CN113975343A

CN113975343A - High-efficiency sterilization and bacteriostasis traditional Chinese medicine spray

Info

Publication number: CN113975343A
Application number: CN202111569312.0A
Authority: CN
Inventors: 姚丹
Original assignee: Qiaofusheng Pharmaceutical Co ltd
Current assignee: Qiaofusheng Pharmaceutical Co ltd
Priority date: 2021-12-21
Filing date: 2021-12-21
Publication date: 2022-01-28

Abstract

The invention discloses an efficient sterilization and bacteriostasis traditional Chinese medicine spray, which consists of traditional Chinese medicine extract, an external bacteriostat and a penetrant, wherein the mass percent of the external bacteriostat in the spray is 0.1-0.2%, the mass percent of the penetrant is 2-5%, and the rest is the traditional Chinese medicine extract; the traditional Chinese medicine extracting solution is prepared from the following raw materials in parts by weight: 20-30 parts of usnea, 35-45 parts of allium macrostemon, 35-40 parts of sophora flavescens, 40-50 parts of radix aconiti agrestis, 20-30 parts of bighead atractylodes rhizome, 20-25 parts of fructus forsythiae, 30-45 parts of radix angelicae, 40-60 parts of honey-fried licorice root, 3-10 parts of folium artemisiae argyi and 20-30 parts of purslane.

Description

High-efficiency sterilization and bacteriostasis traditional Chinese medicine spray

Technical Field

The invention relates to the technical field of traditional Chinese medicine preparations, and particularly relates to an efficient sterilization and bacteriostasis traditional Chinese medicine spray.

Background

The treatment of skin and mucosa infection requires cleaning, i.e. cleaning the necrotic parts of the stratum corneum and subcutaneous fat layer of infected and rotten skin, and then applying bacteriostatic or antibacterial agents. The sterilization and bacteriostasis means that the growth and reproduction of microorganisms are killed or inhibited by a physical or chemical method, and the market continuously demands high-efficiency broad-spectrum bacteriostatic and bactericidal traditional Chinese medicine external preparations.

The most common bacteriostatic or antibacterial drugs in the market at present mainly comprise two types, one type is a liquid prepared from a pure antibacterial preparation, and the bacteriostatic and antibacterial effects are usually exerted only when the bacteriostatic or antibacterial concentration is higher, but the bacteriostatic or antibacterial liquid has obvious irritation such as tingling, dryness and the like, and has strong dependence, drug resistance and toxic and side effects when used. The other is liquid prepared from pure traditional Chinese medicines, the liquid has unobvious bacteriostatic and antibacterial effects, and the effective time and the cure time are still not ideal and need to be further improved.

Disclosure of Invention

Based on at least one of the technical problems, the invention provides the high-efficiency sterilization and bacteriostasis traditional Chinese medicine spray which is convenient to use, good in absorption effect, free of adverse effects and toxic and side effects, excellent in alleviation and treatment effects on dermatophytosis through clinical verification, and suitable for popularization and application in clinical treatment and nursing of dermatophytosis.

In view of the above, according to a first object of the present invention, a high-efficiency sterilization and bacteriostasis traditional Chinese medicine spray is provided, which is composed of a traditional Chinese medicine extract, an external bacteriostat and a penetrant, wherein the mass percentage of the external bacteriostat in the spray is 0.1-0.2%, the mass percentage of the penetrant is 2-5%, and the rest is the traditional Chinese medicine extract; the traditional Chinese medicine extracting solution is prepared from the following raw materials in parts by weight: 20-30 parts of usnea, 35-45 parts of allium macrostemon, 35-40 parts of sophora flavescens, 40-50 parts of radix aconiti agrestis, 20-30 parts of bighead atractylodes rhizome, 20-25 parts of fructus forsythiae, 30-45 parts of radix angelicae, 40-60 parts of honey-fried licorice root, 3-10 parts of folium artemisiae argyi and 20-30 parts of purslane.

In some embodiments, the traditional Chinese medicine extracting solution is prepared from the following raw materials in parts by weight: 20-25 parts of usnea, 30-40 parts of allium macrostemon, 35-38 parts of sophora flavescens, 42-45 parts of radix aconiti kusnezoffii, 20-28 parts of bighead atractylodes rhizome, 20-23 parts of fructus forsythiae, 30-35 parts of radix angelicae, 50-55 parts of honey-fried licorice root, 5-8 parts of folium artemisiae argyi and 23-28 parts of purslane.

In some embodiments, the topical bacteriostatic agent is chlorhexidine acetate, benzalkonium bromide, or aminopyridine.

In some embodiments, the osmotic agent is dimethyl sulfoxide or laurocapram.

According to a second object of the present invention, there is provided a method for preparing the herbal spray of any of the above embodiments, comprising the steps of:

(1) pulverizing usnea, moutan bark and bighead atractylodes rhizome into coarse powder, mixing uniformly, soaking for 12 hours by using 75% ethanol as a solvent, then leaking at the speed of 1-2ml per minute, and collecting 120 parts by weight of leakage liquid of 100-;

(2) pulverizing Bulbus Allii Macrostemi, radix Angelicae Dahuricae, radix Glycyrrhizae Preparata and fructus forsythiae into coarse powder, respectively adding into volatile oil extractor, respectively adding 5-8 times of distilled water for extraction for 10-12 hr, mixing the three volatile oils, adding into glycerol, and stirring to obtain mixed solution;

(3) adding herba Achilleae, folium Artemisiae Argyi and herba Portulacae into an extraction tank, decocting with 2-3 times of water, concentrating to obtain a liquid with a density of 1.05-1.1g/ml, precipitating with ethanol, filtering, recovering ethanol to obtain filtrate, adding the percolate of step (1) and the mixed solution of step (2), dissolving Borneolum with ethanol, adding, stirring, and standing to obtain Chinese medicinal extractive solution;

(4) and (3) adding a bacteriostatic agent and a penetrating agent into the traditional Chinese medicine extracting solution obtained in the step (3), uniformly stirring, and standing to obtain the traditional Chinese medicine.

In some embodiments, the usnea, the moutan bark and the atractylodes macrocephala in the step (1) are crushed into 8-10 mesh coarse powder.

In some embodiments, the allium macrostemon, the radix angelicae, the radix glycyrrhizae preparata and the fructus forsythiae in the step (2) are 10-15 mesh coarse powder.

Wherein the purslane: has cold nature and sweet and sour taste, enters heart, liver, spleen and large intestine channels, and has the functions of astringing dampness, relieving itching, clearing heat, relieving swelling, clearing heat, detoxicating, promoting diuresis, removing dampness, dispelling blood stasis, removing swelling, removing dust, sterilizing, diminishing inflammation, relieving pain, stopping bleeding and cooling blood. The purslane also contains unique bioactive components, can enhance the activity of epithelial cells of a human body, and is beneficial to promoting the healing of ulcer; and has strong inhibiting effect on dysentery bacillus, typhoid bacillus and colibacillus.

Radix Angelicae Dahuricae is warm in nature and pungent in flavor, enters stomach, large intestine and lung channels, and has effects of dispelling pathogenic wind, removing dampness, dredging orifice, relieving pain, subsiding swelling and expelling pus. Can be used for treating common cold, headache, supraorbital bone pain, nasal obstruction, nasosinusitis, toothache, leucorrhea, and pyocutaneous disease with swelling and pain.

Acid-not-slippery root: sour and sweet, warm, cold dispelling, kidney warming, cold hernia treating and scrotum sweating treating, and has antibacterial effect on staphylococcus aureus, typhoid bacillus, paratyphoid bacillus A, paratyphoid bacillus B, escherichia coli O88B7, dysentery Sonnei bacillus and dysentery Freund dysentery bacillus.

Folium artemisiae argyi: regulating qi and blood, dispelling cold and dampness; warm meridians, stop bleeding, prevent abortion. Modern pharmacological research: the folium artemisiae argyi has an antibacterial effect on 10 gram-positive aerophiles such as bacillus anthracis, alpha-hemolytic streptococcus, B-hemolytic streptococcus, corynebacterium diphtheriae, pseudocorynebacterium diphtheriae, pneumococcus, staphylococcus aureus, staphylococcus limosum, staphylococcus albus and bacillus subtilis in vitro;

white atractylodes rhizome: sweet and slightly bitter taste, enters foot yangming stomach and foot taiyin spleen channels, tonifies middle energizer, eliminates dampness, quenches thirst and promotes fluid production, most benefits spleen essence and greatly nourishes stomach qi, has inhibition effect on flocculus epidermophyton and nocardia stellata, has inhibition effect on meningococcus, and reports that bighead atractylodes rhizome decoction and Sijunzi decoction have different degrees of inhibition effect on typhoid bacillus, paratyphoid bacillus typhi, shigella flexneri, escherichia coli, pseudomonas aeruginosa and the like without sterilization effect;

fructus forsythiae: clearing away heat and toxic material, dispersing swelling and dissipating stagnation, and dispelling wind-heat. Modern medical research proves that the fructus forsythiae concentrated decoction has an antibacterial effect in vitro and can inhibit typhoid bacillus, paratyphoid bacillus, escherichia coli, dysentery bacillus, diphtheria bacillus, vibrio cholerae, staphylococcus, streptococcus and the like;

radix angelicae: expelling wind and cold, inducing resuscitation and relieving pain, relieving swelling and pus, eliminating dampness and arresting leucorrhea, promoting blood circulation, expelling wind and cold, removing dampness and dredging collaterals. Modern medical research proves that the angelica dahurica has an inhibiting effect on escherichia coli, dysentery bacillus, proteus bacillus, typhoid bacillus, paratyphoid bacillus, pseudomonas aeruginosa, vibrio cholerae, human type mycobacterium tuberculosis and the like;

honey-fried licorice root: contains multiple chemical components such as glycyrrhizin, glycyrrhetinic acid, glycyrrhiza polysaccharide and the like, has the functions of resisting inflammation and allergic reaction, regulating the immunologic function of organisms, resisting tumors and relieving pain, so the honey-fried licorice root has the main effects of regulating the middle warmer and relieving urgency, moistening lung, detoxifying and harmonizing the medicines.

The usnic acid has the effects of resisting bacteria, stopping bleeding, promoting granulation and relieving pain, and the usnic acid and the sophora flavescens have a synergistic effect, so that the bacteriostatic ability of the sophora flavescens can be improved; the allium macrostemon has the bacteriostatic effect, can inhibit various bacteria and fungi, improves the capability of the asiatic centella in inhibiting dermatophytosis fungi, and has the effect of relieving itching; the penetrant has the functions of promoting the penetration of the spray, accelerating the absorption of the medicine and improving the medicine effect.

The radix sophorae flavescentis, the usnea and the radix angelicae have antibacterial and anti-inflammatory effects; radix Angelicae Dahuricae, herba Portulacae, folium Artemisiae Argyi and Bulbus Allii Macrostemi have effects of clearing away heat and toxic materials and relieving inflammation,

wherein, the purslane, the lightyellow sophora root and the usnea are monarch drugs which have the effects of resisting bacteria, killing insects, relieving allergy and promoting granulation and effectively disinfect and sterilize; folium artemisiae argyi, fructus forsythiae and radix angelicae dahuricae are ministerial drugs and enhance the drug effect of monarch drugs, wherein the radix aconiti kurrooti, the rhizoma atractylodis macrocephalae and the allium macrostemon can enhance the antibacterial and insecticidal effects of the monarch drugs, and the radix glycyrrhizae preparata is used as an assistant and guide together to play the roles of harmonizing ying and weiqi, warming middle-jiao and dispelling cold. The disinfectant can effectively kill various bacteria propagules, viruses, fungi, tubercle bacillus and bacterial spores, and has better skin sterilization and disinfection effects; the components of the invention are rich in vitamin C which is helpful for reducing the amount of histamine released by columnar cells, and when the histamine is released, the decomposition speed of the histamine can be accelerated, thereby preventing and relieving allergic symptoms, promoting the drug effect, simultaneously providing sufficient nutrients for the recovery of the skin of an affected part, promoting the recovery of the skin of the affected part, and inhibiting inflammation and allergy.

The medicines are combined, so that the effects of sterilizing, disinfecting, relieving allergy and promoting tissue regeneration are good, the medicines are mutually regulated, no adverse effect on organisms is caused, and the application is safer. The disinfection spray is a pure traditional Chinese medicine preparation, the selected medicinal materials are compatible, the formula is mild and non-irritant, the disinfection spray contains effective bactericidal components, various pathogenic bacteria can be effectively killed, long-acting bacteriostasis can be realized, no pungent smell exists, the skin of a user can be effectively protected and maintained, and the risk of skin allergy caused by using a disinfection solution is reduced; and has the obvious advantages of strong sterilization and bacteriostasis capacity, high action speed, good stability and long bacteriostasis time.

The use method of the high-efficiency sterilization and bacteriostasis traditional Chinese medicine spray provided by the invention specifically comprises the following steps: for external use, the composition is shaken well before use, and directly sprayed on the skin discomfort part, 2-3 times per time, several times per day.

Detailed Description

In order that the above objects, features and advantages of the present invention can be more clearly understood, the present invention will be described in further detail with reference to specific embodiments. It should be noted that the embodiments of the present invention and features of the embodiments may be combined with each other without conflict.

In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, however, the present invention may be practiced in other ways than those specifically described herein, and therefore the scope of the present invention is not limited by the specific embodiments disclosed below.

Example 1

The embodiment provides an efficient sterilization and bacteriostasis traditional Chinese medicine spray which consists of a traditional Chinese medicine extracting solution, an external bacteriostat and a penetrant, wherein the external bacteriostat in the spray is aminoding, the mass percent of the external bacteriostat is 0.1%, the penetrant is laurocapram, the mass percent of the penetrant is 2%, and the rest is the traditional Chinese medicine extracting solution;

the traditional Chinese medicine extracting solution is prepared from the following raw materials in parts by weight: 20 parts of usnea, 35 parts of allium macrostemon, 40 parts of sophora flavescens, 45 parts of sour-swift-current root, 23 parts of bighead atractylodes rhizome, 22 parts of fructus forsythiae, 30 parts of radix angelicae, 50 parts of honey-fried licorice root, 8 parts of folium artemisiae argyi and 28 parts of purslane.

The preparation of the traditional Chinese medicine spray is carried out according to the following steps:

pulverizing Usnea, cortex moutan and Atractylodis rhizoma into 8 mesh coarse powder, mixing, soaking with 75% ethanol as solvent for 12 hr, percolating at a speed of 2ml per minute, and collecting 100 weight parts of percolate; pulverizing Bulbus Allii Macrostemi, radix Angelicae Dahuricae, radix Glycyrrhizae Preparata and fructus forsythiae into 10 coarse powders, respectively adding into volatile oil extractor, respectively adding 8 times of distilled water for extraction, extracting for 12 hr, mixing the three volatile oils, adding into glycerol, and stirring to obtain mixed solution;

adding herba Achilleae, folium Artemisiae Argyi and herba Portulacae into an extraction tank, decocting with 3 times of water, concentrating to obtain a liquid with a density of 1.05g/ml, precipitating with ethanol, filtering, recovering ethanol to obtain filtrate, adding the percolate and mixed solution, dissolving Borneolum Syntheticum with ethanol, adding, stirring, and standing to obtain Chinese medicinal extractive solution; adding bacteriostatic agent and penetrant into the Chinese medicinal extractive solution, stirring, and standing.

Example 2

The embodiment provides an efficient sterilization and bacteriostasis traditional Chinese medicine spray which consists of a traditional Chinese medicine extracting solution, an external bacteriostat and a penetrant, wherein the external bacteriostat in the spray is chlorhexidine acetate with the mass percent of 0.1 percent, the penetrant is laurocapram with the mass percent of 2 percent, and the rest is the traditional Chinese medicine extracting solution;

the traditional Chinese medicine extracting solution is prepared from the following raw materials in parts by weight: 30 parts of usnea, 45 parts of allium macrostemon, 35 parts of sophora flavescens, 50 parts of sour-swift-current root, 25 parts of bighead atractylodes rhizome, 25 parts of fructus forsythiae, 30 parts of radix angelicae, 60 parts of honey-fried licorice root, 3 parts of folium artemisiae argyi and 20 parts of purslane. The manufacturing method of this embodiment refers to embodiment 1, and is not described herein again.

Example 3

The embodiment provides an efficient sterilization and bacteriostasis traditional Chinese medicine spray which consists of a traditional Chinese medicine extracting solution, an external bacteriostat and a penetrant, wherein the external bacteriostat in the spray is chlorhexidine acetate with the mass percent of 0.2 percent, the penetrant is dimethyl sulfoxide with the mass percent of 4 percent, and the rest is the traditional Chinese medicine extracting solution;

the traditional Chinese medicine extracting solution is prepared from the following raw materials in parts by weight: 25 parts of usnea, 40 parts of allium macrostemon, 38 parts of sophora flavescens, 40 parts of sour-bristled root, 28 parts of bighead atractylodes rhizome, 25 parts of fructus forsythiae, 40 parts of radix angelicae, 41 parts of honey-fried licorice root, 7 parts of folium artemisiae argyi and 30 parts of purslane. The manufacturing method of this embodiment refers to embodiment 1, and is not described herein again.

Example 4

The embodiment provides an efficient sterilization and bacteriostasis traditional Chinese medicine spray which consists of traditional Chinese medicine extract, an external bacteriostat and a penetrant, wherein the external bacteriostat in the spray is benzalkonium bromide with the mass percentage of 0.2%, the penetrant is laurocapram with the mass percentage of 3%, and the rest is the traditional Chinese medicine extract;

the traditional Chinese medicine extracting solution is prepared from the following raw materials in parts by weight: 26 parts of usnea, 42 parts of allium macrostemon, 36 parts of sophora flavescens, 43 parts of sour-swift-current root, 22 parts of bighead atractylodes rhizome, 24 parts of fructus forsythiae, 41 parts of radix angelicae, 50 parts of honey-fried licorice root, 5 parts of folium artemisiae argyi and 24 parts of purslane. The manufacturing method of this embodiment refers to embodiment 1, and is not described herein again.

Example 5

The embodiment provides an efficient sterilization and bacteriostasis traditional Chinese medicine spray which consists of a traditional Chinese medicine extracting solution, an external bacteriostat and a penetrant, wherein the external bacteriostat in the spray is aminoding, the mass percent of the aminoding is 0.1%, the penetrant is laurocapram, the mass percent of the penetrant is 4%, and the rest is the traditional Chinese medicine extracting solution;

the traditional Chinese medicine extracting solution is prepared from the following raw materials in parts by weight: 27 parts of usnea, 37 parts of allium macrostemon, 39 parts of sophora flavescens, 45 parts of sour-bristled root, 24 parts of bighead atractylodes rhizome, 22 parts of fructus forsythiae, 39 parts of radix angelicae, 58 parts of honey-fried licorice root, 4 parts of folium artemisiae argyi and 21 parts of purslane. The manufacturing method of this embodiment refers to embodiment 1, and is not described herein again.

Comparative example 1

The traditional Chinese medicine extracting solution in the embodiment is prepared from the following raw materials in parts by weight: 27 parts of usnea, 37 parts of allium macrostemon, 39 parts of sophora flavescens, 24 parts of bighead atractylodes rhizome, 22 parts of fructus forsythiae, 39 parts of angelica dahurica, 58 parts of honey-fried licorice root and 4 parts of folium artemisiae argyi, and other technical characteristics are the same as those in embodiment 5 and are not repeated.

Comparative example 2

The traditional Chinese medicine extracting solution is prepared from the following raw materials in parts by weight: the traditional Chinese medicine composition comprises, by weight, 45 parts of allium macrostemon, 35 parts of sophora flavescens, 50 parts of sour-swift-flow root, 25 parts of bighead atractylodes rhizome, 25 parts of fructus forsythiae, 30 parts of angelica dahurica, 3 parts of folium artemisiae argyi and 20 parts of purslane. The manufacturing method of this embodiment refers to embodiment 1, and is not described herein again.

Example 6

Experimental species were cultured in nutrient agar medium and nutrient broth medium: the antibacterial experiments of the pseudomonas aeruginosa and the staphylococcus aureus are divided into five experimental groups and two control groups, and the experimental groups respectively use the traditional Chinese medicine spray liquid medicines in the embodiments 1 to 5; the two control groups used the liquid medicine of the Chinese medicinal spray in comparative examples 1-2.

Preparing a drug sensitive tablet: making double-ring qualitative filter paper into round paper with diameter of 6mm with a puncher, placing into a clean and dry penicillin empty bottle, wrapping the bottle mouth with single-layer kraft paper, autoclaving at 121 deg.C for 30min, oven drying at 100 deg.C, and sealing for storage. Respectively soaking paper sheets in the liquid medicine of the traditional Chinese medicine spray in the embodiments 1 to 3 for 2 hours under the aseptic condition, taking out the filter paper sheets after the liquid medicine is completely absorbed by the paper sheets, drying at 50 ℃ to prepare drug sensitive tablets for standby, preparing 10 drug sensitive tablets for each traditional Chinese medicine spray, and simultaneously preparing 10 blank sterilized paper sheets as a control group;

respectively placing Pseudomonas aeruginosa and Staphylococcus aureus in 10ml nutrient broth culture medium, and culturing at 37 deg.C for 18 h; respectively taking 1ml of culture solution, adding 9ml of 0.9% sterile sodium chloride solution, and respectively diluting the two kinds of bacteria solution to 105-106cfu/ml by adopting a 10-time incremental dilution method for later use;

respectively and uniformly inoculating the two test bacterial liquids prepared in the step (2) on two mannitol sodium chloride agar plates, standing for 5min at room temperature, uniformly dividing 40 tablets prepared in the step (1) into two groups which are the same, respectively paving the groups on the agar plates inoculated with Escherichia coli and staphylococcus aureus, inversely placing the plates into an incubator at 37 ℃ for 24h, measuring the diameter (mm) of a bacteriostatic ring of each tablet, and calculating the average value of the diameters of the bacteriostatic rings of each group, wherein the operations are aseptic operations.

Test observation and measurement:

and (4) observation: the zone of no inhibition is represented by "-";

the diameter of the inhibition zone is less than 10mm, which is expressed as 1;

the diameter of the inhibition zone is 10-14mm, which is indicated by 2, and is moderate inhibition;

the diameter of the inhibition zone is more than 14mm, which is expressed as 5;

the numbers obtained in 10 samples in examples 1-5 and comparative examples 1-2 are added, wherein the score of example 1 is 45 points, the score of example 2 is 48 points, the score of example 3 is 42 points, the score of example 4 is 46 points, the score of example 5 is 46 points, the score of comparative example 1 is 26 points, and the score of comparative example 2 is 30 points, wherein the experimental result shows that the traditional Chinese medicine spray has better bactericidal and inhibitory effects on pseudomonas aeruginosa and staphylococcus aureus.

Example 7

The clinical curative effect of the traditional Chinese medicine spray for treating acne provided by the embodiment 2 is summarized as follows:

the traditional Chinese medicine composition is applied to 100 clinical observation cases, wherein 50 men and 50 women have the age of 18-45 years, the patients with the shortest disease course have 2 months, the patients with the longest disease course have 2 years, and the average is 0.5 year. 100 cases are randomly divided into two groups, wherein 50 cases are divided into a control group and 50 cases are divided into an experimental group, the control group is given with external vitamin A acids or oral tetracycline drugs, the experimental group is given with the traditional Chinese medicine spray prepared in the embodiment 6 of the invention, all the dose groups are basically balanced, and baseline values of other research and observation indexes such as personal vital signs, previous medical history, medication, laboratory examination and the like show basic balance among the groups, have no significant statistical difference and are comparable.

Diagnostic criteria:

1. at the beginning of the hair follicle, the hair follicle shows a red papule with the size of millet grains and can also develop into pustules. Then, scleroid white comedones or blackheads can be formed, and sclerosing cysts can be formed in severe cases;

2. it is frequently found on the face, chest and back of male and female in adolescence and is accompanied by seborrhea;

3. often induced by improper diet, overeating a fat, sweet and thick flavor, or affection of exogenous pathogenic factors;

4. after adolescence, most of them can be naturally lightened;

5. women often have irregular menstruation.

The usage and dosage are as follows: in clinical application, the components and dosage of the composition can be increased or decreased according to the weight, age and symptoms of patients. The medicine should be administered by spraying for 2-4 times every day, 6-12 hr every time, and no raw, cold, pungent food should be eaten during administration.

The curative effect standard is as follows:

1. and (3) healing: the skin lesions subside and the subjective symptoms disappear;

2. the effect is shown: the subjective symptoms are obviously relieved, and the skin damage is reduced by more than 70 percent;

3. improvement: the subjective symptoms are obviously relieved, and the skin damage is reduced by more than 30 percent;

4. and (4) invalidation: there was no change in skin lesions or less than 30% regression of symptoms.

Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.

The above is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and various modifications and changes will occur to those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. An efficient sterilization and bacteriostasis traditional Chinese medicine spray is characterized by comprising traditional Chinese medicine extract, an external bacteriostat and a penetrant, wherein the mass percent of the external bacteriostat in the spray is 0.1-0.2%, the mass percent of the penetrant is 2-5%, and the rest is the traditional Chinese medicine extract; the traditional Chinese medicine extracting solution is prepared from the following raw materials in parts by weight: 20-30 parts of usnea, 35-45 parts of allium macrostemon, 35-40 parts of sophora flavescens, 40-50 parts of radix aconiti agrestis, 20-30 parts of bighead atractylodes rhizome, 20-25 parts of fructus forsythiae, 30-45 parts of radix angelicae, 40-60 parts of honey-fried licorice root, 3-10 parts of folium artemisiae argyi and 20-30 parts of purslane.

2. The traditional Chinese medicine spray as claimed in claim 1, wherein the traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 20-25 parts of usnea, 30-40 parts of allium macrostemon, 35-38 parts of sophora flavescens, 42-45 parts of radix aconiti kusnezoffii, 20-28 parts of bighead atractylodes rhizome, 20-23 parts of fructus forsythiae, 30-35 parts of radix angelicae, 50-55 parts of honey-fried licorice root, 5-8 parts of folium artemisiae argyi and 23-28 parts of purslane.

3. The Chinese medicinal spray of claim 1, wherein the external bacteriostatic agent is chlorhexidine acetate, benzalkonium bromide or aminopyridine.

4. The Chinese medicinal spray of claim 1, wherein the penetrant is dimethyl sulfoxide or laurocapram.

5. The method for preparing the Chinese medicinal spray as claimed in any one of claims 1 to 4, comprising the steps of:

6. The method of claim 4, wherein the Usnea, moutan cortex radicis and Atractylodes macrocephala in step (1) are pulverized into coarse powder of 8-10 meshes.

7. The method according to claim 4, wherein the Bulbus Allii Macrostemi, radix Angelicae Dahuricae, radix Glycyrrhizae Preparata and fructus forsythiae in step (2) are 10-15 mesh coarse powder.