CN1134256C - 取代的氨基甲基色原烷应用于预防神经元变性和促进神经元再生 - Google Patents

取代的氨基甲基色原烷应用于预防神经元变性和促进神经元再生 Download PDF

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Publication number
CN1134256C
CN1134256C CNB988114453A CN98811445A CN1134256C CN 1134256 C CN1134256 C CN 1134256C CN B988114453 A CNB988114453 A CN B988114453A CN 98811445 A CN98811445 A CN 98811445A CN 1134256 C CN1134256 C CN 1134256C
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China
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och
represents hydrogen
group
general formula
application
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Expired - Fee Related
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CNB988114453A
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English (en)
Chinese (zh)
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CN1279604A (zh
Inventor
T
T·法里格
I·格尔拉赫
E·霍尔瓦斯
R·乔克
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Bayer AG
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Bayer AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNB988114453A 1997-11-24 1998-11-11 取代的氨基甲基色原烷应用于预防神经元变性和促进神经元再生 Expired - Fee Related CN1134256C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19751949A DE19751949A1 (de) 1997-11-24 1997-11-24 Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration
DE19751949.0 1997-11-24

Publications (2)

Publication Number Publication Date
CN1279604A CN1279604A (zh) 2001-01-10
CN1134256C true CN1134256C (zh) 2004-01-14

Family

ID=7849618

Family Applications (1)

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CNB988114453A Expired - Fee Related CN1134256C (zh) 1997-11-24 1998-11-11 取代的氨基甲基色原烷应用于预防神经元变性和促进神经元再生

Country Status (30)

Country Link
US (2) US6235774B1 (cg-RX-API-DMAC10.html)
EP (1) EP1051170B1 (cg-RX-API-DMAC10.html)
JP (1) JP2001523716A (cg-RX-API-DMAC10.html)
KR (1) KR20010032357A (cg-RX-API-DMAC10.html)
CN (1) CN1134256C (cg-RX-API-DMAC10.html)
AR (1) AR016973A1 (cg-RX-API-DMAC10.html)
AT (1) ATE206615T1 (cg-RX-API-DMAC10.html)
AU (1) AU745759B2 (cg-RX-API-DMAC10.html)
BG (1) BG64167B1 (cg-RX-API-DMAC10.html)
CA (1) CA2311126A1 (cg-RX-API-DMAC10.html)
DE (2) DE19751949A1 (cg-RX-API-DMAC10.html)
DK (1) DK1051170T3 (cg-RX-API-DMAC10.html)
ES (1) ES2164465T3 (cg-RX-API-DMAC10.html)
HN (1) HN1998000169A (cg-RX-API-DMAC10.html)
HU (1) HUP0004369A3 (cg-RX-API-DMAC10.html)
IL (1) IL135904A (cg-RX-API-DMAC10.html)
IS (1) IS5496A (cg-RX-API-DMAC10.html)
MY (1) MY118414A (cg-RX-API-DMAC10.html)
NO (1) NO20002638L (cg-RX-API-DMAC10.html)
NZ (1) NZ504656A (cg-RX-API-DMAC10.html)
PE (1) PE134999A1 (cg-RX-API-DMAC10.html)
PL (1) PL340674A1 (cg-RX-API-DMAC10.html)
PT (1) PT1051170E (cg-RX-API-DMAC10.html)
RU (1) RU2217140C2 (cg-RX-API-DMAC10.html)
SI (1) SI1051170T1 (cg-RX-API-DMAC10.html)
SV (1) SV1998000138A (cg-RX-API-DMAC10.html)
TR (1) TR200001471T2 (cg-RX-API-DMAC10.html)
TW (1) TW524690B (cg-RX-API-DMAC10.html)
WO (1) WO1999026621A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA9810668B (cg-RX-API-DMAC10.html)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19751949A1 (de) * 1997-11-24 1999-05-27 Bayer Ag Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration
UA73981C2 (en) * 2000-03-10 2005-10-17 Merck Patent Gmbh (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit
US20030207890A1 (en) 2001-02-23 2003-11-06 Collier Robert J Compounds with 5-ht1a activity useful for treating disorders of the outer retina
EP1263434A1 (en) * 2000-03-17 2002-12-11 Alcon, Inc Compounds with 5-ht 2 and 5-ht 1a agonist activity for treating glaucoma
DE10058119A1 (de) * 2000-11-22 2002-05-23 Bayer Ag Pepinotan-Kit
SE0004455D0 (sv) * 2000-12-01 2000-12-01 Milos Pekny Method for neuron regeneration in the central nervous system
DE10101917A1 (de) * 2001-01-16 2002-07-18 Bayer Ag Verwendung von Chromanen
ATE352302T1 (de) * 2001-07-26 2007-02-15 Merck Patent Gmbh Verwendung von 2- 5-(4-fluorphenyl)-3- pyridylmethylaminomethyl-chroman und seiner physiologisch annehmbaren salze
WO2003022269A1 (en) * 2001-09-12 2003-03-20 Merck Patent Gmbh Novel use of substituted aminomethyl chromans for the treatment of movement disorders and of adverse effects induced by drugs administered to treat extrapyramidal movement disorders
DE10155075A1 (de) * 2001-11-09 2003-05-22 Merck Patent Gmbh Cyclische Sulfonamide
ITTO20030140U1 (it) * 2003-09-16 2005-03-17 Interfila Srl Matita cosmetica
WO2005033092A1 (en) 2003-09-19 2005-04-14 Galileo Pharmaceuticals, Inc. Chroman derivatives
DE102004017627A1 (de) * 2004-04-10 2005-10-27 Bayer Healthcare Ag Verwendung von vollen 5-HT1A-Agonisten zur Hemmung der opiat/opioid-induzierten Atemdepression
SG10202100724UA (en) 2016-07-29 2021-03-30 Sunovion Pharmaceuticals Inc Compounds and compositions and uses thereof
BR112019001407A2 (pt) 2016-07-29 2019-07-09 Sunovion Pharmaceuticals Inc. compostos e composições e usos dos mesmos
RU2651756C1 (ru) * 2017-05-10 2018-04-23 Федеральное государственное бюджетное образовательное учреждение Высшего Образования Кубанский Государственный Медицинский Университет Министерства Здравоохранения Российской Федерации, КубГМУ Препарат для предотвращения образования глиальных рубцов
MX2020000523A (es) * 2017-08-02 2020-08-20 Sunovion Pharmaceuticals Inc Compuestos de isocromano y usos de los mismos.
JP7703449B2 (ja) 2019-03-14 2025-07-07 スミトモ・ファーマ・アメリカ・インコーポレイテッド イソクロマニル化合物の塩およびその結晶体、ならびにそれらの製造方法、治療用途および医薬組成物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3901814A1 (de) * 1988-07-28 1990-02-01 Bayer Ag Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga
US5300523A (en) 1988-07-28 1994-04-05 Bayer Aktiengesellschaft Substituted aminomethyltetralins and their heterocyclic analogues
FR2662355B1 (fr) 1990-05-22 1994-11-10 Sanofi Sa Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux.
GB9012316D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
DE4135474A1 (de) * 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane
DE19522088A1 (de) 1995-06-19 1997-01-02 Bayer Ag Benzisothiazolyl-substituierte Aminomethylchromane
DE19751949A1 (de) * 1997-11-24 1999-05-27 Bayer Ag Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration

Also Published As

Publication number Publication date
TR200001471T2 (tr) 2000-10-23
IL135904A0 (en) 2001-05-20
MY118414A (en) 2004-10-30
PL340674A1 (en) 2001-02-12
EP1051170B1 (de) 2001-10-10
JP2001523716A (ja) 2001-11-27
ZA9810668B (en) 1999-05-26
DE19751949A1 (de) 1999-05-27
NZ504656A (en) 2002-02-01
NO20002638D0 (no) 2000-05-23
ATE206615T1 (de) 2001-10-15
IL135904A (en) 2003-07-06
EP1051170A1 (de) 2000-11-15
TW524690B (en) 2003-03-21
HUP0004369A2 (hu) 2001-04-28
CN1279604A (zh) 2001-01-10
BG64167B1 (bg) 2004-03-31
PE134999A1 (es) 2000-03-05
WO1999026621A1 (de) 1999-06-03
HN1998000169A (es) 1999-11-03
PT1051170E (pt) 2002-02-28
SI1051170T1 (en) 2001-12-31
US20010018530A1 (en) 2001-08-30
US6235774B1 (en) 2001-05-22
NO20002638L (no) 2000-05-23
US6331561B2 (en) 2001-12-18
BG104466A (en) 2001-02-28
AU1668599A (en) 1999-06-15
DK1051170T3 (da) 2001-12-27
HUP0004369A3 (en) 2002-04-29
CA2311126A1 (en) 1999-06-03
AU745759B2 (en) 2002-03-28
RU2217140C2 (ru) 2003-11-27
AR016973A1 (es) 2001-08-01
DE59801724D1 (de) 2001-11-15
IS5496A (is) 2000-05-15
SV1998000138A (es) 1999-05-25
ES2164465T3 (es) 2002-02-16
KR20010032357A (ko) 2001-04-16

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