BR112021019314A2 - Compostos inibitórios de 5-ht2b de serotonina - Google Patents

Compostos inibitórios de 5-ht2b de serotonina

Info

Publication number
BR112021019314A2
BR112021019314A2 BR112021019314A BR112021019314A BR112021019314A2 BR 112021019314 A2 BR112021019314 A2 BR 112021019314A2 BR 112021019314 A BR112021019314 A BR 112021019314A BR 112021019314 A BR112021019314 A BR 112021019314A BR 112021019314 A2 BR112021019314 A2 BR 112021019314A2
Authority
BR
Brazil
Prior art keywords
serotonin
ht2b
inhibitory compounds
compounds
heart failure
Prior art date
Application number
BR112021019314A
Other languages
English (en)
Inventor
Govindan Subramanian
Jinxia, (Nancy) Deng
Andrew Ewin Richard
Original Assignee
Zoetis Services Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zoetis Services Llc filed Critical Zoetis Services Llc
Publication of BR112021019314A2 publication Critical patent/BR112021019314A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

compostos inibitórios de 5-ht2b de serotonina. os compostos da invenção, como aqui descritos, são antagonistas do 5-ht2b da serotonina inovadores úteis para o tratamento da degeneração da válvula mitral mixomatosa (mmvd), insuficiência cardíaca congestiva (chf) e/ou insuficiência cardíaca assintomática em animais, preferencialmente caninos.
BR112021019314A 2019-03-28 2020-03-26 Compostos inibitórios de 5-ht2b de serotonina BR112021019314A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962825051P 2019-03-28 2019-03-28
PCT/US2020/024969 WO2020198478A1 (en) 2019-03-28 2020-03-26 Serotonin 5-ht2b inhibitory compounds

Publications (1)

Publication Number Publication Date
BR112021019314A2 true BR112021019314A2 (pt) 2021-12-14

Family

ID=70775466

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021019314A BR112021019314A2 (pt) 2019-03-28 2020-03-26 Compostos inibitórios de 5-ht2b de serotonina

Country Status (8)

Country Link
US (1) US20220162183A1 (pt)
EP (1) EP3947360A1 (pt)
JP (1) JP7454589B2 (pt)
CN (1) CN113631548B (pt)
AU (1) AU2020245614B2 (pt)
BR (1) BR112021019314A2 (pt)
CA (1) CA3134952C (pt)
WO (1) WO2020198478A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117729914A (zh) * 2021-07-26 2024-03-19 硕腾服务有限责任公司 血清素5-ht2b抑制化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0515995D0 (en) 2005-08-03 2005-09-07 Sandoz Ag Organic compounds
KR20080094962A (ko) 2006-02-20 2008-10-27 아스텔라스세이야쿠 가부시키가이샤 아미드 유도체 또는 그의 염
TWI415845B (zh) * 2006-10-03 2013-11-21 Arena Pharm Inc 用於治療與５-ｈｔ2ａ血清素受體相關聯病症之作為５-ｈｔ2ａ血清素受體之調節劑的吡唑衍生物
JP2012512877A (ja) 2008-12-18 2012-06-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング セロトニン５−ｈｔ２ｂ受容体阻害剤

Also Published As

Publication number Publication date
JP2022527080A (ja) 2022-05-30
CN113631548A (zh) 2021-11-09
WO2020198478A8 (en) 2021-09-16
CN113631548B (zh) 2023-06-06
AU2020245614B2 (en) 2023-01-19
CA3134952C (en) 2023-08-08
EP3947360A1 (en) 2022-02-09
US20220162183A1 (en) 2022-05-26
CA3134952A1 (en) 2020-10-01
AU2020245614A1 (en) 2021-10-14
JP7454589B2 (ja) 2024-03-22
WO2020198478A1 (en) 2020-10-01

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Legal Events

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