CN113366015A - 白细胞介素-10多肽缀合物、其二聚体及其用途 - Google Patents

白细胞介素-10多肽缀合物、其二聚体及其用途 Download PDF

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Publication number
CN113366015A
CN113366015A CN201980083289.9A CN201980083289A CN113366015A CN 113366015 A CN113366015 A CN 113366015A CN 201980083289 A CN201980083289 A CN 201980083289A CN 113366015 A CN113366015 A CN 113366015A
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amino acid
substituted
polypeptide
amino acids
group
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CN201980083289.9A
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English (en)
Chinese (zh)
Inventor
康名超
卢迎春
N·克努森
Md·H·拉希德
田丰
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Ambrx Inc
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Ambrx Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5428—IL-10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201980083289.9A 2018-10-19 2019-10-19 白细胞介素-10多肽缀合物、其二聚体及其用途 Pending CN113366015A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862748221P 2018-10-19 2018-10-19
US62/748,221 2018-10-19
US201862752952P 2018-10-30 2018-10-30
US62/752,952 2018-10-30
US201962822727P 2019-03-22 2019-03-22
US62/822,727 2019-03-22
PCT/US2019/057103 WO2020082057A1 (en) 2018-10-19 2019-10-19 Interleukin-10 polypeptide conjugates, dimers thereof, and their uses

Publications (1)

Publication Number Publication Date
CN113366015A true CN113366015A (zh) 2021-09-07

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CN201980083289.9A Pending CN113366015A (zh) 2018-10-19 2019-10-19 白细胞介素-10多肽缀合物、其二聚体及其用途

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Country Link
US (1) US20220009986A1 (https=)
EP (1) EP3867265A1 (https=)
JP (1) JP2022512746A (https=)
CN (1) CN113366015A (https=)
AU (1) AU2019361206A1 (https=)
WO (1) WO2020082057A1 (https=)

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ES3059360T3 (en) 2018-11-08 2026-03-19 Synthorx Inc Interleukin 10 conjugates and uses thereof
KR20230017840A (ko) * 2020-05-28 2023-02-06 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 조작된 인터루킨-10 폴리펩타이드 및 이의 용도
EP4232071A4 (en) 2020-10-23 2024-08-28 Asher Biotherapeutics, Inc. FUSIONS WITH CD8 ANTIGEN-BINDING MOLECULES TO MODULATE IMMUNE CELL FUNCTION
WO2022125712A1 (en) * 2020-12-09 2022-06-16 Asher Biotherapeutics, Inc. Fusions of mutant interleukin-10 polypeptides with antigen binding molecules for modulating immune cell function
US20240181089A1 (en) * 2021-03-18 2024-06-06 Xylonix Pte. Ltd Pharmaceutical polymer conjugates
EP4396212A4 (en) * 2021-10-06 2025-08-20 Elixiron Immunotherapeutics Hong Kong Ltd INTERLEUKIN-10 MUTEINS AND FUSION PROTEINS BASED THEREON
IL313171A (en) * 2021-12-01 2024-07-01 Synthekine Inc Variants of IL10 and their uses

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CN103755800A (zh) * 2004-02-02 2014-04-30 Ambrx公司 经修饰的人类生长激素多肽与其用途
CN104245720A (zh) * 2012-02-29 2014-12-24 Ambrx公司 白细胞介素-3多肽结合物和其用途
WO2014204816A2 (en) * 2013-06-17 2014-12-24 Armo Biosciences, Inc. Method for assessing protein identity and stability
CN104245722A (zh) * 2012-02-29 2014-12-24 Ambrx公司 白细胞介素-10多肽结合物和其用途
CN106061997A (zh) * 2014-02-06 2016-10-26 豪夫迈·罗氏有限公司 白介素‑10免疫缀合物
CN107847583A (zh) * 2015-05-28 2018-03-27 阿尔莫生物科技股份有限公司 用于治疗癌症的聚乙二醇化白细胞介素‑10
CN108025040A (zh) * 2015-08-25 2018-05-11 阿尔莫生物科技股份有限公司 使用白介素-10治疗疾病和病症的方法

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