CA2248266C - Immunosuppressive compounds and methods - Google Patents
Immunosuppressive compounds and methods Download PDFInfo
- Publication number
- CA2248266C CA2248266C CA002248266A CA2248266A CA2248266C CA 2248266 C CA2248266 C CA 2248266C CA 002248266 A CA002248266 A CA 002248266A CA 2248266 A CA2248266 A CA 2248266A CA 2248266 C CA2248266 C CA 2248266C
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- CA
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- Prior art keywords
- compound
- triptolide
- treatment
- pharmaceutically acceptable
- acceptable vehicle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/609,277 US5663335A (en) | 1996-03-01 | 1996-03-01 | Immunosuppressive compounds and methods |
| US08/609,277 | 1996-03-01 | ||
| PCT/US1997/003202 WO1997031921A1 (en) | 1996-03-01 | 1997-02-28 | Immunosuppressive compounds and methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2248266A1 CA2248266A1 (en) | 1997-09-04 |
| CA2248266C true CA2248266C (en) | 2007-10-23 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002248266A Expired - Fee Related CA2248266C (en) | 1996-03-01 | 1997-02-28 | Immunosuppressive compounds and methods |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5663335A (https=) |
| EP (1) | EP0907652B1 (https=) |
| JP (1) | JP4267697B2 (https=) |
| CN (1) | CN1133637C (https=) |
| AT (1) | ATE296304T1 (https=) |
| AU (2) | AU2125897A (https=) |
| CA (1) | CA2248266C (https=) |
| DE (1) | DE69733353T2 (https=) |
| DK (1) | DK0907652T3 (https=) |
| ES (1) | ES2242214T3 (https=) |
| PT (1) | PT907652E (https=) |
| WO (2) | WO1997031920A1 (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5880116A (en) * | 1996-12-13 | 1999-03-09 | Neurocal International | Use of celastrol to treat alzheimer's disease |
| US6004999A (en) * | 1997-05-23 | 1999-12-21 | Hoechst Marion Roussel, Inc. | Triptolide derivatives useful in the treatment of autoimmune diseases |
| DK0983275T3 (da) * | 1997-05-23 | 2002-12-23 | Aventis Pharma Inc | Nye triptolidderivater, der er nyttige til behandling af autoimmune sygdomme |
| US5972998A (en) * | 1997-05-23 | 1999-10-26 | Hoechst Marion Roussel, Inc. | Triptolide derivatives useful in the treatment of autoimmune diseases |
| JP2002500647A (ja) * | 1997-05-23 | 2002-01-08 | アベンティス・ファーマスーティカルズ・インコーポレイテッド | 自己免疫疾患の治療に有用な新規なトリプトリド誘導体 |
| EP1375488B1 (en) * | 1998-09-02 | 2006-08-02 | Pharmagenesis, Inc. | Triptolide prodrugs having high aqueous solubility |
| US6548537B1 (en) | 1998-09-02 | 2003-04-15 | Pharmagenesis, Inc. | Triptolide prodrugs having high aqueous solubility |
| CA2342901A1 (en) * | 1998-09-02 | 2000-03-09 | Pharmagenesis, Inc. | Triptolide prodrugs having high aqueous solubility |
| WO2000045800A2 (en) * | 1999-02-02 | 2000-08-10 | K.U. Leuven Research & Development | Immunosurpressive effects of pteridine derivatives |
| US6329148B1 (en) | 1999-02-16 | 2001-12-11 | The Board Of Trustees Of The Leland Stanford University | Combined therapy of diterpenoid triepoxides and death domain receptor ligands for synergistic killing of tumor cells |
| WO2000063212A1 (en) * | 1999-04-16 | 2000-10-26 | Chengdu Diao Pharmaceutical Group Company Limited | Derivatives of triptolide, and preparation and uses thereof |
| US7323471B1 (en) * | 1999-08-13 | 2008-01-29 | Dor Biopharma, Inc. | Topical azathioprine for the treatment of oral autoimmune diseases |
| US6294546B1 (en) * | 1999-08-30 | 2001-09-25 | The Broad Of Trustees Of The Leland Stanford Junior University | Uses of diterpenoid triepoxides as an anti-proliferative agent |
| US6620843B2 (en) * | 2001-01-19 | 2003-09-16 | Pharmagenesis | Anticancer treatment using triptolide prodrugs |
| EP1390358A4 (en) * | 2001-03-15 | 2004-06-16 | Pharmagenesis Inc | AMINO ACID DERIVATIVES OF TRIPTOLIDE COMPOUNDS AS IMMUNOMODULATORS AND ANTICROPHES |
| EP2468277A1 (en) | 2002-05-31 | 2012-06-27 | Pharmagenesis, Inc. | Triptolide derivatives for modulation of apoptosis and immunosuppression |
| CN100398544C (zh) * | 2002-09-18 | 2008-07-02 | 成都达远药物有限公司 | 高免疫抑制活性的水溶性雷公藤内酯醇衍生物及其应用 |
| WO2004058246A1 (en) * | 2002-12-17 | 2004-07-15 | Pharmagenesis, Inc. | Triptolide derivatives as immunomodulator and anticancer agents |
| CN1223595C (zh) | 2002-12-27 | 2005-10-19 | 中国科学院上海药物研究所 | 雷公藤内酯醇衍生物及其应用 |
| US6943259B2 (en) * | 2003-02-25 | 2005-09-13 | Pharmagenesis, Inc. | Halogenated triptolide derivatives as immunomodulators and anticancer agents |
| CN100408583C (zh) * | 2003-02-25 | 2008-08-06 | 美国泛华医药公司 | 用作免疫调节剂和抗癌药的卤代雷公藤内酯醇衍生物 |
| WO2005062913A2 (en) * | 2003-12-24 | 2005-07-14 | Pharmagenesis, Inc. | Triplide 5,6-derivatives as immunomodulators and anticancer agents |
| EP1722806A4 (en) * | 2004-02-09 | 2009-09-16 | Pharmagenesis Inc | METHOD OF ISOLATING TRIPTOLIDE COMPOUNDS FROM TRIPTERYGIUM WILFORDII |
| WO2005084365A2 (en) | 2004-03-02 | 2005-09-15 | Pharmagenesis, Inc. | Triptolide lactone ring derivatives as immunomodulators and anticancer agents |
| WO2006012204A2 (en) * | 2004-06-25 | 2006-02-02 | Pharmagenesis, Inc. | Method for treatment of inflammatory disorders using triptolide compounds |
| WO2006044496A2 (en) | 2004-10-13 | 2006-04-27 | Pharmagenesis, Inc. | Identification and screening of triptolide target molecules |
| EP1924548B1 (en) | 2005-07-13 | 2018-03-28 | Salvia Sciences, Inc. | Ester prodrugs of prostratin and related phorbol compounds |
| WO2008009078A2 (en) | 2006-07-20 | 2008-01-24 | Gilead Sciences, Inc. | 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections |
| US10144736B2 (en) | 2006-07-20 | 2018-12-04 | Gilead Sciences, Inc. | Substituted pteridines useful for the treatment and prevention of viral infections |
| US8067632B2 (en) * | 2007-07-26 | 2011-11-29 | The Board Of Trustees Of The Leland Stanford Junior University | Process to produce prostratin and structural or functional analogs thereof |
| CN101235041B (zh) * | 2007-10-26 | 2013-05-29 | 北京美迪克斯生物技术有限公司 | 四种雷公藤甲素衍生物及其制剂的制备方法 |
| CN104387406A (zh) * | 2009-02-05 | 2015-03-04 | 药物起源公司 | 作为抗癌药和免疫调制剂的雷公藤内酯 c-环衍生物 |
| US9150600B2 (en) | 2009-05-07 | 2015-10-06 | Regents Of The University Of Minnesota | Triptolide prodrugs |
| DK2427467T3 (en) | 2009-05-07 | 2015-11-09 | Univ Minnesota | Triptolid prodrugs |
| CN102286065B (zh) * | 2010-06-18 | 2012-11-14 | 中国科学院上海药物研究所 | 松香烷型二萜衍生物、其制备方法和应用 |
| LT3510860T (lt) | 2012-08-23 | 2021-10-25 | Senestech, Inc. | Žinduolių reprodukcinio pajėgumo sumažinimas |
| US9670205B2 (en) | 2015-03-04 | 2017-06-06 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| WO2016205539A1 (en) * | 2015-06-16 | 2016-12-22 | Board Of Regents Of The Nevada System Of Higher Education, On Behalf Of The University Of Nevada, Reno | Non-hormonal male contraceptive agents and methods using same |
| EP3248981B1 (en) * | 2015-10-29 | 2022-03-09 | Hangzhou Weben Pharmaceuticals Inc. | C14-hydroxyl esterified amino acid derivatives of triptolide, and preparation method and use thereof |
| WO2018045150A1 (en) | 2016-09-02 | 2018-03-08 | Gilead Sciences, Inc. | 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators |
| AU2017318601B2 (en) | 2016-09-02 | 2020-09-03 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| CN106890187A (zh) * | 2017-02-22 | 2017-06-27 | 中山大学附属第三医院 | 雷公藤甲素及其修饰物在抑制b细胞产生抗体中的应用 |
| CN109021061B (zh) * | 2018-09-29 | 2019-07-12 | 郭可点 | 雷公藤甲素靶向前药及其制备方法和应用 |
| TWI751516B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TW202212339A (zh) | 2019-04-17 | 2022-04-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TWI879779B (zh) | 2019-06-28 | 2025-04-11 | 美商基利科學股份有限公司 | 類鐸受體調節劑化合物的製備方法 |
| CN111440185B (zh) * | 2020-03-31 | 2021-05-14 | 中国农业科学院蜜蜂研究所 | 一种半抗原及其在检测雷公藤乙素和雷公藤甲素方面的应用 |
| CN115466269A (zh) * | 2021-06-11 | 2022-12-13 | 复旦大学 | 一种胆碱碳酸酯类前药及其制备方法和应用 |
| CN114478684B (zh) * | 2022-01-21 | 2023-10-31 | 南京中医药大学 | 一类雷公藤甲素前药、其制备方法及其医药用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4005108A (en) * | 1973-04-03 | 1977-01-25 | Research Corporation | Novel anti-leukemic diterpenoid triepoxides |
| CA1310009C (en) * | 1984-03-28 | 1992-11-10 | John Mark Braughler | Ester prodrugs of steroids |
| CN1027371C (zh) * | 1989-09-08 | 1995-01-11 | 中国医学科学院皮肤病研究所 | 二萜内酯化合物的合成方法 |
| CN1052860A (zh) * | 1989-12-22 | 1991-07-10 | 中国医学科学院皮肤病研究所 | 雷藤氯内酯醇的制备方法及抗生育用途 |
| CN1052861A (zh) * | 1989-12-22 | 1991-07-10 | 中国医学科学院皮肤病研究所 | 雷醇内酯的制备方法及抗生育用途 |
| US5430054A (en) * | 1989-12-22 | 1995-07-04 | Jiangsu Family Planning Institute | Preparation methods of diterpene lactone compounds and application of the same to antifertility |
| CN1052859A (zh) * | 1989-12-22 | 1991-07-10 | 中国医学科学院皮肤病研究所 | 17-羟基雷藤内酯醇及类似物的结构与制备方法 |
| AU7570191A (en) * | 1990-03-14 | 1991-10-10 | Board Of Regents, The University Of Texas System | Tripterygium wilfordii hook f extracts and components thereof for immunosuppression |
-
1996
- 1996-03-01 US US08/609,277 patent/US5663335A/en not_active Expired - Lifetime
-
1997
- 1997-02-18 WO PCT/US1997/002331 patent/WO1997031920A1/en not_active Ceased
- 1997-02-18 AU AU21258/97A patent/AU2125897A/en not_active Abandoned
- 1997-02-28 WO PCT/US1997/003202 patent/WO1997031921A1/en not_active Ceased
- 1997-02-28 DK DK97908794T patent/DK0907652T3/da active
- 1997-02-28 EP EP97908794A patent/EP0907652B1/en not_active Expired - Lifetime
- 1997-02-28 AT AT97908794T patent/ATE296304T1/de not_active IP Right Cessation
- 1997-02-28 AU AU20613/97A patent/AU712241B2/en not_active Ceased
- 1997-02-28 PT PT97908794T patent/PT907652E/pt unknown
- 1997-02-28 CA CA002248266A patent/CA2248266C/en not_active Expired - Fee Related
- 1997-02-28 JP JP53117297A patent/JP4267697B2/ja not_active Expired - Fee Related
- 1997-02-28 CN CNB971942471A patent/CN1133637C/zh not_active Expired - Fee Related
- 1997-02-28 DE DE69733353T patent/DE69733353T2/de not_active Expired - Lifetime
- 1997-02-28 ES ES97908794T patent/ES2242214T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2248266A1 (en) | 1997-09-04 |
| AU712241B2 (en) | 1999-11-04 |
| EP0907652B1 (en) | 2005-05-25 |
| DK0907652T3 (da) | 2005-08-08 |
| ES2242214T3 (es) | 2005-11-01 |
| WO1997031920A1 (en) | 1997-09-04 |
| JP2001504437A (ja) | 2001-04-03 |
| CN1133637C (zh) | 2004-01-07 |
| HK1019444A1 (en) | 2000-02-11 |
| AU2061397A (en) | 1997-09-16 |
| EP0907652A1 (en) | 1999-04-14 |
| DE69733353T2 (de) | 2006-02-02 |
| PT907652E (pt) | 2005-08-31 |
| AU2125897A (en) | 1997-09-16 |
| WO1997031921A1 (en) | 1997-09-04 |
| DE69733353D1 (de) | 2005-06-30 |
| US5663335A (en) | 1997-09-02 |
| CN1246121A (zh) | 2000-03-01 |
| JP4267697B2 (ja) | 2009-05-27 |
| ATE296304T1 (de) | 2005-06-15 |
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