AU2019361206A1 - Interleukin-10 polypeptide conjugates, dimers thereof, and their uses - Google Patents

Interleukin-10 polypeptide conjugates, dimers thereof, and their uses Download PDF

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Publication number
AU2019361206A1
AU2019361206A1 AU2019361206A AU2019361206A AU2019361206A1 AU 2019361206 A1 AU2019361206 A1 AU 2019361206A1 AU 2019361206 A AU2019361206 A AU 2019361206A AU 2019361206 A AU2019361206 A AU 2019361206A AU 2019361206 A1 AU2019361206 A1 AU 2019361206A1
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AU
Australia
Prior art keywords
amino acid
substituted
polypeptide
group
amino acids
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Abandoned
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AU2019361206A
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English (en)
Inventor
Mingchao KANG
Nickolas KNUDSEN
Yingchun Lu
Md Harunur RASHID
Feng Tian
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Ambrx Inc
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Ambrx Inc
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/5428IL-10
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2019361206A 2018-10-19 2019-10-19 Interleukin-10 polypeptide conjugates, dimers thereof, and their uses Abandoned AU2019361206A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862748221P 2018-10-19 2018-10-19
US62/748,221 2018-10-19
US201862752952P 2018-10-30 2018-10-30
US62/752,952 2018-10-30
US201962822727P 2019-03-22 2019-03-22
US62/822,727 2019-03-22
PCT/US2019/057103 WO2020082057A1 (en) 2018-10-19 2019-10-19 Interleukin-10 polypeptide conjugates, dimers thereof, and their uses

Publications (1)

Publication Number Publication Date
AU2019361206A1 true AU2019361206A1 (en) 2021-06-03

Family

ID=68470665

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2019361206A Abandoned AU2019361206A1 (en) 2018-10-19 2019-10-19 Interleukin-10 polypeptide conjugates, dimers thereof, and their uses

Country Status (6)

Country Link
US (1) US20220009986A1 (https=)
EP (1) EP3867265A1 (https=)
JP (1) JP2022512746A (https=)
CN (1) CN113366015A (https=)
AU (1) AU2019361206A1 (https=)
WO (1) WO2020082057A1 (https=)

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CA3180304A1 (en) * 2020-05-28 2021-12-02 Kenan Christopher GARCIA Engineered interleukin-10 polypeptides and uses thereof
KR20230112632A (ko) 2020-10-23 2023-07-27 애셔 바이오테라퓨틱스, 인크. 면역 세포 기능을 조절하기 위한 cd8 항원 결합 분자와의 융합
CA3204723A1 (en) * 2020-12-09 2022-06-16 Asher Biotherapeutics, Inc. Fusions of mutant interleukin-10 polypeptides with antigen binding molecules for modulating immune cell function
KR20230158059A (ko) * 2021-03-18 2023-11-17 자일로닉스 피티이. 엘티디 약학적 중합체 접합체
JP2024537239A (ja) * 2021-10-06 2024-10-10 エリクシロン・イミュノセラピューティクス・(ホンコン)・リミテッド インターロイキン-10ムテイン及びその融合タンパク質
WO2023102493A2 (en) * 2021-12-01 2023-06-08 Synthekine, Inc. Il10 variants and uses thereof

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US20220009986A1 (en) 2022-01-13

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