CN113453724B - 基于磺酰基马来酰亚胺的连接子和相应的偶联物 - Google Patents
基于磺酰基马来酰亚胺的连接子和相应的偶联物 Download PDFInfo
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- CN113453724B CN113453724B CN201980077950.5A CN201980077950A CN113453724B CN 113453724 B CN113453724 B CN 113453724B CN 201980077950 A CN201980077950 A CN 201980077950A CN 113453724 B CN113453724 B CN 113453724B
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- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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- Organic Chemistry (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18306270 | 2018-09-27 | ||
| EP18306270.2 | 2018-09-27 | ||
| PCT/IB2019/001114 WO2020065408A1 (en) | 2018-09-27 | 2019-09-27 | Sulfomaleimide-based linkers and corresponding conjugates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113453724A CN113453724A (zh) | 2021-09-28 |
| CN113453724B true CN113453724B (zh) | 2025-02-25 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980077950.5A Active CN113453724B (zh) | 2018-09-27 | 2019-09-27 | 基于磺酰基马来酰亚胺的连接子和相应的偶联物 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US12011485B2 (enExample) |
| EP (1) | EP3856258B1 (enExample) |
| JP (2) | JP2022502431A (enExample) |
| KR (1) | KR102858995B1 (enExample) |
| CN (1) | CN113453724B (enExample) |
| AU (1) | AU2019350536B2 (enExample) |
| BR (1) | BR112021005655A2 (enExample) |
| CA (1) | CA3113378C (enExample) |
| MX (1) | MX2021003295A (enExample) |
| WO (1) | WO2020065408A1 (enExample) |
| ZA (1) | ZA202101990B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201908886D0 (en) * | 2019-06-20 | 2019-08-07 | Almac Discovery Ltd | Anthracycline derivatives |
| CN118955614B (zh) * | 2022-07-05 | 2025-12-30 | 上海药明合联生物技术有限公司 | 偶联连接子 |
| CN120957756A (zh) * | 2023-05-12 | 2025-11-14 | 四川科伦博泰生物医药股份有限公司 | 稠环化合物及其制备方法和用途 |
| CN119751374A (zh) * | 2024-12-09 | 2025-04-04 | 中国科学院水生生物研究所 | 高抑菌活性、低生态毒性的异噻唑啉酮类化合物及其制备方法和应用 |
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|---|---|---|---|---|
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| WO2016064749A2 (en) * | 2014-10-20 | 2016-04-28 | Igenica Biotherapeutics, Inc. | Novel antibody-drug conjugates and related compounds, compositions, and methods of use |
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