PT907652E - Compostos e processos imunossupressores - Google Patents

Compostos e processos imunossupressores

Info

Publication number
PT907652E
PT907652E PT97908794T PT97908794T PT907652E PT 907652 E PT907652 E PT 907652E PT 97908794 T PT97908794 T PT 97908794T PT 97908794 T PT97908794 T PT 97908794T PT 907652 E PT907652 E PT 907652E
Authority
PT
Portugal
Prior art keywords
compounds
immunosupressor
processes
immunosuppressive
methods
Prior art date
Application number
PT97908794T
Other languages
English (en)
Inventor
John H Musser
Qi You Mao
John M Fidler
Original Assignee
Pharmagenesis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmagenesis Inc filed Critical Pharmagenesis Inc
Publication of PT907652E publication Critical patent/PT907652E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
PT97908794T 1996-03-01 1997-02-28 Compostos e processos imunossupressores PT907652E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/609,277 US5663335A (en) 1996-03-01 1996-03-01 Immunosuppressive compounds and methods

Publications (1)

Publication Number Publication Date
PT907652E true PT907652E (pt) 2005-08-31

Family

ID=24440096

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97908794T PT907652E (pt) 1996-03-01 1997-02-28 Compostos e processos imunossupressores

Country Status (13)

Country Link
US (1) US5663335A (pt)
EP (1) EP0907652B1 (pt)
JP (1) JP4267697B2 (pt)
CN (1) CN1133637C (pt)
AT (1) ATE296304T1 (pt)
AU (2) AU2125897A (pt)
CA (1) CA2248266C (pt)
DE (1) DE69733353T2 (pt)
DK (1) DK0907652T3 (pt)
ES (1) ES2242214T3 (pt)
HK (1) HK1019444A1 (pt)
PT (1) PT907652E (pt)
WO (2) WO1997031920A1 (pt)

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US5880116A (en) * 1996-12-13 1999-03-09 Neurocal International Use of celastrol to treat alzheimer's disease
US6004999A (en) * 1997-05-23 1999-12-21 Hoechst Marion Roussel, Inc. Triptolide derivatives useful in the treatment of autoimmune diseases
US5972998A (en) * 1997-05-23 1999-10-26 Hoechst Marion Roussel, Inc. Triptolide derivatives useful in the treatment of autoimmune diseases
KR20010012822A (ko) * 1997-05-23 2001-02-26 게리 디. 스트리트 자가 면역 질환의 치료에 유용한 신규의 트리프톨라이드유도체
NZ500699A (en) * 1997-05-23 2001-08-31 Aventis Pharma Inc Triptolide derivatives substituted with amino acids, useful in the treatment of autoimmune diseases
EP1375488B1 (en) * 1998-09-02 2006-08-02 Pharmagenesis, Inc. Triptolide prodrugs having high aqueous solubility
ATE245145T1 (de) * 1998-09-02 2003-08-15 Pharmagenesis Inc Gut wasserlösliche triptolid-prodrugs
US6548537B1 (en) 1998-09-02 2003-04-15 Pharmagenesis, Inc. Triptolide prodrugs having high aqueous solubility
EP1187615A2 (en) * 1999-02-02 2002-03-20 K.U. Leuven Research & Development Immunosurpressive effects of pteridine derivatives
US6329148B1 (en) 1999-02-16 2001-12-11 The Board Of Trustees Of The Leland Stanford University Combined therapy of diterpenoid triepoxides and death domain receptor ligands for synergistic killing of tumor cells
WO2000063212A1 (en) * 1999-04-16 2000-10-26 Chengdu Diao Pharmaceutical Group Company Limited Derivatives of triptolide, and preparation and uses thereof
US7323471B1 (en) * 1999-08-13 2008-01-29 Dor Biopharma, Inc. Topical azathioprine for the treatment of oral autoimmune diseases
US6294546B1 (en) * 1999-08-30 2001-09-25 The Broad Of Trustees Of The Leland Stanford Junior University Uses of diterpenoid triepoxides as an anti-proliferative agent
US6620843B2 (en) * 2001-01-19 2003-09-16 Pharmagenesis Anticancer treatment using triptolide prodrugs
EP1390358A4 (en) * 2001-03-15 2004-06-16 Pharmagenesis Inc AMINO ACID DERIVATIVES OF TRIPTOLIDE COMPOUNDS AS IMMUNOMODULATORS AND ANTICROPHES
US7847109B2 (en) * 2002-05-31 2010-12-07 Pharmagenesis, Inc. Triptolide derivatives for modulation of apoptosis and immunosuppression
CN100398544C (zh) * 2002-09-18 2008-07-02 成都达远药物有限公司 高免疫抑制活性的水溶性雷公藤内酯醇衍生物及其应用
CA2508217A1 (en) * 2002-12-17 2004-07-15 Pharmagenesis, Inc. Triptolide derivatives as immunomodulators and anticancer agents
CN1223595C (zh) * 2002-12-27 2005-10-19 中国科学院上海药物研究所 雷公藤内酯醇衍生物及其应用
US6943259B2 (en) * 2003-02-25 2005-09-13 Pharmagenesis, Inc. Halogenated triptolide derivatives as immunomodulators and anticancer agents
CN100408583C (zh) * 2003-02-25 2008-08-06 美国泛华医药公司 用作免疫调节剂和抗癌药的卤代雷公藤内酯醇衍生物
WO2005062913A2 (en) * 2003-12-24 2005-07-14 Pharmagenesis, Inc. Triplide 5,6-derivatives as immunomodulators and anticancer agents
EP1722806A4 (en) * 2004-02-09 2009-09-16 Pharmagenesis Inc METHOD OF ISOLATING TRIPTOLIDE COMPOUNDS FROM TRIPTERYGIUM WILFORDII
JP5057966B2 (ja) 2004-03-02 2012-10-24 ファーマジェネシス， インコーポレイテッド 免疫調節剤および抗癌剤としてのトリプトライドラクトン環誘導体
WO2006012204A2 (en) * 2004-06-25 2006-02-02 Pharmagenesis, Inc. Method for treatment of inflammatory disorders using triptolide compounds
US8617906B2 (en) 2004-10-13 2013-12-31 Pharmagenesis, Inc. Identification and screening of triptolide target molecules
EP1924548B1 (en) * 2005-07-13 2018-03-28 Salvia Sciences, Inc. Ester prodrugs of prostratin and related phorbol compounds
US10144736B2 (en) 2006-07-20 2018-12-04 Gilead Sciences, Inc. Substituted pteridines useful for the treatment and prevention of viral infections
WO2008009078A2 (en) 2006-07-20 2008-01-24 Gilead Sciences, Inc. 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
US8067632B2 (en) * 2007-07-26 2011-11-29 The Board Of Trustees Of The Leland Stanford Junior University Process to produce prostratin and structural or functional analogs thereof
CN101235041B (zh) * 2007-10-26 2013-05-29 北京美迪克斯生物技术有限公司 四种雷公藤甲素衍生物及其制剂的制备方法
CA2750844A1 (en) * 2009-02-05 2010-08-12 Pharmagenesis, Inc. Triptolide c-ring derivatives as anticancer agents and immune modulators
US9150600B2 (en) 2009-05-07 2015-10-06 Regents Of The University Of Minnesota Triptolide prodrugs
WO2010129918A1 (en) 2009-05-07 2010-11-11 Regents Of The University Of Minnesota Triptolide prodrugs
CN102286065B (zh) * 2010-06-18 2012-11-14 中国科学院上海药物研究所 松香烷型二萜衍生物、其制备方法和应用
RS62315B1 (sr) * 2012-08-23 2021-09-30 Senestech Inc Smanjenje reproduktivne sposobnosti sisara
CA2978188C (en) 2015-03-04 2020-05-12 Gilead Sciences, Inc. Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds
WO2016205539A1 (en) * 2015-06-16 2016-12-22 Board Of Regents Of The Nevada System Of Higher Education, On Behalf Of The University Of Nevada, Reno Non-hormonal male contraceptive agents and methods using same
ES2909799T3 (es) * 2015-10-29 2022-05-10 Hangzhou Weben Pharmaceuticals Inc Derivados aminoacídicos de triptólido esterificados en el hidroxilo C14 y método de preparación y uso de los mismos
US10640499B2 (en) 2016-09-02 2020-05-05 Gilead Sciences, Inc. Toll like receptor modulator compounds
WO2018045144A1 (en) 2016-09-02 2018-03-08 Gilead Sciences, Inc. Toll like receptor modulator compounds
CN106890187A (zh) * 2017-02-22 2017-06-27 中山大学附属第三医院 雷公藤甲素及其修饰物在抑制b细胞产生抗体中的应用
CN109021061B (zh) * 2018-09-29 2019-07-12 郭可点 雷公藤甲素靶向前药及其制备方法和应用
TW202210480A (zh) 2019-04-17 2022-03-16 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202212339A (zh) 2019-04-17 2022-04-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202115056A (zh) 2019-06-28 2021-04-16 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法
CN111440185B (zh) * 2020-03-31 2021-05-14 中国农业科学院蜜蜂研究所 一种半抗原及其在检测雷公藤乙素和雷公藤甲素方面的应用
CN115466269A (zh) * 2021-06-11 2022-12-13 复旦大学 一种胆碱碳酸酯类前药及其制备方法和应用
CN114478684B (zh) * 2022-01-21 2023-10-31 南京中医药大学 一类雷公藤甲素前药、其制备方法及其医药用途

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US4005108A (en) * 1973-04-03 1977-01-25 Research Corporation Novel anti-leukemic diterpenoid triepoxides
CA1310009C (en) * 1984-03-28 1992-11-10 John Mark Braughler Ester prodrugs of steroids
CN1027371C (zh) * 1989-09-08 1995-01-11 中国医学科学院皮肤病研究所 二萜内酯化合物的合成方法
CN1052861A (zh) * 1989-12-22 1991-07-10 中国医学科学院皮肤病研究所 雷醇内酯的制备方法及抗生育用途
CN1052860A (zh) * 1989-12-22 1991-07-10 中国医学科学院皮肤病研究所 雷藤氯内酯醇的制备方法及抗生育用途
CN1052859A (zh) * 1989-12-22 1991-07-10 中国医学科学院皮肤病研究所 17-羟基雷藤内酯醇及类似物的结构与制备方法
US5430054A (en) * 1989-12-22 1995-07-04 Jiangsu Family Planning Institute Preparation methods of diterpene lactone compounds and application of the same to antifertility
WO1991013627A1 (en) * 1990-03-14 1991-09-19 The Board Of Regents, The University Of Texas System Tripterygium wilfordii hook f extracts and components thereof for immunosuppression

Also Published As

Publication number Publication date
WO1997031920A1 (en) 1997-09-04
CN1246121A (zh) 2000-03-01
JP2001504437A (ja) 2001-04-03
HK1019444A1 (en) 2000-02-11
EP0907652B1 (en) 2005-05-25
DE69733353D1 (de) 2005-06-30
AU712241B2 (en) 1999-11-04
CA2248266C (en) 2007-10-23
DK0907652T3 (da) 2005-08-08
CA2248266A1 (en) 1997-09-04
AU2125897A (en) 1997-09-16
US5663335A (en) 1997-09-02
EP0907652A1 (en) 1999-04-14
ES2242214T3 (es) 2005-11-01
WO1997031921A1 (en) 1997-09-04
ATE296304T1 (de) 2005-06-15
DE69733353T2 (de) 2006-02-02
CN1133637C (zh) 2004-01-07
AU2061397A (en) 1997-09-16
JP4267697B2 (ja) 2009-05-27

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