CN105078826A - Oral care solution - Google Patents
Oral care solution Download PDFInfo
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- CN105078826A CN105078826A CN201510530816.XA CN201510530816A CN105078826A CN 105078826 A CN105078826 A CN 105078826A CN 201510530816 A CN201510530816 A CN 201510530816A CN 105078826 A CN105078826 A CN 105078826A
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Abstract
The invention discloses oral care solution. The oral care solution consists of the following components in percentage by weight: 5-25% of an effective plant extract composition (a), 0.1-5% of an effective taste enhancer composition (b), 0.1-3% of essence (c), 5-35% of solubilizer (d), 5-40% of humectants (e), and 1-10% of ethyl alcohol (f). The oral care solution does not contain synthesized sweetening agents, synthesized essence, pigment, corrosion remover or animal ingredients, and has a good relaxation effect on common oral problems such as gingival inflammation, oral malodor and oral ulcer.
Description
Technical field
The invention belongs to filed of daily-use chemical industry, relate to a kind of common oral care that is applicable to and keep healthy, effectively alleviate the oral nursing liquid of multiple oral cavity malaise symptoms.
Background technology
People have generally formed the custom of sooner or later brushing teeth, but once the process of brushing teeth of two minutes can not protect oral environment for a long time; In addition at some special occasions or crowd and be not suitable for use toothpaste carry out cleaning oral cavity.Oral nursing liquid exactly solves this series of problems.
Have on the market and occurred some mouth care liquid products, sweeting agent, the essence of synthetic are added in common existence; Add the composition of pigment, antiseptic and animal origin.This part product just can not meet the requirement of the safety aspect that consumer strengthens day by day, such as natural, non-stimulated, without interpolation, preservative free, animal origin-free composition etc.
Summary of the invention
Technical problem to be solved by this invention is, provides a kind of oral nursing liquid not only having met different crowd oral cavity health demand but also met security requirement.
The present invention is realized by following technology:
A kind of oral nursing liquid, is characterized in that, composed of the following components:
A) effect composition of plant extracts of oral nursing liquid composition weight 5% to 25% is accounted for, consisting of of this extractive composition:
I. the sage extract of composition weight 1% to 5% is accounted for;
Ii. the Juniperus communis L. berry extract of composition weight 1% to 5% is accounted for;
Iii. the Herba melissae axillaris extract of composition weight 1% to 5% is accounted for;
Iv. the Europe Radix Gentianae extract of composition weight 1% to 5% is accounted for;
V. the Pinus koraiensis wood extract from pine needles of composition weight 1% to 5% is accounted for;
Vi. the Betula gall extract of composition weight 1% to 5% is accounted for;
B) effect palatability enhancers compositions of oral nursing liquid composition weight 0.1% to 5% is accounted for, consisting of of this enhancer compositions:
I. 4-methyl-3-(1-pyrrolidinyl)-2 (the 5H)-furanone of composition weight 0.1% to 2% is accounted for;
Ii. 3,3,5-trimethylcyclohexanone glycerol ketals of composition weight 0.1% to 2% are accounted for;
Iii. (-)-different Mentha arvensis L. syn.M.haplocalyxBrig alcohol of composition weight 0.1% to 2% is accounted for;
C) essence of oral nursing liquid composition weight 0.1% to 3% is accounted for;
D) solubilizing agent of oral nursing liquid composition weight 1% to 35% is accounted for;
E) wetting agent of oral nursing liquid composition weight 5% to 40% is accounted for;
F) ethanol of oral nursing liquid composition weight 1% to 10% is accounted for.
Mouth care fluid composition of the present invention, in its effect plant extract compositions, sage extract, Juniperus communis L. berry extract, Herba melissae axillaris extract, Europe Radix Gentianae extract, Pinus koraiensis wood extract from pine needles, Betula gall extract are the lyophilized powders that corresponding plant obtains after cellulase, pectase or proteases for decomposing, steam distillation, fineness 300 to 400 order.
Mouth care fluid composition of the present invention, in effect plant extract compositions wherein, sage extract, Juniperus communis L. berry extract, Herba melissae axillaris extract, Europe Radix Gentianae extract, Pinus koraiensis wood extract from pine needles, Betula gall extract account for effect plant extract composition weight percentage ratio and are: 2%, 2%, 2%, 2%, 1.5%, 0.5%.
Mouth care fluid composition of the present invention, 4-methyl-3-(1-pyrrolidinyl)-2 (5H)-furanone, 3 in effect palatability enhancers compositions wherein, 3,5-trimethylcyclohexanone glycerol ketals, (-)-different Mentha arvensis L. syn.M.haplocalyxBrig alcohol proportioning by accounting for enhancer compositions percentage by weight are: 0.2%, 0.4%, 0.4%.
Mouth care fluid composition of the present invention, essence is wherein the mixture of one or more arbitrary proportions of Oleum menthae, mentha piperita oil.
Mouth care fluid composition of the present invention, solubilizing agent is wherein the mixture of one or more arbitrary proportions in propylene glycol, Polyethylene Glycol, soybean lecithin.
Mouth care fluid composition of the present invention, wetting agent is wherein the mixture of one or more arbitrary proportions in Sorbitol, xylitol, lactose.
Beneficial effect of the present invention: the oral nursing liquid of multiple oral cavity malaise symptoms is effectively alleviated in the present invention.Be applicable to old people and child and have specific demand crowd to use.This product prosthetic synthetic sweetener, essence; Non-pigment, antiseptic and animal component.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further described in detail.
In the present invention, the plant extract of effect type is widely used in personal-care supplies field.Sage extract in the present invention has anticorrosion, antibacterial effect; Juniperus communis L. berry extract has heat clearing away, the effect of removing toxic substances; Herba melissae axillaris extract has calms the nerves, and analgesic acts on; Europe Radix Gentianae extract has removing toxic substances, the effect of antiinflammatory; Pinus koraiensis wood extract from pine needles has powerful antioxidant, can effective scavenging free radicals; Betula gallbladder (Inonqqus obliquus) extract, anticancer, enhancing immunity.By above-mentioned several natural plant extracts by more composite than row, the effect of Synergistic can be played.
4-methyl-3-(1-pyrrolidinyl)-2 [5H]-furanone comes from the composition in native wheat, its intensity of mint flavored in mouth is 35 times of menthol, intensity on skin is 512 times of menthol, and the persistent period is two times of menthol.(-)-different Mentha arvensis L. syn.M.haplocalyxBrig alcohol of high enantiomeric purity has the fragrance of pure and fresh, happy, refrigerant Fructus Citri tangerinae Fructus Citri tangerinae class.3,3,5-trimethylcyclohexanone glycerol ketals also has the cool effect of the system being better than menthol, and it all has the effect of anthelmintic in addition with (-)-different Mentha arvensis L. syn.M.haplocalyxBrig alcohol.
Most preferred embodiment (implementing by effect composition of plant extracts, palatability enhancers compositions best in quality per distribution ratio)
The preparation method of oral nursing liquid can adopt either method well known to those skilled in the art.
Clinical effectiveness
Select oral cavity malaise symptoms crowd 180 people.Wherein gingivitis patient 60 people, halitosis patient 60 people, oral ulcer patient 60 people.Use the present embodiment product to gargle, use after meal at every turn, one time 15 milliliters, rinsing the mouth 10 minutes, 3 times on the one, continues use 4 time-of-week, respectively at the 7th, 14,21,28 day observe the curative effect.
Experimental applications SPSS16.0 statistical software, technical data adopts χ
2inspection, significant level α=0.05.
Gingivitis patient adopts Loe-Silness index of gingivitis (GI) method of improvement to assess: 0: without gingivitis; 1: slight gingivitis, gingiva color and luster and quality slightly change, but spy is examined without hemorrhage; 2: moderate gingivitis, gingiva light, redness, hypertrophy, palpation are hemorrhage; 3: severe gingivitis, gingiva obviously redness, hypertrophy, have hematostaxis.The observed result display of 4 weeks continues to use the present embodiment oral nursing liquid, and the GI index of patient is lower than before test.The observed result display of 4 weeks continues to use the present embodiment oral nursing liquid, and the index of gingivitis of patient obviously declines, as table 1.
The change of table 1GI index
| Time (my god) | GI | P |
| 7 | 2.89±0.23 | ＞0.05 |
| 14 | 2.20±0.33 | ＜0.05 |
| 21 | 1.78±0.20 | ＜0.05 |
| 28 | 0.98±0.11 | ＜0.05 |
Halitosis patient adopts level (volatilesulfurcompounds, the VSCs) method of volatile sulfur compounds to assess, and measures with instrument Halimeter.The observed result display of 4 weeks continues to use the present embodiment oral nursing liquid, the VSCs of patient significantly lower than before test, as table 2.
The change of table 2VSCs
| Time (my god) | VSCs | P |
| 7 | 5.50±0.46 | ＞0.05 |
| 14 | 3.84±0.47 | ＜0.05 |
| 21 | 3.45±0.36 | ＜0.05 |
| 28 | 3.06±0.32 | ＜0.05 |
Oral ulcer patient adopts DP staging pain index to assess, and adopts Visual analogue scale (visualanalogscale, VAS) to record the pain scores P of ulcer every day
1.0 end represents " painless ", and 10 ends represent " the most violent pain ".The observed result display of 4 weeks continues to use the present embodiment oral nursing liquid, the P of patient
1level significantly lower than test before, as table 3.
Table 3P
1the change of score value
| Time (my god) | P 1 | P |
| 7 | 7.82±0.53 | ＞0.05 |
| 14 | 6.24±0.50 | ＜0.05 |
| 21 | 4.89±0.28 | ＜0.05 |
| 28 | 1.23±0.22 | ＜0.05 |
Product of the present invention, all has good mitigation to common oral problems such as gingivitis, halitosis, oral ulcer.
Claims (7)
1. an oral nursing liquid, is characterized in that, composed of the following components:
A) effect composition of plant extracts of oral nursing liquid composition weight 5% to 25% is accounted for, consisting of of this extractive composition:
I. the sage extract of composition weight 1% to 5% is accounted for;
Ii. the Juniperus communis L. berry extract of composition weight 1% to 5% is accounted for;
Iii. the Herba melissae axillaris extract of composition weight 1% to 5% is accounted for;
Iv. the Europe Radix Gentianae extract of composition weight 1% to 5% is accounted for;
V. the Pinus koraiensis wood extract from pine needles of composition weight 1% to 5% is accounted for;
Vi. the Betula gall extract of composition weight 1% to 5% is accounted for;
B) effect palatability enhancers compositions of oral nursing liquid composition weight 0.1% to 5% is accounted for, consisting of of this enhancer compositions:
I. 4-methyl-3-(1-pyrrolidinyl)-2 (the 5H)-furanone of composition weight 0.1% to 2% is accounted for;
Ii. 3,3,5-trimethylcyclohexanone glycerol ketals of composition weight 0.1% to 2% are accounted for;
Iii. (-)-different Mentha arvensis L. syn.M.haplocalyxBrig alcohol of composition weight 0.1% to 2% is accounted for;
C) essence of oral nursing liquid composition weight 0.1% to 3% is accounted for;
D) solubilizing agent of oral nursing liquid composition weight 1% to 35% is accounted for;
E) wetting agent of oral nursing liquid composition weight 5% to 40% is accounted for;
F) ethanol of oral nursing liquid composition weight 1% to 10% is accounted for.
2. mouth care fluid composition according to claim 1, in its effect plant extract compositions, sage extract, Juniperus communis L. berry extract, Herba melissae axillaris extract, Europe Radix Gentianae extract, Pinus koraiensis wood extract from pine needles, Betula gall extract are the lyophilized powders that corresponding plant obtains after cellulase, pectase or proteases for decomposing, steam distillation, fineness 300 to 400 order.
3. mouth care fluid composition according to claim 1, in effect plant extract compositions wherein, sage extract, Juniperus communis L. berry extract, Herba melissae axillaris extract, Europe Radix Gentianae extract, Pinus koraiensis wood extract from pine needles, Betula gall extract account for effect plant extract composition weight percentage ratio and are: 2%, 2%, 2%, 2%, 1.5%, 0.5%.
4. mouth care fluid composition according to claim 1,4-methyl-3-(1-pyrrolidinyl)-2 (5H)-furanone, 3 in effect palatability enhancers compositions wherein, 3,5-trimethylcyclohexanone glycerol ketals, (-)-different Mentha arvensis L. syn.M.haplocalyxBrig alcohol proportioning by accounting for enhancer compositions percentage by weight are: 0.2%, 0.4%, 0.4%.
5. mouth care fluid composition according to claim 1, is characterized in that: described essence is the mixture of one or more arbitrary proportions of Oleum menthae, mentha piperita oil.
6. mouth care fluid composition according to claim 1, is characterized in that: described solubilizing agent is the mixture of one or more arbitrary proportions in propylene glycol, Polyethylene Glycol, soybean lecithin.
7. mouth care fluid composition according to claim 1, is characterized in that: described wetting agent is the mixture of one or more arbitrary proportions in Sorbitol, xylitol, lactose.
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| CN201510530816.XA CN105078826B (en) | 2015-08-26 | 2015-08-26 | A kind of oral nursing liquid |
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| CN201510530816.XA CN105078826B (en) | 2015-08-26 | 2015-08-26 | A kind of oral nursing liquid |
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| CN105078826B CN105078826B (en) | 2018-04-24 |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105832643A (en) * | 2016-05-31 | 2016-08-10 | 广州宇晟生物科技有限公司 | Oral care composition |
| CN106038414A (en) * | 2016-07-11 | 2016-10-26 | 周晗生 | Manufacturing method of portable mouth care product |
| CN106074275A (en) * | 2016-07-11 | 2016-11-09 | 周晗生 | The manufacture method of graininess oral care composition |
| CN106074341A (en) * | 2016-07-11 | 2016-11-09 | 周晗生 | Portable oral care liquid |
| CN106074277A (en) * | 2016-07-11 | 2016-11-09 | 周晗生 | Portable oral care thing |
| CN106074274A (en) * | 2016-07-11 | 2016-11-09 | 周晗生 | Oral care substance |
| CN106177269A (en) * | 2016-07-07 | 2016-12-07 | 万苏晨 | The pharmaceutical composition of quick curing oral keritonocytes, preparation method and application |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105832643A (en) * | 2016-05-31 | 2016-08-10 | 广州宇晟生物科技有限公司 | Oral care composition |
| CN106177269A (en) * | 2016-07-07 | 2016-12-07 | 万苏晨 | The pharmaceutical composition of quick curing oral keritonocytes, preparation method and application |
| CN106038414A (en) * | 2016-07-11 | 2016-10-26 | 周晗生 | Manufacturing method of portable mouth care product |
| CN106074275A (en) * | 2016-07-11 | 2016-11-09 | 周晗生 | The manufacture method of graininess oral care composition |
| CN106074341A (en) * | 2016-07-11 | 2016-11-09 | 周晗生 | Portable oral care liquid |
| CN106074277A (en) * | 2016-07-11 | 2016-11-09 | 周晗生 | Portable oral care thing |
| CN106074274A (en) * | 2016-07-11 | 2016-11-09 | 周晗生 | Oral care substance |
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| CN105078826B (en) | 2018-04-24 |
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