CN113631548B - 血清素5-ht2b抑制化合物 - Google Patents
血清素5-ht2b抑制化合物 Download PDFInfo
- Publication number
- CN113631548B CN113631548B CN202080024800.0A CN202080024800A CN113631548B CN 113631548 B CN113631548 B CN 113631548B CN 202080024800 A CN202080024800 A CN 202080024800A CN 113631548 B CN113631548 B CN 113631548B
- Authority
- CN
- China
- Prior art keywords
- imidazol
- methanone
- piperidin
- phenyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962825051P | 2019-03-28 | 2019-03-28 | |
| US62/825,051 | 2019-03-28 | ||
| PCT/US2020/024969 WO2020198478A1 (en) | 2019-03-28 | 2020-03-26 | Serotonin 5-ht2b inhibitory compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113631548A CN113631548A (zh) | 2021-11-09 |
| CN113631548B true CN113631548B (zh) | 2023-06-06 |
Family
ID=70775466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080024800.0A Active CN113631548B (zh) | 2019-03-28 | 2020-03-26 | 血清素5-ht2b抑制化合物 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US12240827B2 (https=) |
| EP (1) | EP3947360B1 (https=) |
| JP (1) | JP7454589B2 (https=) |
| CN (1) | CN113631548B (https=) |
| AU (1) | AU2020245614B2 (https=) |
| BR (1) | BR112021019314A2 (https=) |
| CA (1) | CA3134952C (https=) |
| DK (1) | DK3947360T3 (https=) |
| ES (1) | ES2991167T3 (https=) |
| FI (1) | FI3947360T3 (https=) |
| PL (1) | PL3947360T3 (https=) |
| PT (1) | PT3947360T (https=) |
| WO (1) | WO2020198478A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20240027076A (ko) * | 2021-07-26 | 2024-02-29 | 조에티스 서비시즈 엘엘씨 | 세로토닌 5-ht2b 억제 화합물 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101611013A (zh) * | 2006-10-03 | 2009-12-23 | 艾尼纳制药公司 | 作为5-ht2a血清素受体调节剂用于治疗与其相关病症的吡唑衍生物 |
| WO2010080357A1 (en) * | 2008-12-18 | 2010-07-15 | Boehringer Ingelheim International Gmbh | Serotonin 5-ht2b receptor inhibitors |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0515995D0 (en) | 2005-08-03 | 2005-09-07 | Sandoz Ag | Organic compounds |
| WO2007097197A1 (ja) * | 2006-02-20 | 2007-08-30 | Astellas Pharma Inc. | アミド誘導体またはその塩 |
| US8697739B2 (en) | 2010-07-29 | 2014-04-15 | Novartis Ag | Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof |
-
2020
- 2020-03-26 PL PL20726982.0T patent/PL3947360T3/pl unknown
- 2020-03-26 US US17/441,340 patent/US12240827B2/en active Active
- 2020-03-26 EP EP20726982.0A patent/EP3947360B1/en active Active
- 2020-03-26 JP JP2021557368A patent/JP7454589B2/ja active Active
- 2020-03-26 PT PT207269820T patent/PT3947360T/pt unknown
- 2020-03-26 ES ES20726982T patent/ES2991167T3/es active Active
- 2020-03-26 FI FIEP20726982.0T patent/FI3947360T3/fi active
- 2020-03-26 WO PCT/US2020/024969 patent/WO2020198478A1/en not_active Ceased
- 2020-03-26 AU AU2020245614A patent/AU2020245614B2/en active Active
- 2020-03-26 CN CN202080024800.0A patent/CN113631548B/zh active Active
- 2020-03-26 DK DK20726982.0T patent/DK3947360T3/da active
- 2020-03-26 BR BR112021019314A patent/BR112021019314A2/pt unknown
- 2020-03-26 CA CA3134952A patent/CA3134952C/en active Active
-
2025
- 2025-01-21 US US19/032,924 patent/US20250179046A1/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101611013A (zh) * | 2006-10-03 | 2009-12-23 | 艾尼纳制药公司 | 作为5-ht2a血清素受体调节剂用于治疗与其相关病症的吡唑衍生物 |
| WO2010080357A1 (en) * | 2008-12-18 | 2010-07-15 | Boehringer Ingelheim International Gmbh | Serotonin 5-ht2b receptor inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| US20220162183A1 (en) | 2022-05-26 |
| US12240827B2 (en) | 2025-03-04 |
| PL3947360T3 (pl) | 2024-11-04 |
| CA3134952A1 (en) | 2020-10-01 |
| EP3947360A1 (en) | 2022-02-09 |
| AU2020245614A1 (en) | 2021-10-14 |
| US20250179046A1 (en) | 2025-06-05 |
| JP2022527080A (ja) | 2022-05-30 |
| JP7454589B2 (ja) | 2024-03-22 |
| DK3947360T3 (da) | 2024-08-26 |
| WO2020198478A8 (en) | 2021-09-16 |
| ES2991167T3 (es) | 2024-12-02 |
| CA3134952C (en) | 2023-08-08 |
| BR112021019314A2 (pt) | 2021-12-14 |
| CN113631548A (zh) | 2021-11-09 |
| FI3947360T3 (fi) | 2024-10-07 |
| EP3947360B1 (en) | 2024-08-07 |
| WO2020198478A1 (en) | 2020-10-01 |
| AU2020245614B2 (en) | 2023-01-19 |
| PT3947360T (pt) | 2024-09-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |