CA3131588A1 - Improved process for dna integration using rna-guided endonucleases - Google Patents

Improved process for dna integration using rna-guided endonucleases Download PDF

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Publication number
CA3131588A1
CA3131588A1 CA3131588A CA3131588A CA3131588A1 CA 3131588 A1 CA3131588 A1 CA 3131588A1 CA 3131588 A CA3131588 A CA 3131588A CA 3131588 A CA3131588 A CA 3131588A CA 3131588 A1 CA3131588 A1 CA 3131588A1
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Prior art keywords
nucleotides
cells
donor dna
donor
strand
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Pending
Application number
CA3131588A
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English (en)
French (fr)
Inventor
Beibei Ding
Wenzhong Guo
Yanliang Zhang
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Sorrento Therapeutics Inc
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Sorrento Therapeutics Inc
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Publication of CA3131588A1 publication Critical patent/CA3131588A1/en
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/41—Vertebrate antigens
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    • A61K40/41—Vertebrate antigens
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    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • A61K40/41—Vertebrate antigens
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    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
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CA3131588A 2018-02-27 2020-02-27 Improved process for dna integration using rna-guided endonucleases Pending CA3131588A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862635702P 2018-02-27 2018-02-27
US16/288,052 2019-02-27
US16/288,052 US20200224160A1 (en) 2018-02-27 2019-02-27 Process for dna integration using rna-guided endonucleases
PCT/US2020/020121 WO2020176740A1 (en) 2018-02-27 2020-02-27 Improved process for dna integration using rna-guided endonucleases

Publications (1)

Publication Number Publication Date
CA3131588A1 true CA3131588A1 (en) 2020-09-03

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CA3131588A Pending CA3131588A1 (en) 2018-02-27 2020-02-27 Improved process for dna integration using rna-guided endonucleases

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US (2) US20200224160A1 (https=)
EP (1) EP3931322A1 (https=)
JP (2) JP2022521787A (https=)
KR (1) KR20210134000A (https=)
CN (1) CN113906136A (https=)
AU (1) AU2020229848A1 (https=)
CA (1) CA3131588A1 (https=)
IL (1) IL285842A (https=)
MX (1) MX2021010322A (https=)
SG (1) SG11202109332RA (https=)
WO (1) WO2020176740A1 (https=)

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US12365888B2 (en) 2018-12-14 2025-07-22 Pioneer Hi-Bred International, Inc. CRISPR-Cas systems for genome editing
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EP4139345A1 (en) 2020-04-24 2023-03-01 Sorrento Therapeutics, Inc. Memory dimeric antigen receptors
WO2022015956A1 (en) 2020-07-15 2022-01-20 Sorrento Therapeutics, Inc. Improved process for dna integration using rna-guided endonucleases
EP4192941A1 (en) * 2020-08-07 2023-06-14 Neogene Therapeutics B.V. Methods to enrich genetically engineered t cells
CN116829707A (zh) * 2020-11-11 2023-09-29 孟山都技术公司 提高定点整合频率的方法
AU2021392719B2 (en) 2020-12-03 2025-08-14 Scribe Therapeutics Inc. Engineered class 2 type v crispr systems
WO2022215978A1 (ko) * 2021-04-05 2022-10-13 주식회사 셀렌진 Pdcd-1 유전자에 상보적인 가이드 rna 및 이의 용도
WO2026020171A2 (en) 2024-07-19 2026-01-22 Aera Therapeutics, Inc. Chimeric antigen receptor constructs

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