EA201991370A1 - Методы лечения поликистозной болезни почек - Google Patents

Методы лечения поликистозной болезни почек

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Publication number
EA201991370A1
EA201991370A1 EA201991370A EA201991370A EA201991370A1 EA 201991370 A1 EA201991370 A1 EA 201991370A1 EA 201991370 A EA201991370 A EA 201991370A EA 201991370 A EA201991370 A EA 201991370A EA 201991370 A1 EA201991370 A1 EA 201991370A1
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EA
Eurasian Patent Office
Prior art keywords
kidney disease
polycystic kidney
methods
treating polycystic
treating
Prior art date
Application number
EA201991370A
Other languages
English (en)
Inventor
Чарльз Р. Аллерсон
Вишал Д. Пател
Б. Нельсон Чау
Джон Р. Андросавич
Original Assignee
Регьюлэс Терапьютикс Инк.
Дзе Борд Оф Риджентс Оф Дзе Юниверсити Оф Техас Систем
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Регьюлэс Терапьютикс Инк., Дзе Борд Оф Риджентс Оф Дзе Юниверсити Оф Техас Систем filed Critical Регьюлэс Терапьютикс Инк.
Publication of EA201991370A1 publication Critical patent/EA201991370A1/ru

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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Abstract

В данном документе предоставлены способы лечения поликистозной болезни почек, в том числе аутосомно-доминантной поликистозной болезни почек, с использованием модифицированных олигонуклеотидов, нацеленных на miR-17.
EA201991370A 2016-12-05 2017-12-04 Методы лечения поликистозной болезни почек EA201991370A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662430164P 2016-12-05 2016-12-05
PCT/US2017/064432 WO2018106568A1 (en) 2016-12-05 2017-12-04 Methods for treatment of polycystic kidney disease

Publications (1)

Publication Number Publication Date
EA201991370A1 true EA201991370A1 (ru) 2019-12-30

Family

ID=61074503

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201991370A EA201991370A1 (ru) 2016-12-05 2017-12-04 Методы лечения поликистозной болезни почек

Country Status (16)

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US (4) US20190345494A1 (ru)
EP (1) EP3548011B1 (ru)
JP (1) JP7105775B2 (ru)
KR (1) KR20190093207A (ru)
CN (1) CN110225747A (ru)
AU (1) AU2017372695B2 (ru)
BR (1) BR112019011597A2 (ru)
CA (1) CA3045461A1 (ru)
CL (1) CL2019001526A1 (ru)
EA (1) EA201991370A1 (ru)
IL (1) IL266989A (ru)
MA (1) MA46970A (ru)
MX (1) MX2019006337A (ru)
MY (1) MY202466A (ru)
WO (1) WO2018106568A1 (ru)
ZA (1) ZA201903608B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA44836A (fr) 2015-08-26 2018-07-04 Univ Texas Procédés de traitement du syndrome polykystique des reins
JP7499754B2 (ja) 2018-08-23 2024-06-14 ロシュ・イノベーション・センター・コペンハーゲン・アクティーゼルスカブ Ｍｉｃｒｏｒｎａ－１３４バイオマーカー
TW202320808A (zh) * 2021-10-08 2023-06-01 美商雷格勒斯治療公司 用於治療多囊性腎病之方法及組合物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070004957A (ko) * 2004-04-20 2007-01-09 제나코 바이오메디컬 프로덕츠, 인코포레이티드 ｎｃＲＮＡ 검출 방법
GB0523659D0 (en) * 2005-11-21 2005-12-28 Novartis Ag Organic compounds
AU2007303205A1 (en) 2006-10-03 2008-04-10 Tekmira Pharmaceuticals Corporation Lipid containing formulations
CA2690643A1 (en) * 2007-06-14 2008-12-18 Mirx Therapeutics Aps Oligonucleotides for modulation of target rna activity
CA2717792A1 (en) * 2008-03-07 2009-09-11 Santaris Pharma A/S Pharmaceutical compositions for treatment of microrna related diseases
CA2780726A1 (en) * 2009-11-11 2011-05-19 Tariq M. Rana Method for generation and regulation of ips cells and compositions thereof
US20160362688A1 (en) * 2014-02-12 2016-12-15 Thomas Jefferson University Compositions and methods of using microrna inhibitors
MA44836A (fr) * 2015-08-26 2018-07-04 Univ Texas Procédés de traitement du syndrome polykystique des reins
US11157828B2 (en) * 2016-12-08 2021-10-26 Microsoft Technology Licensing, Llc Tomography and generative data modeling via quantum boltzmann training

Also Published As

Publication number Publication date
BR112019011597A2 (pt) 2019-10-22
IL266989A (en) 2019-07-31
US20220213483A1 (en) 2022-07-07
JP7105775B2 (ja) 2022-07-25
KR20190093207A (ko) 2019-08-08
ZA201903608B (en) 2021-10-27
MY202466A (en) 2024-04-30
EP3548011A1 (en) 2019-10-09
AU2017372695B2 (en) 2023-07-20
JP2019536803A (ja) 2019-12-19
WO2018106568A1 (en) 2018-06-14
US20190345494A1 (en) 2019-11-14
CN110225747A (zh) 2019-09-10
US20240141350A1 (en) 2024-05-02
US20200392501A1 (en) 2020-12-17
MX2019006337A (es) 2019-09-26
CL2019001526A1 (es) 2019-10-18
EP3548011B1 (en) 2023-06-14
MA46970A (fr) 2019-10-09
AU2017372695A1 (en) 2019-06-13
CA3045461A1 (en) 2018-06-14

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