BR112021019314A2 - Compostos inibitórios de 5-ht2b de serotonina - Google Patents
Compostos inibitórios de 5-ht2b de serotoninaInfo
- Publication number
- BR112021019314A2 BR112021019314A2 BR112021019314A BR112021019314A BR112021019314A2 BR 112021019314 A2 BR112021019314 A2 BR 112021019314A2 BR 112021019314 A BR112021019314 A BR 112021019314A BR 112021019314 A BR112021019314 A BR 112021019314A BR 112021019314 A2 BR112021019314 A2 BR 112021019314A2
- Authority
- BR
- Brazil
- Prior art keywords
- serotonin
- ht2b
- inhibitory compounds
- compounds
- heart failure
- Prior art date
Links
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title abstract 6
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 229940076279 serotonin Drugs 0.000 title abstract 3
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 206010019280 Heart failures Diseases 0.000 abstract 2
- 229940116892 5 Hydroxytryptamine 2B receptor antagonist Drugs 0.000 abstract 1
- 241000282465 Canis Species 0.000 abstract 1
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 230000007850 degeneration Effects 0.000 abstract 1
- 210000004115 mitral valve Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962825051P | 2019-03-28 | 2019-03-28 | |
| PCT/US2020/024969 WO2020198478A1 (en) | 2019-03-28 | 2020-03-26 | Serotonin 5-ht2b inhibitory compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021019314A2 true BR112021019314A2 (pt) | 2021-12-14 |
Family
ID=70775466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021019314A BR112021019314A2 (pt) | 2019-03-28 | 2020-03-26 | Compostos inibitórios de 5-ht2b de serotonina |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US12240827B2 (https=) |
| EP (1) | EP3947360B1 (https=) |
| JP (1) | JP7454589B2 (https=) |
| CN (1) | CN113631548B (https=) |
| AU (1) | AU2020245614B2 (https=) |
| BR (1) | BR112021019314A2 (https=) |
| CA (1) | CA3134952C (https=) |
| DK (1) | DK3947360T3 (https=) |
| ES (1) | ES2991167T3 (https=) |
| FI (1) | FI3947360T3 (https=) |
| PL (1) | PL3947360T3 (https=) |
| PT (1) | PT3947360T (https=) |
| WO (1) | WO2020198478A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20240027076A (ko) * | 2021-07-26 | 2024-02-29 | 조에티스 서비시즈 엘엘씨 | 세로토닌 5-ht2b 억제 화합물 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0515995D0 (en) | 2005-08-03 | 2005-09-07 | Sandoz Ag | Organic compounds |
| WO2007097197A1 (ja) * | 2006-02-20 | 2007-08-30 | Astellas Pharma Inc. | アミド誘導体またはその塩 |
| TWI415845B (zh) | 2006-10-03 | 2013-11-21 | Arena Pharm Inc | 用於治療與５-ｈｔ2ａ血清素受體相關聯病症之作為５-ｈｔ2ａ血清素受體之調節劑的吡唑衍生物 |
| JP2012512877A (ja) * | 2008-12-18 | 2012-06-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | セロトニン５−ｈｔ２ｂ受容体阻害剤 |
| US8697739B2 (en) | 2010-07-29 | 2014-04-15 | Novartis Ag | Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof |
-
2020
- 2020-03-26 PL PL20726982.0T patent/PL3947360T3/pl unknown
- 2020-03-26 US US17/441,340 patent/US12240827B2/en active Active
- 2020-03-26 EP EP20726982.0A patent/EP3947360B1/en active Active
- 2020-03-26 JP JP2021557368A patent/JP7454589B2/ja active Active
- 2020-03-26 PT PT207269820T patent/PT3947360T/pt unknown
- 2020-03-26 ES ES20726982T patent/ES2991167T3/es active Active
- 2020-03-26 FI FIEP20726982.0T patent/FI3947360T3/fi active
- 2020-03-26 WO PCT/US2020/024969 patent/WO2020198478A1/en not_active Ceased
- 2020-03-26 AU AU2020245614A patent/AU2020245614B2/en active Active
- 2020-03-26 CN CN202080024800.0A patent/CN113631548B/zh active Active
- 2020-03-26 DK DK20726982.0T patent/DK3947360T3/da active
- 2020-03-26 BR BR112021019314A patent/BR112021019314A2/pt unknown
- 2020-03-26 CA CA3134952A patent/CA3134952C/en active Active
-
2025
- 2025-01-21 US US19/032,924 patent/US20250179046A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20220162183A1 (en) | 2022-05-26 |
| US12240827B2 (en) | 2025-03-04 |
| PL3947360T3 (pl) | 2024-11-04 |
| CA3134952A1 (en) | 2020-10-01 |
| EP3947360A1 (en) | 2022-02-09 |
| AU2020245614A1 (en) | 2021-10-14 |
| US20250179046A1 (en) | 2025-06-05 |
| JP2022527080A (ja) | 2022-05-30 |
| JP7454589B2 (ja) | 2024-03-22 |
| DK3947360T3 (da) | 2024-08-26 |
| WO2020198478A8 (en) | 2021-09-16 |
| ES2991167T3 (es) | 2024-12-02 |
| CA3134952C (en) | 2023-08-08 |
| CN113631548A (zh) | 2021-11-09 |
| FI3947360T3 (fi) | 2024-10-07 |
| CN113631548B (zh) | 2023-06-06 |
| EP3947360B1 (en) | 2024-08-07 |
| WO2020198478A1 (en) | 2020-10-01 |
| AU2020245614B2 (en) | 2023-01-19 |
| PT3947360T (pt) | 2024-09-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] |