CN110742267B - 一种炎性肠病全营养配方食品 - Google Patents
一种炎性肠病全营养配方食品 Download PDFInfo
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- CN110742267B CN110742267B CN201911095639.1A CN201911095639A CN110742267B CN 110742267 B CN110742267 B CN 110742267B CN 201911095639 A CN201911095639 A CN 201911095639A CN 110742267 B CN110742267 B CN 110742267B
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- vitamin
- inflammatory bowel
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- potassium
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- 235000002595 Solanum tuberosum Nutrition 0.000 claims description 18
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- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 8
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 7
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- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 7
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Abstract
本发明公开了一种炎性肠病全营养配方食品配方食品,属于特殊医学用途配方食品领域。本发明发现炎性肠病全营养配方食品具有改善肠道炎症状态从而对炎性肠病具有营养支持的作用,具体体现在:(1)对小鼠体重有恢复作用;(2)具有缓解小鼠结肠缩短的作用;(3)降低MPO(髓过氧化物酶)的活性;(4)具有改善肠炎小鼠的结肠病理学症状的作用。因此,本发明中的炎性肠病全营养配方食品在临床应用中具有巨大的应用前景。
Description
技术领域
本发明涉及一种炎性肠病全营养配方食品,属于特殊医学用途配方食品领域。
背景技术
炎性肠病简称IBD,是一种特殊的慢性肠道炎症性疾病。一般来说累及回肠、直肠、结肠的这些都可以叫炎性肠病,临床狭义上炎性肠病主要包括克罗恩病(Crohn’sdisease, CD) 、溃疡性结肠炎(Ulcerative Colitis, UC)。炎性肠病的病因和发病机制尚未完全明确,目前认为这是由多种因素相互作用导致的,主要包括遗传、感染、肠道黏膜屏障功能、环境、免疫等因素。
炎性肠病在北美洲、西欧、北欧、澳大利亚和新西兰最为常见,而且主要是在欧洲血统的白人群体中,故而被称为“西方世界的疾病”。然而,近10年来美国和欧洲等传统高发病率地区的IBD发病率相对稳定。而在以前发病率较低的地区,包括亚洲,这种疾病已变得更为普遍。这一增长很可能与环境和生活方式因素有关,因为亚洲国家正在经历社会经济变化和迅速工业化。
炎性肠病病变范围广泛,消化道症状重,病情反复,病程长,加之代谢改变,极易发生营养不良。炎性肠病病人在初诊时多已伴有营养不良,而病情进展、药物或手术治疗则更加重了营养障碍,研究显示,在病情加重而住院治疗的炎性肠病患者中,蛋白质-能量营养不良发生率高达85%,约2/3的炎性肠病患者可能发生负氮平衡。由于腹泻等原因,炎性肠病患者体内血清中钾、钙、镁、磷等含量降低,一些脂溶性维生素,如维生素A、维生素E、维生素D水平也较正常人明显降低。体重丢失和低蛋白血证是炎性肠病营养不良的主要表现。,因此IBD常伴随着不同程度的营养不良,甚至影响小孩正常的生长发育,营养支持对ibd症
状缓解及促进愈合有重要的作用,因此保持自身良好的营养状态是治疗IBD的一个重要的部分。
对于特殊医学用途配方食品,在美国、欧盟、澳大利亚等发达国家都有相应的规定和开发应用,而我国GB29922-2013《特殊医学用途配方食品通则》食品安全国家标准中明确规定:全营养配方食品:可作为单一营养来源满足目标人群营养需求的特殊医学用途配方食品。特定全营养配方食品:可作为单一营养来源满足目标人群在特定疾病或医学状况下营养需求的特殊医学用途配方食品。
对于炎性肠病全营养配方食品,GB29922-2013《特殊医学用途配方食品通则》食品安全国家标准中明确规定:炎性肠病主要包括溃疡性结肠炎(UC)和克罗恩病(CD)。UC和CD均为肠道非特异性疾病。由于病变主要发生在消化道,既妨碍营养物质的摄入、消化、和吸收,又造成营养物质从肠道不同程度的丢失。针对上述情况,配方应使用易消化吸收的蛋白质和脂肪来源,以改善患者的营养状况和临床症状。
炎性肠病病人用全营养配方食品应满足如下技术要求:
1)可以选用整蛋白、食物蛋白质水解物、肽类和氨基酸作为蛋白质的来源。
2)脂肪供能比应不超过40%,其中中链甘油三脂(MCT)含量应不低于总脂肪的40%。
目前市面上的肠内营养制剂都是针对多种疾病状态的,相对来说,特定全营养配方更加具有针对性,比较符合当下“精准营养”的概念。而国内已获批的特医食品中还没有炎性肠病全营养配方食品。本发明严格按照国家标准,参考中国居民膳食营养素参考摄入量,设计符合国内人群的配方。同时选用多种有益成分,以乳基蛋白,MCT,共轭亚油酸(CLA),麦芽糊精,益生元,为主要原料,辅以复合矿物质。复合维生素。可作为单一营养来源满足炎性肠病患者的需求。
发明内容
本发明在国家标准的基础上,参考中国居民膳食营养素参考摄入量、中国营养科学全书等资料,提供一种特殊医学用途配方食品,其含有丰富的营养成分,能为患者提供全面营养。并且各组分含量合理,适用范围广泛。本发明发现炎性肠病全营养配方通过改善炎症状态对炎性肠病具有营养支持的作用,具体体现在:(1)对小鼠体重有恢复作用;(2)具有缓解小鼠结肠缩短的作用;(3)降低MPO(髓过氧化物酶)的活性;(4)具有改善肠炎小鼠的结肠病理学症状的作用。因此,全营养配方食品在临床应用中具有巨大的应用前景。
本发明的第一个目的是提供一种调节肠道功能的全营养配方食品,每100千卡食品包括如下成分:蛋白质、碳水化合物、膳食纤维、脂肪、复合维生素、复合矿物质、营养强化剂;按功能百分比计,所述蛋白质供能15%-20%,所述脂肪供能20%-30%,所述碳水化合物供能50%-65%;所述蛋白质为乳清蛋白和酪蛋白的混合蛋白;所述脂肪中的中链甘油三脂占总脂肪含量≥40%,所述共轭亚油酸占整个配方的1%(以质量比计),亚油酸提供的能量≥2.0%(以配方整体计),α-亚麻酸提供的能量≥0.5%(以配方整体计);所述膳食纤维≥2.7g,所述复合维生素≥6.2mg,所述复合矿物质≥527.6mg,所述营养强化剂为22.2-166.7mg。
在一种实施方式中,所述乳清蛋白和酪蛋白的质量比为1:1~1.5。
在一种实施方式中,所述碳水化合物为麦芽糊精,麦芽糊精是具有营养价值的多聚糖,经酶法工艺低程度控制水解转化,提纯,干燥而成。其原料是含淀粉质的玉米,大米等。麦芽糊精的流动性良好,无色,无淀粉和其它异臭味,不甜或者甜味极弱。用量比例很高时,也不会掩盖产品原有食品的风味和香味,是一种优良的的载体。麦芽糊精除了含有大量的多糖类,另外还含有钙、铁等对人体有益的微量元素及矿物质,并能促进人体正常的物质代谢。由于麦芽糊精具有许多优良特性,因此,近年来被广泛应用于食品、保健品、医药生产中。
在一种实施方式中,所述脂肪为大豆油、MCT。大豆油取自大豆种子,是世界上产量最多的油脂。其中含有大量的亚油酸,亚油酸是人体必需的脂肪酸,具有重要的生理功能。与大豆油比较,中链甘油三酯(MCT)完全是无臭、无色的透明液体。与普通的油脂和氢化油脂相比,中链甘油三酯不饱和脂肪酸的含量极低,氧化稳定性非常好,MCT在高温和低温下特别稳定。通常在许多临床营养环境中用作特殊能量来源,与长链甘油三酯(LCT)相比,他可以更快地在体内水解消化吸收。被人体利用,达到迅速供能的目地。
在一种实施方式中,所述共轭亚油酸是亚油酸的同分异构体,是一系列在碳9、11或10、12位具有双键的亚油酸的位置和几何异构体,是普遍存在于人和动物体内的营养元素。共轭亚油酸作为一种新发现的营养素,目前在欧美的健康食品界,几乎已经成了预防现代文明病的万灵丹,从抗炎、抗癌到预防心血管疾病、糖尿病,到体重控制上,几乎是生活在二十一世纪现代人不可或缺的健康食品。
在一种实施方式中,所述益生元为菊粉,是植物中储备性多糖,主要来源于植物,菊粉是一种天然的水溶性膳食纤维,几乎不能被胃酸水解和消化,只有在结肠被有益微生物利用,从而改善肠道环境。有研究表明,双歧杆菌的增殖程度取决于人体大肠中初始双歧杆菌的数量,当初始双歧杆菌数量减少时,使用菊粉后增殖效果明显。其次,摄入菊粉后能增强胃肠道蠕动,提高肠胃功能,增加消化和食欲,提高机体免疫力,有助于预防结肠炎。
在一种实施方式中,所述矿物质复合物包括矿物质宏量复合物和矿物质微量复合物。
在一种实施方式中,所述矿物质宏量复合物包含元素钾、钠、钙、镁、氯、磷所述微量复合物包含元素铁、锌、硒、锰、铜、碘、铬、钼。
在一种实施方式中,所述复合矿物质包括如下成分:钠元素≥83mg、钾元素≥111mg、铜元素44-500μg、镁元素≥18.3mg、铁元素0.83-2.30mg、锌元素0.4-2.2mg、锰元素25-611μg、钙元素≥56mg、磷元素≥40mg、碘元素≥6.7μg、氯元素≤218mg、硒元素3.3-22.2μg、铬1.8-55.6μg、钼5.6-50μg。
在一种实施方式中,所述钠元素选自氯化钠、磷酸二氢钠、磷酸氢二钠、柠檬酸钠、碳酸氢钠中的一种或多种;所述钾元素选自磷酸二氢钾、磷酸氢二钾、葡萄糖酸钾、柠檬酸钾、氯化钾中的一种或多种;所述钙元素选自碳酸钙、葡萄糖酸钙、柠檬酸钙、L-乳酸钙、磷酸氢钙、氯化钙、甘油磷酸钙、磷酸三钙、氧化钙、硫酸钙中的一种或多种;所述镁元素选自硫酸镁、氯化镁、氧化镁、碳酸镁、磷酸氢镁、葡萄糖酸镁中的一种或多种;所述铁元素选自焦磷酸铁、硫酸亚铁、葡萄糖酸亚铁、富马酸亚铁、乙二胺四乙酸铁钠、柠檬酸铁、柠檬酸铁铵中的一种或多种;所述锌元素选自硫酸锌、葡萄糖酸锌、氧化锌、乳酸锌、氯化锌、乙酸锌、柠檬酸锌中的一种或多种;所述硒元素选自亚硒酸钠、硒酸钠中的一种或两种;所述锰元素选自硫酸锰、氯化锰、碳酸锰、柠檬酸锰、葡萄糖酸锰中的一种或多种;所述铜元素选自硫酸铜、柠檬酸铜、葡萄糖酸铜、碳酸铜中的一种或多种;所述磷元素选自磷酸钙、磷酸氢钙中的一种或多种;所述碘元素选自碘化钾、碘酸钾、碘化钠中的一种或多种;所述铬元素选自硫酸钙、氯化铬中的一种或多种;所述钼元素选自钼酸钠、钼酸铵中的一种或多种。
在一种实施方式中,所述多种维生素包括维生素A、维生素D、维生素E、维生素K、维生素C和B族维生素。
在一种实施方式中,所述复合维生素包括如下成分:维生素A 39-225μg、维生素D0.8-3.14μg、维生素E≥0.8mg、维生素K1≥4.4μg、维生素B1≥0.07mg、维生素B2≥0.07mg、维生素B6≥0.07mg、维生素B12≥0.13μg、维生素C≥5.6mg、烟酸≥0.2mg、叶酸≥22.2μg、泛酸≥0.29mg、生物素≥2.2μg。
在一种实施方式中,所述维生素A选自醋酸视黄脂、棕榈酸视黄酯、全反式视黄醇、β-胡萝卜素;所述维生素D选自麦角钙化醇、胆钙化醇中的一种或多种;所述维生素E选自d-α-生育酚、dl-α-生育酚、d-α-醋酸生育酚、dl-α-醋酸生育酚、混合生育酚浓缩物、d-α-琥珀酸生育酚、dl-α-琥珀酸生育酚中的一种或多种;所述维生素K选自植物甲萘醌;所述维生素B1选自盐酸硫胺素、硝酸硫胺素中的一种或多种;所述维生素B2选自核黄素、核黄素-5’-磷酸钠中的一种或多种;所述维生素B6选自盐酸吡哆醇、5’-磷酸吡哆醇中的一种或多种;所述维生素B12选自氰钴胺、盐酸氰钴胺、羟钴胺中的一种或多种;所述维生素C选自L-抗坏血酸、L-抗坏血酸钾、L-抗坏血酸钠、L-抗坏血酸钙、抗坏血酸-6-棕榈酸盐中的一种或多种;所述烟酸选自烟酸、烟酰胺中的一种或多种;所述叶酸选自叶酸;所述泛酸选自D-泛酸纳、D-泛酸钙中的一种或多种;所述生物素选自D-生物素。
在一种实施方式中,所述营养强化剂包括牛黄碱、左旋肉碱、肌醇和胆碱中的一种或多种。
在一种实施方式中,所述胆碱选自酒石酸氢胆碱、氯化胆碱中的一种或多种。
在一种实施方式中,所述全营养配方食品含有麦芽糊精609.06g、乳清蛋白92.19、酪蛋白92.19g、大豆油62.29g、MCT 62.29g、共轭亚油酸10g、菊粉40g、维生素A 6696.05IU、维生素D 1254IU、维生素E 55.98mg α-TE、维生素K1 0.24mg、维生素B1 10.25mg、维生素B210.75mg、维生素B6 12.5mg、维生素B12 0.03μg、维生素C 857.825mg、烟酸 91.25mg、叶酸1.2mg、泛酸钙 57.07mg、生物素 0.1mg、氯化钠 9532.28mg、一水柠檬酸钾 2179.2mg、碳酸铜13.88μg、氧化镁 2470.16mg、柠檬酸铁 434.24mg、碳酸锌 103.04mg、碳酸锰 34.78μg、碳酸钙 10051mg、磷酸二氢钾 14663.88mg、碘酸钾 0.89mg、亚硒酸钠 0.61mg、硫酸铬钾3.24mg、四水钼酸铵 0.94mg、氯化胆碱 1675.6mg、牛磺酸500mg。
本发明的第二个目的是提供含有上述任一所述食品的产品。
本一种实施方式中,所述产品的剂型包含粉剂、颗粒或口服液。
本发明提供的所述炎症肠病全营养配方食品的制备方法,该方法包括如下步骤:
(1)称量各原料,并粉碎;
(2)将大豆油、MCT及共轭亚油酸混合,优选过30-50目筛,进一步优选过40目筛,备用;
(3)将麦芽糊精、膳食纤维、蛋白质混合,优选过30-50目筛,进一步优选过40目筛,备用;
(4)将剩余的复合矿物质,复合维生素、牛磺酸、胆碱混合,优选过30-50目筛,进一步优选过40目筛,备用;
(5)将上诉步骤(2)、(3)、(4)得到的物料混合均匀;
(6)将步骤(5)得到的物料混合为粉剂,进一步制成颗粒或者口服液。
本发明还要求保护上述任一所述的食品在制备对炎性肠病具有营养支持作用的营养配方食品的应用。
有益效果:本发明的炎性肠病全营养配方食品可以对造模后体重下降的小鼠有显著的恢复,小鼠体重升高了13.31%;可改善结肠缩短的症状,使结肠长度增加0.83cm;可以降低MPO(髓过氧化物酶)的活性,同时可缓解肠炎小鼠结肠病理学症状、修复肠道屏障。因此,本发明中所述炎性肠病全营养配方食品通过改善炎症状态对炎性肠病患者具有营养支持作用,具有广泛的应用前景。
附图说明
图1是炎性肠病营养配方食品对小鼠体重的恢复作用;
图2是炎性肠病营养配方食品改善结肠缩短的作用;
图3是炎性肠病营养配方食品降低MPO(髓过氧化物酶)的活性;
图4是炎性肠病营养配方食品改善肠炎小鼠的HE染色结果;
图5是不用组别小鼠额度病理学评分;a,b表示不同字母所代表的组别存在显著性的差异(P<0.05)。
具体实施方式
实施例1:含乳基蛋白的营养配方食品
按照下述配方制备营养配方食品,每1000g配方食品中:麦芽糊精609.06g、乳清蛋白92.19、酪蛋白92.19g、大豆油62.29g、MCT 62.29g、共轭亚油酸10g、菊粉40g、维生素A6696.05IU、维生素D 1254IU、维生素E 55.98mg α-TE、维生素K1 0.24mg、维生素B110.25mg、维生素B2 10.75mg、维生素B6 12.5mg、维生素B12 0.03μg、维生素C 857.825mg、烟酸 91.25mg、叶酸 1.2mg、泛酸钙 57.07mg、生物素 0.1mg、氯化钠 9532.28mg、一水柠檬酸钾 2179.2mg、碳酸铜13.88μg、氧化镁 2470.16mg、柠檬酸铁 434.24mg、碳酸锌 103.04mg、碳酸锰 34.78μg、碳酸钙 10051mg、磷酸二氢钾 14663.88mg、碘酸钾 0.89mg、亚硒酸钠0.61mg、硫酸铬钾 3.24mg、四水钼酸铵 0.94mg、氯化胆碱 1675.6mg、牛磺酸500mg。
实施例2:含马铃薯蛋白的营养配方食品
按照下述配方制备营养配方食品,每1000g配方食品中:麦芽糊精609.06g、马铃薯蛋白184.38g、大豆油62.29g、MCT 62.29g、共轭亚油酸10g、菊粉40g、维生素A 6696.05IU、维生素D 1254IU、维生素E 55.98mg α-TE、维生素K1 0.24mg、维生素B1 10.25mg、维生素B210.75mg、维生素B6 12.5mg、维生素B12 0.03μg、维生素C 857.825mg、烟酸 91.25mg、叶酸1.2mg、泛酸钙 57.07mg、生物素 0.1mg、氯化钠 9532.28mg、一水柠檬酸钾 2179.2mg、碳酸铜13.88μg、氧化镁 2470.16mg、柠檬酸铁 434.24mg、碳酸锌 103.04mg、碳酸锰 34.78μg、碳酸钙 10051mg、磷酸二氢钾 14663.88mg、碘酸钾 0.89mg、亚硒酸钠 0.61mg、硫酸铬钾3.24mg、四水钼酸铵 0.94mg、氯化胆碱 1675.6mg、牛磺酸500mg。
实施例3 :含混合蛋白的营养配方食品
按照下述配方制备营养配方食品,每1000g配方食品中:麦芽糊精609.06g、乳清蛋白61.46、酪蛋白61.46g、马铃薯蛋白61.46g、大豆油62.29g、MCT 62.29g、共轭亚油酸10g、菊粉40g、维生素A 6696.05IU、维生素D 1254IU、维生素E 55.98mg α-TE、维生素K10.24mg、维生素B1 10.25mg、维生素B2 10.75mg、维生素B6 12.5mg、维生素B12 0.03μg、维生素C 857.825mg、烟酸 91.25mg、叶酸 1.2mg、泛酸钙 57.07mg、生物素 0.1mg、氯化钠9532.28mg、一水柠檬酸钾 2179.2mg、碳酸铜13.88μg、氧化镁 2470.16mg、柠檬酸铁434.24mg、碳酸锌 103.04mg、碳酸锰 34.78μg、碳酸钙 10051mg、磷酸二氢钾 14663.88mg、碘酸钾 0.89mg、亚硒酸钠 0.61mg、硫酸铬钾 3.24mg、四水钼酸铵 0.94mg、氯化胆碱1675.6mg、牛磺酸500mg。
实施例4 炎性肠病全营养配方食品对体重有恢复的作用
将6-8周SPF级18-20 g健康雄性C57BL/6小鼠40只随机分为4组:空白组、模型组、乳基蛋白组(喂食实施例1制备的营养配方)、混合蛋白组(喂食实施例3制备的营养配方)、马铃薯蛋白组(喂食实施例2制备的营养配方)。每组10只,饲养在江南大学实验动物中心,恒定温度21-26℃,湿度40-70%,噪声小于等于60dB,动物照度15-20LX。所有动物实验程序皆由江南大学动物福利与伦理管理委员会进行审查并批准。
实验第1天到第7天在小鼠的饮水中添加3.5%DSS诱发急性结肠炎,饮用3个周期(每个周期7天的DSS处理,14天的自由饮水,循环3次),以诱发慢性结肠炎。造模期间空白组正常饮水,喂食基础饲料;造模成功后模型组处死;之后乳基蛋白组、混合蛋白组、马铃薯蛋白组在正常饮水,饮食改为营养配方,乳基蛋白组喂食实施例1制备的营养配方、混合蛋白组喂食实施例3制备的营养配方、马铃薯蛋白组喂食实施例2制备的营养配方。每天记录体重变化。
这些结果如附图1所示。由附图1可知,停止造模后本发明中乳基蛋白组的体重恢复较好,恢复期间小鼠体重升高了13.31%。表明本配方通过营养支持对肠炎引起的体重下降具有较好的改善。
实施例5 炎性肠病全营养配方食品改善肠炎小鼠结肠缩短的症状
将6-8周SPF级18-20 g健康雄性C57BL/6小鼠40只随机分为4组:乳基蛋白组(喂食实施例1制备的营养配方)、混合蛋白组(喂食实施例3制备的营养配方)、马铃薯蛋白组(喂食实施例2制备的营养配方)。每组10只,饲养在江南大学实验动物中心,恒定温度21-26℃,湿度40-70%,噪声小于等于60dB,动物照度15-20LX。所有动物实验程序皆由江南大学动物福利与伦理管理委员会进行审查并批准。
实验第1天到第7天在小鼠的饮水中添加3.5%DSS诱发结肠炎,饮用3个周期(每个周期7天的DSS处理,14天的自由饮水,循环3次),以诱发慢性结肠炎。造模期间空白组正常饮水,喂食基础饲料;造模成功后模型组处死;之后乳基蛋白组、混合蛋白组、马铃薯蛋白组在正常饮水,饮食改为营养配方,乳基蛋白组喂食实施例1制备的营养配方、混合蛋白组喂食实施例3制备的营养配方、马铃薯蛋白组喂食实施例2制备的营养配方。每天记录体重变化。第15天(D15)实验结束后取血并处死小鼠。解剖腹腔,取出小鼠结肠,并量长记录。
肠炎伴随着结肠长度缩短,因此,结肠长度可以很好地反映疾病状况。这些结果如附图2所示,与模型组相比,本发明中的乳基蛋白组及混合蛋白组的结肠长度显著增长,分别增长了0.83cm、0.76cm,表明对结肠炎症状的有效改善。
实施例6 炎性肠病全营养配方食品降低MPO(髓过氧化物酶)的活性实验
将6-8周SPF级18-20 g健康雄性C57BL/6小鼠40只随机分为4组:乳基蛋白组(喂食实施例1制备的营养配方)、混合蛋白组(喂食实施例3制备的营养配方)、马铃薯蛋白组(喂食实施例2制备的营养配方)。每组10只,饲养在江南大学实验动物中心,恒定温度21-26℃,湿度40-70%,噪声小于等于60dB,动物照度15-20LX。所有动物实验程序皆由江南大学动物福利与伦理管理委员会进行审查并批准。
实验第1天到第7天在小鼠的饮水中添加3.5%DSS诱发结肠炎,饮用3个周期(每个周期7天的DSS处理,14天的自由饮水,循环3次),以诱发慢性结肠炎。造模期间空白组正常饮水,喂食基础饲料;造模成功后模型组处死;之后乳基蛋白组、混合蛋白组、马铃薯蛋白组在正常饮水,饮食改为营养配方,乳基蛋白组喂食实施例1制备的营养配方、混合蛋白组喂食实施例3制备的营养配方、马铃薯蛋白组喂食实施例2制备的营养配方。每天记录体重变化。第15天(D15)实验结束后取血并处死小鼠。
取小鼠同一位置结肠组织的匀浆液,通过MPO试剂盒进行MPO活性测定。小鼠结肠髓过氧化物酶(MPO)活性反应结肠组织中性粒细胞浸润程度,故MPO值可表征炎症程度,若MPO活性越强,则炎症越严重。
这些结果如附图3所示,本发明中,相对于模型组,各配方组在实验后MPO值均有显著的下降,分别由6.83 pg/mg protein降低至5.52、4.99、5.06 pg/mg protein,表明营养配方可以减轻结肠炎小鼠的炎症状态。
实施例7 炎性肠病全营养配方食品改善肠炎小鼠的结肠病理学症状实验
将6-8周SPF级18-20 g健康雄性C57BL/6小鼠40只随机分为4组:空白组、模型组、乳基蛋白组(喂食实施例1制备的营养配方)、混合蛋白组(喂食实施例3制备的营养配方)、马铃薯蛋白组(喂食实施例2制备的营养配方)。每组10只,饲养在江南大学实验动物中心,恒定温度21-26℃,湿度40-70%,噪声小于等于60dB,动物照度15-20LX。所有动物实验程序皆由江南大学动物福利与伦理管理委员会进行审查并批准。
实验第1天到第7天在水壶中添加3.5%DSS诱发结肠炎,饮用3个周期(每个周期7天的DSS处理,14天的自由饮水,循环3次),以诱发慢性结肠炎。造模期间空白组正常饮水,喂食基础饲料;造模成功后模型组处死;之后乳基蛋白组、混合蛋白组、马铃薯蛋白组在正常饮水,饮食改为营养配方,乳基蛋白组喂食实施例1制备的营养配方、混合蛋白组喂食实施例3制备的营养配方、马铃薯蛋白组喂食实施例2制备的营养配方。每天记录体重变化。第15天(D15)实验结束后取血并处死小鼠,取小鼠同一位置结肠置于4%的多聚甲醛溶液中固定,进行石蜡包埋,HE染色,送病理科进行肺部炎症程度评估,染色结果见图4,炎症程度评估结果见图5。
这些结果如附图4所示,模型组的杯状细胞丢失,肠腺扩张,形成隐窝脓肿;本发明中的乳基蛋白、混合蛋白组可以观察到轻微的炎性细胞浸润;而马铃薯蛋白组中部分杯状细胞丢失,部分肠腺扩张,隐窝脓肿,恢复较差。从图5组织评分可以看出与模型组相比,各组别的HE评分分别由13.67下降到8.0、12.0、9.67,其中,乳基蛋白组的组织损伤评分下降最多。表明本发明中的乳基蛋白配方对小鼠结肠损伤具有改善的作用从而修复肠道屏障。
通过动物实验发现,与模型组相比,本发明中营养配方可改善体重丢失、结肠缩短,降低MPO(髓过氧化物酶)活性,改善结肠病变情况,可有效地缓解小鼠的肠炎症状。
虽然本发明已以较佳实施例公开如上,但其并非用以限定本发明,任何熟悉此技术的人,在不脱离本发明的精神和范围内,都可做各种的改动与修饰,因此本发明的保护范围应该以权利要求书所界定的为准。
Claims (3)
1.一种炎性肠病全营养配方食品,其特征在于,每1000g配方食品中:麦芽糊精609.06g、乳清蛋白61.46、酪蛋白61.46g、马铃薯蛋白61.46g、大豆油62.29g、MCT 62.29g、共轭亚油酸10g、菊粉40g、维生素A 6696.05IU、维生素D 1254IU、维生素E 55.98mgα-TE、维生素K1 0.24mg、维生素B1 10.25mg、维生素B2 10.75mg、维生素B6 12.5mg、维生素B12 0.03μg、维生素C 857.825mg、烟酸 91.25mg、叶酸 1.2mg、泛酸钙 57.07mg、生物素 0.1mg、氯化钠 9532.28mg、一水柠檬酸钾 2179.2mg、碳酸铜13.88μg、氧化镁 2470.16mg、柠檬酸铁434.24mg、碳酸锌 103.04mg、碳酸锰 34.78μg、碳酸钙 10051mg、磷酸二氢钾 14663.88mg、碘酸钾 0.89mg、亚硒酸钠 0.61mg、硫酸铬钾 3.24mg、四水钼酸铵 0.94mg、氯化胆碱1675.6mg、牛磺酸500mg。
2.根据权利要求1所述的炎性肠病全营养配方食品,其特征在于,剂型为粉剂、颗粒或口服液。
3.一种制备权利要求1或2所述炎性肠病全营养配方食品的方法,其特征在于,包括如下步骤:
(1)称量各原料,并粉碎;
(2)将大豆油、MCT及共轭亚油酸混合,过30-50目筛;
(3)将麦芽糊精、菊粉、乳清蛋白、酪蛋白、马铃薯蛋白混合,过30-50目筛;
(4)将剩余的原料混合,过30-50目筛;
(5)将步骤(2)、(3)、(4)得到的物料混合均匀,或将步骤(2)、(3)、(4)得到的物料混合均匀后进一步制成颗粒或者口服液。
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