruit (Citrus paradisi Macfad.), a fruit juice of arrow leaf orange (Citrus hystrix DC.), a fruit juice of fragrant orange (Citrus junos Siebold ex Tanaka), a fruit juice of lime (Citrus sudachi Hort. ex Shiraii), a fruit juice of common orange (Citrus aurantium) and a fruit juice of lemon (Citrus limosum) juice, a fruit juice of lemon (Citrus reticulata fruit juice, a fruit juice of orange (Citrus grandis) and a fruit juice of orange (Citrus grandis, a fruit juice of orange (Citrus grandis) Juice from Citrus hassaku (Citrus aurantium L. subsp. hassaku Hiroe), juice from Citrus depressa Hayata, juice from Citrus tachibana (Makino) Tanaka, juice from Citrus iyo Hort. ex Tanaka, juice from Fortunella orange (Citrus iyo Hort. ex Tanaka), juice from Fortunella orange (Citrus tanderia Hort. ex Tanaka), juice from Citrus unshiu (Swingle) Marco., juice from Citrus bergamia Risso Poit, and juice from Citrus grandis Osbeck. These plant juices may be used alone in 1 kind, or in combination in 2 or more kinds.
Among the above-mentioned plant juices, juice of lime is preferable from the viewpoint of obtaining a more preferable anti-fibrinolytic enzyme activity. Specifically, the juice of lime can be obtained by squeezing the fruit of lime. Specific examples of the lime juice include raw juice and dried juice. In the lime juice needle, raw juice is commercially available from, for example, bolus pharmaceutical co.
The content of the juice of citrus belonging to the family rutaceae in the antiplasmin agent of the present invention is not particularly limited, and may be suitably determined in accordance with the antiplasmin effect to be imparted, and examples thereof include 0.001 to 10% by weight, preferably 0.01 to 10% by weight, more preferably 0.1 to 10% by weight, and still more preferably 1 to 10% by weight in terms of dry weight.
Other ingredients
The antiplasmin agent of the present invention may contain other pharmacological components as required in addition to the above components. Examples of such a pharmacological component include an anti-inflammatory agent, an antioxidant, a bactericide, a refreshing agent, vitamins, mucopolysaccharides, and the like.
The antiplasmin agent of the present invention may contain a base and additives as necessary to prepare a desired formulation. Such a base and additive are not particularly limited insofar as they are pharmaceutically acceptable, and include, for example, aqueous bases such as water, lower alcohols (ethanol, isopropanol, etc.), polyols (glycerin, propylene glycol, dipropylene glycol, 1, 3-butylene glycol, etc.); oily base agents such as natural source oils, mineral oils, ester oils, fatty acid alkyl esters, fatty acids, fatty acid esters, and higher alcohols; a surfactant; additives such as cooling agent, antiseptic, flavoring agent, colorant, viscous agent, pH regulator, wetting agent, stabilizer, antioxidant, ultraviolet absorbent, chelating agent, binder, buffer, solubilizer, cosolvent, and preservative.
Application and preparation form
The anti-plasmin agent of the invention is used for playing antagonistic role on the activity of plasmin and plasminogen activator and directly or indirectly preventing the activity expression of plasmin. The form of the antiplasmin agent of the present invention is not particularly limited, and any of liquid, solid, semisolid, and the like may be used.
Examples
The present invention will be described more specifically with reference to the following examples, but the present invention is not limited thereto.
The anti-plasmin activity was measured by measuring plasmin activity according to The method described in R Homma et al, The International Journal of Biochemistry and Cell Biology 37(2005)1911-1920 in accordance with The method described in Table 1 (BG means 1, 3-butanediol).
(starting Material derived from plants)
[ Table 1]
(method of measuring plasmin Activity)
(1) Reagent and sample preparation
(1-1) base solution
To 5.3mg of substrate (Boc-Val-Leu-Lys-MCA; PEPTIDE INSTITUTE, INC.; 3104-v) was added 860.7. mu.l of DMSO, to prepare a 10mM stock solution, which was stored at-20 ℃. For use, the substrate was diluted with 200mM Tris-HCl (pH8.0) so that the concentration of the substrate became 2 mM.
(1-2) plasmin solution
To 1. mu.l of 34U/. mu.l plasmin solution (FUJIFILM Wako Pure Chemical Corporation; 166-24231), 33. mu.l of 200mM Tris-HCl (pH8.0) was added to prepare plasmin 1U/. mu.l stock solution. When used, the plasmin was diluted with 200mM Tris-HCl (pH8.0) to a concentration of 100 mU/ml.
(1-3) sample solution
Sample solutions were prepared for the scutellaria root extract so as to be 0.09 wt%, 0.45 wt%, and 0.90 wt% in terms of the dry weight of the extract, respectively.
Sample solutions were prepared for each of the turmeric rhizome extracts so that the content of each was 0.08 wt%, 0.40 wt%, and 0.80 wt% in terms of the dry weight of the extract.
Sample solutions were prepared for each of the sanguisorba officinalis (roots and rhizomes) extracts so that the content of each was 0.08 wt%, 0.40 wt%, and 0.80 wt% in terms of the dry weight of the extract.
Sample solutions were prepared for the peony root extract so as to be 0.10 wt%, 0.50 wt%, and 1.00 wt% in terms of the dry weight of the extract, respectively.
Sample solutions were prepared for the extract of malachite frondosa (whole plant) in such a manner that the extract was 0.50 wt%, 2.50 wt%, and 5.00 wt% in terms of the dry weight of the extract, respectively.
Sample solutions were prepared for lime juice so as to be 1.00 wt%, 5.00 wt%, and 10.00 wt% in terms of the dry weight of the juice, respectively.
In the preparation of the sample solutions, when each of the commercial products shown in table 1 was diluted, the dilution was performed using a solvent having the same composition as that of the solvent used for each commercial product.
(2) Assay protocol
(2-1) dispensing operation
(sample)
The sample solution was dispensed in 40. mu.L each in a 96-well microplate.
In each well into which the sample solution was dispensed, a matrix solution was dispensed in an amount of 50. mu.L.
A plasmin solution was dispensed in 10. mu.L each into the wells into which the matrix solution was dispensed.
(control)
The operation of dispensing the matrix solution and the plasmin solution was performed in the same manner as described above except that the 1,3-BG aqueous solution was dispensed instead of the sample solution.
(blank)
After 40. mu.L each of the sample solution and the control was dispensed into a 96-well microplate, 200mM Tris-HCl was dispensed into each well in 60. mu.L each.
(2-2) measurement
Enzymatic reaction of plasmin with the matrix was carried out at 37 ℃. The enzyme reaction time was set to 60 minutes after the start of the enzyme reaction of plasmin with the matrix. The enzyme reaction cleaves the MCA bound to the substrate, thereby releasing the fluorescent substance AMC and emitting fluorescence. The higher the plasmin activity, the stronger the fluorescence intensity. That is, the weaker the fluorescence intensity, the higher the antiplasmin activity. The resulting fluorescence was measured by EnSigt (measurement wavelength: Ex380nm, Em460 nm).
(3) Analysis of
The fluorescence intensity of the blank was subtracted from the fluorescence intensity of each sample, and the ratio (%) of the plasmin activity of each plant-derived component was determined with the plasmin activity of the control as 100%. The results are shown in FIG. 1.
As shown in FIG. 1, both of the plant-derived components were confirmed to have anti-plasmin activity and concentration dependence.
Claims (7)
1. An antiplasmin agent, comprising:
extract of plant of Scutellaria of Labiatae, plant of Curcuma of Zingiberaceae, plant of Ulmus of Rosaceae, plant of Paeonia of Paeoniaceae, and/or plant of Sonchus of Leguminosae; and/or
Fruit juice of plant of Citrus of Rutaceae.
2. The antiplasmin agent according to claim 1, wherein,
said plant of genus Scutellaria of family Labiatae is selected from the group consisting of Scutellaria baicalensis Georgi, Scutellaria lateriflora and Scutellaria barbata.
3. The anti-fibrinolytic agent according to claim 1 or 2, wherein the plant of the genus curcuma of the family zingiberaceae is selected from the group consisting of curcuma longa, zingiber officinale, curcuma aromatica, curcuma zedoaria and curcuma indonesis.
4. The antiplasmin agent according to any one of claims 1 to 3, wherein the plant of genus Ulmus of family Rosaceae is sanguisorba officinalis and/or sanguisorba parvifolia.
5. The anti-plasmin agent of any of claims 1-4, wherein said Paeoniaceae Paeonia plant is selected from the group consisting of peony, Paeonia lactiflora and Paeonia lactiflora.
6. The antiplasmin agent according to any one of claims 1 to 5, wherein the plant of the genus Mallotus of the family Leguminosae is Genistus tikoua.
7. The fibrinolytic agent according to any one of claims 1-6, wherein the Citrus plant of Rutaceae is selected from the group consisting of lime, sweet orange, grapefruit, arrow orange, fragrant orange, lime, stinky, mandarin, lemon, citron, bergamot, summer orange, navel orange, Citrus hassaku, Citrus depressa, Citrus liphi, Citrus iyo, Fortunella, Citrus unshiu, bergamot, and grapefruit.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1232692A (en) * | 1998-02-24 | 1999-10-27 | 株式会社资生堂 | Antiplasmin agent |
| CN101584721A (en) * | 2009-07-06 | 2009-11-25 | 江苏泰灵生物科技有限公司 | Chinese traditional medicine antibiotic hemostatic plaster |
| CN109276318A (en) * | 2018-10-12 | 2019-01-29 | 安徽迈德普斯医疗科技有限公司 | A kind of surgical operation towel |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1232692A (en) * | 1998-02-24 | 1999-10-27 | 株式会社资生堂 | Antiplasmin agent |
| CN101584721A (en) * | 2009-07-06 | 2009-11-25 | 江苏泰灵生物科技有限公司 | Chinese traditional medicine antibiotic hemostatic plaster |
| CN109276318A (en) * | 2018-10-12 | 2019-01-29 | 安徽迈德普斯医疗科技有限公司 | A kind of surgical operation towel |
Non-Patent Citations (1)
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| 王永奇: "八种黄芩属植物中黄芩甙含量的比较及凝血活性的观察" * |
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