BR112019005183A2 - sistema paratransgênico inovador para o biocontrole de mosquitos transmissores de doença - Google Patents

sistema paratransgênico inovador para o biocontrole de mosquitos transmissores de doença

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Publication number
BR112019005183A2
BR112019005183A2 BR112019005183A BR112019005183A BR112019005183A2 BR 112019005183 A2 BR112019005183 A2 BR 112019005183A2 BR 112019005183 A BR112019005183 A BR 112019005183A BR 112019005183 A BR112019005183 A BR 112019005183A BR 112019005183 A2 BR112019005183 A2 BR 112019005183A2
Authority
BR
Brazil
Prior art keywords
innovative
biocontrol
disease
paratransgenic
mosquitoes
Prior art date
Application number
BR112019005183A
Other languages
English (en)
Inventor
Richard Sayre
Jiaannong Xu
Original Assignee
Pebble Labs Usa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pebble Labs Usa Inc filed Critical Pebble Labs Usa Inc
Publication of BR112019005183A2 publication Critical patent/BR112019005183A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/002—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing a foodstuff as carrier or diluent, i.e. baits
    • A01N25/006—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing a foodstuff as carrier or diluent, i.e. baits insecticidal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
    • A01N57/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds containing heterocyclic radicals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/20—Bacteria; Substances produced thereby or obtained therefrom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/60—Isolated nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C12N2330/50—Biochemical production, i.e. in a transformed host cell
    • C12N2330/51—Specially adapted vectors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Biomedical Technology (AREA)
  • Pest Control & Pesticides (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Insects & Arthropods (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Catching Or Destruction (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

a tecnologia da invenção refere-se a estratégias paratransgênicas para o controle de patógenos. a tecnologia da invenção pode incluir especificamente um sistema paratransgênico inovador configurado para entregar uma ou mais moléculas de rna inibitórias para organismos transmissores de doença/patógeno. em uma modalidade preferencial, a invenção pode incluir uma ou mais bactérias entéricas geneticamente modificadas configuradas para entregar uma ou mais moléculas de rna de interferência para mosquitos transmissores de doença/patógeno.
BR112019005183A 2016-09-16 2017-09-19 sistema paratransgênico inovador para o biocontrole de mosquitos transmissores de doença BR112019005183A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662395791P 2016-09-16 2016-09-16
PCT/US2017/052118 WO2018053451A1 (en) 2016-09-16 2017-09-19 Novel paratransgenic system for the biocontrol of disease-transmitting mosquitos

Publications (1)

Publication Number Publication Date
BR112019005183A2 true BR112019005183A2 (pt) 2019-07-02

Family

ID=61619777

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019005183A BR112019005183A2 (pt) 2016-09-16 2017-09-19 sistema paratransgênico inovador para o biocontrole de mosquitos transmissores de doença

Country Status (16)

Country Link
US (3) US10294475B2 (pt)
EP (1) EP3512951A4 (pt)
JP (1) JP2019533477A (pt)
KR (1) KR20190095252A (pt)
CN (1) CN110114462A (pt)
AU (1) AU2017326616A1 (pt)
BR (1) BR112019005183A2 (pt)
CA (1) CA3036892A1 (pt)
CL (1) CL2019000664A1 (pt)
CO (1) CO2019003891A2 (pt)
EC (1) ECSP19027266A (pt)
IL (1) IL265398A (pt)
MX (1) MX2019002949A (pt)
PH (1) PH12019500583A1 (pt)
WO (1) WO2018053451A1 (pt)
ZA (1) ZA201902370B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018217819A1 (en) * 2017-05-22 2018-11-29 Pebble Labs Inc. Transbiotic regulation of bacterial gene expression
US11944676B2 (en) 2017-08-07 2024-04-02 Pebble Labs Inc. Systems and methods for the control of acute hepatopancreatic necrosis disease
WO2020010344A1 (en) * 2018-07-04 2020-01-09 Pebble Labs Usa, Inc. System and methods for engineering bacteria fit for eukaryotic mrna production, export, and translation in a eukaryotic host
WO2020047284A1 (en) * 2018-08-29 2020-03-05 The Penn State Research Foundation Compositions and methods for use in controlling mosquito-borne viruses
WO2020097629A1 (en) * 2018-11-09 2020-05-14 Pebble Labs Usa, Inc. Systems, methods, and compositions for the control of mosquito blood feeding behavior through paratransgenic appetite suppression
WO2020097630A1 (en) * 2018-11-09 2020-05-14 Pebble Labs Usa, Inc. Inactivation of viral genome replication in the midgut of insect vectors by activating endogenous anti-viral defense pathways

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1415502A (en) 1972-05-16 1975-11-26 Platt Saco Lowell Ltd Method of and apparatus for spinning yarn
JP5530632B2 (ja) * 2005-09-16 2014-06-25 デブジェン エヌブイ ＲＮＡｉを使用した害虫の抑制方法
US20110183348A1 (en) * 2010-01-22 2011-07-28 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Compositions and methods for therapeutic delivery with microorganisms
EP2467146A1 (en) * 2009-08-21 2012-06-27 Beeologics Inc. Preventing and curing beneficial insect diseases via plant transcribed molecules
US20130315883A1 (en) * 2010-10-22 2013-11-28 Richard Sayre Control of pathogens and parasites
GB201202119D0 (en) * 2012-02-08 2012-03-21 Univ Swansea Pest and pathogen control
US20170051285A1 (en) * 2014-05-04 2017-02-23 Forrest Innovations Ltd. Compositions and methods of using same for reducing resistance to mosquito larvicides
SG10201913630YA (en) * 2016-02-17 2020-03-30 Curevac Ag Zika virus vaccine

Also Published As

Publication number Publication date
EP3512951A4 (en) 2020-07-08
US20180216110A1 (en) 2018-08-02
CO2019003891A2 (es) 2019-06-28
CA3036892A1 (en) 2018-03-22
MX2019002949A (es) 2020-01-27
IL265398A (en) 2019-05-30
US20190093110A1 (en) 2019-03-28
CN110114462A (zh) 2019-08-09
ECSP19027266A (es) 2019-07-31
EP3512951A1 (en) 2019-07-24
KR20190095252A (ko) 2019-08-14
US10294475B2 (en) 2019-05-21
WO2018053451A1 (en) 2018-03-22
CL2019000664A1 (es) 2019-10-11
PH12019500583A1 (en) 2019-10-28
US11396653B2 (en) 2022-07-26
WO2018053451A8 (en) 2019-04-18
US20190276830A1 (en) 2019-09-12
AU2017326616A1 (en) 2019-04-04
JP2019533477A (ja) 2019-11-21
ZA201902370B (en) 2019-12-18

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B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]