CN104887553A - Toothpaste prepared by olive extract product and preparation method thereof - Google Patents

Abstract

The invention provides a toothpaste prepared by olive extract product and a preparation method thereof (unit: weight part). The method comprises the following steps: 1)crushing olive fruit and/or olive leaf, taking ethanol as a solvent, using an ethanol extraction method to obtain an ethanol extract product, 2)degrading the ethanol extract product by acid, alkali and enzyme to hydroxytyrosol, filtering and concentrating to prepare the extraction crystal, 3)dissolving 0.01-5 parts of crystal in 8-20 parts of water; 4)uniformly mixing 0-70 parts of wetting agent, 0.1-4 parts of foaming agent and 0.1-6 parts of thickening agent to prepare the plant solution, and 5)mixing a saturated solution and a plant solution, and uniformly mixing with 20-60 parts of rubbing agent to grind to obtain the paste which is the toothpaste. The important component olive fruit and/or oil olive extraction component have efficacy of anti-inflammation and pain relieving, bacterium resistance, virus resistance, prevention of periodontitis, gingivitis, bad breath, carious tooth and oral ulcer.

Description

Toothpaste prepared by a kind of Fructus Canrii Albi extract and preparation method thereof

Technical field

The present invention relates to toothpaste technology, refer to the extracting method of hydroxyl butyl alcohol in a kind of Fructus Canarii albi thing especially.

Background technology

Along with the enhancing day by day of consumer healthcare's consciousness, requiring, outside outstanding oral cavity cleaning function, to also proposed the demand of more mouth care, health care to toothpaste, such as auxiliary prevention or treatment oral disease.In current toothpaste market, various functional product demand grows with each passing day, and becomes the market mainstream, wherein, Chinese herbal medicine toothpaste because its effect additive is natural, Be very effective and safety high firmly get consumers.Therefore market is the emphasis that the functional toothpaste of effective ingredient becomes Developing with active components of plants.

In prior art, also have and adopt various active ingredient of Chinese herbs to assist plant as toothpaste, as tianqi toothpaste, mica filled polypropylene, shiny pricklyash toothpaste etc., effect is had nothing in common with each other.To have the plant toothpaste of antiinflammatory, analgesic activity, this type of toothpaste existing is such as: as mica filled polypropylene, tianqi toothpaste, the main composition adopted is pseudo-ginseng, is nearly all adopt more well-known medical material, and this case adopts safer and effective Fructus Canrii Albi extract.

Summary of the invention

The toothpaste that the object of the present invention is to provide a kind of Fructus Canrii Albi extract containing olive polyphenol, hydroxytyrosol, gallic acid composition to prepare and the preparation method of toothpaste thereof.

In order to realize technique scheme, the invention provides a kind of method (unit: weight portion) that Fructus Canrii Albi extract prepares toothpaste, comprising the steps:

Step 1, by olea europaea fruit and/or oily olive, olive leaf is pulverized, and with ethanol or for solvent, obtains ethanol extraction by ethanol extraction method.

Step 2, be hydroxytyrosol by ethanol extraction through acid, alkali and enzymatic degradation, filtering and concentrating is obtained extracts crystal.

Step 3, is dissolved in 8-20 part water by extraction crystal 0.01-5 part.

Step 4, by wetting agent 0-70, foaming agent 0.1-4, thickening agent 0.1-6 mix homogeneously, obtained plant solution.

Step 5, mixes saturated solution, plant solution and by abrasivus 20-60 part mix homogeneously, grinds to form paste, obtained toothpaste.

Abrasivus is its any proportioning mixture of one or more of dicalcium phosphate dihydrate, silicon dioxide, calcium carbonate.

Wetting agent is its any proportioning mixture of one or more of glycerol, sorbitol, Polyethylene Glycol etc.

Binding agent is its any proportioning mixture of one or more of carboxymethyl cellulose, carrageenan, xanthan gum, guar gum etc.

Foaming agent is its any proportioning mixture of one or more of sodium laurylsulfate, lauryl alcohol sodium sarcosinate, cocoa butter sodium etc.

Also add in step 5 and have essence 0.1-2.5 part, sweeting agent 0.1-0.5 part.

A kind of extraction plant toothpaste (unit: weight portion) of hydroxyl butyl alcohol,

Hydroxytyrosol powder 0.01-25%;

Abrasivus 20-60;

Wetting agent 0-70;

Foaming agent 0.1-4;

Thickening agent 0.1-6.

Hydroxytyrosol powder is 0.01-10.

Hydroxytyrosol powder is 0. 1-5.

Abrasivus is its any proportioning mixture of one or more of dicalcium phosphate dihydrate, silicon dioxide, calcium carbonate,

Wetting agent is its any proportioning mixture of one or more of glycerol, sorbitol, Polyethylene Glycol,

Binding agent is its any proportioning mixture of one or more of carboxymethyl cellulose, carrageenan, xanthan gum, guar gum

Foaming agent is its any proportioning mixture of one or more of sodium laurylsulfate, lauryl alcohol sodium sarcosinate, cocoa butter sodium.

The extraction plant toothpaste of a kind of hydroxyl butyl alcohol provided by the invention, its drug effect is wide, there is obvious anti-inflammatory analgetic, antibacterial, antiviral, effect of pre-preventing parodontitis, gingivitis, halitosis, dental caries, oral ulcer, is also specially adapted to the excessive risk patient groups such as blood fat is high, cardiovascular and cerebrovascular disease simultaneously; Also there is increase bone substance density improving function.It is a kind of natural, oral cavity nursing agent safely and effectively.

Detailed description of the invention

Technical scheme in the embodiment of the present invention is clearly and completely described, and obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.

This adopts Chinese medicine material, effect single, provides a kind of plant toothpaste that is safer, that have daily health caring value comprehensively.

The invention provides a kind of method (unit: weight portion) that Fructus Canrii Albi extract prepares toothpaste, comprise the steps:

Step 1, by olea europaea fruit and/or oily olive, olive leaf is pulverized, and with ethanol or for solvent, obtains ethanol extraction by ethanol extraction method.

Step 2, be hydroxytyrosol by ethanol extraction through acid, alkali and enzymatic degradation, filtering and concentrating is obtained extracts crystal.

Step 3, is dissolved in 8-20 part water by extraction crystal 0.01-5 part.

Step 4, by wetting agent 0-70, foaming agent 0.1-4, thickening agent 0.1-6 mix homogeneously, obtained plant solution.

Step 5, mixes saturated solution, plant solution and by abrasivus 20-60 part mix homogeneously, grinds to form paste, obtained toothpaste.

Abrasivus is its any proportioning mixture of one or more of dicalcium phosphate dihydrate, silicon dioxide, calcium carbonate.

Wetting agent is its any proportioning mixture of one or more of glycerol, sorbitol, Polyethylene Glycol etc.

Binding agent is its any proportioning mixture of one or more of carboxymethyl cellulose, carrageenan, xanthan gum, guar gum etc.

Foaming agent is its any proportioning mixture of one or more of sodium laurylsulfate, lauryl alcohol sodium sarcosinate, cocoa butter sodium etc.

Also add in step 5 and have essence 0.1-2.5 part, sweeting agent 0.1-0.5 part.

A kind of extraction plant toothpaste (unit: weight portion) of hydroxyl butyl alcohol,

Hydroxytyrosol powder 0.01-25%;

Abrasivus 20-60;

Wetting agent 0-70;

Foaming agent 0.1-4;

Thickening agent 0.1-6.

Hydroxytyrosol powder is 0.01-10.

Hydroxytyrosol powder is 0. 1-5.

Abrasivus is its any proportioning mixture of one or more of dicalcium phosphate dihydrate, silicon dioxide, calcium carbonate,

Wetting agent is its any proportioning mixture of one or more of glycerol, sorbitol, Polyethylene Glycol,

Binding agent is its any proportioning mixture of one or more of carboxymethyl cellulose, carrageenan, xanthan gum, guar gum

Foaming agent is its any proportioning mixture of one or more of sodium laurylsulfate, lauryl alcohol sodium sarcosinate, cocoa butter sodium.

The technical solution adopted for the present invention to solve the technical problems is: provide a kind of plant toothpaste, containing Fructus Canrii Albi extract in plant lotion of toothpaste.

In plant toothpaste of the present invention, the weight ratio that described Fructus Canrii Albi extract accounts for described plant lotion of toothpaste is 0 ~ 25%.

In plant toothpaste of the present invention, the weight ratio that described Fructus Canrii Albi extract accounts for described plant lotion of toothpaste is 0 ~ 10%.

In plant toothpaste of the present invention, the weight ratio that described Fructus Canrii Albi extract accounts for described plant lotion of toothpaste is 0 ~ 5%.

In plant toothpaste of the present invention, the weight ratio that described Fructus Canrii Albi extract accounts for described plant lotion of toothpaste is can also be 3,8,11,15,18 weight portions

In plant toothpaste of the present invention, also containing abrasivus, wetting agent, foaming agent, thickening agent in described plant lotion of toothpaste.

In plant toothpaste of the present invention, the composition containing following parts by weight in described plant lotion of toothpaste:

Abrasivus 10 ~ 60;

Wetting agent 5 ~ 65;

Foaming agent 0.1 ~ 8;

Thickening agent 0.1 ~ 6.

In plant toothpaste of the present invention, the raw material also containing following parts by weight in described plant lotion of toothpaste:

Sorbitol 10 ~ 65;

Silica 1 ~ 30;

Water 5 ~ 15;

Polyethylene Glycol 1 ~ 10;

Carboxymethyl cellulose 0.5 ~ 2;

Sodium laurylsulfate 1 ~ 8;

Essence 0.5 ~ 1.5;

Sweeting agent 0.1 ~ 0.3;

In the present invention, Fructus Canrii Albi extract is that ethanol extraction method extracts the crystal obtained in olea europaea fruit and/or oily olive.

Implement plant toothpaste of the present invention, there is following beneficial effect: drug effect is wide, there is obvious anti-inflammatory analgetic, effect of pre-preventing parodontitis, gingivitis, halitosis, dental caries, oral ulcer, be also specially adapted to the excessive risk such as hyperlipidemia, cardiovascular and cerebrovascular disease patient groups simultaneously; The safer feature that can be used for regular oral health routine, as important sources fruit for the mankind use for many years.

In plant toothpaste of the present invention, except described Fructus Canrii Albi extract, also comprise the base stock of the preparation toothpaste such as the abrasivus in formulation of tooth-paste, wetting agent, foaming agent, thickening agent, flavoring agent and essence and appropriate water.Abrasivus can be calcium carbonate, calcium hydrogen phosphate; Wetting agent can be xylitol, Polyethylene Glycol, sorbitol, glycerol; Foaming agent can be anion surfactant as sodium lauryl sulphate, lauroyl propylhomoserin sodium, also can be that non-ionic surface active agent is as lauryl alcohol diethanolamine, dodecyl amine oxide, tween.

Below in conjunction with embodiment, the present invention will be further described.Data involved in following table refer to parts by weight, and in embodiment 1 to embodiment 7, the gross weight number of plant lotion of toothpaste is 100.

Table 1, the formula ratio (unit: weight portion) of each raw material in embodiment 1 to embodiment 7

As seen from the above table, in embodiment 1 to embodiment 7, Fructus Canrii Albi extract parts by weight maximum gets 25, and minima gets 0.01, and intermediate value gets 0.1,0.5,1,5 and 10.According to the formula ratio in upper table, get the Fructus Canrii Albi extract of Different Weight number, repeat repeatedly formula test, entrusting 20 respectively often has gingivitis and the unsharp volunteer of implication to carry out effect assessment, frequency of utilization be every day early, evening is each once, consumption is about 1.3g mastic/each, and Brushing time is about 3min.The result obtained shows that the plant toothpaste containing Fructus Canarii albi has obvious antiinflammatory and implication acts on clearly, and from use mouthfeel and effect two aspect evaluation, the weight ratio that Fructus Canrii Albi extract accounts for this plant lotion of toothpaste is 0.01 ~ 25% more suitable, be optimized for 0.1 ~ 10%, optimum optimization is 0.1 ~ 5%.When the weight ratio that Fructus Canrii Albi extract accounts for this plant lotion of toothpaste is 0.1 ~ 5%, drug effect and the mouthfeel of toothpaste are in optimum balance.

Preparation method:

In above-mentioned every embodiment, Fructus Canrii Albi extract can adopt following either method to make.

Get olive fruit, pulverize as fruit jam, with water or ethanol extraction, and be hydroxytyrosol by oleuropein ingredient degradation by crude extract under the effect of acid, alkali and enzyme, and concentrate drying becomes powder or crystal or finite concentration extracting solution.Get Folium olive, pulverize as beans shape, with use water or ethanol extraction, and be hydroxytyrosol by oleuropein ingredient degradation by crude extract under the effect of acid, alkali and enzyme, and concentrate drying becomes powder or crystal or finite concentration extracting solution.

In above-mentioned every embodiment, plant lotion of toothpaste can adopt following methods to make.

According to formula ratio, carboxymethyl cellulose is added in part water, and heating for dissolving, if any insoluble matter, then cross and filter, obtained cmc soln, for subsequent use.According to formula ratio, glycerol, sorbitol, sodium laurylsulfate, essence, sweeting agent and Fructus Canrii Albi extract are added in part water, and stir, obtained plant solution, for subsequent use.

Cmc soln and plant solution are fully mixed, adds (calcium carbonate, silicon dioxide) dicalcium phosphate dihydrate successively according to formula ratio and remain the water that add, after fully stirring, grinding to form thin paste, be finally dispensed in dentifrice tube.

Fructus Canrii Albi extract, as the raw material of natural plants active components of plants, is added in toothpaste, gives the significant antiinflammatory of this plant toothpaste, clear implication effect, and this plant material source is sufficient, and safety is high, is suitable as effective functional component of toothpaste.

Technology point of the present invention is also, in leaf of Fructus oleae europaeae and extract thereof, oleuropein is driffractive ring alkene ethers polyphenolic substance, very easily by the impact of the factors such as air, sunlight, acid, alkali, oxidant, transition metal ions, long-time high temperature, be oxidized, condensation, the reaction such as chelating and wrecking, be unfavorable for the stable of the stable of lotion of toothpaste and toothpaste efficiency.On probation containing waiting the oleuropein of PPM concentration and the toothpaste of hydroxytyrosol by contrasting, to gingivitis, the performance of removing dental plaque, the clear aspect of implication, hydroxytyrosol toothpaste is better than oleuropein toothpaste.

The foregoing is only embodiments of the invention; not thereby the scope of the claims of the present invention is limited; every equivalent structure transformation utilizing description of the present invention to do, or be directly or indirectly used in other relevant oral cavity technical fields, be all in like manner included in scope of patent protection of the present invention.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. a Fructus Canrii Albi extract prepares the method (unit: weight portion) of toothpaste, it is characterized in that, comprises the steps:

Step 1, pulverizes olea europaea fruit and/or leaf of Fructus oleae europaeae, with ethanol or for solvent, obtains ethanol extraction by ethanol extraction method,

Step 2, be hydroxytyrosol by ethanol extraction through acid, alkali and enzymatic degradation, filtering and concentrating is obtained extracts crystal,

Step 3, is dissolved in 8-20 part water by extraction crystal 0.01-5 part,

Step 4, by wetting agent 0-70, foaming agent 0.1-4, thickening agent 0.1-6 mix homogeneously, obtained plant solution,

Step 5, mixes saturated solution, plant solution and by abrasivus 20-60 part mix homogeneously, grinds to form paste, obtained toothpaste.

2. preparation method according to claim 1, is characterized in that:

Abrasivus is its any proportioning mixture of one or more of dicalcium phosphate dihydrate, silicon dioxide, calcium carbonate.

3. preparation method according to claim 1, is characterized in that:

Wetting agent is its any proportioning mixture of one or more of glycerol, sorbitol, Polyethylene Glycol etc.

4. preparation method according to claim 1, is characterized in that:

Binding agent is its any proportioning mixture of one or more of carboxymethyl cellulose, carrageenan, xanthan gum, guar gum etc.

5. preparation method according to claim 1, is characterized in that:

Foaming agent is its any proportioning mixture of one or more of sodium laurylsulfate, lauryl alcohol sodium sarcosinate, cocoa butter sodium etc.

6. preparation method according to claim 1 (unit: weight portion), is characterized in that:

Also add in step 5 and have essence 0.1-2.5 part, sweeting agent 0.1-0.5 part.

7. a kind of plant toothpaste (unit: weight portion), is characterized in that:

Hydroxytyrosol powder 0.01-25%;

Abrasivus 20-60;

Wetting agent 0-70;

Foaming agent 0.1-4;

Thickening agent 0.1-6.

8. plant toothpaste according to claim 7 (unit: weight portion), is characterized in that:

Hydroxytyrosol powder is 0.01-10.

9. plant toothpaste according to claim 2 (unit: weight portion), is characterized in that:

Hydroxytyrosol powder is 0. 1-5.

10. plant toothpaste according to claim 7 (unit: weight portion), is characterized in that:

Abrasivus is its any proportioning mixture of one or more of dicalcium phosphate dihydrate, silicon dioxide, calcium carbonate,

Wetting agent is its any proportioning mixture of one or more of glycerol, sorbitol, Polyethylene Glycol,

Binding agent is its any proportioning mixture of one or more of carboxymethyl cellulose, carrageenan, xanthan gum, guar gum

Foaming agent is its any proportioning mixture of one or more of sodium laurylsulfate, lauryl alcohol sodium sarcosinate, cocoa butter sodium.