CN113424961A - 一种肺科营养素 - Google Patents
一种肺科营养素 Download PDFInfo
- Publication number
- CN113424961A CN113424961A CN202110675968.4A CN202110675968A CN113424961A CN 113424961 A CN113424961 A CN 113424961A CN 202110675968 A CN202110675968 A CN 202110675968A CN 113424961 A CN113424961 A CN 113424961A
- Authority
- CN
- China
- Prior art keywords
- nutrient
- vitamin
- pulmonary
- powder
- powdered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 235000015097 nutrients Nutrition 0.000 title claims abstract description 48
- 210000004072 lung Anatomy 0.000 title abstract description 6
- 239000000843 powder Substances 0.000 claims abstract description 38
- 230000002685 pulmonary effect Effects 0.000 claims abstract description 27
- 235000021388 linseed oil Nutrition 0.000 claims abstract description 21
- 239000000944 linseed oil Substances 0.000 claims abstract description 21
- 239000003921 oil Substances 0.000 claims abstract description 18
- 235000019198 oils Nutrition 0.000 claims abstract description 18
- 235000020238 sunflower seed Nutrition 0.000 claims abstract description 18
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 11
- 239000011707 mineral Substances 0.000 claims abstract description 11
- 235000010755 mineral Nutrition 0.000 claims abstract description 11
- 229940088594 vitamin Drugs 0.000 claims abstract description 11
- 229930003231 vitamin Natural products 0.000 claims abstract description 11
- 235000013343 vitamin Nutrition 0.000 claims abstract description 11
- 239000011782 vitamin Substances 0.000 claims abstract description 11
- 108010046377 Whey Proteins Proteins 0.000 claims abstract description 10
- 102000007544 Whey Proteins Human genes 0.000 claims abstract description 10
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims abstract description 10
- 235000021119 whey protein Nutrition 0.000 claims abstract description 10
- 150000001875 compounds Chemical class 0.000 claims abstract description 9
- 229940057917 medium chain triglycerides Drugs 0.000 claims abstract description 9
- 108010073771 Soybean Proteins Proteins 0.000 claims abstract description 8
- -1 compound vitamin Chemical class 0.000 claims abstract description 8
- 235000019710 soybean protein Nutrition 0.000 claims abstract description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 22
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 14
- 235000019197 fats Nutrition 0.000 claims description 13
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 11
- 235000018102 proteins Nutrition 0.000 claims description 11
- 102000004169 proteins and genes Human genes 0.000 claims description 11
- 108090000623 proteins and genes Proteins 0.000 claims description 11
- 239000000377 silicon dioxide Substances 0.000 claims description 11
- 239000005913 Maltodextrin Substances 0.000 claims description 10
- 229920002774 Maltodextrin Polymers 0.000 claims description 10
- 229940035034 maltodextrin Drugs 0.000 claims description 10
- 235000012239 silicon dioxide Nutrition 0.000 claims description 9
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims description 8
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 8
- 229930003270 Vitamin B Natural products 0.000 claims description 8
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 8
- 235000020197 coconut milk Nutrition 0.000 claims description 8
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 8
- 235000019156 vitamin B Nutrition 0.000 claims description 8
- 239000011720 vitamin B Substances 0.000 claims description 8
- 102000011632 Caseins Human genes 0.000 claims description 7
- 108010076119 Caseins Proteins 0.000 claims description 7
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 7
- 150000001720 carbohydrates Chemical class 0.000 claims description 7
- 229940080237 sodium caseinate Drugs 0.000 claims description 7
- 229960003080 taurine Drugs 0.000 claims description 7
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 6
- 229930003427 Vitamin E Natural products 0.000 claims description 6
- 235000014633 carbohydrates Nutrition 0.000 claims description 6
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 6
- DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 claims description 6
- 229940046009 vitamin E Drugs 0.000 claims description 6
- 235000019165 vitamin E Nutrition 0.000 claims description 6
- 239000011709 vitamin E Substances 0.000 claims description 6
- 239000000230 xanthan gum Substances 0.000 claims description 5
- 229920001285 xanthan gum Polymers 0.000 claims description 5
- 229940082509 xanthan gum Drugs 0.000 claims description 5
- 235000010493 xanthan gum Nutrition 0.000 claims description 5
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 4
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 4
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 4
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 4
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 claims description 4
- 229960000304 folic acid Drugs 0.000 claims description 4
- 235000019152 folic acid Nutrition 0.000 claims description 4
- 239000011724 folic acid Substances 0.000 claims description 4
- 229960003512 nicotinic acid Drugs 0.000 claims description 4
- 235000001968 nicotinic acid Nutrition 0.000 claims description 4
- 239000011664 nicotinic acid Substances 0.000 claims description 4
- 235000019155 vitamin A Nutrition 0.000 claims description 4
- 239000011719 vitamin A Substances 0.000 claims description 4
- 229940045997 vitamin a Drugs 0.000 claims description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 3
- 235000019486 Sunflower oil Nutrition 0.000 claims description 3
- 239000011575 calcium Substances 0.000 claims description 3
- 229910052791 calcium Inorganic materials 0.000 claims description 3
- 239000002600 sunflower oil Substances 0.000 claims description 3
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims description 2
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 2
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 2
- 235000001809 DL-alpha-tocopherylacetate Nutrition 0.000 claims description 2
- 239000011626 DL-alpha-tocopherylacetate Substances 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- 239000002211 L-ascorbic acid Substances 0.000 claims description 2
- 235000000069 L-ascorbic acid Nutrition 0.000 claims description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 2
- 229930003268 Vitamin C Natural products 0.000 claims description 2
- 229930003316 Vitamin D Natural products 0.000 claims description 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 2
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims description 2
- 229960005070 ascorbic acid Drugs 0.000 claims description 2
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims description 2
- 229960002104 cyanocobalamin Drugs 0.000 claims description 2
- 235000000639 cyanocobalamin Nutrition 0.000 claims description 2
- 239000011666 cyanocobalamin Substances 0.000 claims description 2
- 239000011706 ferric diphosphate Substances 0.000 claims description 2
- 235000007144 ferric diphosphate Nutrition 0.000 claims description 2
- CADNYOZXMIKYPR-UHFFFAOYSA-B ferric pyrophosphate Chemical compound [Fe+3].[Fe+3].[Fe+3].[Fe+3].[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O CADNYOZXMIKYPR-UHFFFAOYSA-B 0.000 claims description 2
- 229940036404 ferric pyrophosphate Drugs 0.000 claims description 2
- 229910052742 iron Inorganic materials 0.000 claims description 2
- 239000011777 magnesium Substances 0.000 claims description 2
- 229910052749 magnesium Inorganic materials 0.000 claims description 2
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 2
- 239000001095 magnesium carbonate Substances 0.000 claims description 2
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims description 2
- 229960001708 magnesium carbonate Drugs 0.000 claims description 2
- 235000014380 magnesium carbonate Nutrition 0.000 claims description 2
- 229940055726 pantothenic acid Drugs 0.000 claims description 2
- 235000019161 pantothenic acid Nutrition 0.000 claims description 2
- 239000011713 pantothenic acid Substances 0.000 claims description 2
- 239000011574 phosphorus Substances 0.000 claims description 2
- 229910052698 phosphorus Inorganic materials 0.000 claims description 2
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 claims description 2
- 229960004172 pyridoxine hydrochloride Drugs 0.000 claims description 2
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 claims description 2
- 239000011764 pyridoxine hydrochloride Substances 0.000 claims description 2
- 235000019192 riboflavin Nutrition 0.000 claims description 2
- 229960002477 riboflavin Drugs 0.000 claims description 2
- 239000002151 riboflavin Substances 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 229960000344 thiamine hydrochloride Drugs 0.000 claims description 2
- 235000019190 thiamine hydrochloride Nutrition 0.000 claims description 2
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 2
- 239000011747 thiamine hydrochloride Substances 0.000 claims description 2
- 229940042585 tocopherol acetate Drugs 0.000 claims description 2
- 235000019154 vitamin C Nutrition 0.000 claims description 2
- 239000011718 vitamin C Substances 0.000 claims description 2
- 235000019166 vitamin D Nutrition 0.000 claims description 2
- 239000011710 vitamin D Substances 0.000 claims description 2
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 2
- 239000011647 vitamin D3 Substances 0.000 claims description 2
- 229940046008 vitamin d Drugs 0.000 claims description 2
- 239000011701 zinc Substances 0.000 claims description 2
- 229910052725 zinc Inorganic materials 0.000 claims description 2
- 239000011670 zinc gluconate Substances 0.000 claims description 2
- 235000011478 zinc gluconate Nutrition 0.000 claims description 2
- 229960000306 zinc gluconate Drugs 0.000 claims description 2
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims 1
- 229960004203 carnitine Drugs 0.000 claims 1
- 235000019700 dicalcium phosphate Nutrition 0.000 claims 1
- 229940095079 dicalcium phosphate anhydrous Drugs 0.000 claims 1
- 229940071440 soy protein isolate Drugs 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 abstract description 8
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 7
- 230000003078 antioxidant effect Effects 0.000 abstract description 3
- 230000036039 immunity Effects 0.000 abstract description 2
- 210000001015 abdomen Anatomy 0.000 abstract 1
- 208000019693 Lung disease Diseases 0.000 description 17
- 238000010521 absorption reaction Methods 0.000 description 13
- 150000004668 long chain fatty acids Chemical class 0.000 description 10
- 235000016709 nutrition Nutrition 0.000 description 10
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 230000001684 chronic effect Effects 0.000 description 7
- 230000035764 nutrition Effects 0.000 description 7
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 6
- 206010012735 Diarrhoea Diseases 0.000 description 6
- 230000009286 beneficial effect Effects 0.000 description 6
- 150000004667 medium chain fatty acids Chemical class 0.000 description 6
- 229960001866 silicon dioxide Drugs 0.000 description 6
- 208000024172 Cardiovascular disease Diseases 0.000 description 5
- 206010061218 Inflammation Diseases 0.000 description 5
- 230000001965 increasing effect Effects 0.000 description 5
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 150000004665 fatty acids Chemical class 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 201000005202 lung cancer Diseases 0.000 description 4
- 208000020816 lung neoplasm Diseases 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 3
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 3
- 208000002720 Malnutrition Diseases 0.000 description 3
- 239000001569 carbon dioxide Substances 0.000 description 3
- 229910002092 carbon dioxide Inorganic materials 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000001071 malnutrition Effects 0.000 description 3
- 235000000824 malnutrition Nutrition 0.000 description 3
- 235000012054 meals Nutrition 0.000 description 3
- 208000015380 nutritional deficiency disease Diseases 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- AYRXSINWFIIFAE-SCLMCMATSA-N Isomaltose Natural products OC[C@H]1O[C@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)[C@@H](O)[C@@H](O)[C@@H]1O AYRXSINWFIIFAE-SCLMCMATSA-N 0.000 description 2
- 206010035664 Pneumonia Diseases 0.000 description 2
- 230000009798 acute exacerbation Effects 0.000 description 2
- 230000003064 anti-oxidating effect Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 235000015872 dietary supplement Nutrition 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 230000001079 digestive effect Effects 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 230000007661 gastrointestinal function Effects 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000004199 lung function Effects 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 230000001991 pathophysiological effect Effects 0.000 description 2
- 230000000770 proinflammatory effect Effects 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 229960003471 retinol Drugs 0.000 description 2
- 235000020944 retinol Nutrition 0.000 description 2
- 239000011607 retinol Substances 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 210000000115 thoracic cavity Anatomy 0.000 description 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N (R)-alpha-Tocopherol Natural products OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 description 1
- 235000004758 Bergkiefer Nutrition 0.000 description 1
- 206010011409 Cross infection Diseases 0.000 description 1
- 229930186217 Glycolipid Natural products 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 206010022489 Insulin Resistance Diseases 0.000 description 1
- 108090001005 Interleukin-6 Proteins 0.000 description 1
- 108090001007 Interleukin-8 Proteins 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 206010029803 Nosocomial infection Diseases 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 235000010450 Pino mugo Nutrition 0.000 description 1
- 241001136577 Pinus mugo Species 0.000 description 1
- 235000002914 Pinus uncinata Nutrition 0.000 description 1
- 108010064851 Plant Proteins Proteins 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229940087168 alpha tocopherol Drugs 0.000 description 1
- 235000021120 animal protein Nutrition 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 108091006374 cAMP receptor proteins Proteins 0.000 description 1
- 230000036996 cardiovascular health Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 102000038379 digestive enzymes Human genes 0.000 description 1
- 108091007734 digestive enzymes Proteins 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000030136 gastric emptying Effects 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 230000001926 lymphatic effect Effects 0.000 description 1
- 210000004324 lymphatic system Anatomy 0.000 description 1
- 108700025647 major vault Proteins 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- VUZPPFZMUPKLLV-UHFFFAOYSA-N methane;hydrate Chemical compound C.O VUZPPFZMUPKLLV-UHFFFAOYSA-N 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- 235000012149 noodles Nutrition 0.000 description 1
- 235000015816 nutrient absorption Nutrition 0.000 description 1
- 235000021238 nutrient digestion Nutrition 0.000 description 1
- 235000006180 nutrition needs Nutrition 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 235000021118 plant-derived protein Nutrition 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000004202 respiratory function Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 229940001941 soy protein Drugs 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- 125000001020 α-tocopherol group Chemical group 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/185—Vegetable proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/19—Dairy proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Polymers & Plastics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
本发明公开了一种肺科营养素，包含以下重量百分含量的组分：粉末中链甘油三酯10～20％、浓缩乳清蛋白粉10～18％、大豆分离蛋白粉11～15％、粉末葵花籽油8～12％、粉末亚麻籽油6～8％、复配矿物质3～5％和复配维生素0.3～0.6％；所述粉末中链甘油三酯中包含50～70wt％的中链甘油三酯；所述粉末葵花籽油中包含50～80wt％的葵花籽油；所述粉末亚麻籽油包含45～55wt％的亚麻籽油。本发明所述肺科营养素采用动植物蛋白复合，添加了中链脂肪酸、亚麻籽油、葵花籽油和复配维生素和矿物质，与现有的营养素相比，本发明所述肺科营养素具有以下优点：(1)低糖，不增加呼吸负担；(2)最新的中长链脂肪酸，即可提供最高的能量，又不会拉肚子；(3)全方位强化免疫营养素，有助于抗炎抗氧化。
Description
技术领域
本发明涉及一种营养保健品，具体涉及一种肺科营养素。
背景技术
慢性肺病患者，例如慢阻肺，即使应用最好的药物治疗，也无法逆转疾病的发展，其肺功能呈不可逆地下降。每次急性加重住院，不仅产生庞大的医疗费用(平均住院费用24,372元)，而且会对肺功能造成剧烈的打击，仅1/3的患者能恢复到住院前的水平。研究显示，慢阻肺患者的病情越严重，BMI(体重指数＝体重÷身高2)越低。而且，营养不良将导致院内感染率增加1-2倍，使住院期间的死亡率增加77％，使30天内因为肺炎而再入院的风险增加29％。因此，营养支持是慢性肺病患者不可或缺的治疗组成之一，对于增强肺部抵抗力，减少肺炎发生率，减少肺病急性加重，降低整体治疗费用具有至关重要的作用。
肺病营养治疗当前的局限性：
与老年人营养不良相比，肺病患者具有独特的病理生理特点。而传统全营养素是针对健康人的营养需求而设计的，慢性肺病患者服用后可能导致诸多不利影响：
1)增加呼吸负担：慢性肺病患者均存在呼吸功能下降，而传统全营养中糖类(最终会分解为二氧化碳和水)的能占比高达50％-60％，导致二氧化碳生成增加，进一步增加患者的呼吸负担。
2)增加胃肠负担，吸收少，易腹泻。慢性肺病患者因为长期供氧不足以及合并心功能不全，导致胃肠道淤血和缺氧而影响营养素的消化和吸收。传统全营养素的脂肪以长链脂肪酸为主，①高脂时会导致胃排空延迟，增加胃肠负担，也不利于肺癌术后胃肠功能的恢复；②长链脂肪酸的分子量大，消化吸收路径长，需要更多消化酶的参与，因此吸收慢，吸收少，这在消化吸收障碍者更为明显；③易导致腹泻(脂肪痢)，而影响患者的依从性；④长链脂肪酸必须经过淋巴系统转运才能入血。肺癌患者淋巴结清扫时损伤淋巴管道，导致长链脂肪酸和免疫蛋白丢失，从而增加胸腔引流量，不利于术后早期拔除引流管。
3)影响血糖、血脂，不适用于合并心血管疾病和代谢疾病的患者。慢阻肺患者中，①50％合并心血管疾病。摄入过多的长链脂肪酸会导致甘油三酯和胆固醇水平上升，不利于心血管疾病患者；②18.7％合并糖尿病。传统全营养素为高糖配方，导致血糖明显升高。
4)抗炎、抗氧化能力有限。慢性肺病多存在全身炎症，需要强化抗炎、抗氧化，而传统全营养素无法满足这一需求。
因此，国家卫生健康委员会已经将肺病全营养纳入特殊医学用途配方食品的范畴，以区别于传统的全营养配方食品。但截至2021年4月24日，尚无肺病全营养产品获批特医食品。
发明内容
本发明的目的在于克服现有技术存在的不足之处而提供一种肺科营养素。
为实现上述目的，本发明采取的技术方案为：一种肺科营养素，包含以下重量百分含量的组分：
粉末中链甘油三酯10～20％、浓缩乳清蛋白粉10～18％、大豆分离蛋白粉11～15％、粉末葵花籽油8～12％、粉末亚麻籽油6～8％、复配矿物质3～5％和复配维生素0.3～0.6％；
所述粉末中链甘油三酯中包含50～70wt％的中链甘油三酯；
所述粉末葵花籽油中包含50～80wt％的葵花籽油。
所述粉末亚麻籽油包含45～55wt％的亚麻籽油。
本发明所述肺科营养素专为肺病患者而设计，具体特征如下：
1、添加了上述含量的葵花籽油和亚麻籽油，使本发明所述肺科营养素为高脂低糖配方，能够快速供能，不增加呼吸负担。1g脂肪可提供能量37kJ,呼吸商仅0.7，而1g蛋白质和糖类仅提供17kJ能量，呼吸商分别为0.7和1.0,因此，高脂低糖配方意味着更高的能量密度，高效供能，弥补慢性肺病患者的高代谢损耗，同时不增加呼吸负担；
2、添加了上述含量的中长链脂肪酸，使本发明所述肺科营养素能够有吸收好，腹泻少的特点。中链脂肪酸分子量小，代谢路径短，吸收速率是长链脂肪酸的6倍，脂肪吸收系数比长链脂肪酸高5％-47％，24小时粪便脂肪较长链脂肪酸减少2g-56g，因此中长链脂肪酸(将50％的长链脂肪酸替换为中链脂肪酸)是消化吸收障碍患者的首选，这样既能保证人体必须脂肪酸的供给，又能有效改善吸收，减少腹泻。此外，中长链脂肪酸还有助于减少肺癌术后患者因淋巴管道损伤导致的漏出液过多，从而减少胸腔引流量，缩短引流管留置时间；明显缩短肛门排气时间，说明胃肠功能恢复更快，是肺癌术后患者的营养治疗首选。
3、改善糖脂代谢。配方中，中链脂肪酸可改善血脂，降低肝脏总胆固醇，改善脂蛋白水平，减少45％的餐前血糖生成，使胰岛素抵抗指数降低8.7％；大豆蛋白是最有利于心血管健康的蛋白，对血脂、血压均会产生积极的影响。因此，所述肺科营养素同样适用于合并心血管疾病和糖尿病的肺病患者。
因此，本发明所述肺科全营养素，是根据肺病患者独特的病理生理特点而设计的全营养素，很好地弥补了传统全营养素的不足。
本发明所述肺科营养素可用温开水冲服，可以根据患者的能量需求来确定使用量。
所述粉末中链甘油三酯、粉末亚麻籽油、粉末葵花籽油可购自市场，其中含有一定量的赋形剂和添加剂，优选地，所述粉末中链甘油三酯为中链甘油三酯、低聚异麦芽糖、酪蛋白酸钠、单，双硬脂酸甘油酯和二氧化硅的混合物；所述粉末亚麻籽油为亚麻籽油、低聚异麦芽糖、酪蛋白酸钠、单，双硬脂酸甘油酯、二氧化硅和维生素E的混合物；所述粉末葵花籽油为葵花籽油、低聚异麦芽糖、酪蛋白酸钠、单，双硬脂酸甘油酯、二氧化硅和维生素E的混合物。
优选地，所述浓缩乳清蛋白粉中包含18～22wt％的乳清蛋白；优选地，所述大豆分离蛋白粉中包含88～92wt％的蛋白质。
所述复配矿物质和复配维生素均可购自市场，优选地，所述复配矿物质为磷酸氢钙、碳酸镁、葡萄糖酸锌、焦磷酸铁和麦芽糊精的混合物。优选地，所述复配维生素为L-抗坏血酸、dl-α-醋酸生育酚、烟酸、醋酸维生素A、D-泛酸钙、盐酸吡哆醇、盐酸硫胺素、核黄素、维生素D3、叶酸、氰钴胺和麦芽糊精的混合物。
优选地，还包含以下重量百分含量的组分：麦芽糊精15～25％、椰浆粉7.0～11.0％、左旋肉碱0.7～1.0％、二氧化硅0.5～0.8％、黄原胶0.2～0.5％和牛磺酸0.09～0.14％。
优选地，所述椰浆粉包含椰浆、麦芽糊精和酪朊酸钠。
优选地，每100克所述肺科营养素中包含以下营养成分：能量500～600kcal、蛋白质23～27g、脂肪25～30g、碳水化合物40～48g、钠225～240mg、维生素A 900～1100μg RE、维生素D1.4～1.8μg RE、维生素E12～15mg a-TE、维生素B1 1.0～1.2mg、维生素B2 1.2～1.4mg、维生素B6 1.2～1.4mg、维生素B12 3.2～3.6μg、维生素C120～160mg、烟酸20～24mg、叶酸330～370mg、泛酸5～5.5mg、钙780～850mg、磷600～700mg、镁130～200mg、铁13～19mg、锌12～18mg、左旋肉碱700～1000mg和牛磺酸90～140mg。其中RE(Retinolequivalent)为视黄醇当量，a-TE为α-生育酚当量。
n-6为脂肪酸增加炎症水平(促炎)，n-3为脂肪酸抗炎，n-6:n-3＞10:1时具有促炎的效果；n-6:n-3＜5:1时具有抗炎效果，对心血管疾病，风湿性关节炎和哮喘等有利(参考文献：Ricker MA,Haas WC.Anti-Inflammatory Diet in Clinical Practice:AReview.Nutr Clin Pract.2017Jun；32(3):318-325.doi:10.1177/0884533617700353.Epub 2017Mar 28.PMID:28350517.)本发明所述肺科营养素采用独特的脂肪酸抗炎配比，免疫维生素含量加倍，实现强化抗炎、抗氧化功效，降低CRP、TNF-α、IL-6、IL-8的水平，利于缓解肺病患者的全身炎症。
本发明的有益效果在于：本发明提供了一种肺科营养素，本发明所述肺科营养素采用动植物蛋白复合，添加了中链脂肪酸、亚麻籽油、葵花籽油和复配维生素和矿物质，与现有的营养素相比，本发明所述肺科营养素具有以下优点：(1)低糖，不增加呼吸负担；(2)中长链脂肪酸(长链脂肪酸源自粉末葵花籽油和粉末亚麻籽油，中链脂肪酸源自中链甘油三酯)既可提供最高的能量，又不会拉肚子；(3)全方位强化免疫营养素，有助于抗炎抗氧化。
具体实施方式
为更好地说明本发明的目的、技术方案和优点，下面将结合具体实施例对本发明作进一步说明。
本发明实施例所述物质成分的来源如下：
麦芽糊精购自山东西王糖业有限公司；
粉末中链甘油三酯购自广州汇健生物科技公司，其中，中链甘油三酯的含量为70％；
浓缩乳清蛋白粉购自广州汇健生物科技公司的WPC80；
大豆分离蛋白粉购自临沂山松生物制品有限公司的SD-100；
粉末葵花籽油购自西安欣禄生物科技有限公司；其中，葵花籽油的含量为50％；
椰浆粉购自海南南派实业有限公司的椰浆粉A106；
粉末亚麻籽油购自西安海斯夫生物科技公司，其中亚麻籽油的含量为50％；
复配矿物质购自上海绝尘生物科技有限公司；
左旋肉碱购自辽宁科硕营养科技股份有限公司；
二氧化硅购自上海绝尘生物科技有限公司；
黄原胶购自山东阜丰发酵有限公司；
复配维生素购自广州汇健生物科技公司；
牛磺酸购自青岛青尔源药业有限公司的66-12。
实施例1
本发明所述肺科营养素的一种实施例，本实施例所述肺科营养素包含以下重量百分含量的组分：
麦芽糊精22％、粉末中链甘油三酯17％、浓缩乳清蛋白粉15％、大豆分离蛋白粉13％、粉末葵花籽油10％、椰浆粉9％、粉末亚麻籽油7％、复配矿物质4.38％、左旋肉碱1％、二氧化硅0.7％、黄原胶0.35％、复配维生素0.45％和牛磺酸0.12％。
实施例2
本发明所述肺科营养素的一种实施例，本实施例所述肺科营养素包含以下重量百分含量的组分：
麦芽糊精15％、粉末中链甘油三酯20％、浓缩乳清蛋白粉18％、大豆分离蛋白粉13％、粉末葵花籽油8％、椰浆粉11％、粉末亚麻籽油8％、复配矿物质4.6％、左旋肉碱1％、二氧化硅0.6％、黄原胶0.3％、复配维生素0.41％和牛磺酸0.09％。
传统的全营养素用于肺病患者，副作用主要有3个：1、碳水化合物摄入过多，增加二氧化碳生成和呼吸做功；2、糖脂代谢异常，增加心血管风险；3、吸收差，增加腹泻的风险；参见参考文献：1、Pumonary Rehabilitation:Guidelines to Success,4thEdition.Elsevier(Singapore)Pte Ltd.2009；2、Maltais F，etal.am.J.Respir.Crit.Care Med.2014May；189(9):e15-e62。
实施例1所述肺科营养素属于低糖高脂高蛋白的配方，可以用于代餐。实施例2所述肺科营养素属于超低糖高脂高蛋白的配方，可以用于患者的营养补充，患者日常还可进食部分碳水化合物，如米饭、面条等。
产品封装为20克一小袋。使用时用35-40度的温开水冲调至100-150毫升。根据患者的能量需求来确定用量。
用于营养补充时，200-500千卡/天，餐间补充。服用实施例2，x2袋/天(约200千卡)，x3袋/天(约300千卡)，x4袋/天(约400千卡)，x5袋/天(约500千卡)。
用于代餐时，需求为能量25-30千卡/公斤体重/天、蛋白质1.2-2.0克/公斤体重/天。服用实施例1，根据患者的需求来确定每日用量。例如：体重50公斤的患者x10袋/天(约1100千卡)、x12袋/天(约1320千卡)或更多袋/天。
本产品为存在营养不良和营养风险的肺病患者提供全面的营养素，包括脂肪、蛋白质、碳水化合物、多种维生素和矿物质、左旋肉碱、硫磺酸。
实施例1和实施例2所述肺科营养素通过患者志愿使用，目前实施例1使用人数为20人，实施例2的使用人数为20人，使用三个月后，患者的使用情况反馈见表1。
表1
从表1可以看出，实施例1和实施例2所述肺科营养素经患者试用，有较大比重的体重增加反馈和继续使用意愿反馈，且均未出现腹泻的情况。
最后所应当说明的是，以上实施例仅用以说明本发明的技术方案而非对本发明保护范围的限制，尽管参照较佳实施例对本发明作了详细说明，本领域的普通技术人员应当理解，可以对本发明的技术方案进行修改或者等同替换，而不脱离本发明技术方案的实质和范围。
Claims (10)
1.一种肺科营养素，其特征在于，包含以下重量百分含量的组分：
粉末中链甘油三酯10～20％、浓缩乳清蛋白粉10～18％、大豆分离蛋白粉11～15％、粉末葵花籽油8～12％、粉末亚麻籽油6～8％、复配矿物质3～5％和复配维生素0.3～0.6％；
所述粉末中链甘油三酯中包含50～70wt％的中链甘油三酯；
所述粉末葵花籽油中包含50～80wt％的葵花籽油；
所述粉末亚麻籽油包含45～55wt％的亚麻籽油。
2.如权利要求1所述肺科营养素，其特征在于，所述粉末中链甘油三酯为中链甘油三酯、低聚异麦芽糖、酪蛋白酸钠、单，双硬脂酸甘油酯和二氧化硅的混合物。
3.如权利要求1所述肺科营养素，其特征在于，所述粉末亚麻籽油为亚麻籽油、低聚异麦芽糖、酪蛋白酸钠、单，双硬脂酸甘油酯、二氧化硅和维生素E的混合物。
4.如权利要求1所述肺科营养素，其特征在于，所述粉末葵花籽油为葵花籽油、低聚异麦芽糖、酪蛋白酸钠、单，双硬脂酸甘油酯、二氧化硅和维生素E的混合物。
5.如权利要求1所述肺科营养素，其特征在于，所述浓缩乳清蛋白粉中包含18～22wt％的乳清蛋白。
6.如权利要求1所述肺科营养素，其特征在于，所述大豆分离蛋白粉中包含88～92wt％的蛋白质。
7.如权利要求1所述肺科营养素，其特征在于，所述复配矿物质为磷酸氢钙、碳酸镁、葡萄糖酸锌、焦磷酸铁和麦芽糊精的混合物。
8.如权利要求1所述肺科营养素，其特征在于，所述复配维生素为L-抗坏血酸、dl-α-醋酸生育酚、烟酸、醋酸维生素A、D-泛酸钙、盐酸吡哆醇、盐酸硫胺素、核黄素、维生素D3、叶酸、氰钴胺和麦芽糊精的混合物。
9.如权利要求1所述肺科营养素，其特征在于，还包含以下重量百分含量的组分：麦芽糊精15～25％、椰浆粉7.0～11.0％、左旋肉碱0.7～1.0％、二氧化硅0.5～0.8％、黄原胶0.2～0.5％和牛磺酸0.09～0.14％。
10.如权利要求9所述肺科营养素，其特征在于，每100克所述肺科营养素中包含以下营养成分：能量500～600kcal、蛋白质23～27g、脂肪25～30g、碳水化合物40～48g、钠225～240mg、维生素A 900～1100μg RE、维生素D 1.4～1.8μgRE、维生素E 12～15mg a-TE、维生素B1 1.0～1.2mg、维生素B2 1.2～1.4mg、维生素B6 1.2～1.4mg、维生素B12 3.2～3.6μg、维生素C 120～160mg、烟酸20～24mg、叶酸330～370mg、泛酸5～5.5mg、钙780～850mg、磷600～700mg、镁130～200mg、铁13～19mg、锌12～18mg、左旋肉碱700～1000mg和牛磺酸90～140mg。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110675968.4A CN113424961A (zh) | 2021-06-17 | 2021-06-17 | 一种肺科营养素 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110675968.4A CN113424961A (zh) | 2021-06-17 | 2021-06-17 | 一种肺科营养素 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113424961A true CN113424961A (zh) | 2021-09-24 |
Family
ID=77756406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110675968.4A Pending CN113424961A (zh) | 2021-06-17 | 2021-06-17 | 一种肺科营养素 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113424961A (zh) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109198625A (zh) * | 2017-06-30 | 2019-01-15 | 况代武 | 一种短肽型营养食品配方 |
| CN111387487A (zh) * | 2020-01-16 | 2020-07-10 | 山东特康药业有限公司 | 一种用于肺病患者的特殊医学用途配方营养粉及制备方法 |
| CN111990463A (zh) * | 2019-05-27 | 2020-11-27 | 上海天龙生物科技有限公司 | 一种牛初乳复合粉 |
| CN112189839A (zh) * | 2020-05-26 | 2021-01-08 | 上海轻姿健康管理有限公司 | 一种辅助降血脂组合物及其应用 |
| CN112715930A (zh) * | 2021-01-04 | 2021-04-30 | 湖南慧泽生物医药科技有限公司 | 一种供糖尿病患者食用的配方食品 |
-
2021
- 2021-06-17 CN CN202110675968.4A patent/CN113424961A/zh active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109198625A (zh) * | 2017-06-30 | 2019-01-15 | 况代武 | 一种短肽型营养食品配方 |
| CN111990463A (zh) * | 2019-05-27 | 2020-11-27 | 上海天龙生物科技有限公司 | 一种牛初乳复合粉 |
| CN111387487A (zh) * | 2020-01-16 | 2020-07-10 | 山东特康药业有限公司 | 一种用于肺病患者的特殊医学用途配方营养粉及制备方法 |
| CN112189839A (zh) * | 2020-05-26 | 2021-01-08 | 上海轻姿健康管理有限公司 | 一种辅助降血脂组合物及其应用 |
| CN112715930A (zh) * | 2021-01-04 | 2021-04-30 | 湖南慧泽生物医药科技有限公司 | 一种供糖尿病患者食用的配方食品 |
Non-Patent Citations (3)
| Title |
|---|
| LUBOS SOBOTKA: "《临床营养基础》", 31 August 2002, 复旦大学出版社 * |
| 无: "肾病特医产品介绍", 《搜狐》 * |
| 王玲: "《儿童重症护理与操作技术》", 31 December 2017, 河南科学技术出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2886951T3 (es) | Composición para su uso en la modulación de la microbiota | |
| EP1313378B1 (en) | Nutritional composition and method for improving protein deposition | |
| CN110226741A (zh) | 一种溃疡性结肠炎专用型临床营养配方及其制备方法 | |
| Dutta et al. | Impact of zinc supplementation in malnourished children with acute watery diarrhoea | |
| CN105054025B (zh) | 一种用于炎症性肠病患者的低脂低渗低渣型肠内营养粉剂 | |
| ES2390620T3 (es) | Ácidos dicarboxílicos de cadena mediana y sus derivados y trastornos metabólicos | |
| CN106578093A (zh) | 一种创伤、感染、手术及其它应激状态专用型临床营养配方及其制备方法 | |
| CN110638043A (zh) | 一种富含益生菌的全营养配方食品及其制备方法与应用 | |
| CN110742267B (zh) | 一种炎性肠病全营养配方食品 | |
| CN113632848A (zh) | 一种有利于骨骼增长的儿童奶粉及其制备方法 | |
| CN107467193B (zh) | 一种以羊奶为基础的粉剂全营养特殊医学用途配方食品及其制备方法 | |
| TW201332555A (zh) | 在妊娠期間使用特定碳水化合物系統以降低後代後續生命中之不利健康效應 | |
| CN108703376A (zh) | 一种短肽型肠内营养多聚合剂 | |
| CN113424961A (zh) | 一种肺科营养素 | |
| CN109380734A (zh) | 一种克罗恩氏病患者专用特膳食品 | |
| CN116172191A (zh) | 营养组合物及其在制备抗炎产品中的应用 | |
| TWI613969B (zh) | 用於營養素輸送之組成物和方法 | |
| CN113598365A (zh) | 一种用于肺损伤病患的特殊医学用途全营养配方食品 | |
| CN112806577B (zh) | 产丁酸的益生元益生菌增效组合 | |
| CN111513332A (zh) | 大肠癌专用型临床营养配方及其制备方法 | |
| Rhoads | Management of acute diarrhea in infants | |
| CN112656933B (zh) | 一种适用于肺炎患者的肠外营养液 | |
| CN109043524A (zh) | 呼吸衰竭患者食用的特定全营养配方食品及其制备方法 | |
| CN117598475A (zh) | 一种成人特殊医学用途全营养配方食品及其制备方法 | |
| CN116548608B (zh) | 一种儿童全营养配方粉及其制备方法和应用 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210924 |