CN105832643A - Oral care composition - Google Patents
Oral care composition Download PDFInfo
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- CN105832643A CN105832643A CN201610378289.XA CN201610378289A CN105832643A CN 105832643 A CN105832643 A CN 105832643A CN 201610378289 A CN201610378289 A CN 201610378289A CN 105832643 A CN105832643 A CN 105832643A
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- Prior art keywords
- cleaning efficacy
- oral
- composition
- compositions
- oral care
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a composition with a cleaning efficacy and an oral care composition based on the composition with the cleaning efficacy. The composition with the cleaning efficacy is mainly prepared from olive leaf extract, salvia extract, mint extract, propolis and the like. The composition is free of artificial sweetening agents and essences and free of pigments, preservatives and animal ingredients, has antibacterial and anti-inflammatory effects on common oral problems such as oral ulcer and oral malodor caused by air pollution, dust, haze and smoking and is capable of not only alleviating symptoms but also preventing respiratory diseases.
Description
Technical field
The invention belongs to filed of daily-use chemical industry, especially oral care techniques field, be specifically related to a kind of applicable daily mouth
Chamber nursing health, can effectively alleviate the oral care composition of multiple oral cavity malaise symptoms.
Background technology
Oral cavity is human consumption and the important ingredient of respiratory system, along with air pollution, ecological deterioration and diet are tied
The impact of the factors such as structure, oral disease often perplexs and affects daily life in recent years, as the common pulpitis of clinic,
Periodontitis, oral ulcer, dental caries and halitosis etc., cause the major reason of oral disease be generally placed upon oral cavity do not obtain in time and
Clean thoroughly.People have generally formed the custom sooner or later brushed teeth, but once the process of brushing teeth of two minutes do not ensure that by
Residues in oral cavity etc. are thoroughly removed, it is also difficult to reach to protect for a long time the effect of oral environment；Additionally at some special occasions
Lower or special population is not appropriate for using ordinary toothpaste to clean oral cavity, and it is a series of that oral care composition exactly solves this
Problem.
Occur in that some oral care products, but commercially available oral care product has generally existed interpolation people
The sweeting agent of work synthesis, essence；Add pigment, preservative and the composition of animal origin or containing compositions such as antibiotic.This portion
Requirement in terms of dividing product cannot meet the safety that consumer strengthens day by day, the most natural, non-stimulated, additive-free, without anti-
Rotten agent, animal origin-free composition etc..Prior art there is also some and add medicinal herb components or the mouth of plant-derived component
Chamber care product, but medicinal herb components therein may bring the problem of the aspect such as abnormal smells from the patient, mouthfeel or be confined to dissolve
The factors such as degree need to add in a large number solvent；Or some plant-derived component is only complementary adding ingredient, wherein also need to add
Other the functional antipathogenic composition adding non-plant origin plays main cleaning efficacy.The application is by using All Pure Nature source
One-tenth subassembly nontoxic, non-irritating forms cleaning efficacy compositions and plays oral cavity cleaning and nursing role, overcomes existing
Disadvantages mentioned above present in technology.
Summary of the invention
It is an object of the invention to provide one and overcome prior art defect, effective ingredient is natural, environmental protection, safety oral cavity protect
Reason product, not only meets the oral cavity health demand of different crowd but also meets routine use demand.
Technical solution of the present invention is as follows:
On the one hand, it is desirable to provide a kind of cleaning efficacy compositions that can be used in mouth care, exist with each component
Shared parts by weight meter in cleaning efficacy compositions, containing following composition:
1) Olive leaf P.E (Olive Leaf Extract, wherein the content of oleuropein is no less than 4.4mg/mL)
60-99.5 part, preferably 70-99.2 part, more preferably 80-99 part, more preferably 90-98.5 part；
2) sage extract (Sage Leaf Extract) 0.01-15 part, preferably 0.05-10 part, more preferably 0.1-5
Part, more preferably 0.5-2 part；
3) Folium Menthae extract (Peppermint Extract) 0.01-12 part, preferably 0.05-8 part, more preferably 0.1-5 part,
More preferably 0.2-1 part；
4) propolis 0.01-8 part, preferably 0.02-5 part, more preferably 0.05-2 part, more preferably 0.08-1 part；
Furthermore it is also possible to be added as needed on other composition commonly used in the art, such as Oleum menthae (Peppermint
Oil) 0.01-10 part, preferably 0.05-6 part, more preferably 0.1-4 part, more preferably 0.2-1 part；Natural lemon essence (Natural
Lemon Flavor) 0.001-2 part, preferably 0.005-1 part, more preferably 0.01-0.5 part, more preferably 0.05-0.2 part.
If for child, it is contemplated that mouthfeel and the degree that is easily accepted by of abnormal smells from the patient, the cleaning efficacy compositions (child of the present invention
Type cleaning efficacy compositions), by each component in cleaning efficacy compositions in terms of shared parts by weight, containing following composition:
1) Olive leaf P.E (Olive Leaf Extract, wherein the content of oleuropein is no less than 4.4mg/mL)
80-99.8 part, preferably 85-99.5 part, more preferably 88-99.2 part, more preferably 90-99 part；
2) sage extract (Sage Leaf Extract) 0.01-15 part, preferably 0.05-10 part, more preferably 0.1-5
Part, more preferably 0.5-2 part；
3) propolis 0.01-5 part, preferably 0.02-2 part, more preferably 0.05-1 part, more preferably 0.08-0.5 part；
4) Oleum menthae (Peppermint Oil) 0.005-2 part, preferably 0.01-1 part, more preferably 0.02-0.4 part is more excellent
Select 0.03-0.8 part.
On the other hand, it is desirable to provide a kind of oral care composition, with each component in oral care composition
Shared parts by weight meter, containing following composition:
A) 2-40 part cleaning efficacy as above compositions, preferably 4-35 part, more preferably 5-30 part, more preferably 10-20
Part；
B) mouthfeel enhancing ingredients of 0.1-8 part, preferably 0.3-6 part, more preferably 0.5-3 part, more preferably 0.8-2 part；
C) solubilizing agent of 2-35 part, preferably 4-30 part, more preferably 6-20 part, more preferably 8-15 part；
D) wetting agent of 2-40 part, preferably 3-30 part, more preferably 4-20 part, more preferably 5-10 part；
E) ethanol of 0.5-10 part, preferably 1-8 part, more preferably 2-6 part, more preferably 3-5 part；
F) essence of 0-3 part, preferably 0.01-2 part, more preferably 0.1-1 part, more preferably 0.2-0.5 part.
Wherein, mouthfeel enhancing ingredients can select mouthfeel commonly used in the art improve component and use these components to exist
The conventional amount used of this area, such as: 4-methyl-3-(1-pyrrolidinyl)-2 (5H)-furanone, its consumption can be to account for mouth care
The 0.1-2 weight portion of compositions, preferably 0.2 part；3,3,5-trimethylcyclohexanone glycerol ketals, its consumption can be to account for oral cavity to protect
The 0.1-2 weight portion of reason compositions, preferably 0.4 part；(-)-different Mentha arvensis L. syn.M.haplocalyxBrig alcohol, its consumption can be to account for oral care composition
0.1-2 weight portion, preferably 0.4 part.
In the cleaning efficacy compositions of the present invention, Olive leaf P.E (oleuropein content is no less than 4.4mg/mL),
Propolis, sage extract, Folium Menthae extract are commercially available product can directly buy use, it is also possible to by it is well known that
Conventional method extract, it mostly is corresponding plant or raw material and steams through cellulase, pectase or proteases for decomposing, water
The lyophilized powder of fineness 300 to 400 mesh prepared after steam distillation or semi-solid extractum.
The oral care composition of the present invention, essence therein can select commonly used in the art to can be used in oral cavity
The essence of care product, such as mixing of one or more arbitrary proportions in Oleum menthae, mentha piperita oil, natural lemon essence
Compound.
The oral care composition of the present invention, solubilizing agent therein can select propylene glycol, Polyethylene Glycol, soybean lecithin
In the mixture of one or more arbitrary proportions.
The oral care composition of the present invention, wetting agent therein can select in Sorbitol, xylitol, lactose
The mixture of one or more arbitrary proportions.
The cleaning efficacy compositions of the present invention can individually be packed as the group preparing various oral care product further
Polymer component.
The oral care composition of the present invention can be prepared as various dosage form commonly used in the art, as oral cavity is protected
Reason liquid, nurses wet tissue, toothpaste, dentifrice, dental floss, boiled goods, soft candy, lozenge, chewing gum, paster, lollipop, mouthspray, bacterium
Speckle removes liquid etc..
The oral care composition of the present invention can effectively alleviate multiple oral cavity malaise symptoms, prosthetic synthetic sweetener,
Essence；Non-pigment, preservative and animal component, be suitable for old people and child and have specific demand crowd to use.
Olive leaf P.E in the present invention is main cleaning efficacy component, is wherein mainly composed of iridoids bitter
Puckery material, its activity the highest for cleupin Oleuropein) and hydroxytyrosol (Hydroxytyrosol).There is wide spectrum resist
Bacterium, antivirus action, have antioxidation and booster immunization systemic effect concurrently simultaneously.Propolis is that Apidae animal Apis etc. repairs Nidus Vespae
The yellowish-brown used or the stickum of pitchy, can be used as medicine, and its property is put down, bitter in the mouth, pungent, micro-sweet, has skin moistening granulation promoting, and antiinflammatory is only
The diseases such as effect of pain, can treat gastric ulcer, oral ulcer, burn and scald, skin splitting pain, radioprotective.Sage extract has
Anticorrosion, antibacterial effect；Folium Menthae extract contains volatile oil, is mainly menthol (menthol), menthone (Menthone) in oil
And Herba Menthae esters etc., contribute to refrigerant skin and mucosa, and there is calm effect.The material of above-mentioned several natural origins is pressed
Ratio compounds, comprehensive antibiotic cleaning effect playing each composition, and cooperative compensating overcomes the limitation of single component, enhancing composition
Overall efficacy.4-methyl-3-(1-pyrrolidinyl)-2 [5H]-furanone in mouthfeel enhancing ingredients comes from native wheat
Composition, its mint flavored intensity in mouth is 35 times of menthol, and the intensity on skin is 512 times of menthol, and
And the persistent period is two times of menthol.High enantiomeric purity (-)-different Mentha arvensis L. syn.M.haplocalyxBrig alcohol has pure and fresh, happy, clear
The fragrance of cool Fructus Citri tangerinae Fructus Citri tangerinae class.3,3,5-trimethylcyclohexanone glycerol ketals also have a cool effect of system being better than menthol, and itself and
(-)-different Mentha arvensis L. syn.M.haplocalyxBrig alcohol all has the effect of also anthelmintic, increases as mouthfeel during therefore they are commonly used for mouth care series products
Strong composition.
Detailed description of the invention
Being discussed further the cleaning efficacy compositions of the present invention below in conjunction with embodiment, constituent content is with each group
Divide shared parts by weight meter in cleaning efficacy compositions.
Embodiment 1: cleaning efficacy compositions
Embodiment 2: cleaning efficacy compositions
Embodiment 3: cleaning efficacy compositions (child form)
Embodiment 4: cleaning efficacy compositions (child form)
Being discussed further the oral care composition of the present invention below in conjunction with embodiment, constituent content is with each group
Divide shared parts by weight meter in oral care composition.
Embodiment 5: oral nursing liquid
Wherein cleaning efficacy compositions such as embodiment 1 or embodiment 3 is defined.
Embodiment 6: oral nursing liquid
Wherein cleaning efficacy compositions such as embodiment 2 or embodiment 4 is defined.
The preparation method of the application oral care composition can use those skilled in the art to know according to corresponding dosage form
Arbitrary conventional method prepare.
Clinical effectiveness
Select long-term smoking symptom crowd 180 people.Wherein pharyngitis patient 60 people, halitosis patient 60 people, oral ulcer
Patient 60 people.Use spray 4-6 time in product oral cavity every day of the present embodiment 6, persistently use 4 time-of-weeks, respectively the 7th, 14,
21, within 28 days, curative effect is observed.Experimental applications SPSS16.0 statistical software, technical data uses χ2Inspection, significant level α=0.05.
Pharynx inflammatory patients uses voice VAS scoring, GRBAS subjective evaluation and Voice acoustic analysis.Pharyngitis patient VAS marks
Slight raise, total hoarse degree and roughness is light, moderate abnormal.Compared with Healthy People, pharyngitis patient's jitter, Shimmer increase
Add, the longest phonation time (M PT), dysphonia index (DSI) and the 1st, 2,3 formants (F1, F2, F3) value all reduce (P ＜
0.05)；Conclusion: pharyngeal inflammation sexually transmitted disease (STD) becomes the morphosis that may change pharyngeal cavity, and remote-effects vocal cord vibration, thus causes portion
Divide patients with chronic pharyngitis voice function mile abnormality.The observed result of 4 weeks shows the oral nursing liquid persistently using the present invention, suffers from
The voice function of person is obviously improved, and pain substantially alleviates, and feels pharyngeal nice and cool comfortable, and effective percentage reaches 95%.
Halitosis patient uses level (volatilesulfurcompounds, the VSCs) method of volatile sulfur compounds
Assess, measure with instrument Halimeter.The observed result of 4 weeks shows the oral nursing liquid persistently using the present invention, patient
VSCs be substantially less than test before, effective percentage reaches 91.7%.
Oral ulcer patient uses DP staging pain index to be estimated, and uses Visual analogue scale
(visualanalogscale, VAS) records pain scores P of ulcer every day1.0 end represents " painless ", and 10 ends represent " the most violent
Pain ".The observed result of 4 weeks shows the oral nursing liquid persistently using this present invention, the P of patient1Level is substantially less than to be surveyed
Before examination, effective percentage reaches 88.3%.
The product of the above result of the test display present invention is equal to common oral problems such as pharyngitis, halitosis, oral ulcer
There is good mitigation and respiratory function can be significantly improved.
Specific embodiments of the present invention are merely illustrative, and do not constitute the restriction to technical solution of the present invention, ability
Field technique personnel carry out various change in the design of the present invention and modify the scheme without departing from basic fundamental of the present invention design
All within scope.
Claims (11)
1. the cleaning efficacy compositions for mouth care, it is characterised in that with each component in cleaning efficacy compositions
Shared parts by weight meter, containing following composition:
1) Olive leaf P.E 60-99.5, preferably 70-99.2, more preferably 80-99, more preferably 90-98.5；
2) sage extract 0.01-15, preferably 0.05-10, more preferably 0.1-5, more preferably 0.5-2；
3) Folium Menthae extract 0.01-12, preferably 0.05-8, more preferably 0.1-5, more preferably 0.2-1；
4) propolis 0.01-8, preferably 0.02-5, more preferably 0.05-2, more preferably 0.08-1.
2. cleaning efficacy compositions as claimed in claim 1, wherein possibly together with Oleum menthae 0.01-10 part, preferably 0.05-6 part,
More preferably 0.1-4 part, more preferably 0.2-1 part and natural lemon essence 0.001-2 part, preferably 0.005-1 part, more preferably 0.01-
0.5 part, more preferably 0.05-0.2 part.
3. the cleaning efficacy compositions for mouth care that an applicable child uses, it is characterised in that with each component clearly
Shared parts by weight meter in clean efficacy, containing following composition:
1) Olive leaf P.E 80-99.8, preferably 85-99.5, more preferably 88-99.2, more preferably 90-99；
2) sage extract 0.01-15, preferably 0.05-10, more preferably 0.1-5, more preferably 0.5-2；
3) propolis 0.01-5, preferably 0.02-2, more preferably 0.05-1, more preferably 0.08-0.5；
4) Oleum menthae 0.005-2, preferably 0.01-1, more preferably 0.02-0.4, more preferably 0.03-0.8.
4. the cleaning efficacy compositions as described in claim 1 or 3, the wherein content of the oleuropein in Olive leaf P.E
No less than 4.4mg/mL.
5. an oral care composition, in terms of shared parts by weight, contains following one-tenth by each component in oral care composition
Point:
The cleaning efficacy compositions of 2-40, preferably 4-35, more preferably 5-30, more preferably 10-20；
The mouthfeel enhancing ingredients of 0.1-8, preferably 0.3-6, more preferably 0.5-3, more preferably 0.8-2；
The solubilizing agent of 2-35, preferably 4-30, more preferably 6-20, more preferably 8-15；
The wetting agent of 2-40, preferably 3-30, more preferably 4-20, more preferably 5-10；
The ethanol of 0.5-10, preferably 1-8, more preferably 2-6, more preferably 3-5；
The essence of 0-3, preferably 0.01-2, more preferably 0.1-1, more preferably 0.2-0.5；
Cleaning efficacy compositions therein defines as any one of claim 1-3, and described oral care composition is prepared as
Various dosage form commonly used in the art, such as oral nursing liquid, nurse wet tissue, toothpaste, dentifrice, dental floss, boiled goods, soft sweet
Really, lozenge, chewing gum, paster, lollipop, mouthspray, plaque removal liquid.
6. oral care composition as claimed in claim 5, wherein mouthfeel enhancing ingredients is selected from 4-methyl-3-(1-pyrrolidinyl)-2
(5H)-furanone, 3,3,5-trimethylcyclohexanone glycerol ketals and (-)-different Mentha arvensis L. syn.M.haplocalyxBrig alcohol；Solubilizing agent is selected from propylene glycol, gathers
The mixture of one or more arbitrary proportions in ethylene glycol, soybean lecithin；Wetting agent is selected from Sorbitol, xylose
The mixture of one or more arbitrary proportions in alcohol, lactose；Essence is selected from Oleum menthae, mentha piperita oil, natural lemon
The mixture of one or more arbitrary proportions of lemon essence.
7. oral care composition as claimed in claim 6, the wherein use of 4-methyl-3-(1-pyrrolidinyl)-2 (5H)-furanone
Amount is to account for the 0.1-2 weight portion of oral care composition, preferably 0.2 part；The consumption of 3,3,5-trimethylcyclohexanone glycerol ketals
For accounting for the 0.1-2 weight portion of oral care composition, preferably 0.4 part；The consumption of (-)-different Mentha arvensis L. syn.M.haplocalyxBrig alcohol is for accounting for mouth care
The 0.1-2 weight portion of compositions, preferably 0.4 part.
8. the cleaning efficacy compositions for mouth care, it is characterised in that with each component in cleaning efficacy compositions
Shared parts by weight meter, containing following composition:
9. the cleaning efficacy compositions for mouth care that an applicable child uses, it is characterised in that with each component clearly
Shared parts by weight meter in clean efficacy, containing following composition:
10. an oral nursing liquid, by each component in oral nursing liquid in terms of shared parts by weight, containing following composition:
Wherein cleaning efficacy compositions is as defined in claim 8 or 9.
11. oral nursing liquids according to claim 10, in terms of shared parts by weight, contain such as in oral nursing liquid by each component
Lower composition:
Wherein cleaning efficacy compositions is as defined in claim 8 or 9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610378289.XA CN105832643A (en) | 2016-05-31 | 2016-05-31 | Oral care composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610378289.XA CN105832643A (en) | 2016-05-31 | 2016-05-31 | Oral care composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105832643A true CN105832643A (en) | 2016-08-10 |
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ID=56595972
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610378289.XA Pending CN105832643A (en) | 2016-05-31 | 2016-05-31 | Oral care composition |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114848707A (en) * | 2022-04-18 | 2022-08-05 | 北京邮雁科技有限公司 | Oral cavity atomized liquid and its use |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101829030A (en) * | 2010-05-07 | 2010-09-15 | 天津蓝天集团股份有限公司 | Cleupin-containing toothpaste |
| CN104721117A (en) * | 2015-02-12 | 2015-06-24 | 青岛食安生物工程有限公司 | Active calcium bacteriostatic mouth wash |
| CN104887553A (en) * | 2015-05-06 | 2015-09-09 | 广东雪洁日化用品有限公司 | Toothpaste prepared by olive extract product and preparation method thereof |
| CN105078826A (en) * | 2015-08-26 | 2015-11-25 | 拉芳家化股份有限公司 | Oral care solution |
-
2016
- 2016-05-31 CN CN201610378289.XA patent/CN105832643A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101829030A (en) * | 2010-05-07 | 2010-09-15 | 天津蓝天集团股份有限公司 | Cleupin-containing toothpaste |
| CN104721117A (en) * | 2015-02-12 | 2015-06-24 | 青岛食安生物工程有限公司 | Active calcium bacteriostatic mouth wash |
| CN104887553A (en) * | 2015-05-06 | 2015-09-09 | 广东雪洁日化用品有限公司 | Toothpaste prepared by olive extract product and preparation method thereof |
| CN105078826A (en) * | 2015-08-26 | 2015-11-25 | 拉芳家化股份有限公司 | Oral care solution |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114848707A (en) * | 2022-04-18 | 2022-08-05 | 北京邮雁科技有限公司 | Oral cavity atomized liquid and its use |
| CN114848707B (en) * | 2022-04-18 | 2023-01-31 | 北京邮雁科技有限公司 | Oral cavity atomized liquid and its use |
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Application publication date: 20160810 |