CN113318007A - Plumeria rubra polysaccharide antibacterial hand sanitizer and preparation method thereof - Google Patents
Plumeria rubra polysaccharide antibacterial hand sanitizer and preparation method thereof Download PDFInfo
- Publication number
- CN113318007A CN113318007A CN202110651486.5A CN202110651486A CN113318007A CN 113318007 A CN113318007 A CN 113318007A CN 202110651486 A CN202110651486 A CN 202110651486A CN 113318007 A CN113318007 A CN 113318007A
- Authority
- CN
- China
- Prior art keywords
- parts
- polysaccharide
- frangipani
- hand sanitizer
- betaine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/604—Alkylpolyglycosides; Derivatives thereof, e.g. esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials Engineering (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Sustainable Development (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses an egg flower polysaccharide antibacterial hand sanitizer which is prepared from the following raw materials in parts by weight: 3-30 parts of frangipani polysaccharide, 1-3 parts of alkyl glucoside, 1-5 parts of betaine, 1.5-5 parts of coconut oil, 2-6 parts of food-grade glycerol, 0.1-0.5 part of starch, 1-3 parts of citric acid and the balance of deionized water. The invention adopts frangipani polysaccharide with good bacteriostatic effect to replace bacteriostatic agents in the traditional hand sanitizer, and natural surfactants betaine and alkyl glucoside are used to replace surfactants such as cetyl pyridinium ammonium chloride, lauryl sodium sulfate and the like in the traditional hand sanitizer to prepare the novel hand sanitizer. The product can be cleaned efficiently and has a bacteriostatic action, meanwhile, the plant polysaccharide has a good moisturizing effect and an antioxidant function, has little stimulation to skin, can have a skin-care moisturizing effect, and is a green and environment-friendly hand sanitizer.
Description
Technical Field
The invention relates to an egg flower polysaccharide antibacterial hand sanitizer and a preparation method thereof.
Background
Humans are saturated with pathogenic microorganisms, such as sars in 2003, ebola virus in 2014, and new coronavirus that persists to date by the end of 2019. The most contacting parts of the human body are the hands and the arms, and the hands touch the oral cavity, the nasal cavity or the eyes, which can cause various diseases if the user does not pay attention to cleaning. Therefore, the daily chemical product hand sanitizer for cleaning hands daily has a basic cleaning function and also has a bacteriostatic action. However, the conventional hand sanitizer sold in the market at present mainly contains Parachlorometaxylenol (PCMX), o-phenylphenol (OPP), Trichlorocarban (TCC) and the like, and although the conventional hand sanitizer has a good bacteriostatic effect, the conventional hand sanitizer has potential safety hazards to the body, especially during the epidemic situation of new coronary pneumonia, the hand cleaning is more important and frequent, and in order to reduce the irritation of chemical components to the hand skin, the natural green components are adopted to replace the chemical components. The natural plant components such as plant polysaccharide have the effects of clearing away heat and toxic materials, resisting bacteria and preserving moisture, have small toxic and side effects and good biocompatibility, have good antibacterial, antioxidant and moisturizing effects, and can reduce the damage to hand skin and the damage to the body.
The plant polysaccharide is a natural polymer formed by linking aldose or ketose through glycosidic bond, has rich biological activity, and has certain inhibiting effect on gram-positive bacteria and gram-negative bacteria. In addition, it has antioxidant activity for reducing the formation of free radicals and scavenging the free radicals. The frangipani is used as a medicine-food homologous plant, has safe source, and the frangipani polysaccharide used as the plant polysaccharide has the characteristics of biocompatibility, biodegradability and nontoxicity.
Disclosure of Invention
The invention aims to provide a preparation method of a frangipani polysaccharide hand sanitizer which is clean, bacteriostatic, mild, non-irritant, skin-care, skin-nourishing and anti-aging, and aims to solve the problems. The invention adopts an ultrasonic-assisted water body method to extract the frangipani polysaccharide, and determines the optimal extraction conditions through orthogonal experiments so as to facilitate high-efficiency extraction. The frangipani polysaccharide and the coconut oil with good bacteriostatic activity are used for replacing bacteriostatic agents in the traditional hand sanitizer; substituting surfactants such as cetyl pyridinium ammonium chloride, lauryl sodium sulfate, etc. in the traditional hand sanitizer with natural surfactants such as betaine and alkyl glucoside; citric acid is used as a chelating agent; food grade glycerin is used as a humectant; starch is used as a thickener.
Preferably, the preparation method of the frangipani polysaccharide comprises the following steps:
step 1), putting the dried frangipani flowers into a grinder, and grinding the dried frangipani flowers into powder to obtain frangipani flower powder;
step 2), adding petroleum ether into the dried frangipani flower powder, and performing reflux extraction;
step 3), ultrasonically extracting the dried frangipani pollen powder treated by petroleum ether to obtain an aqueous extract of the frangipani;
step 4), centrifuging and decompressing the water extract;
step 5) adding 95% ethanol into the concentrated solution for alcohol precipitation to obtain a precipitate;
step 6), centrifuging the alcohol precipitate and washing the alcohol precipitate by using absolute ethyl alcohol and acetone;
step 7), freezing and drying the washed precipitate to obtain crude frangipani polysaccharide;
more preferably, 10 times the amount of petroleum ether is added in the step 2).
More preferably, the ultrasonic extraction conditions in step 3) are that the ultrasonic power is 264W, the material-liquid ratio is 1: 50(g/mL), an ultrasonic time of 40 ℃ and an ultrasonic temperature of 50 (g/mL).
More preferably, the centrifugation conditions in the step 4) are 6000rpm/min, 20min of time and 4 ℃.
The invention also provides a preparation method of the antibacterial hand sanitizer containing the frangipani polysaccharide, which is characterized in that the raw materials comprise 3-30 per mill of the frangipani polysaccharide, 1-3 per mill of alkyl glucoside, 1-5 per mill of betaine, 1.5-5 per mill of coconut oil, 2-6 per mill of food-grade glycerol, 0.1-0.5 per mill of starch, 1-3 per mill of citric acid and the balance of deionized water by mass percent:
step 1) dissolving alkyl glucoside, betaine and coconut oil in partial deionized water, heating and stirring to form a phase A;
step 2) dissolving food-grade glycerol, starch and citric acid in partial deionized water, heating and stirring to form a phase B;
step 3) dissolving the food frangipani polysaccharide in partial deionized water, heating and stirring to form a phase C;
step 4), uniformly mixing the phase A, the phase B and the phase C, and adjusting the pH value to 5-6; stirring uniformly to obtain transparent gel, and standing for 24 hr.
More preferably, the heating temperature in the step 1) is 45 ℃, and the stirring speed is 500 rpm/min.
More preferably, the heating temperature in the step 2) is 45 ℃, and the stirring speed is 500 rpm/min.
More preferably, the heating temperature in the step 3) is 35 ℃, and the stirring speed is 500 rpm/min.
As a preferable scheme, the hand sanitizer further comprises 0.2-0.6 per mill of soapnut saponin.
As a preferred embodiment, the betaine is selected from any one of lauramidopropyl betaine, cocamidopropyl betaine, and stearamidopropyl betaine.
Compared with the prior art, the invention has the beneficial effects that:
the main components of the invention are frangipani polysaccharide, betaine, coconut oil, alkyl glucoside, food-grade glycerol, starch and citric acid. The natural plant components are used for replacing the traditional chemical synthesis components, so that the product is green and safe. Wherein, the frangipani is a homologous plant of medicine and food, the source is safe, and the frangipani polysaccharide has good bacteriostatic and antioxidant activity, and is an excellent natural bacteriostatic agent. At the same time, the alkyl glucoside has the advantages of common nonionic and anionic surfactants: high surface activity, high viscosity, rich foam, fineness and stability, and obvious synergistic effect when being compounded with betaine. Therefore, the product can be cleaned efficiently and can play a role in bacteriostasis, meanwhile, the plant polysaccharide has good moisturizing effect and antioxidation function and can play a role in skin care and moisturizing, and the frangipani is also a raw material for preparing rare essential oil, so that the natural fragrance can give people excellent sensory experience and make people happy.
Detailed Description
Example 1
The composition comprises 3 parts of frangipani polysaccharide, 1 part of alkyl glucoside, 1 part of lauramidopropyl betaine, 1.5 parts of coconut oil, 2 parts of food-grade glycerol, 0.1 part of starch, 1 part of citric acid and the balance of water.
Example 2
The composition comprises 30 parts of frangipani polysaccharide, 3 parts of alkyl glucoside, 5 parts of cocamidopropyl betaine, 5 parts of coconut oil, 6 parts of food-grade glycerol, 0.5 part of starch, 3 parts of citric acid, 0.2 part of soapberry saponin and the balance of water.
Example 3
The composition comprises 15 parts of frangipani polysaccharide, 2 parts of alkyl glucoside, 3 parts of octadecyl amido propyl betaine, 3.5 parts of coconut oil, 4 parts of food grade glycerol, 0.3 part of starch, 2 parts of citric acid, 0.6 part of soapberry saponin and the balance of water.
Example 4
The composition comprises 20 parts of frangipani polysaccharide, 3 parts of alkyl glucoside, 4 parts of cocamidopropyl betaine, 2.5 parts of coconut oil, 5 parts of food grade glycerol, 0.4 part of starch, 3 parts of citric acid, 0.4 part of soapberry saponin and the balance of water.
Experimental data demonstrating therapeutic efficacy
1. Specific experimental procedures
Experiment 1: the frangipani polysaccharide bacteriostatic hand sanitizer prepared by the invention is used for inhibition experiments on escherichia coli, staphylococcus aureus and candida albicans.
The experimental method comprises the following steps:
1) multiple dilution method
Preparing the Escherichia coli (ATCC25922), Staphylococcus aureus (ATCC25923) and Candida albicans (ATCC90028) into 0.5 McLeod turbidity with nutrient broth, and diluting 1000 times; preparing the frangipani polysaccharide bacteriostatic hand sanitizer prepared in the embodiment 1, the embodiment 2, the embodiment 3 and the embodiment 4 into 50mg/mL aqueous solution for later use; diluting and inoculating the antibacterial drug in a 96-well plate, adding 100 mu L of liquid soap aqueous solution into the 1 st well, adding 100 mu L of liquid culture medium into each well of 2-11 wells, and adding 200 mu L of liquid culture medium into each well of 12 wells; diluting to 10 th hole; adding 100 mu L of bacterial liquid into 1-11 holes; incubate at 37 ℃ for 16-18 hours.
2) Determination of minimum inhibitory concentration
OD (optical density) of mixed sample and bacterial liquid is measured by using enzyme-linked immunosorbent assay600A value of the minimum inhibitory concentration at a sample concentration having no light-absorbing hole at all; the minimum inhibitory concentration was determined by repeated plate culture, and the results are shown in Table 1.
Experiment 2: the experiment on the removal of hydroxyl free radicals by the prepared frangipani polysaccharide antibacterial hand sanitizer is carried out.
The hydroxyl free radical is one of the most active and toxic free radicals, can react with any molecule in living cells of organisms to trigger cytopathic effect of organism tissues, so that diseases and aging of the organisms are caused, and the reaction speed is high, so that the research on the hydroxyl free radical has important significance in the aspects of biological damage and aging.
The experimental method comprises the following steps: configuring 8.8mmol/L H2O2、9mmol/LFeSO4Taking 50 mu L of the prepared 1mg/mL aqueous solution of the bacteriostatic liquid soap of the frangipani polysaccharide in 96-well plates respectively, adding 50 mu L of 9mmol/LFeSO4, adding 50 mu L of salicylic acid-ethanol solution, and finally adding 50 mu L H2O2The reaction was initiated and the absorbance at 510nm was measured as test group A0(ii) a The salicylic acid solution was replaced with pure water as a negative control group of A1(ii) a As a test group, 50. mu.L of pure water was used as A instead of the sample2(ii) a The experiment was repeated three times and the mean value was taken. Radical scavenging rate (%) ═ 1- (A)0-A1)/A2X 100 and the results are shown in Table 2.
2. Results of the experiment
TABLE 1 Minimum Inhibitory Concentration (MIC) of the frangipani bacteriostatic hand sanitizer of the invention on escherichia coli, staphylococcus aureus and candida albicans
The experimental result shows that the product has good bacteriostatic effect on escherichia coli, staphylococcus aureus and candida albicans.
Table 2 experiment of hydroxyl radical scavenging rate of frangipani polysaccharide antibacterial hand sanitizer of the present invention
From the experimental results, the invention has better scavenging effect on hydroxyl free radicals, and further can generate certain protective effect on skin.
The foregoing is a more detailed description of the invention in connection with specific preferred embodiments and it is not intended that the invention be limited to these specific details. It should be noted that any changes or modifications can be made by those skilled in the art without departing from the technical principle of the present invention, and these should be construed as the scope of the present invention.
Claims (3)
1. The composition of the frangipani polysaccharide antibacterial hand sanitizer is characterized in that: comprises 3-30 parts of frangipani polysaccharide, 1-3 parts of alkyl glucoside, 1-5 parts of betaine, 1.5-5 parts of coconut oil, 2-6 parts of food-grade glycerol, 0.1-0.5 part of starch, 1-3 parts of citric acid and the balance of water. The frangipani polysaccharide belongs to plant polysaccharide, and the frangipani is a medicine-food homologous plant, is one of the raw materials of Guangdong herbal tea, and is safe in source. The frangipani polysaccharide has good bacteriostatic effect on gram-positive bacteria, gram-negative bacteria and fungi, has broad-spectrum bacteriostatic activity, and simultaneously has antioxidant activity for reducing the formation of free radicals and removing the free radicals.
It has the features of biocompatibility, less toxic side effect and biodegradability.
Alkyl glucoside: the surfactant has the advantages of common nonionic and anionic surfactants, and has high surface activity, high viscosity, rich foam, and good fineness and stability; has obvious synergistic effect when being compounded with other surfactants. And is stable, non-toxic, soluble, readily biodegradable, and has low irritation to skin.
Betaine: can be compatible with surfactant raw materials, has good stability, low irritation to skin, good biodegradability, excellent decontamination and sterilization effects and good air bubble capability.
Coconut oil: is oil extracted from endosperm of coconut as palm plant by grinding, oven drying and steaming.
Coconut oil is the only grease composed of medium-chain fatty acid in our daily food, the medium-chain fatty acid has natural comprehensive antibacterial ability, when we take medium-chain triglyceride, it is converted into monoglyceride and medium-chain fatty acid in our body, and the two substances have strong antibacterial ability and can kill bacteria, fungi, viruses and parasites which cause diseases.
Glycerol: it can form a film when applied on skin, has effects of isolating air and preventing water evaporation, and can absorb water in air, and keep skin soft and elastic.
Citric acid: the hand sanitizer is an important organic acid, has good hard water resistance, is mild in performance, and can improve the cleaning effect of the hand sanitizer in hard water.
2. The composition of claim 1, wherein: also contains 0.5-1 part of soapnut saponin.
Soapberry saponin: is a natural non-ionic surfactant, can reduce the surface tension of water, has rich foam, fine hand feeling and strong detergency, and has the characteristics of antibiosis, environmental protection, no public nuisance, rich foam, dirt removal, antibiosis, beauty treatment, skin tenderness, whitening, freckle removal, acne removal, skin disease prevention and treatment and the like. The addition of this substance can achieve a more effective cleaning effect.
3. The composition of claim 1, wherein: the betaine is at least one of lauramidopropyl betaine, cocamidopropyl betaine, and stearamidopropyl betaine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110651486.5A CN113318007A (en) | 2021-06-11 | 2021-06-11 | Plumeria rubra polysaccharide antibacterial hand sanitizer and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110651486.5A CN113318007A (en) | 2021-06-11 | 2021-06-11 | Plumeria rubra polysaccharide antibacterial hand sanitizer and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113318007A true CN113318007A (en) | 2021-08-31 |
Family
ID=77420539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110651486.5A Pending CN113318007A (en) | 2021-06-11 | 2021-06-11 | Plumeria rubra polysaccharide antibacterial hand sanitizer and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113318007A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114392209A (en) * | 2021-12-29 | 2022-04-26 | 安吉鲁沃夫生物科技有限公司 | Hand sanitizer with long-acting sterilization effect |
| CN116004326A (en) * | 2023-01-09 | 2023-04-25 | 家宝生物科技香港有限公司 | Infant washing powder and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103610607A (en) * | 2013-11-21 | 2014-03-05 | 云南菩拉美生物科技开发有限公司 | Frangipani hand sanitizer |
| CN105411899A (en) * | 2015-11-24 | 2016-03-23 | 澳宝化妆品（惠州）有限公司 | Plumeria rubra scalp care composition |
| CN107157801A (en) * | 2017-06-13 | 2017-09-15 | 甘肃民族师范学院 | Containing natural Radix Salviae Miltiorrhizae polysaccharide compound antibacterial hand sanitizer and preparation method thereof |
| CN108619032A (en) * | 2018-07-03 | 2018-10-09 | 南京融祥环保科技有限公司 | A kind of apple extract hand cleanser and preparation method thereof |
| CN108935823A (en) * | 2018-09-21 | 2018-12-07 | 广西皇人食品有限公司 | A kind of frangipanis tea beverage and preparation method thereof |
-
2021
- 2021-06-11 CN CN202110651486.5A patent/CN113318007A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103610607A (en) * | 2013-11-21 | 2014-03-05 | 云南菩拉美生物科技开发有限公司 | Frangipani hand sanitizer |
| CN105411899A (en) * | 2015-11-24 | 2016-03-23 | 澳宝化妆品（惠州）有限公司 | Plumeria rubra scalp care composition |
| CN107157801A (en) * | 2017-06-13 | 2017-09-15 | 甘肃民族师范学院 | Containing natural Radix Salviae Miltiorrhizae polysaccharide compound antibacterial hand sanitizer and preparation method thereof |
| CN108619032A (en) * | 2018-07-03 | 2018-10-09 | 南京融祥环保科技有限公司 | A kind of apple extract hand cleanser and preparation method thereof |
| CN108935823A (en) * | 2018-09-21 | 2018-12-07 | 广西皇人食品有限公司 | A kind of frangipanis tea beverage and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 刘莉主编: "《蔬菜营养学》", 30 June 2014, 天津大学出版社 * |
| 高则睿等: "鸡蛋花挥发性成分及药理作用研究进展", 《安徽农业科学》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114392209A (en) * | 2021-12-29 | 2022-04-26 | 安吉鲁沃夫生物科技有限公司 | Hand sanitizer with long-acting sterilization effect |
| CN116004326A (en) * | 2023-01-09 | 2023-04-25 | 家宝生物科技香港有限公司 | Infant washing powder and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107438427B (en) | Shampoo | |
| CN101485622A (en) | Shampoo containing extract of Moringa oleifera and preparation method thereof | |
| CN113318007A (en) | Plumeria rubra polysaccharide antibacterial hand sanitizer and preparation method thereof | |
| EP2563356A2 (en) | A composition for skin sanitization and protection and method of its use | |
| CN103735458A (en) | Novel anti-allergy repairing composition for skin | |
| CN105326681B (en) | A kind of anti-bacterial hand lotion containing Folium Artemisiae Argyi extract and preparation method thereof | |
| CN109125096A (en) | Foam liquid soap and preparation method thereof | |
| CN108113942A (en) | A kind of sterilization non-water hand cleanser and preparation method thereof | |
| CN105482915A (en) | Skin-protecting bactericidal cleanser essence | |
| CA2882392C (en) | Antiseptic, antiseborrheic and exfoliating composition to remove or prevent acne | |
| KR102226774B1 (en) | Detergent comprising the extract of astragalus membranaceus, polydonati rhizoma and pine leaf, and the method of manufacturing thereof | |
| CN109453083B (en) | Moisturizing and allergy-relieving composition and application thereof | |
| CN109010178B (en) | Shower gel and production process thereof | |
| CN104490679B (en) | A kind of composite bactericidal hand cleanser and preparation method thereof | |
| CN112641699A (en) | Antibacterial wet tissue and preparation method thereof | |
| CN112675086A (en) | Passion fruit hand-washing-free gel hand sanitizer and preparation method thereof | |
| CN108451799A (en) | A kind of hand cleanser and preparation method thereof | |
| CN104248528A (en) | Natural seaweed gel-containing multifunctional shower gel | |
| CN106361595A (en) | Zhiyan introduced solvent essence | |
| CN105326680A (en) | Hand sanitizer for children | |
| CN104414909A (en) | Chitosan washing-free hand sanitizer | |
| CN108852888B (en) | Mild and non-irritant shower gel and preparation method thereof | |
| KR20150116504A (en) | A cosmetics composition containing tea tree and solt | |
| CN108403492A (en) | A kind of biological enzyme processing and corrosion-resistant antiallergy plant extraction liquid and the preparation method and application thereof | |
| CN104224605A (en) | Enteromorpha fiber antibacterial sanitary wet tissue |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20210831 |