CN113906136A - 使用rna引导的核酸内切酶进行dna整合的改进工艺 - Google Patents

使用rna引导的核酸内切酶进行dna整合的改进工艺 Download PDF

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CN113906136A
CN113906136A CN202080031829.1A CN202080031829A CN113906136A CN 113906136 A CN113906136 A CN 113906136A CN 202080031829 A CN202080031829 A CN 202080031829A CN 113906136 A CN113906136 A CN 113906136A
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nucleotides
donor dna
cells
donor
strand
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丁蓓蓓
郭文忠
张延良
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Sorento Pharmaceutical Co ltd
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Sorento Pharmaceutical Co ltd
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CN202080031829.1A 2018-02-27 2020-02-27 使用rna引导的核酸内切酶进行dna整合的改进工艺 Pending CN113906136A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862635702P 2018-02-27 2018-02-27
US16/288,052 2019-02-27
US16/288,052 US20200224160A1 (en) 2018-02-27 2019-02-27 Process for dna integration using rna-guided endonucleases
PCT/US2020/020121 WO2020176740A1 (en) 2018-02-27 2020-02-27 Improved process for dna integration using rna-guided endonucleases

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US (2) US20200224160A1 (https=)
EP (1) EP3931322A1 (https=)
JP (2) JP2022521787A (https=)
KR (1) KR20210134000A (https=)
CN (1) CN113906136A (https=)
AU (1) AU2020229848A1 (https=)
CA (1) CA3131588A1 (https=)
IL (1) IL285842A (https=)
MX (1) MX2021010322A (https=)
SG (1) SG11202109332RA (https=)
WO (1) WO2020176740A1 (https=)

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KR20200124702A (ko) 2018-02-23 2020-11-03 파이어니어 하이 부렛드 인터내쇼날 인코포레이팃드 신규한 cas9 오르소로그
US12365888B2 (en) 2018-12-14 2025-07-22 Pioneer Hi-Bred International, Inc. CRISPR-Cas systems for genome editing
SG11202109163YA (en) * 2019-02-26 2021-09-29 Sorrento Therapeutics Inc Antigen binding proteins that bind bcma
AU2020232691B2 (en) 2019-03-05 2023-06-29 Nkarta, Inc. CD19-directed chimeric antigen receptors and uses thereof in immunotherapy
PH12021553076A1 (en) 2019-06-07 2023-08-14 Scribe Therapeutics Inc Engineered casx systems
EP4139345A1 (en) 2020-04-24 2023-03-01 Sorrento Therapeutics, Inc. Memory dimeric antigen receptors
WO2022015956A1 (en) 2020-07-15 2022-01-20 Sorrento Therapeutics, Inc. Improved process for dna integration using rna-guided endonucleases
EP4192941A1 (en) * 2020-08-07 2023-06-14 Neogene Therapeutics B.V. Methods to enrich genetically engineered t cells
CN116829707A (zh) * 2020-11-11 2023-09-29 孟山都技术公司 提高定点整合频率的方法
AU2021392719B2 (en) 2020-12-03 2025-08-14 Scribe Therapeutics Inc. Engineered class 2 type v crispr systems
WO2022215978A1 (ko) * 2021-04-05 2022-10-13 주식회사 셀렌진 Pdcd-1 유전자에 상보적인 가이드 rna 및 이의 용도
WO2026020171A2 (en) 2024-07-19 2026-01-22 Aera Therapeutics, Inc. Chimeric antigen receptor constructs

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US20170051296A1 (en) * 2013-03-15 2017-02-23 Cibus Us Llc Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
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