CN1133637C - 雷公藤内酯类似物及其组合物和应用 - Google Patents

雷公藤内酯类似物及其组合物和应用 Download PDF

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Publication number
CN1133637C
CN1133637C CNB971942471A CN97194247A CN1133637C CN 1133637 C CN1133637 C CN 1133637C CN B971942471 A CNB971942471 A CN B971942471A CN 97194247 A CN97194247 A CN 97194247A CN 1133637 C CN1133637 C CN 1133637C
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China
Prior art keywords
triptolide
compound
application
compounds
immunosuppressive
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Expired - Fee Related
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CNB971942471A
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English (en)
Chinese (zh)
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CN1246121A (zh
Inventor
����ì
齐友矛
Hi
约翰·H·马瑟
M���Ƶ�
约翰·M·菲德勒
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Pharmagenesis Inc
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Pharmagenesis Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
CNB971942471A 1996-03-01 1997-02-28 雷公藤内酯类似物及其组合物和应用 Expired - Fee Related CN1133637C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/609,277 US5663335A (en) 1996-03-01 1996-03-01 Immunosuppressive compounds and methods
US08/609,277 1996-03-01

Publications (2)

Publication Number Publication Date
CN1246121A CN1246121A (zh) 2000-03-01
CN1133637C true CN1133637C (zh) 2004-01-07

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ID=24440096

Family Applications (1)

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CNB971942471A Expired - Fee Related CN1133637C (zh) 1996-03-01 1997-02-28 雷公藤内酯类似物及其组合物和应用

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US (1) US5663335A (https=)
EP (1) EP0907652B1 (https=)
JP (1) JP4267697B2 (https=)
CN (1) CN1133637C (https=)
AT (1) ATE296304T1 (https=)
AU (2) AU2125897A (https=)
CA (1) CA2248266C (https=)
DE (1) DE69733353T2 (https=)
DK (1) DK0907652T3 (https=)
ES (1) ES2242214T3 (https=)
PT (1) PT907652E (https=)
WO (2) WO1997031920A1 (https=)

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US7626044B2 (en) 2002-12-27 2009-12-01 Shanghai Institute Of Materia Medica Chinese Academy Of Sciences Triptolide derivatives and their uses

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US5880116A (en) * 1996-12-13 1999-03-09 Neurocal International Use of celastrol to treat alzheimer's disease
US6004999A (en) * 1997-05-23 1999-12-21 Hoechst Marion Roussel, Inc. Triptolide derivatives useful in the treatment of autoimmune diseases
DK0983275T3 (da) * 1997-05-23 2002-12-23 Aventis Pharma Inc Nye triptolidderivater, der er nyttige til behandling af autoimmune sygdomme
US5972998A (en) * 1997-05-23 1999-10-26 Hoechst Marion Roussel, Inc. Triptolide derivatives useful in the treatment of autoimmune diseases
JP2002500647A (ja) * 1997-05-23 2002-01-08 アベンティス・ファーマスーティカルズ・インコーポレイテッド 自己免疫疾患の治療に有用な新規なトリプトリド誘導体
EP1375488B1 (en) * 1998-09-02 2006-08-02 Pharmagenesis, Inc. Triptolide prodrugs having high aqueous solubility
US6548537B1 (en) 1998-09-02 2003-04-15 Pharmagenesis, Inc. Triptolide prodrugs having high aqueous solubility
CA2342901A1 (en) * 1998-09-02 2000-03-09 Pharmagenesis, Inc. Triptolide prodrugs having high aqueous solubility
WO2000045800A2 (en) * 1999-02-02 2000-08-10 K.U. Leuven Research & Development Immunosurpressive effects of pteridine derivatives
US6329148B1 (en) 1999-02-16 2001-12-11 The Board Of Trustees Of The Leland Stanford University Combined therapy of diterpenoid triepoxides and death domain receptor ligands for synergistic killing of tumor cells
WO2000063212A1 (en) * 1999-04-16 2000-10-26 Chengdu Diao Pharmaceutical Group Company Limited Derivatives of triptolide, and preparation and uses thereof
US7323471B1 (en) * 1999-08-13 2008-01-29 Dor Biopharma, Inc. Topical azathioprine for the treatment of oral autoimmune diseases
US6294546B1 (en) * 1999-08-30 2001-09-25 The Broad Of Trustees Of The Leland Stanford Junior University Uses of diterpenoid triepoxides as an anti-proliferative agent
US6620843B2 (en) * 2001-01-19 2003-09-16 Pharmagenesis Anticancer treatment using triptolide prodrugs
EP1390358A4 (en) * 2001-03-15 2004-06-16 Pharmagenesis Inc AMINO ACID DERIVATIVES OF TRIPTOLIDE COMPOUNDS AS IMMUNOMODULATORS AND ANTICROPHES
EP2468277A1 (en) 2002-05-31 2012-06-27 Pharmagenesis, Inc. Triptolide derivatives for modulation of apoptosis and immunosuppression
CN100398544C (zh) * 2002-09-18 2008-07-02 成都达远药物有限公司 高免疫抑制活性的水溶性雷公藤内酯醇衍生物及其应用
WO2004058246A1 (en) * 2002-12-17 2004-07-15 Pharmagenesis, Inc. Triptolide derivatives as immunomodulator and anticancer agents
US6943259B2 (en) * 2003-02-25 2005-09-13 Pharmagenesis, Inc. Halogenated triptolide derivatives as immunomodulators and anticancer agents
CN100408583C (zh) * 2003-02-25 2008-08-06 美国泛华医药公司 用作免疫调节剂和抗癌药的卤代雷公藤内酯醇衍生物
WO2005062913A2 (en) * 2003-12-24 2005-07-14 Pharmagenesis, Inc. Triplide 5,6-derivatives as immunomodulators and anticancer agents
EP1722806A4 (en) * 2004-02-09 2009-09-16 Pharmagenesis Inc METHOD OF ISOLATING TRIPTOLIDE COMPOUNDS FROM TRIPTERYGIUM WILFORDII
WO2005084365A2 (en) 2004-03-02 2005-09-15 Pharmagenesis, Inc. Triptolide lactone ring derivatives as immunomodulators and anticancer agents
WO2006012204A2 (en) * 2004-06-25 2006-02-02 Pharmagenesis, Inc. Method for treatment of inflammatory disorders using triptolide compounds
WO2006044496A2 (en) 2004-10-13 2006-04-27 Pharmagenesis, Inc. Identification and screening of triptolide target molecules
EP1924548B1 (en) 2005-07-13 2018-03-28 Salvia Sciences, Inc. Ester prodrugs of prostratin and related phorbol compounds
WO2008009078A2 (en) 2006-07-20 2008-01-24 Gilead Sciences, Inc. 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
US10144736B2 (en) 2006-07-20 2018-12-04 Gilead Sciences, Inc. Substituted pteridines useful for the treatment and prevention of viral infections
US8067632B2 (en) * 2007-07-26 2011-11-29 The Board Of Trustees Of The Leland Stanford Junior University Process to produce prostratin and structural or functional analogs thereof
CN101235041B (zh) * 2007-10-26 2013-05-29 北京美迪克斯生物技术有限公司 四种雷公藤甲素衍生物及其制剂的制备方法
CN104387406A (zh) * 2009-02-05 2015-03-04 药物起源公司 作为抗癌药和免疫调制剂的雷公藤内酯 c-环衍生物
US9150600B2 (en) 2009-05-07 2015-10-06 Regents Of The University Of Minnesota Triptolide prodrugs
DK2427467T3 (en) 2009-05-07 2015-11-09 Univ Minnesota Triptolid prodrugs
CN102286065B (zh) * 2010-06-18 2012-11-14 中国科学院上海药物研究所 松香烷型二萜衍生物、其制备方法和应用
LT3510860T (lt) 2012-08-23 2021-10-25 Senestech, Inc. Žinduolių reprodukcinio pajėgumo sumažinimas
US9670205B2 (en) 2015-03-04 2017-06-06 Gilead Sciences, Inc. Toll like receptor modulator compounds
WO2016205539A1 (en) * 2015-06-16 2016-12-22 Board Of Regents Of The Nevada System Of Higher Education, On Behalf Of The University Of Nevada, Reno Non-hormonal male contraceptive agents and methods using same
EP3248981B1 (en) * 2015-10-29 2022-03-09 Hangzhou Weben Pharmaceuticals Inc. C14-hydroxyl esterified amino acid derivatives of triptolide, and preparation method and use thereof
WO2018045150A1 (en) 2016-09-02 2018-03-08 Gilead Sciences, Inc. 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators
AU2017318601B2 (en) 2016-09-02 2020-09-03 Gilead Sciences, Inc. Toll like receptor modulator compounds
CN106890187A (zh) * 2017-02-22 2017-06-27 中山大学附属第三医院 雷公藤甲素及其修饰物在抑制b细胞产生抗体中的应用
CN109021061B (zh) * 2018-09-29 2019-07-12 郭可点 雷公藤甲素靶向前药及其制备方法和应用
TWI751516B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202212339A (zh) 2019-04-17 2022-04-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI879779B (zh) 2019-06-28 2025-04-11 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法
CN111440185B (zh) * 2020-03-31 2021-05-14 中国农业科学院蜜蜂研究所 一种半抗原及其在检测雷公藤乙素和雷公藤甲素方面的应用
CN115466269A (zh) * 2021-06-11 2022-12-13 复旦大学 一种胆碱碳酸酯类前药及其制备方法和应用
CN114478684B (zh) * 2022-01-21 2023-10-31 南京中医药大学 一类雷公藤甲素前药、其制备方法及其医药用途

Citations (2)

* Cited by examiner, † Cited by third party
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CN1052861A (zh) * 1989-12-22 1991-07-10 中国医学科学院皮肤病研究所 雷醇内酯的制备方法及抗生育用途
CN1052860A (zh) * 1989-12-22 1991-07-10 中国医学科学院皮肤病研究所 雷藤氯内酯醇的制备方法及抗生育用途

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US4005108A (en) * 1973-04-03 1977-01-25 Research Corporation Novel anti-leukemic diterpenoid triepoxides
CA1310009C (en) * 1984-03-28 1992-11-10 John Mark Braughler Ester prodrugs of steroids
CN1027371C (zh) * 1989-09-08 1995-01-11 中国医学科学院皮肤病研究所 二萜内酯化合物的合成方法
US5430054A (en) * 1989-12-22 1995-07-04 Jiangsu Family Planning Institute Preparation methods of diterpene lactone compounds and application of the same to antifertility
CN1052859A (zh) * 1989-12-22 1991-07-10 中国医学科学院皮肤病研究所 17-羟基雷藤内酯醇及类似物的结构与制备方法
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CN1052860A (zh) * 1989-12-22 1991-07-10 中国医学科学院皮肤病研究所 雷藤氯内酯醇的制备方法及抗生育用途

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7626044B2 (en) 2002-12-27 2009-12-01 Shanghai Institute Of Materia Medica Chinese Academy Of Sciences Triptolide derivatives and their uses

Also Published As

Publication number Publication date
CA2248266A1 (en) 1997-09-04
AU712241B2 (en) 1999-11-04
EP0907652B1 (en) 2005-05-25
DK0907652T3 (da) 2005-08-08
ES2242214T3 (es) 2005-11-01
WO1997031920A1 (en) 1997-09-04
JP2001504437A (ja) 2001-04-03
CA2248266C (en) 2007-10-23
HK1019444A1 (en) 2000-02-11
AU2061397A (en) 1997-09-16
EP0907652A1 (en) 1999-04-14
DE69733353T2 (de) 2006-02-02
PT907652E (pt) 2005-08-31
AU2125897A (en) 1997-09-16
WO1997031921A1 (en) 1997-09-04
DE69733353D1 (de) 2005-06-30
US5663335A (en) 1997-09-02
CN1246121A (zh) 2000-03-01
JP4267697B2 (ja) 2009-05-27
ATE296304T1 (de) 2005-06-15

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Granted publication date: 20040107

Termination date: 20100228