BR112019011597A2 - método para tratamento da doença renal policística, método para reduzir o declínio da função renal ao longo do tempo em um sujeito com doença renal policística, método para reduzir o declínio da função renal ao longo do tempo e composto - Google Patents

método para tratamento da doença renal policística, método para reduzir o declínio da função renal ao longo do tempo em um sujeito com doença renal policística, método para reduzir o declínio da função renal ao longo do tempo e composto

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Publication number
BR112019011597A2
BR112019011597A2 BR112019011597A BR112019011597A BR112019011597A2 BR 112019011597 A2 BR112019011597 A2 BR 112019011597A2 BR 112019011597 A BR112019011597 A BR 112019011597A BR 112019011597 A BR112019011597 A BR 112019011597A BR 112019011597 A2 BR112019011597 A2 BR 112019011597A2
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BR
Brazil
Prior art keywords
kidney disease
decline
reducing
polycystic kidney
over time
Prior art date
Application number
BR112019011597A
Other languages
English (en)
Inventor
Nelson Chau B
R Allerson Charles
R Androsavich John
D Patel Vishal
Original Assignee
Regulus Therapeutics Inc
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regulus Therapeutics Inc, Univ Texas filed Critical Regulus Therapeutics Inc
Publication of BR112019011597A2 publication Critical patent/BR112019011597A2/pt

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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Abstract

são fornecidos, neste documento, métodos para o tratamento de doença renal policística, incluindo doença renal policística dominante autossômica, usando oligonucleotídeos modificados direcionados para mir-17.
BR112019011597A 2016-12-05 2017-12-04 método para tratamento da doença renal policística, método para reduzir o declínio da função renal ao longo do tempo em um sujeito com doença renal policística, método para reduzir o declínio da função renal ao longo do tempo e composto BR112019011597A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662430164P 2016-12-05 2016-12-05
PCT/US2017/064432 WO2018106568A1 (en) 2016-12-05 2017-12-04 Methods for treatment of polycystic kidney disease

Publications (1)

Publication Number Publication Date
BR112019011597A2 true BR112019011597A2 (pt) 2019-10-22

Family

ID=61074503

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019011597A BR112019011597A2 (pt) 2016-12-05 2017-12-04 método para tratamento da doença renal policística, método para reduzir o declínio da função renal ao longo do tempo em um sujeito com doença renal policística, método para reduzir o declínio da função renal ao longo do tempo e composto

Country Status (16)

Country Link
US (4) US20190345494A1 (pt)
EP (1) EP3548011B1 (pt)
JP (1) JP7105775B2 (pt)
KR (1) KR20190093207A (pt)
CN (1) CN110225747A (pt)
AU (1) AU2017372695B2 (pt)
BR (1) BR112019011597A2 (pt)
CA (1) CA3045461A1 (pt)
CL (1) CL2019001526A1 (pt)
EA (1) EA201991370A1 (pt)
IL (1) IL266989A (pt)
MA (1) MA46970A (pt)
MX (1) MX2019006337A (pt)
MY (1) MY202466A (pt)
WO (1) WO2018106568A1 (pt)
ZA (1) ZA201903608B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA44836A (fr) 2015-08-26 2018-07-04 Univ Texas Procédés de traitement du syndrome polykystique des reins
WO2020038968A1 (en) 2018-08-23 2020-02-27 Roche Innovation Center Copenhagen A/S Microrna-134 biomarker
CA3234547A1 (en) * 2021-10-08 2023-04-13 Regulus Therapeutics Inc. Methods and compositions for treatment of polycystic kidney disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ551019A (en) * 2004-04-20 2009-08-28 Genaco Biomedical Products Inc Method for detecting ncRNA
GB0523659D0 (en) * 2005-11-21 2005-12-28 Novartis Ag Organic compounds
CN110066224A (zh) 2006-10-03 2019-07-30 阿尔尼拉姆医药品有限公司 含脂质的制品
CA2690643A1 (en) * 2007-06-14 2008-12-18 Mirx Therapeutics Aps Oligonucleotides for modulation of target rna activity
US8404659B2 (en) * 2008-03-07 2013-03-26 Santaris Pharma A/S Pharmaceutical compositions for treatment of MicroRNA related diseases
US20110189137A1 (en) 2009-11-11 2011-08-04 Sanford-Burnham Medical Research Institute Method for generation and regulation of ips cells and compositions thereof
JP2017511694A (ja) * 2014-02-12 2017-04-27 トーマス・ジェファーソン・ユニバーシティ マイクロｒｎａ阻害剤を使用するための組成物および方法
MA44836A (fr) 2015-08-26 2018-07-04 Univ Texas Procédés de traitement du syndrome polykystique des reins
US11157828B2 (en) 2016-12-08 2021-10-26 Microsoft Technology Licensing, Llc Tomography and generative data modeling via quantum boltzmann training

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Publication number Publication date
ZA201903608B (en) 2021-10-27
AU2017372695A1 (en) 2019-06-13
CL2019001526A1 (es) 2019-10-18
US20200392501A1 (en) 2020-12-17
JP2019536803A (ja) 2019-12-19
EP3548011A1 (en) 2019-10-09
MA46970A (fr) 2019-10-09
US20220213483A1 (en) 2022-07-07
CN110225747A (zh) 2019-09-10
JP7105775B2 (ja) 2022-07-25
AU2017372695B2 (en) 2023-07-20
US20240141350A1 (en) 2024-05-02
IL266989A (en) 2019-07-31
MX2019006337A (es) 2019-09-26
EA201991370A1 (ru) 2019-12-30
US20190345494A1 (en) 2019-11-14
KR20190093207A (ko) 2019-08-08
CA3045461A1 (en) 2018-06-14
WO2018106568A1 (en) 2018-06-14
MY202466A (en) 2024-04-30
EP3548011B1 (en) 2023-06-14

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Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]